Erratum: Control of cell growth: Rag GTPases in activation of TORC1 (Cellular and Molecular Life Sciences (DOI 10.1007/s00018-012-1195-y));Control of cell growth: Rag GTPases in activation of TORC1

Cellular and Molecular Life Sciences

Volumn 70, Issue 16, 2013, Pages 2873-2885

  Yang, Huirong ^a,b   Gong, Rui ^a,b   Xu, Yanhui ^a,b,c  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Amino acid; Cell growth; Rag GTPase; Target of rapamycin; TORC1

Indexed keywords

AMINO ACID; BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; LEUCINE TRANSFER RNA LIGASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN P62; PROTEIN SH3BP4; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAGULATOR COMPLEX; RAS ASSOCIATED GUANOSINE TRIPHOSPHATASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VAM6 PROTEIN;

CELL ENERGY; CELL GROWTH; CELL STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STRUCTURE; GROWTH REGULATION; HUMAN; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84881154184     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1271-y     Document Type: Erratum

References (115)

1. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124(3):471-484
2. Yang Q, Guan KL (2007) Expanding mTOR signaling. Cell Res 17(8):666-681
3. Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12(1):9-22
4. Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12(1):21-35
5. Kim J, Guan KL (2011) Amino acid signaling in TOR activation. Annu Rev Biochem 80:1001-1032
6. Russell RC, Fang C, Guan KL (2011) An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development 138(16):3343-3356
7. Tormos KV, Anso E, Hamanaka RB, et al. (2011) Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metab 14(4):537-544
8. Laplante M, Sabatini DM (2009) An emerging role of mTOR in lipid biosynthesis. Curr Biol 19(22):R1046-R1052
9. Duran RV, Hall MN (2012) Regulation of TOR by small GTPases. EMBO Rep 13(2):121-128
10. Tee AR, Blenis J (2005) mTOR, translational control and human disease. Semin Cell Dev Biol 16(1):29-37
11. Inoki K, Corradetti MN, Guan KL (2005) Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37(1):19-24
12. Harrington LS, Findlay GM, Lamb RF (2005) Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci 30(1):35-42
13. Polak P, Hall MN (2009) mTOR and the control of whole body metabolism. Curr Opin Cell Biol 21(2):209-218
14. Dazert E, Hall MN (2011) mTOR signaling in disease. Curr Opin Cell Biol 23(6):744-755
15. Benjamin D, Colombi M, Moroni C, et al. (2011) Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov 10(11):868-880
16. Hara K, Yonezawa K, Weng QP, et al. (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273(23):14484-14494
17. Kim E, Goraksha-Hicks P, Li L, et al. (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10(8):935-945
18. Sancak Y, Peterson TR, Shaul YD, et al. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320(5882):1496-1501
19. Zoncu R, Bar-Peled L, Efeyan A, et al. (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 334(6056):678-683
20. Sancak Y, Bar-Peled L, Zoncu R, et al. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141(2):290-303
21. Gong R, Li L, Liu Y, et al. (2011) Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes Dev 25(16):1668-1673
22. Kogan K, Spear ED, Kaiser CA, et al. (2010) Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals. J Mol Biol 402(2):388-398
23. Binda M, Peli-Gulli MP, Bonfils G, et al. (2009) The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell 35(5):563-573
24. Han JM, Jeong SJ, Park MC, et al. (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149(2):410-424
25. Bonfils G, Jaquenoud M, Bontron S, et al. (2012) Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol Cell 46(1):105-110
26. Kim YM, Stone M, Hwang TH, et al. (2012) SH3BP4 is a negative regulator of amino acid-rag GTPase-mTORC1 signaling. Mol Cell 46(6):833-846
27. Heitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253(5022):905-909
28. Siekierka JJ, Wiederrecht G, Greulich H, et al. (1990) The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase. J Biol Chem 265(34):21011-21015
29. Sabatini DM, Erdjument-Bromage H, Lui M, et al. (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78(1):35-43
30. Peng T, Golub TR, Sabatini DM (2002) The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol 22(15):5575-5584
31. Sengupta S, Peterson TR, Sabatini DM (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40(2):310-322
32. Holz MK, Ballif BA, Gygi SP, et al. (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123(4):569-580
33. Holz MK, Blenis J (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 280(28):26089-26093
34. Gingras AC, Gygi SP, Raught B, et al. (1999) Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev 13(11):1422-1437
35. Pause A, Belsham GJ, Gingras AC, et al. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371(6500):762-767
36. Hara K, Yonezawa K, Kozlowski MT, et al. (1997) Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem 272(42):26457-26463
37. Beamish H, Williams R, Chen P, et al. (1996) Rapamycin resistance in ataxia-telangiectasia. Oncogene 13(5):963-970
38. Pullen N, Thomas G (1997) The modular phosphorylation and activation of p70s6k. FEBS Lett 410(1):78-82
39. Ma XM, Blenis J (2009) Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10(5):307-318
40. Harrington LS, Findlay GM, Gray A, et al. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166(2):213-223
41. Codogno P, Meijer AJ (2005) Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12(Suppl 2):1509-1518
42. Kamada Y, Funakoshi T, Shintani T, et al. (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150(6):1507-1513
43. Hosokawa N, Hara T, Kaizuka T, et al. (2009) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 20(7):1981-1991
44. Jung CH, Jun CB, Ro SH, et al. (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20(7):1992-2003
45. Ganley IG, du Lam H, Wang J, et al. (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284(18):12297-12305
46. Schieke SM, Finkel T (2006) Mitochondrial signaling, TOR, and life span. Biol Chem 387(10-11):1357-1361
47. Schieke SM, Phillips D, McCoy JP Jr, et al. (2006) The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem 281(37):27643-27652
48. Inoki K, Li Y, Xu T, et al. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17(15):1829-1834
49. Garami A, Zwartkruis FJ, Nobukuni T, et al. (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11(6):1457-1466
50. Tee AR, Manning BD, Roux PP, et al. (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13(15):1259-1268
51. Manning BD, Tee AR, Logsdon MN, et al. (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10(1):151-162
52. Potter CJ, Pedraza LG, Xu T (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4(9):658-665
53. Stocker H, Radimerski T, Schindelholz B, et al. (2003) Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 5(6):559-565
54. Saucedo LJ, Gao X, Chiarelli DA, et al. (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 5(6):566-571
55. Sancak Y, Thoreen CC, Peterson TR, et al. (2007) PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25(6):903-915
56. Hardie DG (2007) AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 8(10):774-785
57. Inoki K, Zhu T, Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115(5):577-590
58. Inoki K, Ouyang H, Zhu T, et al. (2006) TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126(5):955-968
59. Corradetti MN, Inoki K, Bardeesy N, et al. (2004) Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18(13):1533-1538
60. Gwinn DM, Shackelford DB, Egan DF, et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30(2):214-226
61. Brugarolas J, Lei K, Hurley RL, et al. (2004) Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18(23):2893-2904
62. Reiling JH, Hafen E (2004) The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev 18(23):2879-2892
63. Ellisen LW, Ramsayer KD, Johannessen CM, et al. (2002) REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 10(5):995-1005
64. Feng Z, Zhang H, Levine AJ, et al. (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 102(23):8204-8209
65. Stambolic V, MacPherson D, Sas D, et al. (2001) Regulation of PTEN transcription by p53. Mol Cell 8(2):317-325
66. Wang X, Campbell LE, Miller CM, et al. (1998) Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem J 334(Pt 1):261-267
67. Byfield MP, Murray JT, Backer JM (2005) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280(38):33076-33082
68. 2+/CaM signaling to hVps34. Cell Metab 7(5):456-465
69. Nobukuni T, Kozma SC, Thomas G (2007) hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Curr Opin Cell Biol 19(2):135-141
70. Juhasz G, Hill JH, Yan Y, et al. (2008) The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol 181(4):655-666
71. Findlay GM, Yan L, Procter J, et al. (2007) A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J 403(1):13-20
72. Yan L, Mieulet V, Burgess D, et al. (2010) PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. Mol Cell 37(5):633-642
73. 2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Biochem J 417(3):747-755
74. Duran A, Amanchy R, Linares JF, et al. (2011) p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell 44(1):134-146
75. Pisarewicz K, Mora D, Pflueger FC, et al. (2005) Polypeptide chains containing d-gamma-hydroxyvaline. J Am Chem Soc 127(17):6207-6215
76. McArthur KE, Isenberg JI, Hogan DL, et al. (1983) Intravenous infusion of l-isomers of phenylalanine and tryptophan stimulate gastric acid secretion at physiologic plasma concentrations in normal subjects and after parietal cell vagotomy. J Clin Invest 71(5):1254-1262
77. 2+-sensing receptor. Proc Natl Acad Sci USA 97(9):4814-4819
78. San Gabriel A, Uneyama H (2012) Amino acid sensing in the gastrointestinal tract. Amino Acids
79. Crespo JL, Powers T, Fowler B, et al. (2002) The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci USA 99(10):6784-6789
80. Iiboshi Y, Papst PJ, Kawasome H, et al. (1999) Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem 274(2):1092-1099
81. Bun-Ya M, Harashima S, Oshima Y (1992) Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol Cell Biol 12(7):2958-2966
82. Nakashima N, Hayashi N, Noguchi E, et al. (1996) Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae. J Cell Sci 109(Pt 9):2311-2318
83. Nakashima N, Noguchi E, Nishimoto T (1999) Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152(3):853-867
84. Schurmann A, Brauers A, Massmann S, et al. (1995) Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. J Biol Chem 270(48):28982-28988
85. Hirose E, Nakashima N, Sekiguchi T, et al. (1998) RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. J Cell Sci 111(Pt 1):11-21
86. Sekiguchi T, Hirose E, Nakashima N, et al. (2001) Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J Biol Chem 276(10):7246-7257
87. Dubouloz F, Deloche O, Wanke V, et al. (2005) The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19(1):15-26
88. Gao M, Kaiser CA (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8(7):657-667
89. Nada S, Hondo A, Kasai A, et al. (2009) The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J 28(5):477-489
90. Wunderlich W, Fialka I, Teis D, et al. (2001) A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J Cell Biol 152(4):765-776
91. Kurzbauer R, Teis D, de Araujo ME, et al. (2004) Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci USA 101(30):10984-10989
92. Lunin VV, Munger C, Wagner J, et al. (2004) The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling. J Biol Chem 279(22):23422-23430
93. Qi J, Wang Y, Forgac M (2007) The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation. J Bioenerg Biomembr 39(5-6):423-426
94. Jefferies KC, Forgac M (2008) Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F. J Biol Chem 283(8):4512-4519
95. Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, et al. (2011) Regulation of TFEB and V-ATPases by mTORC1. EMBO J 30(16):3242-3258
96. Moscat J, Diaz-Meco MT (2009) p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137(6):1001-1004
97. Proud CG (2011) A new link in the chain from amino acids to mTORC1 activation. Mol Cell 44(1):7-8
98. Zlatic SA, Tornieri K, L'Hernault SW, et al. (2011) Metazoan cell biology of the HOPS tethering complex. Cell Logist 1(3):111-117
99. Zurita-Martinez SA, Puria R, Pan X, et al. (2007) Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics 176(4):2139-2150
100. Valbuena N, Guan KL, Moreno S (2012) The Vam6-Gtr1/Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. J Cell Sci
101. Flinn RJ, Yan Y, Goswami S, et al. (2010) The late endosome is essential for mTORC1 signaling. Mol Biol Cell 21(5):833-841
102. Flinn RJ, Backer JM (2010) mTORC1 signals from late endosomes: taking a TOR of the endocytic system. Cell Cycle 9(10):1869-1870
103. Kim DH, Sarbassov DD, Ali SM, et al. (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 11(4):895-904
104. Wullschleger S, Loewith R, Oppliger W, et al. (2005) Molecular organization of target of rapamycin complex 2. J Biol Chem 280(35):30697-30704
105. Peterson TR, Laplante M, Thoreen CC, et al. (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137(5):873-886
106. Zhao Y, Xiong X, Sun Y (2011) DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell 44(2):304-316
107. Kim DH, Sarbassov DD, Ali SM, et al. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110(2):163-175
108. Hara K, Maruki Y, Long X, et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110(2):177-189
109. Sarbassov DD, Ali SM, Kim DH, et al. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14(14):1296-1302
110. Thedieck K, Polak P, Kim ML, et al. (2007) PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS ONE 2(11):e1217
111. Vander Haar E, Lee SI, Bandhakavi S, et al. (2007) Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9(3):316-323
112. Woo SY, Kim DH, Jun CB, et al. (2007) PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling. J Biol Chem 282(35):25604-25612
113. Pearce LR, Huang X, Boudeau J, et al. (2007) Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J 405(3):513-522
114. Frias MA, Thoreen CC, Jaffe JD, et al. (2006) mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2 s. Curr Biol 16(18):1865-1870
115. Yang Q, Inoki K, Ikenoue T, et al. (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20(20):2820-2832