메뉴 건너뛰기




Volumn 488, Issue 7412, 2012, Pages 540-544

The human CST complex is a terminator of telomerase activity

Author keywords

[No Author keywords available]

Indexed keywords

CDC13 STN1 TEN1 PROTEIN COMPLEX; MULTIPROTEIN COMPLEX; TELOMERASE; UNCLASSIFIED DRUG;

EID: 84865263603     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11269     Document Type: Article
Times cited : (263)

References (22)
  • 1
    • 78149435151 scopus 로고    scopus 로고
    • Telomeric strategies:means to an end
    • Jain, D.&Cooper, J. P. Telomeric strategies:means to an end. Annu. Rev. Genet. 44, 243-269 (2010).
    • (2010) Annu. Rev. Genet. , vol.44 , pp. 243-269
    • Jain, D.1    Cooper, J.P.2
  • 2
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • de Lange, T. How telomeres solve the end-protection problem. Science 326, 948-952 (2009).
    • (2009) Science , vol.326 , pp. 948-952
    • De Lange, T.1
  • 3
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352 (1998).
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 4
    • 77953427257 scopus 로고    scopus 로고
    • TIN2-tethered TPP1 recruits humantelomerase to telomeres in vivo
    • Abreu, E. et al. TIN2-tethered TPP1 recruits humantelomerase to telomeres in vivo. Mol. Cell. Biol. 30, 2971-2982 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 2971-2982
    • Abreu, E.1
  • 5
    • 33846692105 scopus 로고    scopus 로고
    • TPP1 is a homologue of ciliate TEBP-b and interacts with POT1 to recruit telomerase
    • Xin, H. et al. TPP1 is a homologue of ciliate TEBP-b and interacts with POT1 to recruit telomerase. Nature 445, 559-562 (2007).
    • (2007) Nature , vol.445 , pp. 559-562
    • Xin, H.1
  • 6
    • 79955512470 scopus 로고    scopus 로고
    • Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions
    • Zhao, Y. et al. Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Mol. Cell 42, 297-307 (2011).
    • (2011) Mol. Cell , vol.42 , pp. 297-307
    • Zhao, Y.1
  • 7
    • 70350031814 scopus 로고    scopus 로고
    • RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to singlestranded DNA and protects telomeres independently of the Pot1 pathway
    • Miyake, Y. et al. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to singlestranded DNA and protects telomeres independently of the Pot1 pathway. Mol. Cell 36, 193-206 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 193-206
    • Miyake, Y.1
  • 8
    • 65549148649 scopus 로고    scopus 로고
    • A DNA polymerase - Aprimase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells
    • Casteel, D. E. et al. A DNA polymerase-aprimase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J. Biol. Chem. 284, 5807-5818 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 5807-5818
    • Casteel, D.E.1
  • 9
    • 70350036241 scopus 로고    scopus 로고
    • Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes
    • Surovtseva, Y. V. et al. Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol. Cell 36, 207-218 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 207-218
    • Surovtseva, Y.V.1
  • 10
    • 84855295468 scopus 로고    scopus 로고
    • Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract
    • Nakaoka, H., Nishiyama, A., Saito, M. & Ishikawa, F. Xenopus laevis Ctc1-Stn1-Ten1 (xCST) protein complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract. J. Biol. Chem. 287, 619-627 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 619-627
    • Nakaoka, H.1    Nishiyama, A.2    Saito, M.3    Ishikawa, F.4
  • 11
    • 84861198042 scopus 로고    scopus 로고
    • CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion
    • Gu, P. et al. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 31, 2309-2321 (2012).
    • (2012) EMBO J , vol.31 , pp. 2309-2321
    • Gu, P.1
  • 12
    • 33846691378 scopus 로고    scopus 로고
    • The POT1-TPP1 telomere complex is a telomerase processivity factor
    • Wang, F. et al. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445, 506-510 (2007).
    • (2007) Nature , vol.445 , pp. 506-510
    • Wang, F.1
  • 13
    • 77649317032 scopus 로고    scopus 로고
    • POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
    • Latrick, C. M. & Cech, T. R. POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J. 29, 924-933 (2010).
    • (2010) EMBO J , vol.29 , pp. 924-933
    • Latrick, C.M.1    Cech, T.R.2
  • 15
    • 0035830494 scopus 로고    scopus 로고
    • Cdc13 delivers separate complexes to the telomere for end protection and replication
    • Pennock, E., Buckley, K. & Lundblad, V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104, 387-396 (2001).
    • (2001) Cell , vol.104 , pp. 387-396
    • Pennock, E.1    Buckley, K.2    Lundblad, V.3
  • 16
    • 0034661246 scopus 로고    scopus 로고
    • The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit ofDNA polymerase a and the telomeraseassociated Est1 protein
    • Qi, H. & Zakian, V. A. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit ofDNA polymerase a and the telomeraseassociated Est1 protein. Genes Dev. 14, 1777-1788 (2000).
    • (2000) Genes Dev , vol.14 , pp. 1777-1788
    • Qi, H.1    Zakian, V.A.2
  • 17
    • 2442564703 scopus 로고    scopus 로고
    • Pol12 the B subunit of DNA polymerase a, functions in both telomere capping and length regulation
    • Grossi, S., Puglisi, A., Dmitriev, P. V., Lopes, M. & Shore, D. Pol12, the B subunit of DNA polymerase a, functions in both telomere capping and length regulation. Genes Dev. 18, 992-1006 (2004).
    • (2004) Genes Dev , vol.18 , pp. 992-1006
    • Grossi, S.1    Puglisi, A.2    Dmitriev, P.V.3    Lopes, M.4    Shore, D.5
  • 18
    • 35348879158 scopus 로고    scopus 로고
    • Protection of telomeres by a conserved Stn1-Ten1 complex
    • Martin, V., Du, L. L., Rozenzhak, S. & Russell, P. Protection of telomeres by a conserved Stn1-Ten1 complex. Proc. Natl Acad. Sci. US 104, 14038-14043 (2007).
    • (2007) Proc. Natl Acad. Sci. US , vol.104 , pp. 14038-14043
    • Martin, V.1    Du, L.L.2    Rozenzhak, S.3    Russell, P.4
  • 19
    • 4243937106 scopus 로고    scopus 로고
    • A highly selective telomerase inhibitor limiting human cancer cell proliferation
    • Damm, K. et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 20, 6958-6968 (2001).
    • (2001) EMBO J , vol.20 , pp. 6958-6968
    • Damm, K.1
  • 20
    • 32544443342 scopus 로고    scopus 로고
    • Telomere length homeostasis requires that telomerase levels are limiting
    • Cristofari, G. & Lingner, J. Telomere length homeostasis requires that telomerase levels are limiting. EMBO J. 25, 565-574 (2006).
    • (2006) EMBO J , vol.25 , pp. 565-574
    • Cristofari, G.1    Lingner, J.2
  • 21
    • 68049088928 scopus 로고    scopus 로고
    • Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells
    • Zhao, Y. et al. Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell 138, 463-475 (2009).
    • (2009) Cell , vol.138 , pp. 463-475
    • Zhao, Y.1
  • 22
    • 35848958333 scopus 로고    scopus 로고
    • Low-to high-throughput analysis of telomerase modulators with Telospot
    • Cristofari, G. et al. Low-to high-throughput analysis of telomerase modulators with Telospot. Nature Methods 4, 851-853 (2007).
    • (2007) Nature Methods , vol.4 , pp. 851-853
    • Cristofari, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.