Analysis of telomerase processivity: Mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance

Molecular Cell

Volumn 7, Issue 6, 2001, Pages 1201-1211

  Peng, Yun ^a   Mian, I Saira ^b   Lue, Neal F ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; GENE MUTATION; GENETIC ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PROTEIN DOMAIN; PROTEIN MOTIF; RETROPOSON; RETROVIRUS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TELOMERE;

GOES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SACCHAROMYCES CEREVISIAE; UNIDENTIFIED RETROVIRUS;

EID: 0034964393     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00268-4     Document Type: Article

References (46)

1. The processivity of DNA synthesis exhibited by drug-resistant variants of human immunodeficiency virus type-1 reverse transcriptase
2. Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme
3. Reconstitution of human telomerase activity in vitro
4. Telomerases
5. Telomerase and the maintenance of chromosome ends
6. A mutant of tetrahymena telomerase reverse transcriptase with increased processivity
7. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytrica trifallax
8. Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication
9. Secondary structure of vertebrate telomerase RNA
10. Telomerase in yeast
11. The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex
12. Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution
13. Telomerase and retrotransposons: Which came first?
14. Est1 and Cdc13 as comediators of telomerase access
15. Disruption of the catalytic telomerase subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA
16. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants
17. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
18. Telomerase is processive
19. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
20. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
21. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe
22. Inhibition of telomerase limits the growth of human cancer cells
23. Human telomerase contains evolutionarily conserved catalytic and structural subunits
24. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
25. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
26. The Est3 protein is a subunit of yeast telomerase
27. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
28. Specific association of human telomerase activity with immortal cells and cancer
29. Senescence mutants of saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
30. Purification of telomerase from Euplotes aediculatis: Requirement of a primer 3′ overhang
31. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity
32. Reverse transcriptase motifs in the catalytic subunit of telomerase
33. Negative regulation of yeast telomerase activity through an interaction with an upstream region of the DNA primer
34. Species-specific and sequence-specific recognition of the dG-rich strand of telomeres by yeast telomerase
35. Putative telomerase catalytic subunits from giardia lamblia and caenorhabditis elegans
36. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
37. Template definition by Tetrahymena telomerase reverse transcriptase
38. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
39. Reversing time: Origin of telomerase
40. Telomerase catalytic subunit homologs from fission yeast and human
41. The telomerase reverse transcriptase: Components and regulation
42. Molecular cloning and characterization of AtTERT, a telomerase reverse transcriptase homolog in Arabidopsis thaliana
43. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal non-processivity in vivo and in vitro
44. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
45. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase
46. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells