Intestinal immune barrier integrity in rats with nonalcoholic hepatic steatosis and steatohepatitis

Chinese Medical Journal

Volumn 125, Issue 2, 2012, Pages 306-311

  Su, Lin ^a,b   Wang, Jian Hua ^b   Cong, Xu ^a   Wang, Li Hong ^a   Liu, Feng ^a   Xie, Xing Wang ^a   Zhang, Heng Hui ^a   Wang, Jiang Hua ^a,b   Fei, Ran ^a   Liu, Yu Lan ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

CD4 CD8; Endotoxins; Immunoglobulin A; Intestinal immune barrier; Non alcoholic fatty liver disease; Secretory

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE; SECRETORY IMMUNOGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; BLOOD LEVEL; CD4 CD8 RATIO; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; HEPATITIS; IMMUNOPATHOGENESIS; INTESTINE MUCOSA PERMEABILITY; INTESTINE SECRETION; LIPID DIET; MALE; MUCOSAL IMMUNITY; NONALCOHOLIC FATTY LIVER; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PEYER PATCH; PROTEIN EXPRESSION; RAT; STEATOHEPATITIS; UPREGULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FATTY LIVER; IMMUNOGLOBULIN A, SECRETORY; INTESTINES; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862923545     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2012.02.026     Document Type: Article

References (39)

1. Day CP, James O. Steatohepatitis: a tale of two "hits"? Gastroenterol 1998; 114: 842-845.
2. Day CP. Non-alcoholic steatohepatitis (NASH): where are we now and where are we going? Gut 2002; 50: 585-588.
3. Poonawala A, Nair SP, Thuluvath PJ. Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 2000; 32: 689-692.
4. Reid AE. Nonalcoholic steatohepatitis. Gastroenterology 2001; 121: 710-723.
5. Brun P, Castagliuolo I, Di Leo V, Buda A, Pinzani M, Palu G,et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 292: G518-G525.
6. Farhadi A, Gundlapalli S, Shaikh M, Frantzides C, Harrell L, Kwasny M, et al. Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis. Liver Int 2008; 28: 1026-1033.
7. Harte AL, da Silva NF, Creely SJ, McGee KC, Billyard T, Youssef-Elabd EM, et al. Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflamm (Lond) 2010; 7: 15.
8. Creely SJ, McTernan PG, Kusminski CM, Fisher M, Da Silva NF, Khanolkar M, et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 2007; 292: E740-E747.
9. Baumgart DC, Dignass AU. Intestinal barrier function. Curr Opin Clin Nutr Metab Care 2002; 5: 685-694.
10. Sakaguchi T, Brand S, Reinecker HC. Mucosal barrier and immune mediators. Curr Opin Gastroenterol 2001; 17: 573-577.
11. Tlaskalová-Hogenová H, Farré-Castany MA, Stepánková R, Kozáková H, Tucková L, Funda DP, et al. The gut as a lymphoepithelial organ: the role of intestinal epithelial cells in mucosal immunity. Folia Microbiol (Praha) 1995; 40: 385-391.
12. Sydora BC, Martin SM, Lupicki M, Dieleman LA, Doyle J, Walker JW, et al. Bacterial antigens alone can influence intestinal barrier integrity, but live bacteria are required for initiation of intestinal inflammation and injury. Inflamm Bowel Dis 2006; 12: 429-436.
13. Wigg AJ, Roberts-Thomson I, Dymock R, McCarthy PJ, Grose RH, Cummins AG. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumor necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 2001; 48: 206-211.
14. Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009; 49: 1877-1887.
15. Solga SF, Diehl A. Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. J Hepatol 2003; 38: 681-687.
16. Kim CS, Lee SC, Kim YM, Kim BS, Choi HS, Kawada T, et al. Visceral fat accumulation induced by a high-fat diet causes the atrophy of mesenteric lymph nodes in obese mice. Obesity 2008; 16: 1261-1269.
17. Adams DH, Eksteen B, Curbishley SM. Immunology of the gut and liver: a love/hate relationship. Gut 2008; 57: 838-848.
18. Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307: 254-258.
19. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001; 2: 361-367.
20. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321.
21. Thurman RG. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998; 275: G605-G611.
22. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 2007; 13: 1324-1332.
23. Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Königsrainer A, et al. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr 2008; 138: 1452-1455.
24. Li S, Wu W, He C, Han Z, Jin D, Wang L. Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats. World J Gastroenterol 2008; 14: 3254-3258.
25. Matsuzawa N, Takamura T, Kurita S, Misu H, Ota T, Ando H, et al. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 2007; 46: 1392-1403.
26. Brun P, Castagliuolo I, Floreani AR, Buda A, Blasone L, Palu G, et al. Increased risk of NASH in patients carrying the C(-159)T polymorphism in the CD14 gene promoter region. Gut 2006; 55: 1212.
27. Haas P, Straub RH, Bedoui S, Nave H. Peripheral but not central leptin treatment increases numbers of circulating NK cells, granulocytes and specific monocyte subpopulations in non-endotoxaemic lean and obese LEW-rats. Regul Pept 2008; 151: 26-34.
28. Li H, Lelliott C, Håkansson P, Ploj K, Tuneld A, Verolin-Johansson M. Intestinal, adipose, and liver inflammation in diet-induced obese mice. Metabolism 2008; 57: 1704-1710.
29. Svec P, Vásárhelyi B, Pászthy B, Komer A, Kovacs L, Tulassay T, et al. Do regulatory T cells contribute to Th1 skewness in obesity? Exp Clin Endocrinol Diabetes 2007; 115: 439-443.
30. Li S, Wu WC, He CY, Han Z, Jin DY, Wang L. Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats. World J Gastroenterol 2008; 14: 3254-3258.
31. Zaret KS. Regulatory phases of early liver development: paradigms of organogenesis. Nat Rev Genet 2002; 3: 499-512.
32. Broome U, Olsson R, Loof L, Bodemar G, Hultcrantz R, Danielsson A, et al. Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis. Gut 1996; 38: 610-615.
33. Bigorgne AE, Bouchet-Delbos L, Naveau S, Dagher I, Prévot S, Durand-Gasselin I, et al. Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of fatty liver inflammation in obese mice. Gastroenterology 2008; 134: 1459-1469.
34. Knolle PA, Limmer A. Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells. Trends Immunol 2001; 22: 432-437.
35. Uhrig A, Banafsche R, Kremer M, Hegenbarth S, Hamann A, Neurath M, et al. Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver. J Leukoc Biol 2005; 77: 626-633.
36. Knolle PA, Gerken G. Local control of the immune response in the liver. Immunol Rev 2000; 174: 21-34.
37. Darshan D, Anderson GJ. Liver-gut axis in the regulation of iron homeostasis. World J Gastroenterol 2007; 13: 4737-4745.
38. Limmer A, Ohl J, Wingender G, Berg M, Jüngorkes F, Schumak B, et al. Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur J Immunol 2005; 35: 2970-2981.
39. Lunz JG 3rd, Specht SM, Murase N, Isse K, Demetris AJ. Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity. Hepatology 2007; 46: 1946-1959.