The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization

Nucleic Acids Research

Volumn 38, Issue 6, 2009, Pages 2019-2035

  Sealey, David C F ^a,b   Zheng, Le ^a,b   Taboski, Michael A S ^a,b   Jennifer Cruickshank, ^b   Ikura, Mitsuhiko ^a,b   Harrington, Lea A ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; DNA; DNA BINDING PROTEIN; HYBRID PROTEIN; TERT PROTEIN, HUMAN;

ARTICLE; BACTERIAL CELL; BINDING AFFINITY; CELL IMMORTALIZATION; CELL SURVIVAL; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; HUMAN; MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN NUCLEIC ACID INTERACTION; PROTEIN PURIFICATION; SEQUENCE ALIGNMENT; BIOSYNTHESIS; CELL LINE; CELL PROLIFERATION; CHEMISTRY; ESCHERICHIA COLI; GENETICS; METABOLISM; TELOMERE;

ESCHERICHIA COLI;

CELL LINE; CELL LINE, TRANSFORMED; CELL PROLIFERATION; DNA; DNA-BINDING PROTEINS; ESCHERICHIA COLI; HUMANS; MUTATION; RECOMBINANT FUSION PROTEINS; TELOMERASE; TELOMERE;

EID: 77951237385     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp1160     Document Type: Article

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