Human lactoferrin activates NF-κB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

FEBS Journal

Volumn 277, Issue 9, 2010, Pages 2051-2066

  Ando, Ken ^a   Hasegawa, Keiichi ^a   Shindo, Ken Ichi ^a   Furusawa, Tomoyasu ^a   Fujino, Tomofumi ^a   Kikugawa, Kiyomi ^a   Nakano, Hiroyasu ^b   Takeuchi, Osamu ^c   Akira, Shizuo ^c   Akiyama, Taishin ^d   Gohda, Jin ^d   Inoue, Jun Ichiro ^d   Hayakawa, Makio ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Human lactoferrin; Innate immunity; Lipopolysaccharide; Nuclear factor B (NF B); Toll like receptor 4 (TLR4)

Indexed keywords

CHEMOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTOFERRIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOREGULATION; INNATE IMMUNITY; LEUKEMIA CELL LINE; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WILD TYPE;

ANIMALS; CATTLE; CELL LINE; HUMANS; LACTOFERRIN; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 77951225235     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07620.x     Document Type: Article

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