Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 8, 2013, Pages 1730-1747

  Chatterton, Dereck E W ^a   Nguyen, Duc Ninh ^a   Bering, Stine Brandt ^a   Sangild, Per Torp ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Inflammation; Milk proteins; Necrotizing enterocolitis; Nutrition; Preterm infant

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ALKALINE PHOSPHATASE; ALPHA LACTALBUMIN; BETA LACTOGLOBULIN; CASEIN; CD14 ANTIGEN; COMPLEMENT COMPONENT C3B; EPIDERMAL GROWTH FACTOR; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 12; INTERLEUKIN 6; LACTADHERIN; LACTOFERRIN; LACTOPEROXIDASE; MILK PROTEIN; OSTEOPONTIN; PHOSPHOLIPASE A2; SOMATOMEDIN B; SOMATOMEDIN C; SUPEROXIDE DISMUTASE; THROMBOCYTE ACTIVATING FACTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; TREFOIL PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; BIOLOGICAL ACTIVITY; BREAST EPITHELIUM; BREAST FEEDING; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; INTRACELLULAR SIGNALING; ISOELECTRIC POINT; NECROTIZING ENTEROCOLITIS; NONHUMAN; OXIDATIVE STRESS; PASTEURIZATION; PREMATURITY; PROTEIN PHOSPHORYLATION; PROTEOMICS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; STOMACH PH; UBIQUITINATION; UPREGULATION; VERY LOW BIRTH WEIGHT;

BOVINAE; LOTUS;

EID: 84879045334     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.04.028     Document Type: Review

References (320)

1. Abu-Soud HM, Hazen SL. Nitric oxide is a physiological substrate for mammalianperoxidases. Journal of Biological Chemistry 2000;275:37524-32.. (Pubitemid 32004861)
2. Adair-Kirk TL, Senior RM. Fragments of extracellular matrix as mediatorsof inflammation. International Journal of Biochemistry and Cell Biology 2008;40:1101-10..
3. Adel-Patient K, Wavrin S, Bernard H, Meziti N, Ah-Leung S, Wal JM. Oral tol-erance and Treg cells are induced in BALB/c mice after gavage with bovinebeta-lactoglobulin. Allergy 2011;66:1312-21..
4. Agnihotri R, Crawford HC, Haro H, Matrisian LM, Havrda MC, Liaw L. Osteo-pontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1)and matrix metalloproteinase-7 (matrilysin). Journal of Biological Chemistry 2001;276:28261-7..
5. Aisen P, Listowsky I. Iron transport and storage proteins. Annual Review of Bio-chemistry 1980;49:357-93..
6. Akira S, Sato S. Toll-like receptors and their signaling mechanisms. Scandinavian Journal of Infectious Diseases 2003;35:555-62.. (Pubitemid 37336872)
7. An L, Liu CT, Yu MJ, Chen ZH, Guo XG, Peng W, et al. Heme oxygenase-1 system, inflammation and ventilator-induced lung injury. European Journal of Pharma-cology 2011;677:1-4..
8. Andersen MH, Berglund L, Rasmussen JT, Petersen TE. Bovine PAS-6/7 binds alpha vbeta 5 integrins and anionic phospholipids through two domains. Biochemistry 1997;36:5441-6.. (Pubitemid 27200040)
9. Andersen MH, Graversen H, Fedosov SN, Petersen TE, Rasmussen JT. Functionalanalyses of two cellular binding domains of bovine lactadherin. Biochemistry 2000;39:6200-6.. (Pubitemid 30327097)
10. Anderson BF, Baker HM, Dodson EJ, Norris GE, Rumball SV, Waters JM, et al. Structureof human lactoferrin at 3.2-A resolution. Proceedings of the National Academyof Sciences United States of America 1987;84:1769-73.. (Pubitemid 17054094)
11. Ando K, Hasegawa K, Shindo K, Furusawa T, Fujino T, Kikugawa K, et al. Humanlactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway whileit interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS Journal 2010;277:2051-66..
12. Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y, et al. Orally adminis-tered TGF-beta is biologically active in the intestinal mucosa and enhances oraltolerance. Journal of Allergy and Clinical Immunology 2007;120:916-23.. (Pubitemid 47531831)
13. Appelmelk BJ, An YQ, Geerts M, Thijs BG, de Boer HA, Mac Laren DM, et al. Lactoferrinis a lipid A-binding protein. Infection and Immunity 1994;62:2628-32..
14. Asano M, Komiyama K. Polymeric immunoglobulin receptor. Journal of Oral Science 2011;53:147-56..
15. Ashare A, Powers LS, Butler NS, Doerschug KC, Monick MM, Hunninghake GW. Anti-inflammatory response is associated with mortality and severity of infection insepsis. American Journal of Physiology-Lung Cellular and Molecular Physiology 2005;288:L633-40.. (Pubitemid 40404130)
16. Aziz M, Jacob A, Matsuda A, Wu R, Zhou M, Dong W, et al. Pre-treatment of recom-binant mouse MFG-E8 downregulates LPS-induced TNF-alpha production inmacrophages via STAT3-mediated SOCS3 activation. PLoS One 2011;6:e27685..
17. Baghdadi M, Chiba S, Yamashina T, Yoshiyama H, Jinushi M. MFG-E8 regulates theimmunogenic potential of dendritic cells primed with necrotic cell-mediatedinflammatory signals. PLoS One 2012;7:e39607..
18. Baker EN. Structure and reactivity of transferrins. In: Sykes AG, editor. Advances ininorganic chemistry. Elsevier; 1994. p. 389-463..
19. Baker HM, Baker EN. Lactoferrin and iron: structural and dynamic aspects of bindingand release. Biometals 2004;17:209-16.. (Pubitemid 38987139)
20. Ball ED, Graziano RF, Shen L, Fanger MW. Monoclonal antibodies to novel myeloidantigens reveal human neutrophil heterogeneity. Proceedings of the National Academy of Sciences United States of America 1982;79:5374-8.. (Pubitemid 13233740)
21. Bastian SE, Dunbar AJ, Priebe IK, Owens PC, Goddard C. Measurement of beta-cellulin levels in bovine serum, colostrum and milk. Journal of Endocrinology 2001;168:203-12.. (Pubitemid 32099367)
22. Baveye S, Elass E, Fernig DG, Blanquart C, Mazurier J, Legrand D. Human lactofer-rin interacts with soluble CD14 and inhibits expression of endothelial adhesionmolecules, E-selectin and ICAM-1, induced by the CD14- lipopolysaccharidecomplex. Infection and Immunity 2000;68:6519-25.. (Pubitemid 32463349)
23. Bayless KJ, Davis GE. Identification of dual alpha 4beta1 integrin binding sites withina 38 amino acid domain in the N-terminal thrombin fragment of human osteo-pontin. Journal of Biological Chemistry 2001;276:13483-9..
24. Bering SB, Bai S, Zhang K, Sangild PT. Prematurity does not markedly affect intesti-nal sensitivity to endotoxins and feeding in pigs. British Journal of Nutrition 2012;108:672-81..
25. Berlutti F, Schippa S, Morea C, Sarli S, Perfetto B, Donnarumma G, et al. Lactoferrindownregulates pro-inflammatory cytokines upexpressed in intestinal epithelialcells infected with invasive or noninvasive Escherichia coli strains. Biochemistryand Cell Biology 2006;84:351-7.. (Pubitemid 44341310)
26. Bexkorovainy A. Human mild and colostrum proteins: a review. Journal of Dairy Science 1977;60:1023-37..
27. Bianchi L, Puglia M, Landi C, Matteoni S, Perini D, Armini A, et al. Solubilizationmethods and reference 2-DE map of cow milk fat globules. Journal of Proteomics 2009;72:853-64..
28. Bister V, Salmela MT, Heikkila P, Anttila A, Rintala R, Isaka K, et al. Matrilysins-1and -2 (MMP-7 and -26) and metalloelastase (MMP-12), unlike MMP-19, areup-regulated in necrotizing enterocolitis. Journal of Pediatric Gastroenterologyand Nutrition 2005;40:60-6.. (Pubitemid 40180059)
29. Bojsen A, Buesa J, Montava R, Kvistgaard AS, Kongsbak MB, Petersen TE, et al. Inhibitory activities of bovine macromolecular whey proteins on rotavirus infec-tions in vitro and in vivo. Journal of Dairy Science 2007;90:66-74.. (Pubitemid 350042839)
30. Borthakur A, Bhattacharyya S, Alrefai WA, Tobacman JK, Ramaswamy K, Dudeja PK. Platelet-activating factor-induced NF-kappaB activation and IL-8 productionin intestinal epithelial cells are Bcl10-dependent. Inflammatory Bowel Diseases 2010;16:593-603..
31. Brandenburg K, Jurgens G, Muller M, Fukuoka S, Koch MH. Biophysical character-ization of lipopolysaccharide and lipid A inactivation by lactoferrin. Biological Chemistry 2001;382:1215-25.. (Pubitemid 32894028)
32. Brandtzaeg P. Mucosal immunity: integration between mother and the breast-fedinfant. Vaccine 2003;21:3382-8.. (Pubitemid 36792091)
33. Brasier AR, Jamaluddin M, Han Y, Patterson C, Runge MS. Angiotensin II inducesgene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor. Molecular and Cellular Biochemistry 2000;212:155-69..
34. Brissette MJ, Lepage S, Lamonde AS, Sirois I, Groleau J, Laurin LP, et al. MFG-E8released by apoptotic endothelial cells triggers anti-inflammatory macrophagereprogramming. PLoS One 2012;7:e36368..
35. Buccigrossi V, de Marco G, Bruzzese E, Ombrato L, Bracale I, Polito G, et al. Lactoferrininduces concentration-dependent functional modulation of intestinal prolifer-ation and differentiation. Pediatric Research 2007;61:410-4.. (Pubitemid 46569292)
36. Bult H, Herman AG. Inflammatory mediators released by complement-derived pep-tides. Agents and Actions 1983;13:405-14..
37. Burrin DG, Stoll B, Fan MZ, Dudley MA, Donovan SM, Reeds PJ. Oral IGF-I alters theposttranslational processing but not the activity of lactase-phlorizin hydrolasein formula-fed neonatal pigs. Journal of Nutrition 2001;131:2235-41.. (Pubitemid 32851862)
38. Cals MM, Mailliart P, Brignon G, Anglade P, Dumas BR. Primary structure of bovinelactoperoxidase, a fourth member of a mammalian heme peroxidase family. European Journal of Biochemistry 1991;198:733-9..
39. Caplan M, Hsueh W, Kelly A, Donovan M. Serum PAF acetylhydrolase increasesduring neonatal maturation. Prostaglandins 1990;39:705-14.. (Pubitemid 20189833)
40. Caplan MS, Lickerman M, Adler L, Dietsch GN, Yu A. The role of recombinantplatelet-activating factor acetylhydrolase in a neonatal rat model of necrotizingenterocolitis. Pediatric Research 1997;42:779-83.. (Pubitemid 27509535)
41. Carpenter GW, Wahl MI. The epidermal growth factor family. In Handbook Exptl. Pharmacol.; 1990. p. 69-171..
42. Castellote C, Casillas R, Ramirez-Santana C, Perez-Cano FJ, Castell M, Moretones MG, et al. Premature delivery influences the immunological compositionof colostrum and transitional and mature human milk. Journal of Nutrition 2011;141:1181-7..
43. Cavaillon JM. Cytokines and macrophages. Biomedicine & Pharmacotherapy 1994;48:445-53..
44. Cavaletto M, Giuffrida MG, Conti A. Milk fat globule membrane components - aproteomic approach. Advances in Experimental Medicine and Biology 2008;606:129-41..
45. Chabance B, Marteau P, Rambaud JC, Migliore-Samour D, Boynard M, Perrotin P, et al. Casein peptide release and passage to the blood in humans during digestion ofmilk or yogurt. Biochimie 1998;80:155-65.. (Pubitemid 28185054)
46. Chatterton DEW, Rasmussen JT, Heegaard CW, Sorensen ES, Petersen TE. In vitrodigestion of novel milk protein ingredients for use in infant formulas: researchon biological functions. Trends in Food Science & Technology 2004;15:373-83.. (Pubitemid 38583553)
47. Chatterton DEW, Smithers G, Roupas P, Brodkorb A. Bioactivity of beta-lactoglobulinand alpha-lactalbumin - technological implications for processing. International Dairy Journal 2006;16:1229-40.. (Pubitemid 44348873)
48. Chaudhari K, Xavier PL, Pradeep T. Understanding the evolution of luminescent goldquantum clusters in protein templates. ACS Nano 2011;5:8816-27..
49. Chogle A, Bu HF, Wang X, Brown JB, Chou PM, Tan XD. Milk fat globule-EGF factor8 is a critical protein for healing of dextran sodium sulfate-induced acute colitisin mice. Molecular Medicine 2011;17:502-7..
50. Chokshi NK, Guner YS, Hunter CJ, Upperman JS, Grishin A, Ford HR. The role ofnitric oxide in intestinal epithelial injury and restitution in neonatal necrotizingenterocolitis. Seminars in Perinatology 2008;32:92-9.. (Pubitemid 351381164)
51. Christensen B, Kazanecki CC, Petersen TE, Rittling SR, Denhardt DT, Sorensen ES. Cell type-specific post-translational modifications of mouse osteopontin areassociated with different adhesive properties. Journal of Biological Chemistry 2007;282:19463-72.. (Pubitemid 47100061)
52. Christensen B, Nielsen MS, Haselmann KF, Petersen TE, Sorensen ES. Post-translationally modified residues of native human osteopontin are located inclusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. Biochemical Journal 2005;390:285-92.. (Pubitemid 41192254)
53. Christensen RD, Gordon PV, Besner GE. Can we cut the incidence of necrotizingenterocolitis in half-today? Fetal and Pediatric Pathology 2010;29:185-98..
54. Chtourou A, Brignon G, Ribadeau-Dumas B. Quantification of beta-casein in humanmilk. Journal of Dairy Research 1985;52:239-47..
55. Clark JA, Clark AT, Hotchkiss RS, Buchman TG, Coopersmith CM. Epidermal growthfactor treatment decreases mortality and is associated with improved gutintegrity in sepsis. Shock 2008;30:36-42..
56. Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, et al. Epi-dermal growth factor reduces intestinal apoptosis in an experimental model ofnecrotizing enterocolitis. American Journal of Physiology- Gastrointestinal andLiver Physiology 2005;288:G755-62.. (Pubitemid 40388187)
57. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentallyregulated IkappaB expression in intestinal epithelium and susceptibility toflagellin-induced inflammation. Proceedings of the National Academy of Sci-ences United States of America 2004;101:7404-8.. (Pubitemid 38638045)
58. Claud EC, Savidge T, Walker WA. Modulation of human intestinal epithelial cell IL-8secretion by human milk factors. Pediatric Research 2003;53:419-25.. (Pubitemid 36237396)
59. Cuilliere ML, Tregoat V, Bene MC, Faure G, Montagne P. Changes in the kappa-casein and beta-casein concentrations in human milk during lactation. Journalof Clinical Laboratory Analysis 1999;13:213-8.. (Pubitemid 29468469)
60. Curran CS, Demick KP, Mansfield JM. Lactoferrin activates macrophages viaTLR4-dependent and -independent signaling pathways. Cellular Immunology 2006;242:23-30.. (Pubitemid 44894393)
61. da Silva AP, Ellen RP, Sorensen ES, Goldberg HA, Zohar R, Sodek J. Osteopontinattenuation of dextran sulfate sodium-induced colitis in mice. Laboratory Inves-tigation 2009;89:1169-81..
62. Da Silva AP, Pollett A, Rittling SR, Denhardt DT, Sodek J, Zohar R. Exacerbatedtissue destruction in DSS-induced acute colitis of OPN-null mice is associatedwith downregulation of TNF-alpha expression and non-programmed cell death. Journal of Cellular Physiology 2006;208:629-39.. (Pubitemid 44141888)
63. Daddaoua A, Puerta V, Zarzuelo A, Suarez MD, Sanchez de Medina F, Martinez-Augustin O. Bovine glycomacropeptide is anti-inflammatory in rats withhapten-induced colitis. Journal of Nutrition 2005;135:1164-70.. (Pubitemid 40638322)
64. Denizot Y, Dassa E, Benveniste J, Thomas Y. Paf-acether production by Escherichiacoli. Biochemical and Biophysical Research Communications 1989;161:939-43..
65. Derynck R. SMAD proteins and mammalian anatomy. Nature 1998;393:737-9.. (Pubitemid 28299470)
66. Derynck R, Feng XH. TGF-beta receptor signaling. Biochimica et Biophysica Acta 1997;1333:F105-50..
67. Dewey KG, Heinig MJ, Nommsen-Rivers LA. Differences in morbidity betweenbreast-fed and formula-fed infants. Journal of Pediatrics 1995;126:696-702..
68. Di Lorenzo M, Krantis A. Nitric oxide synthase isoenzyme activities in a prema-ture piglet model of necrotizing enterocolitis: effects of nitrergic manipulation. Pediatric Surgery International 2002;18:624-9.. (Pubitemid 36069919)
69. Dominguez-Melendez V, Silvestre-Santana O, Moreno-Fierros L, Aguiniga-SanchezI, Martinez L, Marroquin-Segura R, et al. Sodium caseinate induces mouse gran-ulopoiesis. Inflammation Research 2012;61:367-73..
70. Dube PE, Brubaker PL. Frontiers in glucagon-like peptide-2: multiple actions, mul-tiple mediators. American Journal of Physiology-Endocrinology andMetabolism 2007;293:E460-5.. (Pubitemid 47205088)
71. Dunbar AJ, Priebe IK, Belford DA, Goddard C. Identification of betacellulin as amajor peptide growth factor in milk: purification, characterization and molecu-lar cloning of bovine betacellulin. Biochemical Journal 1999;344(Pt 3):713-21.. (Pubitemid 30032518)
72. Dutta B, Mukhopadhyay D, Roy N, Das G, Karande AA. Cloning, expression, purifica-tion, and immunocharacterization of placental protein-14. Protein Expressionand Purification 1998;14:327-34.. (Pubitemid 29020366)
73. Dvorak B. Milk epidermal growth factor and gut protection. Journal of Pediatrics 2010;156:S31-5..
74. Ek-Rylander B, Andersson G. Osteoclast migration on phosphorylated osteopontinis regulated by endogenous tartrate-resistant acid phosphatase. Experimental Cell Research 2010;316:443-51..
75. Elass-Rochard E, Roseanu A, Legrand D, Trif M, Salmon V, Motas C, et al. Lactoferrin-lipopolysaccharide interaction: involvement of the 28-34 loop region of humanlactoferrin in the high-affinity binding to Escherichia coli 055B5 lipopolysaccha-ride. Biochemical Journal 1995;312(Pt 3):839-45.. (Pubitemid 26005997)
76. Elfstrand L, Lindmark-Månsson H, Paulsson M, Nyberg L, Åkesson B. Immunoglob-ulins, growth factors and growth hormone in bovine colostrum and the effectsof processing. International Dairy Journal 2002;12:879-87.. (Pubitemid 36021671)
77. Emmett PM, Rogers IS. Properties of human milk and their relationship with mater-nal nutrition. Early Human Development 1997;49(Suppl.):S7-28..
78. Endo Y, Matsushita M, Fujita T. The role of ficolins in the lectin pathwayof innate immunity. International Journal of Biochemistry and Cell Biology 2011;43:705-12..
79. Engin AB. Dual function of nitric oxide in carcinogenesis, reappraisal. Current Drug Metabolism 2011;12:891-9..
80. Eriksson U, Duc G, Froesch ER, Zapf J. Insulin-like growth factors (IGF) I and II and IGFbinding proteins (IGFBPs) in human colostrum/transitory milk during the firstweek postpartum: comparison with neonatal and maternal serum. Biochemicaland Biophysical Research Communications 1993;196:267-73.. (Pubitemid 23309503)
81. Fassolitis AC, Novelli RM, Larkin EP. Serum substitute in epithelial cell culture media:nonfat dry milk filtrate. Applied and Environment Microbiology 1981;42:200-3..
82. Feng J, Besner GE. Heparin-binding epidermal growth factor-like growth factor pro-motes enterocyte migration and proliferation in neonatal rats with necrotizingenterocolitis. Journal of Pediatrics Surgery 2007;42:214-20.. (Pubitemid 46037740)
83. Fong BY, Norris CS. Quantification of milk fat globule membrane proteins usingselected reaction monitoring mass spectrometry. Journal of Agricultural andFood Chemistry 2009;57:6021-8..
84. Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H, Ikeda H. Molecular mecha-nisms of macrophage activation and deactivation by lipopolysaccharide: rolesof the receptor complex. Pharmacology & Therapeutics 2003;100:171-94.. (Pubitemid 37377912)
85. Furukawa M, Narahara H, Yasuda K, Johnston JM. Presence of platelet-activatingfactor-acetylhydrolase in milk. Journal of Lipid Research 1993;34:1603-9..
86. Fusunyan RD, Nanthakumar NN, Baldeon ME, Walker WA. Evidence for an innateimmune response in the immature human intestine: toll-like receptors on fetalenterocytes. Pediatric Research 2001;49:589-93.. (Pubitemid 32274975)
87. Gaggar A, Jackson PL, Noerager BD, O'Reilly PJ, McQuaid DB, Rowe SM, et al. A novelproteolytic cascade generates an extracellular matrix-derived chemoattractantin chronic neutrophilic inflammation. Journal of Immunology 2008;180:5662-9..
88. Ganea D, Delgado M. Vasoactive intestinal peptide (VIP) and pituitary adenylatecyclase-activating polypeptide (PACAP) as modulators of both innate and adap-tive immunity. Critical Reviews in Oral Biology & Medicine 2002;13:229-37.. (Pubitemid 34791208)
89. Gao C, Guo H, Wei J, Mi Z, Wai P, Kuo PC. S-nitrosylation of heteroge-neous nuclear ribonucleoprotein A/B regulates osteopontin transcription inendotoxin-stimulated murine macrophages. Journal of Biological Chemistry 2004;279:11236-43.. (Pubitemid 38401619)
90. Gauthier SF, Pouliot Y, Maubois J-L. Growth factors from bovine milk and colostrum:composition, extraction and biological activities. Le Lait 2006;86:99-125.. (Pubitemid 43667355)
91. Gill SE, Parks WC. Metalloproteinases and their inhibitors: regulators of wound heal-ing. International Journal of Biochemistry and Cell Biology 2008;40:1334-47..
92. Gougerot-Pocidalo MA, el Benna J, Elbim C, Chollet-Martin S, Dang MC. Regulationof human neutrophil oxidative burst by pro- and anti-inflammatory cytokines. Journal de la Société de Biologie 2002;196:37-46..
93. Grave GD, Nelson SA, Walker WA, Moss RL, Dvorak B, Hamilton FA, et al. Newtherapies and preventive approaches for necrotizing enterocolitis: report of aresearch planning workshop. Pediatric Research 2007;62:510-4.. (Pubitemid 47476215)
94. Gregory KE. Clinical predictors of necrotizing enterocolitis in premature infants. Nursing Research 2008;57:260-70..
95. Guo H, Cai CQ, Schroeder RA, Kuo PC. Osteopontin is a negative feedback regu-lator of nitric oxide synthesis in murine macrophages. Journal of Immunology 2001;166:1079-86.. (Pubitemid 32060266)
96. Guo H, Wai PY, Mi Z, Gao C, Zhang J, Kuo PC. Osteopontin mediates Stat1 degradationto inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. Surgery 2008;144:182-8..
97. Habte HH, Kotwal GJ, Lotz ZE, Tyler MG, Abrahams M, Rodriques J, et al. Antiviralactivity of purified human breast milk mucin. Neonatology 2007;92:96-104.. (Pubitemid 47230735)
98. Hamosh M, Peterson JA, Henderson TR, Scallan CD, Kiwan R, Ceriani RL, et al. Pro-tective function of human milk: the milk fat globule. Seminars in Perinatology 1999;23:242-9.. (Pubitemid 29295805)
99. Haversen L, Ohlsson BG, Hahn-Zoric M, Hanson LA, Mattsby-Baltzer I. Lactoferrindown-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cellular Immunology 2002;220:83-95.. (Pubitemid 36349060)
100. Hawkes JS, Bryan DL, James MJ, Gibson RA. Cytokines (IL-1beta, IL-6, TNF-alpha, TGF-beta1, and TGF-beta2) and prostaglandin E2 in human milk during the firstthree months postpartum. Pediatric Research 1999;46:194-9.. (Pubitemid 29362734)
101. Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, et al. The MAD-related proteinSmad7 associates with the TGFbeta receptor and functions as an antagonist ofTGFbeta signaling. Cell 1997;89:1165-73.. (Pubitemid 127678749)
102. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane tonucleus through SMAD proteins. Nature 1997;390:465-71.. (Pubitemid 28013118)
103. Henry MC, Moss RL. Necrotizing enterocolitis. Annual Review of Medicine 2009;60:111-24..
104. Hering NA, Andres S, Fromm A, van Tol EA, Amasheh M, Mankertz J, et al. Transforming growth factor-beta, a whey protein component, strengthens theintestinal barrier by upregulating claudin-4 in HT-29/B6 cells. Journal of Nutri-tion 2011;141:783-9..
105. Hettinga K, van Valenberg H, de Vries S, Boeren S, van Hooijdonk T, van Aren-donk J, et al. The host defense proteome of human and bovine milk. PLoS One 2011;6:e19433..
106. Hicks CL, Bucy J, Stofer W. Heat inactivation of superoxide dismutase in bovine milk. Journal of Dairy Science 1979;62:529-32..
107. Higashiyama M, Hokari R, Hozumi H, Kurihara C, Ueda T, Watanabe C, et al. HIF-1in T cells ameliorated dextran sodium sulfate-induced murine colitis. Journal ofLeukocyte Biology 2012;91:901-9..
108. Higashiyama S, Lau K, Besner GE, Abraham JA, Klagsbrun M. Structure ofheparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein. Journal of Biological Chemistry 1992;267:6205-12..
109. Hoffmann P, Reinshagen M, Zeeh JM, Lakshmanan J, Wu VS, Goebell H, et al. Increased expression of epidermal growth factor-receptor in an experimental model of colitis in rats. Scandinavian Journal of Gastroenterology 2000;35:1174-80..
110. Holt PG, Jones CA. The development of the immune system during pregnancy and early life. Allergy 2000;55:688-97.. (Pubitemid 30619484)
111. Howarth GS, Xian CJ, Read LC. Insulin-like growth factor-I partially attenuatescolonic damage in rats with experimental colitis induced by oral dextran sul-phate sodium. Scandinavian Journal of Gastroenterology 1998;33:180-90.. (Pubitemid 28098234)
112. Howe KL, Reardon C, Wang A, Nazli A, McKay DM. Transforming growth factor-betaregulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased perme-ability. American Journal of Pathology 2005;167:1587-97.. (Pubitemid 41713312)
113. Hsueh W, Caplan MS, Qu XW, Tan XD, De Plaen IG, Gonzalez-Crussi F. Neona-tal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatric and Developmental Pathology 2003;6:6-23.. (Pubitemid 36323623)
114. Hunninghake GW, Doerschug KC, Nymon AB, Schmidt GA, Meyerholz DK, AshareA. Insulin-like growth factor-1 levels contribute to the development of bacte-rial translocation in sepsis. American Journal of Respiratory and Critical Care Medicine 2010;182:517-25..
115. Hvarregaard J, Andersen MH, Berglund L, Rasmussen JT, Petersen TE. Character-ization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules. European Journal of Biochemistry 1996;240:628-36.. (Pubitemid 26321165)
116. Inglingstad RA, Devold TG, Eriksen EK, Holm H, Jacobsen M, Liland KH, et al. Compar-ison of the digestion of caseins and whey proteins in equine, bovine, caprine and human milks by human gastrointestinal enzymes. Dairy Science & Technology 2010;90:549-63..
117. Izumi H, Ishizuka S, Inafune A, Hira T, Ozawa K, Shimizu T, et al. alpha-Lactalbuminhydrolysate stimulates glucagon-like peptide-2 secretion and small intestinalgrowth in suckling rats. Journal of Nutrition 2009;139:1322-7..
118. Jahovic N, Ercan F, Gedik N, Yuksel M, Sener G, Alican I. The effect of angiotensin-converting enzyme inhibitors on experimental colitis in rats. Regulatory Peptides 2005;130:67-74.. (Pubitemid 40966024)
119. Jiang P, Jensen ML, Cilieborg MS, Thymann T, Wan JM, Sit WH, et al. Antibi-otics increase gut metabolism and antioxidant proteins and decrease acutephase response and necrotizing enterocolitis in preterm neonates. PLoS One 2012;7:e44929..
120. Juillerat-Jeanneret L, Robert MC, Juillerat MA. Peptides from Lactobacillushydrolysates of bovine milk caseins inhibit prolyl-peptidases of human coloncells. Journal of Agricultural and Food Chemistry 2011;59:370-7..
121. Kim EY, Kim BC. Lipopolysaccharide inhibits transforming growth factor-beta1-stimulated Smad6 expression by inducing phosphorylation of thelinker region of Smad3 through a TLR4-IRAK1-ERK1/2 pathway. FEBS Letters 2011;585:779-85..
122. Kruzel ML, Harari Y, Mailman D, Actor JK, Zimecki M. Differential effects of pro-phylactic, concurrent and therapeutic lactoferrin treatment on LPS-inducedinflammatory responses in mice. Clinical and Experimental Immunology 2002;130:25-31..
123. Kuhara T, Yamauchi K, Tamura Y, Okamura H. Oral administration of lactofer-rin increases NK cell activity in mice via increased production of IL-18 and type I IFN in the small intestine. Journal of Interferon & Cytokine Research 2006;26:489-99.. (Pubitemid 44061089)
124. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10- deficient micedevelop chronic enterocolitis. Cell 1993;75:263-74..
125. Kumosinski TF, King G, Farrell HM Jr. Comparison of the three-dimensional molec-ular models of bovine submicellar caseins with small-angle X-ray scattering. Influence of protein hydration. Journal of Protein Chemistry 1994;13:701-14..
126. Kunz C, Lonnerdal B. Human-milk proteins: analysis of casein and casein subunitsby anion-exchange chromatography, gel electrophoresis, and specific stainingmethods. American Journal of Clinical Nutrition 1990;51:37-46..
127. Kussendrager KD, van Hooijdonk AC. Lactoperoxidase: physico-chemical properties, occurrence, mechanism of action and applications. British Journal of Nutrition 2000;84(Suppl. 1):S19-25.. (Pubitemid 32106826)
128. Kusunoki R, Ishihara S, Aziz M, Oka A, Tada Y, Kinoshita Y. Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation. Digestion 2012;85:103-7..
129. Kvistgaard AS, Pallesen LT, Arias CF, Lopez S, Petersen TE, Heegaard CW, et al. Inhibitory effects of human and bovine milk constituents on rotavirus infections. Journal of Dairy Science 2004;87:4088-96.. (Pubitemid 39606240)
130. L'Abbe MR, Friel JK. Superoxide dismutase and glutathione peroxidase contentof human milk from mothers of premature and full-term infants during thefirst 3 months of lactation. Journal of Pediatric Gastroenterology and Nutrition 2000;31:270-4..
131. Labeta MO, Vidal K, Nores JE, Arias M, Vita N, Morgan BP, et al. Innate recogni-tion of bacteria in human milk is mediated by a milk-derived highly expressedpattern recognition receptor, soluble CD14. Journal of Experimental Medicine 2000;191:1807-12.. (Pubitemid 30331577)
132. Larson BLJR. Characterization of the sulphydryl groups and the kinetics of the heatdenaturation of crystalline beta-lactoglobulin. Journal of American Chemical Society 1952;74:3090-3..
133. Le TT, Van de Wiele T, Do TN, Debyser G, Struijs K, Devreese B, et al. Stability ofmilk fat globule membrane proteins toward human enzymatic gastrointestinaldigestion. Journal of Dairy Science 2012;95:2307-18..
134. Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, et al. A critical role for TLR4in the pathogenesis of necrotizing enterocolitis by modulating intestinal injuryand repair. Journal of Immunology 2007;179:4808-20..
135. LeBouder E, Rey-Nores JE, Rushmere NK, Grigorov M, Lawn SD, Affolter M, et al. Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2signaling are present in human plasma and breast milk. Journal of Immunology 2003;171:6680-9.. (Pubitemid 37532100)
136. Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW. Hypoxia-inducible factor (HIF-1)alpha:its protein stability and biological functions. Experimental and Molecular Medicine 2004;36:1-12..
137. Letterio JJ, Geiser AG, Kulkarni AB, Roche NS, Sporn MB, Roberts AB. Maternal rescueof transforming growth factor-beta 1 null mice. Science 1994;264:1936-8.. (Pubitemid 24245640)
138. Levay PF, Viljoen M. Lactoferrin: a general review. Haematologica 1995;80:252-67..
139. Levieux D, Ollier A. Bovine immunoglobulin G, beta-lactoglobulin, alpha-lactalbumin and serum albumin in colostrum and milk during the early postpartum period. Journal of Dairy Research 1999;66:421-30.. (Pubitemid 29380830)
140. Li MO, Flavell RA. Contextual regulation of inflammation: a duet by transforminggrowth factor-beta and interleukin-10. Immunity 2008;28:468-76.. (Pubitemid 351467045)
141. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nature Reviews Immunology 2002;2:725-34..
142. Lin IC, Su SL, Kuo CD. Induction of cell death in RAW 264.7 cells by alpha-lactalbumin. Food and Chemical Toxicology 2008;46:842-53..
143. Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet 2006;368:1271-83.. (Pubitemid 44485800)
144. Linden GAC. Alkaline-phosphatase in human, cow and sheep milks-molecular and catalytic properties and metal-ion action. Annales de biologie animale biochimiebiophysique 1978;18:749-58..
145. Liu X, Murali SG, Holst JJ, Ney DM. Whey protein potentiates the intestinotrophicaction of glucagon-like peptide-2 in parenterally fed rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2009;297:R1554-62..
146. Lonnerdal B, Forsum E. Casein content of human milk. American Journal of Clinical Nutrition 1985;41:113-20.. (Pubitemid 15165161)
147. Lonnerdal B, Iyer S. Lactoferrin: molecular structure and biological function. Annual Review of Nutrition 1995;15:93-110..
148. Lonnerdal B, Lien EL. Nutritional and physiologic significance of alpha-lactalbuminin infants. Nutrition Reviews 2003;61:295-305.. (Pubitemid 37259920)
149. Lonnerdal B, Woodhouse LR, Glazier C. Compartmentalization and quantitation ofprotein in human milk. Journal of Nutrition 1987;117:1385-95.. (Pubitemid 17160385)
150. Lopez-Posadas R, Requena P, Gonzalez R, Suarez MD, Zarzuelo A, Sanchez de MedinaF, et al. Bovine glycomacropeptide has intestinal antiinflammatory effects in ratswith dextran sulfate-induced colitis. Journal of Nutrition 2010;140:2014-9..
151. Lu J, Pierce M, Franklin A, Jilling T, Stafforini DM, Caplan M. Dual roles of endoge-nous platelet-activating factor acetylhydrolase in a murine model of necrotizingenterocolitis. Pediatric Research 2010;68:225-30..
152. Lucas A, Cole TJ. Breast milk and neonatal necrotising enterocolitis. Lancet 1990;336:1519-23..
153. Ma L, Xu RJ. Oral insulinlike growth factor-I stimulates intestinal enzyme maturationin newborn rats. Life Science 1997;61:51-8.. (Pubitemid 27288320)
154. Machnicki M, Zimecki M, Zagulski T. Lactoferrin regulates the release of tumournecrosis factor alpha and interleukin 6 in vivo. International Journal of Experi-mental Pathology 1993;74:433-9.. (Pubitemid 23304079)
155. Madureira AR, Pereira CI, Gomes AMP, Pintado ME, Malcata FX. Bovine wheyproteins - overview on their main biological properties. Food Research Inter-national 2007;40:1197-211.. (Pubitemid 47599960)
156. Mahe S, Roos N, Benamouzig R, Davin L, Luengo C, Gagnon L, et al. Gastrojejunalkinetics and the digestion of [15 N]beta-lactoglobulin and casein in humans: theinfluence of the nature and quantity of the protein. American Journal of Clinical Nutrition 1996;63:546-52..
157. Malven PV, Head HH, Collier RJ, Buonomo FC. Periparturient changes in secretionand mammary uptake of insulin and in concentrations of insulin and insulin-likegrowth factors in milk of dairy cows. Journal of Dairy Science 1987;70:2254-65..
158. Manthey HD, Woodruff TM, Taylor SM, Monk PN. Complement component 5a (C5a). International Journal of Biochemistry and Cell Biology 2009;41:2114-7..
159. Manzoni P, Rinaldi M, Cattani S, Pugni L, Romeo MG, Messner H, et al. Bovine lactofer-rin supplementation for prevention of late-onset sepsis in very low-birth-weightneonates: a randomized trial. JAMA 2009;302:1421-8..
160. Mason S. Some aspects of gastric function in the newborn. Archives of Disease inChildhood 1962;37:387-91..
161. Mather IH. A review and proposed nomenclature for major proteins of the milk-fatglobule membrane. Journal of Dairy Science 2000;83:203-47..
162. Mather IH, Keenan TW. Origin and secretion of milk lipids. Journal of Mammary Gland Biology and Neoplasia 1998;3:259-73.. (Pubitemid 128693197)
163. Matsuda A, Jacob A, Wu R, Zhou M, Aziz M, Wang P. Milk fat globule-EGF factor VIIIameliorates liver injury after hepatic ischemia-reperfusion. Journal of Surgi-cal Research 2013;180(1):e37-47, http://dx.doi.org/10.1016/j.jss.2012. 03.021, Epub 2012 Mar 31..
164. Matsuda A, Jacob A, Wu R, Zhou M, Nicastro JM, Coppa GF, et al. Milk fat globule-EGF factor VIII in sepsis and ischemia-reperfusion injury. Molecular Medicine 2011;17:126-33..
165. Mehta VB, Besner GE. Inhibition of NF-kappa B activation and its target genesby heparin-binding epidermal growth factor-like growth factor. Journal ofImmunology 2003;171:6014-22.. (Pubitemid 37467220)
166. Mehta VB, Besner GE. Heparin-binding epidermal growth factor-like growth factorinhibits cytokine-induced NF-kappa B activation and nitric oxide production viaactivation of the phosphatidylinositol 3-kinase pathway. Journal of Immunology 2005;175:1911-8.. (Pubitemid 41023098)
167. Mei J, Zhang YQ, Wang T, Sangild PT, Xu RJ. Oral ingestion of colostrum altersintestinal transforming growth factor-beta receptor intensity in newborn pigs. Livestock Science 2006;105:214-22.. (Pubitemid 44646924)
168. Meisel H. Biochemical properties of regulatory peptides derived from milk proteins. Biopolymers 1997;43:119-28.. (Pubitemid 27291390)
169. Michalsky MP, Lara-Marquez M, Chun L, Besner GE. Heparin-binding EGF-likegrowth factor is present in human amniotic fluid and breast milk. Journal ofPediatrics Surgery 2002;37:1-6.. (Pubitemid 34038629)
170. Miguel-Carrasco JL, Zambrano S, Blanca AJ, Mate A, Vazquez CM. Captopril reducescardiac inflammatory markers in spontaneously hypertensive rats by inactiva-tion of NF-kB. Journal of Inflammation (London) 2010;7:1-9..
171. Miksa M, Wu R, Dong W, Komura H, Amin D, Ji Y, et al. Immature dendriticcell-derived exosomes rescue septic animals via milk fat globule epider-mal growth factor-factor VIII [corrected]. Journal of Immunology 2009;183:5983-90..
172. Miller MJ, McNeill H, Mullane KM, Caravella SJ, Clark DA. SOD prevents damageand attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. American Journal of Physiology 1988;255:G556-65..
173. Miyauchi J, Watanabe Y. Immunocytochemical localization of lactoferrin in humanneutrophils. An ultrastructural and morphometrical study. Cell Tissue Research 1987;247:249-58.. (Pubitemid 17006739)
174. Moller HK, Thymann T, Fink LN, Frokiaer H, Kvistgaard AS, Sangild PT. Bovinecolostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs. British Journal of Nutrition 2011;105:44-53..
175. Monnai M, Horimoto Y, Otani H. Immunodificatory effect of dietary bovine kappa-caseinoglycopeptide on serum antibody levels and proliferative responses oflymphocytes in mice. Milchwissenschaft 1998:53..
176. Montagne P, Cuilliere ML, Mole C, Bene MC, Faure G. Immunological and nutri-tional composition of human milk in relation to prematurity and mother's parityduring the first 2 weeks of lactation. Journal of Pediatric Gastroenterology andNutrition 1999;29:75-80.. (Pubitemid 30345832)
177. Monti JC, Mermoud AF, Jolles P. Anti-bovine beta-lactoglobulin antibodies react witha human lactoferrin fragment and bovine beta-lactoglobulin present in humanmilk. Experientia 1989;45:178-80.. (Pubitemid 19062384)
178. Moore SA, Anderson BF, Groom CR, Haridas M, Baker EN. Three-dimensional struc-ture of diferric bovine lactoferrin at 2.8 A resolution. Journal of Molecular Biology 1997;274:222-36.. (Pubitemid 27520608)
179. Murray BA, Fitz Gerald RJ. Angiotensin converting enzyme inhibitory peptidesderived from food proteins: biochemistry, bioactivity and production. Current Pharmaceutical Design 2007;13:773-91.. (Pubitemid 46591099)
180. Maayan-Metzger A, Avivi S, Schushan-Eisen I, Kuint J. Human milk versus for-mula feeding among preterm infants: short-term outcomes. American Journalof Perinatology 2012;29:121-6..
181. Nabil S, Gauthier SF, Drouin R, Poubelle PE, Pouliot Y. In vitro digestion of pro-teins and growth factors in a bovine whey protein extract as determined using acomputer-controlled dynamic gastrointestinal system (TIM-1). Food Digestion 2011;2:13-22..
182. Nadler EP, Dickinson E, Knisely A, Zhang XR, Boyle P, Beer-Stolz D, et al. Expression ofinducible nitric oxide synthase and interleukin-12 in experimental necrotizingenterocolitis. Journal of Surgical Research 2000;92:71-7.. (Pubitemid 30437462)
183. Nagata S, Hanayama R, Kawane K. Autoimmunity and the clearance of dead cells. Cell 2010;140:619-30..
184. Nagatomo T, Ohga S, Takada H, Nomura A, Hikino S, Imura M, et al. Microar-ray analysis of human milk cells: persistent high expression of osteopontinduring the lactation period. Clinical and Experimental Immunology 2004;138:47-53.. (Pubitemid 39279964)
185. Nair RR, Warner BB, Warner BW. Role of epidermal growth factor and other growthfactors in the prevention of necrotizing enterocolitis. Seminars in Perinatology 2008;32:107-13.. (Pubitemid 351381169)
186. Nakamura Y, Miyata M, Ando T, Shimokawa N, Ohnuma Y, Katoh R, et al. The latentform of transforming growth factor-beta administered orally is activated bygastric acid in mice. Journal of Nutrition 2009;139:1463-8..
187. Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, et al. Identifi-cation of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 1997;389:631-5..
188. Nanthakumar NN, Fusunyan RD, Sanderson I, Walker WA. Inflammation in thedeveloping human intestine: a possible pathophysiologic contribution to necro-tizing enterocolitis. Proceedings of the National Academy of Sciences United States of America 2000;97:6043-8.. (Pubitemid 30367520)
189. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB Journal 1992;6:3051-64..
190. Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell 1994;78:915-8.. (Pubitemid 24292319)
191. Neu J, Walker WA. Medical progress: necrotizing enterocolitis. New England Journalof Medicine 2011a;364:255-64..
192. Neu J, Walker WA. Necrotizing enterocolitis. New England Journal of Medicine 2011b;364:255-64..
193. Newburg DS, Walker WA. Protection of the neonate by the innate immunesystem of developing gut and of human milk. Pediatric Research 2007;61:2-8.. (Pubitemid 46352307)
194. Nielsen SM, Hansen GH, Danielsen EM. Lactoferrin targets T cells in the small intes-tine. Journal of Gastroenterology 2010;45:1121-8..
195. Nojiri T, Yoshizato T, Fukami T, Obama H, Yagi H, Yotsumoto F, et al. Clinical signif-icance of amphiregulin and epidermal growth factor in colostrum. Archives ofGynecology and Obstetrics 2012;286:643-7..
196. Nordenfelt P, Tapper H. Phagosome dynamics during phagocytosis by neutrophils. Journal of Leukocyte Biology 2011;90:271-84..
197. Nowicki PT, Caniano DA, Hammond S, Giannone PJ, Besner GE, Reber KM, et al. Endothelial nitric oxide synthase in human intestine resected for necrotizingenterocolitis. Journal of Pediatrics 2007;150:40-5.. (Pubitemid 44940888)
198. Nuijens JH, van Berkel PH, Schanbacher FL. Structure and biological actionsof lactoferrin. Journal of Mammary Gland Biology and Neoplasia 1996;1:285-95..
199. Ogge G, Romero R, Lee DC, Gotsch F, Than NG, Lee J, et al. Chronic chorioamnionitisdisplays distinct alterations of the amniotic fluid proteome. Journal of Pathology 2011;223:553-65..
200. Okada K, Fujii T, Ohtsuka Y, Yamakawa Y, Izumi H, Yamashiro Y, et al. Over-feeding can cause NEC-like enterocolitis in premature rat pups. Neonatology 2010;97:218-24..
201. Orange JS, Jain A, Ballas ZK, Schneider LC, Geha RS, Bonilla FA. The presenta-tion and natural history of immunodeficiency caused by nuclear factor kappaBessential modulator mutation. Journal of Allergy and Clinical Immunology 2004;113:725-33.. (Pubitemid 38530430)
202. Oz HS, Ray M, Chen TS, McClain CJ. Efficacy of a transforming growth factorbeta 2 containing nutritional support formula in a murine model of inflam-matory bowel disease. Journal of American College of Nutrition 2004;23:220-6.. (Pubitemid 38746110)
203. Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, et al. Transfor-ming growth factor-beta activity in commercially available pasteurized cowmilk provides protection against inflammation in mice. Journal of Nutrition 2009;139:69-75..
204. Ozen S, Akisu M, Baka M, Yalaz M, Sozmen EY, Berdeli A, et al. Insulin-like growthfactor attenuates apoptosis and mucosal damage in hypoxia/reoxygenation-induced intestinal injury. Biology of the Neonate 2005;87:91-6.. (Pubitemid 40278611)
205. Pakkanen RAJ. Growth factors and antimicrobial factors of bovine colostrum. Inter-national Dairy Journal 1997;7:285-97..
206. Pallesen LT, Pedersen LR, Petersen TE, Rasmussen JT. Characterization of carbohy-drate structures of bovine MUC15 and distribution of the mucin in bovine milk. Journal of Dairy Science 2007;90:3143-52.. (Pubitemid 350045283)
207. Parker P, Sando L, Pearson R, Kongsuwan K, Tellam RL, Smith S. Bovine Muc1inhibits binding of enteric bacteria to Caco-2 cells. Glycoconjugate Journal 2010;27:89-97..
208. Pavelic J, Matijevic T, Knezevic J. Biological & physiological aspects of action ofinsulin-like growth factor peptide family. Indian Journal of Medical Research 2007;125:511-22.. (Pubitemid 47099107)
209. Pedersen NL, Nagain-Domaine C, Mahe S, Chariot J, Roze C, Tome D. Caseino-macropeptide specifically stimulates exocrine pancreatic secretion in theanesthetized rat. Peptides 2000;21:1527-35..
210. Pender SL, Braegger C, Gunther U, Monteleone G, Meuli M, Schuppan D, et al. Matrix metalloproteinases in necrotising enterocolitis. Pediatric Research 2003;54:160-4.. (Pubitemid 36918147)
211. Peng SL. Forkhead transcription factors in chronic inflammation. International Jour-nal of Biochemistry and Cell Biology 2010;42:482-5..
212. Penttila I. Effects of transforming growth factor-beta and formula feeding on sys-temic immune responses to dietary beta-lactoglobulin in allergy-prone rats. Pediatric Research 2006;59:650-5.. (Pubitemid 43740005)
213. Penttila IA. Milk-derived transforming growth factor-beta and the infant immuneresponse. Journal of Pediatrics 2010;156:S21-5..
214. Peroni DG, Piacentini GL, Bodini A, Pigozzi R, Boner AL. Transforming growth factor-beta is elevated in unpasteurized cow's milk. Pediatric Allergy and Immunology 2009;20:42-4..
215. Persson BA, Lund M, Forsman J, Chatterton DE, Akesson T. Molecular evi-dence of stereo-specific lactoferrin dimers in solution. Biophysical Chemistry 2010;151:187-9..
216. Peterson JA, Hamosh M, Scallan CD, Ceriani RL, Henderson TR, Mehta NR, et al. Milkfat globule glycoproteins in human milk and in gastric aspirates of mother'smilk-fed preterm infants. Pediatric Research 1998;44:499-506.. (Pubitemid 28447334)
217. Peterson JA, Scallan CD, Ceriani RL, Hamosh M. Structural and functional aspects ofthree major glycoproteins of the human milk fat globule membrane. Advancesin Experimental Medicine and Biology 2001;501:179-87.. (Pubitemid 34102195)
218. Petrosyan M, Guner YS, Williams M, Grishin A, Ford HR. Current concepts regardingthe pathogenesis of necrotizing enterocolitis. Pediatric Surgery International 2009;25:309-18..
219. Philipps AF, Anderson GG, Dvorak B, Williams CS, Lake M, Lebouton AV, et al. Growthof artificially fed infant rats: effect of supplementation with insulin-like growthfactor I. American Journal of Physiology 1997;272:R1532-9..
220. Picariello G, Ferranti P, Mamone G, Klouckova I, Mechref Y, Novotny MV, et al. Gel-free shotgun proteomic analysis of human milk. Journal of Chromatography A2012;1227:219-33..
221. Pierce A, Colavizza D, Benaissa M, Maes P, Tartar A, Montreuil J, et al. Molecularcloning and sequence analysis of bovine lactotransferrin. European Journal ofBiochemistry 1991;196:177-84..
222. Pietzcker J, Kluthea C, Klinghammer K, Buhrer C, Rustow B, Guthmann F. Devel-opmental delay in hypoxia-induced HO-1 expression predisposes to gut injury. Journal of Perinatal Medicine 2012;40:191-7..
223. Plaisancie P, Claustre J, Estienne M, Henry G, Boutrou R, Paquet A, et al. A novelbioactive peptide from yoghurts modulates expression of the gel-forming MUC2mucin as well as population of goblet cells and Paneth cells along the smallintestine. Journal of Nutritional Biochemistry 2013;24:213-21..
224. Pothoulakis C, Castagliuolo I, Leeman SE. Neuroimmune mechanisms of intesti-nal responses to stress. Role of corticotropin-releasing factor and neurotensin. Annals of New York Academy of Sciences 1998;840:635-48..
225. Prioult G, Pecquet S, Fliss I. Stimulation of interleukin-10 production by acidicbeta-lactoglobulin-derived peptides hydrolyzed with Lactobacillus paraca-sei NCC2461 peptidases. Clinical and Diagnostic Laboratory Immunology 2004;11:266-71.. (Pubitemid 38380805)
226. Przybylska J, Albera E, Kankofer M. Antioxidants in bovine colostrum. Reproductionin Domestic Animals 2007;42:402-9.. (Pubitemid 47041840)
227. Qin YD, Luo X, Huang DL, Xu CZ. Dynamic changes of enzymes activities and growth factors contents in human colostrum. Zhonghua Fu Chan Ke Za Zhi 2004;39:449-52..
228. Quaranta S, Giuffrida MG, Cavaletto M, Giunta C, Godovac-Zimmermann J, CanasB, et al. Human proteome enhancement: high-recovery method and improvedtwo-dimensional map of colostral fat globule membrane proteins. Electrophore-sis 2001;22:1810-8..
229. Rautava S, Lu L, Nanthakumar NN, Dubert-Ferrandon A, Walker WA. TGF-beta2induces maturation of immature human intestinal epithelial cells and inhibitsinflammatory cytokine responses induced via the NF-kappaB pathway. Journalof Pediatric Gastroenterology and Nutrition 2012;54:630-8..
230. Rautava S, Nanthakumar NN, Dubert-Ferrandon A, Lu L, Rautava J, Walker WA. Breast milk-transforming growth factor-beta(2) specifically attenuates IL-1beta-induced inflammatory responses in the immature human intestine viaan SMAD6- and ERK-dependent mechanism. Neonatology 2011;99:192-201..
231. Raymond A, Ensslin MA, Shur BD. SED1/MFG-E8: a bi-motif protein that orchestratesdiverse cellular interactions. Journal of Cellular Biochemistry 2009;106:957-66..
232. Reddy IM, Kella NKD, Kinsella JE. Structural and conformational basis of the resis-tance of beta-lactoglobulin to peptic and chymotryptic digestion. Journal ofAgricultural and Food Chemistry 1988;36:737-41..
233. Reinhardt TA, Lippolis JD. Bovine milk fat globule membrane proteome. Journal ofDairy Research 2006;73:406-16.. (Pubitemid 44624069)
234. Reinhardt TA, Lippolis JD. Developmental changes in the milk fat globule membraneproteome during the transition from colostrum to milk. Journal of Dairy Science 2008;91:2307-18.. (Pubitemid 351807974)
235. Requena P, Daddaoua A, Guadix E, Zarzuelo A, Suarez MD, Sanchez de Medina F, et al. Bovine glycomacropeptide induces cytokine production in human monocytesthrough the stimulation of the MAPK and the NF-kappaB signal transductionpathways. British Journal of Pharmacology 2009;157:1232-40..
236. Requena P, Daddaoua A, Martinez-Plata E, Gonzalez M, Zarzuelo A, Suarez MD, et al. Bovine glycomacropeptide ameliorates experimental rat ileitis by mechanismsinvolving downregulation of interleukin 17. British Journal of Pharmacology 2008;154:825-32.. (Pubitemid 351835972)
237. Requena P, Gonzalez R, Lopez-Posadas R, Abadia-Molina A, Suarez MD, ZarzueloA, et al. The intestinal antiinflammatory agent glycomacropeptide hasimmunomodulatory actions on rat splenocytes. Biochemical Pharmacology 2010;79:1797-804..
238. Restani P, Ballabio C, Di Lorenzo C, Tripodi S, Fiocchi A. Molecular aspects of milkallergens and their role in clinical events. Analytical and Bioanalytical Chemistry 2009;395:47-56..
239. Riedemann J, Macaulay VM. IGF1R signalling and its inhibition. Endocrine Related Cancer 2006;13(Suppl. 1):S33-43.. (Pubitemid 46219247)
240. Riggle KM, Rentea RM, Welak SR, Pritchard KA, Oldham KT, Gourlay DM. Intestinalalkaline phosphatase prevents the systemic inflammatory response associatedwith necrotizing enterocolitis. Journal of Surgical Research 2013;180:21-6..
241. Rival SG, Fornaroli S, Boeriu CG, Wichers HJ. Caseins and casein hydrolysates. 1. Lipoxygenase inhibitory properties. Journal of Agricultural and Food Chemistry 2001;49:287-94.. (Pubitemid 32104524)
242. Rocourt DV, Mehta VB, Besner GE. Heparin-binding EGF-like growth factor decreasesinflammatory cytokine expression after intestinal ischemia/reperfusion injury. Journal of Surgical Research 2007;139:269-73.. (Pubitemid 46551173)
243. Rodriguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chavez M, Herrera-Acosta J, et al. Reduction of renal immune cell infiltration results in blood pressure control ingenetically hypertensive rats. American Journal of Physiology Renal Physiology 2002;282:F191-201.. (Pubitemid 34654549)
244. Rogler G, Andus T. Cytokines in inflammatory bowel disease. World Journal ofSurgery 1998;22:382-9.. (Pubitemid 28113526)
245. Rossol M, Heine H, Meusch U, Quandt D, Klein C, Sweet MJ, et al. LPS-inducedcytokine production in human monocytes and macrophages. Critical Reviewsin Immunology 2011;31:379-446..
246. Roth-Walter F, Berin MC, Arnaboldi P, Escalante CR, Dahan S, Rauch J, et al. Pasteur-ization of milk proteins promotes allergic sensitization by enhancing uptakethrough Peyer's patches. Allergy 2008;63:882-90.. (Pubitemid 351832791)
247. Ruiz-Ortega M, Lorenzo O, Suzuki Y, Ruperez M, Egido J. Proinflammatory actions ofangiotensins. Current Opinion in Nephrology and Hypertension 2001;10:321-9..
248. Rusu D, Drouin R, Pouliot Y, Gauthier S, Poubelle PE. A bovine whey pro-tein extract stimulates human neutrophils to generate bioactive IL-1Rathrough a NF-kappaB- and MAPK-dependent mechanism. Journal of Nutrition 2010;140:382-91..
249. Saeland E, de Jong MA, Nabatov AA, Kalay H, Geijtenbeek TB, van Kooyk Y. MUC1in human milk blocks transmission of human immunodeficiency virus fromdendritic cells to T cells. Molecular Immunology 2009;46:2309-16..
250. Saito T, Nakamura T, Kitazawa H, Kawai Y, Itoh T. Isolation and structural analysis ofantihypertensive peptides that exist naturally in Gouda cheese. Journal of Dairy Science 2000;83:1434-40..
251. Sanchez L, Calvo M, Brock JH. Biological role of lactoferrin. Archives of Disease inChildhood 1992;67:657-61..
252. Sando L, Pearson R, Gray C, Parker P, Hawken R, Thomson PC, et al. Bovine Muc1is a highly polymorphic gene encoding an extensively glycosylated mucin thatbinds bacteria. Journal of Dairy Science 2009;92:5276-91..
253. Sangild PT, Mei J, Fowden AL, Xu RJ. The prenatal porcine intestine has low trans-forming growth factor-beta ligand and receptor density and shows reducedtrophic response to enteral diets. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2009;296:R1053-62..
254. Sangild PT, Siggers RH, Schmidt M, Elnif J, Bjornvad CR, Thymann T, et al. Diet-and colonization-dependent intestinal dysfunction predisposes to necrotizingenterocolitis in preterm pigs. Gastroenterology 2006;130:1776-92.. (Pubitemid 43668865)
255. Santiago-Osorio E, Mora L, Bautista M, Montesinos JJ, Martinez I, Ramos-MandujanoG, et al. Sodium caseinate induces secretion of macrophage colony-stimulatingfactor from neutrophils. Immunobiology 2010;215:332-9..
256. Sare M, Bozkurt S, Onuk E, Oguz M, Gurel M, Ercan S. The effects ofindomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandinE2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. Prostaglandins, Leukotrienes and Essential Fatty Acids 1996;55:379-83.. (Pubitemid 27014125)
257. Savilahti E, Saarinen KM. Colostrum TGF-beta-1 associates with the duration ofbreast-feeding. European Journal of Nutrition 2007;46:238-42.. (Pubitemid 46798944)
258. Schack L, Lange A, Kelsen J, Agnholt J, Christensen B, Petersen TE, et al. Considerablevariation in the concentration of osteopontin in human milk, bovine milk, and infant formulas. Journal of Dairy Science 2009;92:5378-85..
259. Schmukle AC, Walczak H. No one can whistle a symphony alone - how differentubiquitin linkages cooperate to orchestrate NF-kappaB activity. Journal of Cell Science 2012;125:549-59..
260. Scholz C, Toth B, Brunnhuber R, Rampf E, Weissenbacher T, Santoso L, et al. Gly-codelin A induces a tolerogenic phenotype in monocyte-derived dendritic cellsin vitro. American Journal of Reproductive Immunology 2008;60:501-12..
261. Schraufstatter IU, Trieu K, Sikora L, Sriramarao P, DiScipio R. Complement c3a and c5a induce different signal transduction cascades in endothelial cells. Journal ofImmunology 2002;169:2102-10.. (Pubitemid 34857676)
262. Schromm AB, Brandenburg K, Loppnow H, Zahringer U, Rietschel ET, Carroll SF, et al. The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity. Journal of Immunology 1998;161:5464-71.. (Pubitemid 28519109)
263. Schulz S, Wong RJ, Jang KY, Kalish F, Chisholm KM, Zhao H, et al. Heme oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-likeintestinal injury in a newborn mouse model. American Journal of Physiology-Gastrointestinal and Liver Physiology 2013..
264. Shah KG, Wu R, Jacob A, Molmenti EP, Nicastro J, Coppa GF, et al. Recombinanthuman milk fat globule-EGF factor 8 produces dose-dependent benefits in sep-sis. Intensive Care Medicine 2012;38:128-36..
265. Sheng YH, Lourie R, Linden SK, Jeffery PL, Roche D, Tran TV, et al. The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelialcell apoptosis. Gut 2011;60:1661-70..
266. Sheng YH, Triyana S, Wang R, Das I, Gerloff K, Florin TH, et al. MUC1and MUC13 differentially regulate epithelial inflammation in response toinflammatory and infectious stimuli. Mucosal Immunology 2013;6:557-68, http://dx.doi.org/10. 1038/mi.2012.98 (Epub 2012 Nov 14)..
267. Shin K, Tomita M, Lonnerdal B. Identification of lactoperoxidase in mature humanmilk. Journal of Nutritional Biochemistry 2000;11:94-102..
268. Shin K, Wakabayashi H, Yamauchi K, Yaeshima T, Iwatsuki K. Recombinant humanintelectin binds bovine lactoferrin and its peptides. Biological and Pharmaceu-tical Bulletin 2008;31:1605-8..
269. Shoji H, Oguchi S, Shinohara K, Shimizu T, Yamashiro Y. Effects of iron-unsaturatedhuman lactoferrin on hydrogen peroxide-induced oxidative damage in intesti-nal epithelial cells. Pediatric Research 2007;61:89-92.. (Pubitemid 46352322)
270. Siggers RH, Siggers J, Thymann T, Boye M, Sangild PT. Nutritional modulation ofthe gut microbiota and immune system in preterm neonates susceptible tonecrotizing enterocolitis. Journal of Nutritional Biochemistry 2011;22:511-21..
271. Sodek J, Ganss B, McKee MD. Osteopontin. Critical Reviews in Oral Biology &Medicine 2000;11:279-303..
272. Soliman A, Michelsen KS, Karahashi H, Lu J, Meng FJ, Qu X, et al. Platelet-activatingfactor induces TLR4 expression in intestinal epithelial cells: implication for thepathogenesis of necrotizing enterocolitis. PLoS One 2010;5:e15044..
273. Sorensen ES, Hojrup P, Petersen TE. Posttranslational modifications of bovineosteopontin: identification of twenty-eight phosphorylation and three O-glycosylation sites. Protein Science 1995;4:2040-9..
274. Spagnuolo PA, Hoffman-Goetz L. Dietary lactoferrin does not prevent dextran sulfatesodium induced murine intestinal lymphocyte death. Experimental Biology andMedicine (Maywood) 2008;233:1099-108..
275. Spencer WJ, Binette A, Ward TL, Davis LD, Blais DR, Harrold J, et al. Alpha-lactalbuminin human milk alters the proteolytic degradation of soluble CD14 by forming acomplex. Pediatric Research 2010;68:490-3..
276. Stuart DI, Acharya KR, Walker NP, Smith SG, Lewis M, Phillips DC. Alpha-lactalbuminpossesses a novel calcium binding loop. Nature 1986;324:84-7.. (Pubitemid 16008423)
277. Su Y, Yang J, Besner GE. HB-EGF promotes intestinal restitution by affecting integrin-extracellular matrix interactions and intercellular adhesions. Growth Factors 2013;31:39-55..
278. Suikkari AM. Insulin-like growth factor (IGF-I) and its low molecular weight bind-ing protein in human milk. European Journal of Obstetrics & Gynecology andReproductive Biology 1989;30:19-25..
279. Sun XM, Hsueh W. Platelet-activating factor produces shock, in vivo comple-ment activation, and tissue injury in mice. Journal of Immunology 1991;147:509-14..
280. Suzuki YA, Shin K, Lonnerdal B. Molecular cloning and functional expression of ahuman intestinal lactoferrin receptor. Biochemistry 2001;40:15771-9.. (Pubitemid 34015206)
281. Swaisgood HE. Chemistry of the caseins. In: Fox PJ, editor. Advanced dairy chemistry. Essex: Elsevier; 1992. p. 63-110..
282. Syrbu SI, Waterman WH, Molski TF, Nagarkatti D, Hajjar JJ, Sha'afi RI. Phosphoryla-tion of cytosolic phospholipase A2 and the release of arachidonic acid in humanneutrophils. Journal of Immunology 1999;162:2334-40.. (Pubitemid 29288859)
283. Takakura N, Wakabayashi H, Yamauchi K, Takase M. Influences of orallyadministered lactoferrin on IFN-gamma and IL-10 production by intestinal intraepithelial lymphocytes and mesenteric lymph-node cells. Biochemistry andCell Biology 2006;84:363-8.. (Pubitemid 44341312)
284. Talukder MJ, Harada E. Bovine lactoferrin protects lipopolysaccharide- induced diar-rhea modulating nitric oxide and prostaglandin E2 in mice. Canadian Journal ofPhysiology and Pharmacology 2007;85:200-8.. (Pubitemid 46846431)
285. Tanida S, Kataoka H, Mizoshita T, Shimura T, Kamiya T, Joh T. Intranucleartranslocation signaling of HB-EGF carboxy-terminal fragment and mucosaldefense through cell proliferation and migration in digestive tracts. Digestion 2010;82:145-9..
286. Tsun A, Li YY, Li B. You, me and Foxp3: immune regulation for two. Immunotherapy 2011;3:1139-42..
287. Uauy RD, Fanaroff AA, Korones SB, Phillips EA, Phillips JB, Wright LL. Necrotizingenterocolitis in very low birth weight infants: biodemographic and clinical cor-relates. National Institute of Child Health and Human Development Neonatal Research Network. Journal of Pediatrics 1991;119:630-8..
288. Upperman JS, Potoka D, Grishin A, Hackam D, Zamora R, Ford HR. Mechanismsof nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis. Seminars in Pediatric Surgery 2005;14:159-66.. (Pubitemid 41111602)
289. Van Cong N, Vaisse C, Gross MS, Slim R, Milgrom E, Bernheim A. The human placen-tal protein 14 (PP14) gene is localized on chromosome 9q34. Human Genetics 1991;86:515-8..
290. Verweij WR, Bentala H, Huizinga-van der Vlag A, Miek van Loenen-Weemaes A, Kooi K, Meijer DK, et al. Protection against an Escherichia coli-induced sepsisby alkaline phosphatase in mice. Shock 2004;22:174-9.. (Pubitemid 40228197)
291. Vestergaard EM, Nexo E, Wendt A, Guthmann F. Trefoil factors in human milk. Early Human Development 2008;84:631-5..
292. von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature 2012;490:107-11..
293. Vordenbaumen S, Braukmann A, Petermann K, Scharf A, Bleck E, von Mikecz A, et al. Casein alpha s1 is expressed by human monocytes and upregulates the produc-tion of GM-CSF via p38 MAPK. Journal of Immunology 2011;186:592-601..
294. Wallace JL, Miller MJ. Nitric oxide in mucosal defense: a little goes a long way. Gastroenterology 2000;119:512-20.. (Pubitemid 30622002)
295. Wallis R, Mitchell DA, Schmid R, Schwaeble WJ, Keeble AH. Paths reunited: initiationof the classical and lectin pathways of complement activation. Immunobiology 2010;215:1-11..
296. Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clinical Cancer Research 2008;14:6735-41..
297. Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA Jr, Oldham KT, et al. Theprotective role of intestinal alkaline phosphatase in necrotizing enterocolitis. Journal of Surgical Research 2010b;163:79-85..
298. Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S, Jones DW, et al. Mesenteric nitric oxideand superoxide production in experimental necrotizing enterocolitis. Journal ofSurgical Research 2010;161:1-8..
299. Wilson NL, Robinson LJ, Donnet A, Bovetto L, Packer NH, Karlsson NG. Glycopro-teomics of milk: differences in sugar epitopes on human and bovine milk fatglobule membranes. Journal of Proteome Research 2008;7:3687-96..
300. Witko-Sarsat V, Rieu P, Descamps-Latscha B, Lesavre P, Halbwachs-Mecarelli L. Neutrophils: molecules, functions and pathophysiological aspects. Laboratory Investigation 2000;80:617-53..
301. Wolf HM, Hauber I, Gulle H, Samstag A, Fischer MB, Ahmad RU, et al. Anti-inflammatory properties of human serum IgA: induction of IL-1 receptorantagonist and Fc alpha R (CD89)-mediated down-regulation of tumour necrosisfactor-alpha (TNF-alpha) and IL-6 in human monocytes. Clinical and Experimen-tal Immunology 1996;105:537-43.. (Pubitemid 26297901)
302. Wolf HM, Vogel E, Fischer MB, Rengs H, Schwarz HP, Eibl MM. Inhibition of receptor-dependent and receptor-independent generation of the respiratory burst inhuman neutrophils and monocytes by human serum IgA. Pediatric Research 1994;36:235-43.. (Pubitemid 24222487)
303. Wong SH, Francis N, Chahal H, Raza K, Salmon M, Scheel-Toellner D, et al. Lactoferrinis a survival factor for neutrophils in rheumatoid synovial fluid. Rheumatology 2009;48:39-44..
304. Wong TP, Debnam ES, Leung PS. Involvement of an enterocyte renin-angiotensinsystem in the local control of SGLT1-dependent glucose uptake acrossthe rat small intestinal brush border membrane. Journal of Physiology 2007;584:613-23.. (Pubitemid 47578343)
305. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. Mechanism of activation ofthe TGF-beta receptor. Nature 1994;370:341-7..
306. Wu ZQ, Han XD, Wang Y, Yuan KL, Jin ZM, Di JZ, et al. Interleukin-1 recep-tor antagonist reduced apoptosis and attenuated intestinal mucositis in a5-fluorouracil chemotherapy model in mice. Cancer Chemotherapy and Phar-macology 2011;68:87-96..
307. Xu RJ, Mellor DJ, Birtles MJ, Breier BH, Gluckman PD. Effects of oral IGF-I orIGF-II on digestive organ growth in newborn piglets. Biology of the Neonate 1994;66:280-7..
308. Yagi H, Suzuki S, Noji T, Nagashima K, Kuroume T. Epidermal growth fac-tor in cow's milk and milk formulas. Acta Paediatrica Scandinavica 1986;75:233-5.. (Pubitemid 16137647)
309. Yamaguchi M, Uchida M. Alpha-lactalbumin suppresses interleukin-6 release afterintestinal ischemia/reperfusion via nitric oxide in rats. Inflammopharmacology 2007;15:43-7.. (Pubitemid 46333880)
310. Yamaguchi M, Yoshida K, Uchida M. Novel functions of bovine milk-derivedalpha-lactalbumin: anti-nociceptive and anti-inflammatory activity caused byinhibiting cyclooxygenase-2 and phospholipase A2. Biological and Pharmaceu-tical Bulletin 2009a;32:366-71..
311. Yamaguchi N, Kawaguchi K, Yamamoto N. Study of the mechanism of antihyperten-sive peptides VPP and IPP in spontaneously hypertensive rats by DNA microarrayanalysis. European Journal of Pharmacology 2009b;620:71-7..
312. Ye A, Singh H, Taylor MW, Anema S. Characterization of protein components of nat-ural and heat-treated milk fat globule membranes. International Dairy Journal 2002;12:393-402.. (Pubitemid 34416025)
313. Yongqing T, Drentin N, Duncan RC, Wijeyewickrema LC, Pike RN. Mannose-bindinglectin serine proteases and associated proteins of the lectin pathway of comple-ment: two genes, five proteins and many functions? Biochimica et Biophysica Acta 2012;1824:253-62..
314. Zakharova ET, Kostevich VA, Sokolov AV, Vasilyev VB. Human apo-lactoferrin as aphysiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha. Biometals 2012;25:1247-59, http://dx.doi.org/10.1007/s10534-012-9586-y(Epub 2012 Sep 22)..
315. Zani A, Eaton S, Leon FF, Malerba A, Hall NJ, De Coppi P, et al. Captopril reduces theseverity of bowel damage in a neonatal rat model of necrotizing enterocolitis. Journal of Pediatrics Surgery 2008;43:308-14.. (Pubitemid 351226219)
316. Zhang F, Shah KG, Qi L, Wu R, Barrera R, Nicastro J, et al. Milk fat globule epi-dermal growth factor-factor 8 mitigates inflammation and tissue injury afterhemorrhagic shock in experimental animals. Journal of Trauma and Acute Care Surgery 2012;72:861-9..
317. Zhao QJ, Yu YB, Zuo XL, Dong YY, Li YQ. Milk fat globule-epidermal growth factor8 is decreased in intestinal epithelium of ulcerative colitis patients and therebycauses increased apoptosis and impaired wound healing. Molecular Medicine 2012;18:497-506..
318. Zhong J, Eckhardt ER, Oz HS, Bruemmer D, de Villiers WJ. Osteopontin deficiencyprotects mice from Dextran sodium sulfate-induced colitis. Inflammatory Bowel Diseases 2006;12:790-6.. (Pubitemid 44253763)
319. Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM. The platelet-activatingfactor signaling system and its regulators in syndromes of inflammation and thrombosis. Critical Care Medicine 2002;30:S294-301.. (Pubitemid 34508006)
320. Zittle CA, Dellamonica ES. Use of butanol in the purification of the alkaline phos-phatase of bovine milk. Archives of Biochemistry and Biophysics 1952;35:321-5..