-
1
-
-
0030595339
-
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973-83.
-
(1996)
Cell
, vol.86
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
Reichhart, J.M.4
Hoffmann, J.A.5
-
2
-
-
0034886143
-
Toll-like receptors: Critical proteins linking innate and acquired immunity
-
Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2: 675-80.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 675-680
-
-
Akira, S.1
Takeda, K.2
Kaisho, T.3
-
3
-
-
0034680145
-
Toll-like receptors in the induction of the innate immune response
-
Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406: 782-7.
-
(2000)
Nature
, vol.406
, pp. 782-787
-
-
Aderem, A.1
Ulevitch, R.J.2
-
5
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-8.
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Van Huffel, C.5
Du, X.6
-
6
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
-
Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999; 162: 3749-52.
-
(1999)
J. Immunol.
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
-
7
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999; 189: 1777-82.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1777-1782
-
-
Shimazu, R.1
Akashi, S.2
Ogata, H.3
Nagai, Y.4
Fukudome, K.5
Miyake, K.6
Kimoto, M.7
-
8
-
-
0032541661
-
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
-
Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang M, et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 1998; 395: 284-8.
-
(1998)
Nature
, vol.395
, pp. 284-288
-
-
Yang, R.B.1
Mark, M.R.2
Gray, A.3
Huang, A.4
Xie, M.H.5
Zhang, M.6
-
9
-
-
0033213590
-
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
-
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999; 11: 443-51.
-
(1999)
Immunity
, vol.11
, pp. 443-451
-
-
Takeuchi, O.1
Hoshino, K.2
Kawai, T.3
Sanjo, H.4
Takada, H.5
Ogawa, T.6
-
10
-
-
0034662239
-
Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
-
Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol 2000; 165: 618-22.
-
(2000)
J. Immunol.
, vol.165
, pp. 618-622
-
-
Hirschfeld, M.1
Ma, Y.2
Weis, J.H.3
Vogel, S.N.4
Weis, J.J.5
-
11
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
-
Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 13766-71.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
Underhill, D.M.2
Fontenot, J.D.3
Hajjar, A.M.4
Smith, K.D.5
Wilson, C.B.6
-
12
-
-
0034922923
-
Discrimination of bacterial lipoproteins by Toll-like receptor 6
-
Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A, et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 2001; 13: 933-40.
-
(2001)
Int. Immunol.
, vol.13
, pp. 933-940
-
-
Takeuchi, O.1
Kawai, T.2
Muhlradt, P.F.3
Morr, M.4
Radolf, J.D.5
Zychlinsky, A.6
-
13
-
-
0036644042
-
Role of TLR1 in mediating immune response to microbial lipoproteins
-
Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, et al. Role of TLR1 in mediating immune response to microbial lipoproteins. J Immunol 2002; 169: 10.
-
(2002)
J. Immunol.
, vol.169
, pp. 10
-
-
Takeuchi, O.1
Sato, S.2
Horiuchi, T.3
Hoshino, K.4
Takeda, K.5
Dong, Z.6
-
14
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413: 732-8.
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
15
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001; 410: 1099-103.
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
Smith, K.D.2
Ozinsky, A.3
Hawn, T.R.4
Yi, E.C.5
Goodlett, D.R.6
-
16
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002; 3: 196-200.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
-
17
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740-5.
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
-
18
-
-
0036160406
-
Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity
-
Wagner H. Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr Opin Microbiol 2002; 5: 62-9.
-
(2002)
Curr. Opin. Microbiol.
, vol.5
, pp. 62-69
-
-
Wagner, H.1
-
19
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, Akira S, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 2001; 98: 9237-42.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9237-9242
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
-
20
-
-
0037443644
-
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
-
Hemmi H, Kaisho T, Takeda K, Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 2003; 170: 3059-64.
-
(2003)
J. Immunol.
, vol.170
, pp. 3059-3064
-
-
Hemmi, H.1
Kaisho, T.2
Takeda, K.3
Akira, S.4
-
21
-
-
0033637315
-
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
-
Chu W, Gong X, Li Z, Takabayashi K, Ouyang H, Chen Y, et al. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 2000; 103: 909-18.
-
(2000)
Cell
, vol.103
, pp. 909-918
-
-
Chu, W.1
Gong, X.2
Li, Z.3
Takabayashi, K.4
Ouyang, H.5
Chen, Y.6
-
22
-
-
0037465251
-
The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
-
Dunne A, O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE 2003; 171: re3.
-
(2003)
Sci. STKE
, vol.171
-
-
Dunne, A.1
O'Neill, L.A.2
-
23
-
-
0032127279
-
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
-
Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998; 9: 143-50.
-
(1998)
Immunity
, vol.9
, pp. 143-150
-
-
Adachi, O.1
Kawai, T.2
Takeda, K.3
Matsumoto, M.4
Tsutsui, H.5
Sakagami, M.6
-
24
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11: 115-22.
-
(1999)
Immunity
, vol.11
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
25
-
-
0035889228
-
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
-
Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, Sato S, et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 2002; 167: 5887-94.
-
(2002)
J. Immunol.
, vol.167
, pp. 5887-5894
-
-
Kawai, T.1
Takeuchi, O.2
Fujita, T.3
Inoue, J.4
Muhlradt, P.F.5
Sato, S.6
-
26
-
-
0036222241
-
TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages
-
Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S, et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 2002; 3: 392-8.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 392-398
-
-
Toshchakov, V.1
Jones, B.W.2
Perera, P.Y.3
Thomas, K.4
Cody, M.J.5
Zhang, S.6
-
27
-
-
0035339861
-
Endotoxin-induced maturation of MyD88-deficient dendritic cells
-
Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 2001; 166: 5688-94.
-
(2001)
J. Immunol.
, vol.166
, pp. 5688-5694
-
-
Kaisho, T.1
Takeuchi, O.2
Kawai, T.3
Hoshino, K.4
Akira, S.5
-
28
-
-
0035555301
-
TIRAP: An adapter molecule in the Toll signaling pathway
-
Horng T, Barton GM, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2001; 2: 835-41.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
29
-
-
0035817925
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001; 413: 78-83.
-
(2001)
Nature
, vol.413
, pp. 78-83
-
-
Fitzgerald, K.A.1
Palsson-McDermott, E.M.2
Bowie, A.G.3
Jefferies, C.A.4
Mansell, A.S.5
Brady, G.6
-
30
-
-
0037153191
-
Essential role of TIRAP/Mal for activation of the signaling cascade shared by TLR2 and TLR4
-
Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, et al. Essential role of TIRAP/Mal for activation of the signaling cascade shared by TLR2 and TLR4. Nature 2002; 420: 324-9.
-
(2002)
Nature
, vol.420
, pp. 324-329
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Sanjo, H.4
Uematsu, S.5
Kaisho, T.6
-
31
-
-
0037153130
-
The adaptor molecule TIRAP provides signaling specificity for Toll-like receptors
-
Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signaling specificity for Toll-like receptors. Nature 2002; 420: 329-33.
-
(2002)
Nature
, vol.420
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
Medzhitov, R.4
-
32
-
-
0037114185
-
A novel TIR domain-containing adaptor that preferentially activates the interferon-β promoter
-
Yamamoto M, Sato S, Mori K, Takeuchi O, Hoshino K, Takeda K, Akira S. A novel TIR domain-containing adaptor that preferentially activates the interferon-β promoter. J Immunol 2002; 169: 6668-72.
-
(2002)
J. Immunol.
, vol.169
, pp. 6668-6672
-
-
Yamamoto, M.1
Sato, S.2
Mori, K.3
Takeuchi, O.4
Hoshino, K.5
Takeda, K.6
Akira, S.7
-
33
-
-
0037320451
-
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
-
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 2003; 4: 161-7.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
Akazawa, T.4
Seya, T.5
-
34
-
-
20244384395
-
Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
-
Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, et al. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000; 164: 3476-9.
-
(2000)
J. Immunol.
, vol.164
, pp. 3476-3479
-
-
Nomura, F.1
Akashi, S.2
Sakao, Y.3
Sato, S.4
Kawai, T.5
Matsumoto, M.6
-
35
-
-
0034671772
-
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways
-
Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt PF, Takeda K, Akira S. Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol 2000; 165: 7096-101.
-
(2000)
J. Immunol.
, vol.165
, pp. 7096-7101
-
-
Sato, S.1
Nomura, F.2
Kawai, T.3
Takeuchi, O.4
Muhlradt, P.F.5
Takeda, K.6
Akira, S.7
-
36
-
-
0036319517
-
A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways
-
Sato S, Takeuchi O, Fujita T, Tomizawa H, Takeda K, Akira S. A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int Immunol 2002; 14: 783-91.
-
(2002)
Int. Immunol.
, vol.14
, pp. 783-791
-
-
Sato, S.1
Takeuchi, O.2
Fujita, T.3
Tomizawa, H.4
Takeda, K.5
Akira, S.6
-
37
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter FA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002; 416: 603-7.
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, F.A.1
Rifkin, I.R.2
Hohlbaum, A.M.3
Beaudette, B.C.4
Shlomchik, M.J.5
Marshak-Rothstein, A.6
|