Mechanisms of hepatic fibrogenesis

Best Practice and Research: Clinical Gastroenterology

Volumn 25, Issue 2, 2011, Pages 195-206

  Lee, Ursula E ^a   Friedman, Scott L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adipokines; Fibrogenesis; Growth factors; Immune cells; Stellate cell; Tyrosine kinase

Indexed keywords

ADIPONECTIN; ANTIOXIDANT; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; EPIDERMAL GROWTH FACTOR; FARNESOID X RECEPTOR; HEPARAN SULFATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOQUINONE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLATELET DERIVED GROWTH FACTOR; RANTES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SORAFENIB; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANGIOGENESIS; ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CHRONIC LIVER DISEASE; COMPETITIVE INHIBITION; CYTOKINE RELEASE; DENDRITIC CELL; DOWN REGULATION; EFFECTOR CELL; EXTRACELLULAR MATRIX; FIBROGENESIS; GENE CONTROL; HEPATIC FIBROGENESIS; HEPATITIS C; HUMAN; IMMUNOCOMPETENT CELL; KUPFFER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER PARENCHYMA; LIVER PROTECTION; LIVER REGENERATION; LIVER TOXICITY; NATURAL KILLER CELL; NEUTROPHIL CHEMOTAXIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STELLATE CELL; WOUND HEALING;

ANIMALS; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; SIGNAL TRANSDUCTION;

EID: 79954487874     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpg.2011.02.005     Document Type: Article

References (102)

1. K. Wake Structure of the sinusoidal wall in the liver E. Wisse, D.L. Knook, K. Wake, Cells of the hepatic sinusoid 1995 The Kupffer Cell Foundation Leiden 241 246
2. P. Bioulac-Sage, M.E. Lafon, and J. Saric Nerves and perisinusoidal cells in human liver J Hepatol 10 1990 105 112 (Pubitemid 20006996)
3. T. Ueno, M. Sata, and R. Sakata Hepatic stellate cells and intralobular innervation in human liver cirrhosis Hum Pathol 28 1997 953 959 (Pubitemid 27355556)
4. A. Bonacchi, I. Petrai, and R.M. Defranco The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C Gastroenterology 125 2003 1060 1076 (Pubitemid 37193453)
5. R. Bataller, and D.A. Brenner Liver fibrosis J Clin Invest 115 2005 209 218 (Pubitemid 40385459)
6. S.L. Friedman Mechanisms of hepatic fibrosis and therapeutic implications Nat Clin Pract Gastroenterol Hepatol 1 2004 98 105 (Pubitemid 40823677)
7. V. Krizhanovsky, M. Yon, and R.A. Dickins Senescence of activated stellate cells limits liver fibrosis Cell 134 2008 657 667
8. L. Wong, G. Yamasaki, and R.J. Johnson Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture J Clin Invest 94 1994 1563 1569
9. J.D. Kelly, B.A. Haldeman, and F.J. Grant Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation J Biol Chem 266 1991 8987 8992 (Pubitemid 21906608)
10. P. Failli, C. Ruocco, and F.R. De The mitogenic effect of platelet-derived growth factor in human hepatic stellate cells requires calcium influx Am J Physiol 1995 C1133 C1139
11. E. Borkham-Kamphorst, E. Kovalenko, and C.R. van Roeyen Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury Lab Invest 88 2008 1090 1100
12. E. Borkham-Kamphorst, D. Stoll, and A.M. Gressner Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis Biochem Biophys Res Commun 321 2004 413 423 (Pubitemid 39055762)
13. S. Ogawa, T. Ochi, and H. Shimada Anti-PDGF-B monoclonal antibody reduces liver fibrosis development Hepatol Res 40 2010 1128 1141
14. Y. Wang, J. Gao, and D. Zhang New insights into the anti-fibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis J Hepatol 2010
15. J. Kluwe, J.P. Pradere, and G.Y. Gwak Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition Gastroenterology 138 2010 347 359
16. D.H. Meyer, M.G. Bachem, and A.M. Gressner Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type beta 1 and type alpha Biochem Biophys Res Commun 171 1990 1122 1129 (Pubitemid 20318067)
17. K.M. Win, F. Charlotte, and A. Mallat Mitogenic effect of transforming growth factor-beta 1 on human Ito cells in culture: evidence for mediation by endogenous platelet-derived growth factor Hepatology 18 1993 137 145 (Pubitemid 23193628)
18. B. Mullhaupt, A. Feren, and E. Fodor Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration J Biol Chem 269 1994 19667 19670
19. F. Marra, G. Grandaliano, and A.J. Valente Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury Hepatology 22 1995 780 787
20. F. Marra, R. DeFranco, and C. Grappone Expression of the thrombin receptor in human liver: up-regulation during acute and chronic injury Hepatology 27 1998 462 471 (Pubitemid 28081061)
21. H. Steiling, M. Muhlbauer, and F. Bataille Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease Am J Pathol 165 2004 1233 1241 (Pubitemid 39297729)
22. C. Yu, F. Wang, and C. Jin Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis Am J Pathol 163 2003 1653 1662 (Pubitemid 37175112)
23. D. Schuppan, M. Ruehl, and R. Somasundaram Matrix as modulator of stellate cell and hepatic fibrogenesis Semin Liver Dis 21 2001 351 372 (Pubitemid 32923765)
24. B. Brown, K. Lindberg, and J. Reing The basement membrane component of biologic scaffolds derived from extracellular matrix Tissue Eng 12 2006 519 526 (Pubitemid 43673457)
25. Y. Inagaki, and I. Okazaki Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis Gut 56 2007 284 292
26. K. Breitkopf, P. Godoy, and L. Ciuclan TGF-beta/Smad signaling in the injured liver Z Gastroenterol 44 2006 57 66
27. Yang L, Pang Y, Moses HL. TGF-beta and immune cells: an important regulatory axis in the tumour microenvironment and progression. Trends Immunol; 31:220-227.
28. Z. Li, J.A. Oben, and S. Yang Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis Hepatology 40 2004 434 441 (Pubitemid 39062861)
29. L. Chen, A.L. Charrier, and A. Leask Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor J Hepatol 2010
30. C. Hora, F. Negro, and G. Leandro Connective tissue growth factor, steatosis and fibrosis in patients with chronic hepatitis C Liver Int 28 2008 370 376 (Pubitemid 351279585)
31. O.A. Gressner, B. Lahme, and I. Demirci Differential effects of TGF-beta on connective tissue growth factor [CTGF/CCN2] expression in hepatic stellate cells and hepatocytes J Hepatol 47 2007 699 710 (Pubitemid 47503426)
32. E. Kovalenko, F. Tacke, and O.A. Gressner Validation of connective tissue growth factor [CTGF/CCN2] and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis J Viral Hepat 2009
33. Wasmuth HE, Tacke F, Trautwein C. Chemokines in liver inflammation and fibrosis. Semin Liver Dis; 30:215-225.
34. H. Sahin, C. Trautwein, and H.E. Wasmuth Functional role of chemokines in liver disease models Nat Rev Gastroenterol Hepatol 7 2010 682 690
35. R.F. Schwabe, R. Bataller, and D.A. Brenner Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration Am J Physiol Gastrointest Liver Physiol 285 2003 G949 G958
36. E. Seki, S. De Minicis, and G.Y. Gwak CCR1 and CCR5 promote hepatic fibrosis in mice J Clin Invest 119 2009 1858 1870
37. M.M. Zaldivar, K. Pauels, and P. von Hundelshausen CXC chemokine ligand 4 [Cxcl4] is a platelet-derived mediator of experimental liver fibrosis Hepatology 51 2010 1345 1353
38. H.E. Wasmuth, F. Lammert, and M.M. Zaldivar Anti-fibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans Gastroenterology 137 2009 309 319 319 e1-3
39. F. Marra, and C. Bertolani Adipokines in liver diseases Hepatology 50 2009 957 969
40. K. Ikejima, K. Okumura, and K. Kon Role of adipocytokines in hepatic fibrogenesis J Gastroenterol Hepatol 22 Suppl. 1 2007 S87 S92
41. I.A. Leclercq, G.C. Farrell, and R. Schriemer Leptin is essential for the hepatic fibrogenic response to chronic liver injury J Hepatol 37 2002 206 213 (Pubitemid 34833082)
42. M.A. Hoteit, and F.A. Anania Treatment of fibrosis in nonalcoholic fatty liver disease Curr Gastroenterol Rep 9 2007 47 53 (Pubitemid 46487024)
43. Y. Zhou, X. Jia, and G. Wang PI-3 K/AKT and ERK signaling pathways mediate leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells Mol Cell Biochem 325 2009 131 139
44. S.S. Choi, W.K. Syn, and G.F. Karaca Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway J Biol Chem 2010
45. I. Wedemeyer, L.P. Bechmann, and M. Odenthal Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: therapeutic implications for hepatitis C J Hepatol 50 2009 140 149
46. K. Yamaguchi, L. Yang, and S. McCall Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis Hepatology 45 2007 1366 1374 (Pubitemid 46918320)
47. B. Mukhopadhyay, J. Liu, and D. Osei-Hyiaman Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma J Biol Chem 285 2010 19002 19011
48. W.I. Jeong, D. Osei-Hyiaman, and O. Park Paracrine activation of hepatic CB[1] receptors by stellate cell-derived Endocannabinoids mediates alcoholic fatty liver Cell Metab 7 2008 227 235 (Pubitemid 351285525)
49. J. Tam, V.K. Vemuri, and J. Liu Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity J Clin Invest 120 2010 2953 2966
50. F. Teixeira-Clerc, B. Julien, and P. Grenard CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis Nat Med 12 2006 671 676 (Pubitemid 43865236)
51. F. Teixeira-Clerc, M.P. Belot, and S. Manin Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration Hepatology 52 2010 1046 1059
52. S. De Minicis, C. Candelaresi, and M. Marzioni Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo Gut 57 2008 352 364 (Pubitemid 351288102)
53. R.G. Ruddell, F. Oakley, and Z. Hussain A role for serotonin [5-HT] in hepatic stellate cell function and liver fibrosis Am J Pathol 169 2006 861 876 (Pubitemid 44411953)
54. I. Zvibel, D. Atias, and A. Phillips Thyroid hormones induce activation of rat hepatic stellate cells through increased expression of p75 neurotrophin receptor and direct activation of Rho Lab Invest 90 2010 674 684
55. C. Hellerbrand, S.C. Wang, and H. Tsukamoto Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells Hepatology 24 1996 670 676 (Pubitemid 26296014)
56. M. Bomble, F. Tacke, and L. Rink Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts Biochem Biophys Res Commun 396 2010 342 347
57. B. Gao, S. Radaeva, and O. Park Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases J Leukoc Biol 86 2009 513 528
58. G. Szabo, P. Mandrekar, and A. Dolganiuc Innate immune response and hepatic inflammation Semin Liver Dis 27 2007 339 350 (Pubitemid 350071835)
59. N. Muhanna, L.A. Tair, and S. Doron Amelioration of hepatic fibrosis by NK cell activation Gut 60 2011 90 98
60. T.A. Wynn, and L. Barron Macrophages: master regulators of inflammation and fibrosis Semin Liver Dis 30 2010 245 257
61. C. Liu, Q. Tao, and M. Sun Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats Lab Invest 90 2010 1805 1816
62. P.A. Knolle, and G. Gerken Local control of the immune response in the liver Immunol Rev 174 2000 21 34 (Pubitemid 30201376)
63. J. Guo, J. Loke, and F. Zheng Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of toll-like receptor 4 to hepatic stellate cell responses Hepatology 49 2009 960 968
64. J.P. Pradere, J.S. Troeger, and D.H. Dapito Toll-like receptor 4 and hepatic fibrogenesis Semin Liver Dis 30 2010 232 244
65. E. Seki, S. De Minicis, and C.H. Osterreicher TLR4 enhances TGF-beta signaling and hepatic fibrosis Nat Med 13 2007 1324 1332 (Pubitemid 350073596)
66. M. Pinzani, H.E. Abboud, and L. Gesualdo Regulation of macrophage colony-stimulating factor in liver fat-storing cells by peptide growth factors Am J Physiol 262 1992 C876 C881
67. M.J. Czaja, A. Geerts, and J. Xu Monocyte chemoattractant protein 1 [MCP-1] expression occurs in toxic rat liver injury and human liver disease J Leukoc Biol 55 1994 120 126 (Pubitemid 24039594)
68. A.M. Tiggelman, W. Boers, and C. Linthorst Interleukin-6 production by human liver [myo]fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha J Hepatol 23 1995 295 306
69. Z. Li, S. Yang, and H. Lin Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology 37 2003 343 350 (Pubitemid 36152533)
70. E.L. Guimaraes, C. Empsen, and A. Geerts Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells J Hepatol 52 2010 389 397
71. H. Jaeschke Inflammation in response to hepatocellular apoptosis Hepatology 35 2002 964 966
72. S.S. Zhan, J.X. Jiang, and J. Wu Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo Hepatology 43 2006 435 443
73. J.X. Jiang, K. Mikami, and S. Venugopal Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways J Hepatol 51 2009 139 148
74. A. Watanabe, A. Hashmi, and D.A. Gomes Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9 Hepatology 46 2007 1509 1518 (Pubitemid 350155533)
75. A. Melhem, N. Muhanna, and A. Bishara Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC J Hepatol 45 2006 60 71 (Pubitemid 43850614)
76. W. Mehal, and A. Imaeda Cell death and fibrogenesis Semin Liver Dis 30 2010 226 231
77. T. Knittel, C. Dinter, and D. Kobold Expression and regulation of cell adhesion molecules by hepatic stellate cells [HSC] of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair Am J Pathol 154 1999 153 167 (Pubitemid 29031623)
78. O. Rosmorduc, and C. Housset Hypoxia: a link between fibrogenesis, angiogenesis, and carcinogenesis in liver disease Semin Liver Dis 30 2010 258 270
79. N. Kinnman, and C. Housset Peribiliary myofibroblasts in biliary type liver fibrosis Front Biosci 7 2002 D496 D503
80. D. Sims Recent Advances in pericyte biology and implications for health and disease Can J Cardiol 7 1991 431 443
81. M.S. Thimgan, and H.F. Yee Jr. Quantitation of rat hepatic stellate cell contraction: stellate cells' contribution to sinusoidal resistance Am J Physiol 277 1999 G137 G143
82. R. Shao, W. Yan, and D.C. Rockey Regulation of endothelin-1 synthesis by endothelin-converting enzyme-1 during wound healing J Biol Chem 274 1999 3228 3234 (Pubitemid 29075413)
83. X. Zhang, P. Shan, and L.E. Otterbein Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3 J Biol Chem 278 2003 1248 1258 (Pubitemid 36790808)
84. N.G. Theodorakis, Y.N. Wang, and J.M. Wu Role of endothelial nitric oxide synthase in the development of portal hypertension in the carbon tetrachloride induced liver fibrosis model Am J Physiol Gastrointest Liver Physiol 2009
85. G.A. MacDonald, K.R. Bridle, and P.J. Ward Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3 J Gastroenterol Hepatol 16 2001 599 606 (Pubitemid 34188832)
86. S. De Minicis, and D.A. Brenner NOX in liver fibrosis Arch Biochem Biophys 462 2007 266 272 (Pubitemid 46856330)
87. Rao VA, Klein SR, Bonar SJ, et al. The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. J Biol Chem; 285:34447-34459.
88. Gane EJ, Weilert F, Orr DW, et al. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int; 30:1019-1026.
89. H. Wobser, C. Dorn, and T.S. Weiss Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells Cell Res 19 2009 996 1005
90. A. Kasdallah-Grissa, B. Mornagui, and E. Aouani Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver Life Sci 80 2007 1033 1039 (Pubitemid 46204723)
91. L.P. Bechmann, D. Zahn, and R.K. Gieseler Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells Hepatol Res 39 2009 601 608
92. J. Mann, and D.A. Mann Transcriptional regulation of hepatic stellate cells Adv Drug Deliv Rev 61 2009 497 512
93. R.A. Rippe, and D.A. Brenner From quiescence to activation: gene regulation in hepatic stellate cells Gastroenterology 127 2004 1260 1262 (Pubitemid 39345894)
94. J. Mann, F. Oakley, and F. Akiboye Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis Cell Death Differ 14 2007 275 285 (Pubitemid 46092230)
95. H. Tsukamoto, H. She, and S. Hazra Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation J Gastroenterol Hepatol 21 Suppl. 3 2006 S102 S105
96. S.L. Friedman Hepatic stellate cells - protean, multifunctional, and enigmatic cells of the liver Physiol Rev 88 2008 125 172
97. E. Wandzioch, A. Kolterud, and M. Jacobsson Lhx2-/- mice develop liver fibrosis Proc Natl Acad Sci U S A 101 2004 16549 16554 (Pubitemid 39557750)
98. M. Adachi, Y. Osawa, and H. Uchinami The Forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells Gastroenterology 132 2007 1434 1446 (Pubitemid 46627569)
99. G.C. Huang, J.S. Zhang, and Q.Q. Tang Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells Biochem Biophys Res Commun 324 2004 1309 1318
100. K. Ramani, H. Yang, and J. Kuhlenkamp Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation Hepatology 51 2010 986 995
101. R. Garzon, G. Marcucci, and C.M. Croce Targeting microRNAs in cancer: rationale, strategies and challenges Nat Rev Drug Discov 9 2010 775 789
102. C. Roderburg, G.W. Urban, and K. Bettermann Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis Hepatology 2010