RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

Molecular Cell

Volumn 36, Issue 2, 2009, Pages 193-206

  Miyake, Yasuyuki ^a   Nakamura, Mirai ^a   Nabetani, Akira ^a   Shimamura, Shintaro ^a   Tamura, Miki ^a   Yonehara, Shin ^a   Saito, Motoki ^a   Ishikawa, Fuyuki ^a  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

DNA; PROTEINS

Indexed keywords

CELL CYCLE PROTEIN; REPLICATION FACTOR A; SINGLE STRANDED DNA; TELOMERASE; TELOMERE BINDING PROTEIN;

ARABIDOPSIS; ARTICLE; CELL BUDDING; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA DEGRADATION; DNA METABOLISM; DNA REPLICATION; DNA SEQUENCE; EUKARYOTE; NONHUMAN; PROTEIN BINDING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SUPPRESSOR GENE; TELOMERE;

ANIMALS; BASE SEQUENCE; DNA, SINGLE-STRANDED; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; REPLICATION PROTEIN A; SEQUENCE HOMOLOGY, AMINO ACID; TELOMERE; TELOMERE-BINDING PROTEINS;

EUKARYOTA; MAMMALIA; SACCHAROMYCETALES;

EID: 70350031814     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2009.08.009     Document Type: Article

References (34)

1. Adams Martin A., Dionne I., Wellinger R.J., and Holm C. The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis. Mol. Cell. Biol. 20 (2000) 786-796
2. Baumann P., and Cech T.R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292 (2001) 1171-1175
3. Carson M.J., and Hartwell L. CDC17: an essential gene that prevents telomere elongation in yeast. Cell 42 (1985) 249-257
4. Casteel D.E., Zhuang S., Zeng Y., Perrino F.W., Boss G.R., Goulian M., and Pilz R.B. A DNA polymerase-α·primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J. Biol. Chem. 284 (2009) 5807-5818
5. Chakhparonian M., and Wellinger R.J. Telomere maintenance and DNA replication: how closely are these two connected?. Trends Genet. 19 (2003) 439-446
6. Evans S.K., and Lundblad V. Est1 and Cdc13 as comediators of telomerase access. Science 286 (1999) 117-120
7. Fanning E., Klimovich V., and Nager A.R. A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res. 34 (2006) 4126-4137
8. Gao H., Cervantes R.B., Mandell E.K., Otero J.H., and Lundblad V. RPA-like proteins mediate yeast telomere function. Nat. Struct. Mol. Biol. 14 (2007) 208-214
9. Garvik B., Carson M., and Hartwell L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15 (1995) 6128-6138
10. Goulian M., Heard C.J., and Grimm S.L. Purification and properties of an accessory protein for DNA polymerase alpha/primase. J. Biol. Chem. 265 (1990) 13221-13230
11. Grandin N., Reed S.I., and Charbonneau M. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev. 11 (1997) 512-527
12. Grandin N., Damon C., and Charbonneau M. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 20 (2001) 1173-1183
13. Grossi S., Puglisi A., Dmitriev P.V., Lopes M., and Shore D. Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev. 18 (2004) 992-1006
14. Hartwell L.H., and Smith D. Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110 (1985) 381-395
15. Hockemeyer D., Sfeir A.J., Shay J.W., Wright W.E., and de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24 (2005) 2667-2678
16. Hughes T.R., Weilbaecher R.G., Walterscheid M., and Lundblad V. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein. Proc. Natl. Acad. Sci. USA 97 (2000) 6457-6462
17. Lei M., Podell E.R., and Cech T.R. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat. Struct. Mol. Biol. 11 (2004) 1223-1229
18. Lin J.J., and Zakian V.A. The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc. Natl. Acad. Sci. USA 93 (1996) 13760-13765
19. Martin V., Du L.L., Rozenzhak S., and Russell P. Protection of telomeres by a conserved Stn1-Ten1 complex. Proc. Natl. Acad. Sci. USA 104 (2007) 14038-14043
20. Nakamura M., Nabetani A., Mizuno T., Hanaoka F., and Ishikawa F. Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha. Mol. Cell. Biol. 25 (2005) 11073-11088
21. Nugent C.I., Hughes T.R., Lue N.F., and Lundblad V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274 (1996) 249-252
22. Palm W., and de Lange T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42 (2008) 301-334
23. Pennock E., Buckley K., and Lundblad V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104 (2001) 387-396
24. Petreaca R.C., Chiu H.C., Eckelhoefer H.A., Chuang C., Xu L., and Nugent C.I. Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p. Nat. Cell Biol. 8 (2006) 748-755
25. Qi H., and Zakian V.A. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes Dev. 14 (2000) 1777-1788
26. Salic A., and Mitchison T.J. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc. Natl. Acad. Sci. USA 105 (2008) 2415-2420
27. Sfeir A.J., Chai W., Shay J.W., and Wright W.E. Telomere-end processing the terminal nucleotides of human chromosomes. Mol. Cell 18 (2005) 131-138
28. Song X., Leehy K., Warrington R.T., Lamb J.C., Surovtseva Y.V., and Shippen D.E. STN1 protects chromosome ends in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 105 (2008) 19815-19820
29. Takai H., Smogorzewska A., and de Lange T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13 (2003) 1549-1556
30. Theobald D.L., Mitton-Fry R.M., and Wuttke D.S. Nucleic acid recognition by OB-fold proteins. Annu. Rev. Biophys. Biomol. Struct. 32 (2003) 115-133
31. Veldman T., Etheridge K.T., and Counter C.M. Loss of hPot1 function leads to telomere instability and a cut-like phenotype. Curr. Biol. 14 (2004) 2264-2270
32. Wang F., Podell E.R., Zaug A.J., Yang Y., Baciu P., Cech T.R., and Lei M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445 (2007) 506-510
33. Wellinger R.J., Wolf A.J., and Zakian V.A. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 72 (1993) 51-60
34. Wold M.S. Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. 66 (1997) 61-92