Cajal bodies: A long history of discovery

Annual Review of Cell and Developmental Biology

Volumn 21, Issue , 2005, Pages 105-131

  Cioce, Mario ^a   Lamond, Angus I ^b  

^a IRBM   (Italy)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Coilin; Disease; Nucleus; snRNP; Stress

Indexed keywords

ATAXIN 1; COILIN; CYCLIN DEPENDENT KINASE 7; CYCLIN E; FIBRILLARIN; FIBROBLAST GROWTH FACTOR 2; PEROXIREDOXIN; PROFILIN; PROTEIN FRG1; PROTEIN LSM; PROTEIN NOPP140; PROTEIN NPAT; PROTEIN P110; PROTEIN P53; PROTEIN P80; PROTEIN PIGPEN; PROTEIN SM; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEOLAR RNA; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; CANCER; CELL CYCLE; CELL NUCLEUS; CELL STRUCTURE; COILED BODY; DEGENERATIVE DISEASE; DROSOPHILA; HEALTH SURVEY; HISTORY OF MEDICINE; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; MOLECULAR BIOLOGY; NONHUMAN; PATHOLOGICAL ANATOMY; PATHOPHYSIOLOGY; PLANT; PRIORITY JOURNAL; REVIEW; SPINAL MUSCULAR ATROPHY; STRESS; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; CELL NUCLEUS; COILED BODIES; FORECASTING; HISTORY, 20TH CENTURY; HUMANS; INTRANUCLEAR INCLUSION BODIES; MODELS, BIOLOGICAL; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA-BINDING PROTEINS;

ANIMALIA; MAMMALIA;

EID: 28444456713     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.20.010403.103738     Document Type: Review

References (136)

1. Abbott J, Marzluff WF, Gall JG. 1999. The stem-loop binding protein (SLBP1) is present in coiled bodies of the Xenopus germinal vesicle. Mol. Biol. Cell 10:487-99
2. Acevedo R, Samaniego R, Moreno Diaz de la Espina S. 2002. Coiled bodies in nuclei from plant cells evolving from dormancy to proliferation. Chromosoma 110:559-69
3. Alliegro MC, Alliegro MA. 1996a. Identification of a new coiled body component. Exp. Cell Res. 227:386-90
4. Alliegro MC, Alliegro MA. 1996b. A nuclear protein regulated during the transition from active to quiescent phenotype in cultured endothelial cells. Dev. Biol. 174:288-97
5. Alliegro MC, Alliegro MA. 2002. Nuclear injection of anti-pigpen antibodies inhibits endothelial cell division. J. Biol. Chem. 277:19037-11
6. Aman P, Ron D, Mandahl N, Fioretos T, Heim S, et al. 1992. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Genes Chromosomes Cancer 5:278-85
7. Anderson KN, Baban D, Oliver PL, Potter A, Davies KE. 2004. Expression profiling in spinal muscular atrophy reveals an RNA binding protein deficit. Neuromuscular Disord. 14:711-22
8. Andrade LE, Chan EK, Raska I, Peebles CL, Roos G, Tan EM. 1991. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. J. Exp. Med. 173:1407-19
9. Andrade LE, Tan EM, Chan EK. 1993. Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation. Proc. Natl. Acad. Sci. USA 90:1947-51
10. Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. 2004. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431:805-10
11. Bachand F, Boisvert FM, Cote J, Richard S, Autexier C. 2002. The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Mol. Biol. Cell 13:3192-202
12. Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP. 2004. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat. Cell Biol. 6:665-72
13. Bettinger BT, Gilbert DM, Amberg DC. 2004. Actin up in the nucleus. Nat. Rev. Mol. Cell. Biol. 5:410-15
14. Beven AF, Simpson GG, Brown JW, Shaw PJ. 1995. The organization of spliceosomal components in the nuclei of higher plants. J. Cell Sci. 108(Pt 2):509-18
15. Bohmann K, Ferreira JA, Lamond AI. 1995. Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus. J. Cell Biol. 131:817-31
16. Boisvert FM, Cote J, Boulanger MC, Cleroux P, Bachand F, et al. 2002. Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. J. Cell Biol. 159:957-69
17. Boudonck K, Dolan L, Shaw PJ. 1998. Coiled body numbers in the Arabidopsis root epidermis are regulated by cell type, developmental stage and cell cycle parameters. J. Cell Sci. 111(Pt 24):3687-94
18. Boudonck K, Dolan L, Shaw PJ. 1999. The movement of coiled bodies visualized in living plant cells by the green fluorescent protein. Mol. Biol. Cell 10:2297-307
19. Boulon S, Verheggen C, Jady BE, Girard C, Pescia C, et al. 2004. PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli. Mol. Cell 16:777-87
20. Buschges R, Ichimura K, Weber RG, Reifenberger G, Collins VP. 2002. Allelic gain and amplification on the long arm of chromosome 17 in anaplastic meningiomas. Brain Pathol. 12:145-53
21. Carmo-Fonseca M, Ferreira J, Lamond AI. 1993. Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis-evidence that the coiled body is a kinetic nuclear structure. J. Cell Biol. 120:841-52
22. Carmo-Fonseca M, Pepperkok R, Carvalho MT, Lamond AI. 1992. Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies. J. Cell Biol. 117:1-14
23. Claus P, Doring F, Gringel S, Muller-Ostermeyer F, Fuhlrott J, et al. 2003. Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein. J. Biol. Chem. 278:479-85
24. Cmarko D, Verschure PJ, Martin TE, Dahmus ME, Krause S, et al. 1999. Ultrastructural analysis of transcription and splicing in the cell nucleus after bromo-UTP microinjection. Mol. Biol. Cell 10:211-23
25. Costa Lima MA, Pimentel MM. 2004. Dynamic mutation and human disorders: the spinocerebellar ataxias (review). Int. J. Mol. Med. 13:299-302
26. Cuddihy AR, Wong AH, Tam NW, Li S, Koromilas AE. 1999. The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. Oncogene 18:2690-702
27. Darzacq X, Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T. 2002. Cajal body-specific small nuclear RNAs: a novel class of 2′-O-methylation and pseudouridylation guide RNAs. EMBO J. 21:2746-56
28. Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, et al. 2004. In vivo kinetics of Cajal body components. J. Cell Biol. 164:831-12
29. Dyck JA, Maul GG, Miller WH Jr, Chen JD, Kakizuka A, Evans RM. 1994. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76:333-13
30. Fagioli M, Alcalay M, Tomassoni L, Ferrucci PF, Mencarelli A, et al. 1998. Cooperation between the RING + B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival. Oncogene 16:2905-13
31. Feder M, Pas J, Wyrwicz LS, Bujnicki JM. 2003. Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2′-O-methyltransferases. Gene 302:129-38
32. Fernandez R, Pena E, Navascues J, Casafont I, Lafarga M, Berciano MT. 2002. cAMP-dependent reorganization of the Cajal bodies and splicing machinery in cultured Schwann cells. Glia 40:378-88
33. Flodstrom-Tullberg M, Hultcrantz M, Stotland A, Maday A, Tsai D, et al. 2005. RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell eefense during Coxsackievirus infection. J. Immunol. 174:1171-77
34. Frey MR, Bailey AD, Weiner AM, Matera AG. 1999. Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts. Curr. Biol. 9:126-35
35. Frey MR, Matera AG. 1995. Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cells. Proc. Natl. Acad. Sci. USA 92:5915-19
36. Frey MR, Matera AG. 2001. RNA-mediated interaction of Cajal bodies and U2 snRNA genes. J. Cell Biol. 154:499-509
37. Frugier T, Tiziano FD, Cifuentes-Diaz C, Miniou P, Roblot N, et al. 2000. Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy. Hum. Mol. Genet. 9:849-58
38. Galcheva-Gargova Z, Konstantinov KN, Wu IH, Klier FG, Barrett T, Davis RJ. 1996. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science 272:1797-802
39. Gangwani L, Mikrut M, Theroux S, Sharma M, Davis RJ. 2001. Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein. Nat. Cell Biol. 3:376-83
40. Gao L, Frey MR, Matera AG. 1997. Human genes encoding U3 snRNA associate with coiled bodies in interphase cells and are clustered on chromosome 17p11.2 in a complex inverted repeat structure. Nucleic Acids Res. 25:4740-47
41. Gedge LJ, Morrison EE, Blair GE, Walker JH. 2005. Nuclear actin is partially associated with Cajal bodies in human cells in culture and relocates to the nuclear periphery after infection of cells by adenovirus 5. Exp. Cell Res. 303:229-39
42. Goransson M, Wedin M, Aman P. 2002. Temperature-dependent localization of TLS-CHOP to splicing factor compartments. Exp. Cell Res. 278:125-32
43. Gorisch SM, Wachsmuth M, Ittrich C, Bacher CP, Rippe K, Lichter P. 2004. Nuclear body movement is determined by chromatin accessibility and dynamics. Proc. Natl. Acad. Sci. USA 101:13221-26
44. Goti D, Katzen SM, Mez J, Kurtis N, Kiluk J, et al. 2004. A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration. J. Neurosci. 24:10266-79
45. Hahn WC, Meyerson M. 2001. Telomerase activation, cellular immortalization and cancer. Ann. Med. 33:123-29
46. Hande MP, Samper E, Lansdorp P, Blasco MA. 1999. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144:589-601
47. Hardin JH, Spicer SS, Greene WB. 1969. The paranucleolar structure, accessory body of Cajal, sex chromatin, and related structures in nuclei of rat trigeminal neurons: a cytochemical and ultrastructural study. Anat. Rec. 164:403-31
48. Hebert MD, Matera AG. 2000. Self-association of coilin reveals a common theme in nuclear body localization. Mol. Biol. Cell 11:4159-71
49. Hebert MD, Shpargel KB, Ospina JK, Tucker KE, Matera AG. 2002. Coilin methylation regulates nuclear body formation. Dev. Cell 3:329-37
50. Hebert MD, Szymczyk PW, Shpargel KB, Matera AG. 2001. Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. Genes Dev. 15:2720-29
51. Hofmann I, Schnolzer M, Kaufmann I, Franke WW. 2002. Symplekin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytes. Mol. Biol. Cell 13:1665-76
52. Hong S, Ka S, Kim S, Park Y, Kang S. 2003. p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product. Biochim. Biophys. Acta 1638:35-42
53. Ichikawa H, Shimizu K, Hayashi Y, Ohki M. 1994. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res. 54:2865-68
54. Insinga A, Monestiroli S, Ronzoni S, Carbone R, Pearson M, et al. 2004. Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J. 23:1144-54
55. Irwin S, Vandelft M, Pinchev D, Howell JL, Graczyk J, et al. 2005. RNA association and nucleocytoplasmic shuttling by ataxin-1. J. Cell Sci. 118:233-42
56. Isaac C, Yang Y, Meier UT. 1998. Nopp140 functions as a molecular link between the nucleolus and the coiled bodies. J. Cell Biol. 142:319-29
57. Jacobs EY, Frey MR, Wu W, Ingledue TC, Gebuhr TC, et al. 1999. Coiled bodies preferentially associate with U4, U11, and U12 small nuclear RNA genes in interphase HeLa cells but not with U6 and U7 genes. Mol. Biol. Cell 10:1653-63
58. Jady BE, Bertrand E, Kiss T. 2004. Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal. J. Cell Biol. 164:647-52
59. Jady BE, Darzacq X, Tucker KE, Matera AG, Bertrand E, Kiss T. 2003. Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm. EMBO J. 22:1878-88
60. Jimenez-Garcia LF, Green SR, Mathews MB, Spector DL. 1993. Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells. J. Cell Sci. 106(Pt 1):11-22
61. Jin S, Levine AJ. 2001. The p53 functional circuit. J. Cell Sci. 114:4139-40
62. Jones KW, Gorzynski K, Hales CM, Fischer U, Badbanchi F, et al. 2001. Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin. J. Biol. Chem. 276:38645-51
63. Jordan P, Cunha C, Carmo-Fonseca M. 1997. The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies. Mol. Biol. Cell 8:1207-17
64. Joy A, Moffett J, Neary K, Mordechai E, Stachowiak EK, et al. 1997. Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells. Oncogene 14:171-83
65. Klement IA, Skinner PJ, Kaytor MD, Yi H, Hersch SM, et al. 1998. Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 95:41-53
66. Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, et al. 1997. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol. Cell Biol. 17:7220-29
67. Kropotov AV, Grudinkin PS, Pleskach NM, Gavrilov BA, Tomilin NV, Zhivotovsky B. 2004. Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks. FEBS Lett. 572:75-79
68. Lafarga M, Hervas JP, Santa-Cruz MC, Villegas J, Crespo D. 1983. "The accessory body" of Cajal in the neuronal nucleus. A light and electron microscopic approach. Anat. Embryol. (Berl) 166:19-30
69. Lefebvre S, Burlet P, Liu Q, Bertrandy S, Clermont O, et al. 1997. Correlation between severity and SMN protein level in spinal muscular atrophy. Nat. Genet. 16:265-69
70. Liu J, Hebert MD, Ye Y, Templeton DJ, Kung H, Matera AG. 2000. Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies. J. Cell Sci. 113(Pt 9):1543-52
71. Liu Q, Dreyfuss G. 1996. A novel nuclear structure containing the survival of motor neurons protein. EMBO J. 15:3555-65
72. Lyon CE, Bohmann K, Sleeman J, Lamond AI. 1997. Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus. Exp. Cell Res. 230:84-93
73. Ma T, Van Tine BA, Wei Y, Garrett MD, Nelson D, et al. 2000. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14:2298-313
74. Malatesta M, Zancanaro C, Martin TE, Chan EK, Amalric F, et al. 1994. Cytochemical and immunocytochemical characterization of nuclear bodies during hibernation. Eur. J. Cell Biol. 65:82-93
75. Matera AG, Ward DC. 1993. Nucleoplasmic organization of small nuclear ribonucleoproteins in cultured human cells. J. Cell Biol. 121:715-27
76. Matsuzaki K, Minami T, Tojo M, Honda Y, Saitoh N, et al. 2003. PML-nuclear bodies are involved in cellular serum response. Genes Cells 8:275-86
77. Meier UT, Blobel G. 1992. Nopp140 shuttles on tracks between nucleolus and cytoplasm. Cell 70:127-38
78. Monneron A, Bernhard W. 1969. Fine structural organization of the interphase nucleus in some mammalian cells. J. Ultrastruct. Res. 27:266-88
79. Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, et al. 1998. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. Gene 221:191-98
80. Narayanan U, Achsel T, Luhrmann R, Matera AG. 2004. Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein. Mol. Cell 16:223-34
81. Navascues J, Berciano MT, Tucker KE, Lafarga M, Matera AG. 2004. Targeting SMN to Cajal bodies and nuclear gems during neuritogenesis. Chromosoma 112:398-409
82. Newton K, Petfalski E, Tollervey D, Caceres JF. 2003. Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Mol. Cell Biol. 23:8519-27
83. Ochs RL, Stein TW Jr, Andrade LE, Gallo D, Chan EK, et al. 1995. Formation of nuclear bodies in hepatocytes of estrogen-treated roosters. Mol. Biol. Cell 6:345-56
84. Ochs RL, Stein TW Jr, Tan EM. 1994. Coiled bodies in the nucleolus of breast cancer cells. J. Cell Sci. 107(Pt2):385-99
85. Pearn J. 1980. Classification of spinal muscular atrophies. Lancet 1:919-22
86. Pellizzoni L, Baccon J, Charroux B, Dreyfuss G. 2001. The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr. Biol. 11:1079-88
87. Pillai RS, Will CL, Luhrmann R, Schumperli D, Muller B. 2001. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. EMBO J. 20:5470-79
88. Platani M, Goldberg I, Lamond AI, Swedlow JR. 2002. Cajal body dynamics and association with chromatin are ATP-dependent. Nat. Cell Biol. 4:502-8
89. Platani M, Goldberg I, Swedlow JR, Lamond AI. 2000. In vivo analysis of Cajal body movement, separation, and joining in live human cells. J. Cell Biol. 151:1561-74
90. Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ. 2003. ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. Mol. Biol. Cell 14:1517-28
91. Ramon y Cajal S. 1903. Un sencillo metodo de coloracion seletiva del reticulo protoplasmatico y sus efectos en los diversos organos nerviosos de vertebrados e invertebrados. Trab. Lab. Invest. Biol. (Madrid) 2:129-221
92. Raska I. 1995. Nuclear ultrastructures associated with the RNA synthesis and processing. J. Cell. Biochem. 59:11-26
93. Raska I, Andrade LE, Ochs RL, Chan EK, Chang CM, et al. 1991. Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies. Exp. Cell Res. 195:27-37
94. Rebelo L, Almeida F, Ramos C, Bohmann K, Lamond AI, Carmo-Fonseca M. 1996. The dynamics of coiled bodies in the nucleus of adenovirus-infected cells. Mol. Biol. Cell 7:1137-51
95. Rodrigues SH, Silva NP, Delicio LR, Granato C, Andrade LE. 1996. The behavior of the coiled body in cells infected with adenovirus in vitro. Mol. Biol. Rep. 23:183-89
96. Satyanarayana A, Manns MP, Rudolph KL. 2004. Telomeres, telomerase and cancer: an endless search to target the ends. Cell Cycle 3:1138-50
97. Schneider E, Montenarh M, Wagner P. 1998. Regulation of CAK kinase activity by p53. Oncogene 17:2733-41
98. Schrank B, Gotz R, Gunnersen JM, Ure JM, Toyka KV, et al. 1997. Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. Proc. Natl. Acad. Sci. USA 94:9920-25
99. Schul W, Groenhout B, Koberna K, Takagaki Y, Jenny A, et al. 1996. The RNA 3′ cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. EMBO J. 15:2883-92
100. Schul W, van Der Kraan I, Matera AG, van Driel R, de Jong L. 1999. Nuclear domains enriched in RNA 3′-processing factors associate with coiled bodies and histone genes in a cell cycle-dependent manner. Mol. Biol. Cell 10:3815-24
101. Schul W, van Driel R, de Jong L. 1998. Coiled bodies and U2 snRNA genes adjacent to coiled bodies are enriched in factors required for snRNA transcription. Mol. Biol. Cell 9:1025-36
102. Shaw PJ, Brown JW. 2004. Plant nuclear bodies. Curr. Opin. Plant Biol. 7:614-20
103. Shinobu N, Maeda T, Aso T, Ito T, Kondo T, et al. 1999. Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J. Biol. Chem. 274:17003-10
104. Shopland LS, Byron M, Stein JL, Lian JB, Stein GS, Lawrence JB. 2001. Replication-dependent histone gene expression is related to Cajal body (CB) association but does not require sustained CB contact. Mol. Biol. Cell 12:565-76
105. Shpargel KB, Ospina JK, Tucker KE, Matera AG, Hebert MD. 2003. Control of Cajal body number is mediated by the coilin C-terminus. J. Cell Sci. 116:303-12
106. Skare P, Kreivi JP, Bergstrom A, Karlsson R. 2003. Profilin I colocalizes with speckles and Cajal bodies: a possible role in pre-mRNA splicing. Exp. Cell Res. 286:12-21
107. Skinner PJ, Koshy BT, Cummings CJ, Klement IA, Helin K, et al. 1997. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature 389:971-74
108. Sleeman J, Lyon CE, Platani M, Kreivi JP, Lamond AI. 1998. Dynamic interactions between splicing snRNPs, coiled bodies and nucleoli revealed using snRNP protein fusions to the green fluorescent protein. Exp. Cell Res. 243:290-304
109. Sleeman JE, Ajuh P, Lamond AI. 2001. snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN. J. Cell Sci. 114:4407-19
110. Sleeman JE, Lamond AI. 1999. Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. Curr. Biol. 9:1065-74
111. Sleeman JE, Trinkle-Mulcahy L, Prescott AR, Ogg SC, Lamond AI. 2003. Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo. J. Cell Sci. 116:2039-50
112. Smith KP, Carter KC, Johnson CV, Lawrence JB. 1995. U2 and U1 snRNA gene loci associate with coiled bodies. J. Cell Biochem. 59:473-85
113. Smith KP, Lawrence JB. 2000. Interactions of U2 gene loci and their nuclear transcripts with Cajal (coiled) bodies: evidence for PreU2 within Cajal bodies. Mol. Biol. Cell 11:2987-98
114. Spector DL, Lark G, Huang S. 1992. Differences in snRNP localization between transformed and nontransformed cells. Mol. Biol. Cell 3:555-69
115. Stachowiak MK, Moffett J, Maher P, Tucholski J, Stachowiak EK. 1997. Growth factor regulation of cell growth and proliferation in the nervous system. A new intracrine nuclear mechanism. Mol. Neurobiol. 15:257-83
116. Stanek D, Rader SD, Klingauf M, Neugebauer KM. 2003. Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. J. Cell Biol. 160:505-16
117. Su C, Gao G, Schneider S, Helt C, Weiss C, et al. 2004. DNA damage induces downregulation of histone gene expression through the G(1) checkpoint pathway. EMBO J. 23:1133-43
118. Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, et al. 2001. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. J. Cell Biol. 154:293-307
119. van Koningsbruggen S, Dirks RW, Mommaas AM, Onderwater JJ, Deidda G, et al. 2004. FRG1P is localised in the nucleolus, Cajal bodies, and speckles. J. Med. Genet. 41:e46
120. Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, et al. 2002. Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments. EMBO J. 21:2736-45
121. Wang A, Ikura T, Eto K, Ota MS. 2004. Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry. Biochem. Biophys. Res. Commun. 325:1509-16
122. Wiederschain D, Kawai H, Gu J, Shilatifard A, Yuan ZM. 2003. Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol. Cell Biol. 23:4230-46
123. Witke W. 2004. The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol. 14:461-69
124. Wu CH, Gall JG. 1993. U7 small nuclear RNA in C snurposomes of the Xenopus germinal vesicle. Proc. Natl. Acad. Sci. USA 90:6257-59
125. Wu Z, Murphy C, Gall JG. 1994. Human p80-coilin is targeted to sphere organelles in the amphibian germinal vesicle. Mol. Biol. Cell 5:1119-27
126. Yamada M, Sato T, Shimohata T, Hayashi S, Igarashi S, et al. 2001. Interaction between neuronal intranuclear inclusions and promyelocytic leukemia protein nuclear and coiled bodies in CAG repeat diseases. Am. J. Pathol. 159:1785-95
127. Yannoni YM, White K. 1997. Association of the neuron-specific RNA binding domain-containing protein ELAV with the coiled body in Drosophila neurons. Chromosoma 105:332-41
128. Ye X, Wei Y, Nalepa G, Harper JW. 2003. The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells. Mol. Cell Biol. 23:8586-600
129. Young PJ, Day PM, Zhou J, Androphy EJ, Morris GE, Lorson CL. 2002. A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy. J. Biol. Chem. 277:2852-59
130. Young PJ, Le TT, Dunckley M, Nguyen TM, Burghes AH, Morris GE. 2001. Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN. Exp. Cell Res. 265:252-61
131. Young PJ, Le TT, thi Man N, Burghes AH, Morris GE. 2000. The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells. Exp. Cell Res. 256:365-74
132. Zhang HL, Pan F, Hong D, Shenoy SM, Singer RH, Bassell GJ. 2003. Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization. J. Neurosci. 23:6627-37
133. Zhao J, Dynlacht B, Imai T, Hori T, Harlow E. 1998. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 12:456-61
134. Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, et al. 2000. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 14:2283-97
135. Zhou Y, Kok KH, Chun AC, Wong CM, Wu HW, et al. 2000. Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. Biochem. Biophys. Res. Commun. 268:921-27
136. Zhu Y, Tomlinson RL, Lukowiak AA, Terns RM, Terns MP. 2004. Telomerase RNA accumulates in Cajal bodies in human cancer cells. Mol. Biol. Cell 15:81-90