Growth factors from bovine milk and colostrum: Composition, extraction and biological activities

Lait

Volumn 86, Issue 2, 2006, Pages 99-125

  Gauthier, Sylvie F ^a   Pouliot, Yves ^b   Maubois, Jean Louis ^b  

^a LAVAL UNIVERSITY   (Canada)

^b UMR1253   (France)

Author keywords

Biological activity; Colostrum; Extraction process; Growth factors; Milk; Whey

Indexed keywords

BOVINAE;

EID: 33646354902     PISSN: 00237302     EISSN: 12979694     Source Type: Journal    
DOI: 10.1051/lait:2005048     Document Type: Review

References (241)

1. Alexander A.N., Carey H.V., Oral IGF-I enhances nutrient and electrolyte absorption in neonatal piglet intestine, Am. J. Physiol. 277(1999) G619-G625.
2. +-dependent glutamine absorption in piglet enterocytes, Dig. Dis. Sci. 47 (2002) 1129-1134.
3. Araki F.,Nakamura H.,Nojima N.,Tsukumo K., Sakamoto S., Stability of recombinant human epidermal growth factor in various solutions, Chem. Pharm. Bull. (Tokyo) 37 (1989)404-406.
4. Arandjelovic S., Freed T.A., Gonias S.L., Growth factor-binding sequence in human alpha2-macroglobulin targets the receptorbinding site in transforming growth factorbeta. Biochemistry 42 (2003) 6121-6127.
5. [51 Ballard F.J., Francis G.L., Regester G.O., Milk protein mixture for promoting growth of animal cells or treating wounds and a method of making and methods employing the mixture, US Patent 5 866 418, 1999.
6. Basolo F., Conaldi P.G., Fiore L., Calvo S., Toniolo A., Normal breast epithelial cells produce interleukins 6 and 8 together with tumor-necrosis factor: defective IL6 expression in mammary carcinoma, Int. J. Cancer 55(1993)926-930.
7. Bastian S.E., Dunbar A.J., Priebe I.K., Owens P.C., Goddard C., Measurement of betacellulin levels in bovine serum, colostrum and milk, J. Endocrinol. 168 (2001) 203-212.
8. Baumrucker C.R., Blum J.W., Effects of dietary recombinant human insulin-like growth factor-I on concentrations of hormones and growth factors in the blood of newborn calves, J. Endocrinol. 140(1994) 15-21.
9. Baumrucker C.R., Green M.H., Blum J.W., Effects of dietary rhIGF-I in neonatal calves on the appearance of glucose, insulin, Dxylose, globulins and gamma-glutamyl transferase in blood. Dornest. Anim. Endocrinol. II (1994)393-403.
10. Baumrucker C.R., Hadsell D.L., Blum J.W., Effects of dietary insulin-like growth factor I on growth and insulin-like growth factor receptors in neonatal calf intestine, J. Anim. Sci. 72(1994)428-433.
11. Baxter R.C., Zaltsman Z., Turtle J.R., Immunoreactive somatomedin-C/insulin-like growth factor I and its binding protein in human milk, J. Clin. Endocrinol. Metab. 58 ( 1984) 955-959.
12. Beardmore J.M., Lewis-Jones D.I., Richards R.C., Urogastrone and lactose concentrations in precolostrum, colostrum, and milk. Pediatr. Res. 17 (1983) 825-828.
13. Beiford D.A., Rogers M.-L., Regester G.O., Francis G.L., Smithers G.W., Liepe I.J., Priebe I.K., Ballard F.J., Milk-derived growth factors as serum supplements for the growth of fibroblast and epithelial cells, In Vitro Cell. Dev. Biol. (Animal) 31 (1995) 752-760.
14. Beltbrd D.A., Rogers M.-L., Francis G.L., Payne C., Ballard F.J., Goddard C., Platelet-derived growth factor, insulin-like growth factors, fibroblast growth factors and transforming growth factor β do not account for the cell growth activity present in bovine milk, J. Endocrinol. 154 (1997) 45-55.
15. Beiford D.A., Rogers M.L., Regester G.O., Smithers G.W., Ballard F.J., Francis G.L., Modified milk growth factor, US Patent 6 194 208 B 1, 2001.
16. Blum J.W., Hammon H., Colostrum effects on the gastrointestinal tract, and on nutritional, endocrine and metabolic parameters in neonatal calves, Livest. Prod. Sci. 66 (2000) 151-159.
17. Bocci V., Von Bremen K., Corradeschi F., Franchi F., Luzzi E., Paulesu L., Presence of interferon-gamma and interleukin-6 in colostrum of normal women, Lymphokine CytokineRes. 12(1993)21-24.
18. Bonner J.C., Osornio-Vargas A.R., Differential binding and regulation of platelet-derived growth factor A and B chain isoforms by alpha 2-macroglobulin. J. Biol. Chem. 270 (1995)16236-16242.
19. Bottcher M.F., Jenmalm M.C., Garofalo R.P., Bjorksten B., Cytokines in breast milk from allergic and nonallergic mothers, Pediatr. Res. 47 (2000) 157-162.
20. Brigstock D.R., Heap R.B., Barker P.J., Brown K.D., Purification and characterization of heparin-binding growth factors from porcine uterus, Biochem. J. 266 (1990) 273-282.
21. Britton J.R., George-Naseimento C., Koldovsky O., Luminal hydrolysis of recombinant human epidermal growth factor in the rat gastrointestinal tract: segmental and developmental differences. Life Sci. 43 (1988) 1339-1347.
22. Britton J.R., George-Nascimento C., Udall J.N., Koldovsky O., Minimal hydrolysis of epidermal growth factor by gastric fluid of preterm infants. Gut 30 ( 1989) 327-332.
23. Brown K.D., Blakeley D.M., Cell growth-promoting activity in mammary secretions of the goat, cow and sheep, Br. Vet. J. 139 (1983) 68-78.
24. Bryan D.L., Hawkes J.S., Gibson R.A., Interleukin-12 in human milk, Pediatr. Res. 45(1999)858-859.
25. Burgess W.H., Maciag T., The heparin-binding (fibroblast) growth factor family of proteins, Annu. Rev. Biochem. 58 (1989) 575-606.
26. Calhoun D.A., Christensen R.D., Human developmental biology of granulocyte colony-stimulating factor. Clin. Perinatol. 27 (2000) 559-576.
27. Calhoun D.A., Lunoe M., Du Y., Staba S.L., Christensen R.D., Concentrations of granulocyte colony-stimulating factor in human milk after in vitro simulations of digestion, Pediatr. Res. 46 (1999) 767-771.
28. Calhoun D.A., Lunoe M., Du Y., Christensen R.D., Granulocyte colony-stimulating factor is present in human milk and its receptor is present in human fetal intestine, Pediatrics 105 (2000) e7.
29. Calnan D.P., Fagbemi A., Berlanga-Acosta J., Marchbank T., Sizer T., Lakhoo K., Edwards A.D., Playford R.J., Potency and stability of C terminal truncated human epidermal growth factor, Gut 47 (2000) 622627.
30. Campbell P.G., Baumrucker C.R., Insulin-like growth factor-I and its association with binding proteins in bovine milk, J. Endocrinol. 120(1989)21-29.
31. Capiaumont J., Legrand C., Dousset B., Belleville F., Nabel P., Hybridoma culture in polyether sponge with bovine whey, In Vitro Cell. Dev. Biol. Anim. 31 (1995) 412-414.
32. Capiaumont J., Ostrovidov S., Legrand C., Belleville F., Nabet P., Bovine whey, a substitute for FBS in CHO-K1 cell cultures. In Vitro Cell. Dev. Biol. Anim. 32 (1996) 8-12.
33. Carlsson L.C., Westrom B.R., Karlsson B.W., Intestinal absorption of proteins by the neonatal piglet fed on sow's colostrum with either natural or experimentally eliminated trypsin-inhibiting activity, Biol. Neonate 38 (1980)309-320.
34. Carpenter G., Epidermal growth factor is a major growth-promoting agent in human milk, Science 210 (1980) 198-199.
35. Chen C.H., Poucher S.M., Lu J., Henry P.D., Fibroblast growth factor 2: from laboratory evidence to clinical application, Curr. Vase. Pharmacol. 2 (2004) 33-43.
36. Clarke J., Butler R., Howarth G., Read L., Regester G., Exposure of oral mucosa to bioactive milk factors reduces severity of chemotherapy-induced mucositis in the hamster, Oral Oncol. 38 (2002) 478-485.
37. Clemmons D.R., Smith-Banks A., Underwood L.E., Reversal of diet-induced catabolism by infusion of recombinant insulin-like growth factor-I in humans, J. Clin. Endocrinol. Metab. 75(1992) 234-238.
38. [38) Collier R.J., Miller M.A., Hildebrandt J.R., Torkelson A.R., White T.C., Madsen K.S., Vicini J.L., Eppard P.J., LanzaG.M., Factors affecting insulin-like growth factor-I concentration in bovine milk, J. Dairy Sci. 74 ( 1991 ) 2905-2911.
39. Connolly J.M., Rose D.P., Epidermal growth factor-like proteins in breast fluid and human milk, Life Sci. 42 (1988) 1751-1756.
40. Corps A.N., Brown K.D., Stimulation of intestinal epithelial cell proliferation in culture by growth factors in human and ruminant mammary secretions, J. Endocrinol. 113(1987) 285-290.
41. Corps A.N., Blakeley D.M., Carr J., Rees L.H., Brown K.D., Synergistic stimulation of Swiss mouse 3T3 fibroblasts by epidermal growth factor and other factors in human mammary secretions, J. Endocrinol. 112 (1987) 151-159.
42. Corps A.N., Brown K.D., Rees L.H., Carr J., Prosser C.G., The insulin-like growth factor I content in human milk increases between early and full lactation, J. Clin. Endocrinol. Metab. 67(1988)25-29.
43. Cox D., Bürk R., A polypeptide growth factor from milk, European Patent EP 0313515, 1989.
44. Cox D.A., Bürk R., Isolation and characterization of milk growth factor, a transforminggrowth-factor-β2-related polypeptide, from bovine milk, Eur. J. Biochem. 197 (1991) 353-358.
45. Damerdji O., Derouiche F., Legrand C., Capiaumont J., Bour J.M., Maugras M., Belleville F., Nabel P., Paquet D., Linden G., Utilization of whey fractions as a substitute for fetal calf serum in culture media, Biotechnol. Tech. 2 (1988) 253-258.
46. Daopin S., Piez K.A., Ogawa Y., Davies D.R., Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily, Science 257 (1992) 369-373.
47. Derouiche A.F., Legrand C., Bour J.M., Capiaumont J., Gelot M.A., Dousset B., Belleville F., Nabel P., Linden G., Biochemical aspects of a whey fraction capable of promoting hybridoma proliferation. Comparison with fetal calf serum, Lait 70 (1990) 313-324.
48. Donovan S.M., Hintz R.L., Rosenfeld R.G., Insulin-like growth factors I and II and their binding proteins in human milk: effect of heat treatment on IGF and IGF binding protein stability, J. Pediatr. Gastroenterol. Nutr. 13 (1991)242-253.
49. Dunbar A.J., Goddard C., Structure-function and biological role of betacellulin, Int. J. Biochem. Cell Biol. 32 (2000) 805-815.
50. Dunbar A.J., Priebe I.K., Beiford D.A., Goddard C., Identification of betacellulin as a major peptide growth factor in milk: purification, characterization and molecular cloning of bovine betacellulin, Biochem. J. 344 (1999)713-721.
51. [511 Elfstrand L., Lindmark-Mansson H., Paulsson M., Nyberg L., Akesson B., Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effect of processing. Int. Dairy J. 12 (2002) 879-887.
52. Eriksson U., Duc G., Froesch E.R., Zapf J., Insulin-like growth factors (IGF) I and II and IGF binding proteins (IGFBPs) in human colostrum/transitory milk during the first week postpartum: comparison with neonatal and maternal serum, Biochem. Biophys. Res. Commun. 196 (1993) 267-273.
53. Fassolitis A.C., Novelli R.M., Larkin E.P., Serum substitute in epithelial cell culture media: nonfat dry milk filtrate, Appl. Environ. Microbiol. 42 (1981) 200-203.
54. Fell J.M., Paintin M., Donnet-Hughes A., Amaud-Battandier F., MacDonald T.T., Walker-Smith J.A., Remission induced by a new specific oral polymeric diet in children with Crohn's disease, Nestle Nutr. Workshop Ser. Clin. Perform. Programme 2, 1999, pp. 187198.
55. Fell J.M., Paintin M., Arnaud-Battandier F., Beattie R.M., Hollis A., Kitching P., DonnetHughes A., MacDonald T.T., Walker-Smith J.A., Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease, Aliment. Pharmacol. Ther. 14(2000)281-289.
56. Flaumenhaft R. Moscatelli D., Rifkin D.B., Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor, J. Cell Biol. 111 (1990) 1651-1659.
57. Foster B., Germain B., Hammerstone K., Novel TGF-β protein purification, US Patent application 20030036629, 2003.
58. Francis G.L., Read L.C., Ballard F.J., Bagley C.J., Upton P.M., Gravestock P.M., Wallace J.C., Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum, Biochem. J. 233 (1986) 207-213.
59. Francis G.L., Upton P.M., Ballard F.J., McNeil K.A., Wallace J.C., Insulin-like growth factors 1 and 2 in bovine colostrum, Biochem. J. 251 (1988) 95-103.
60. Francis G.L., Regester G.O., Webb H.A., Ballard F.J., Extraction from cheese whey by cation-exchange chromatography of factors that stimulate the growth of mammalian cells, J. Dairy Sei. 78 (1995) 1209-1218.
61. [61 ] Fukumoto L.R., Li-Chan E., Kwan L., Nakai S., Isolation of immunoglobulin from cheese whey using ultrafiltration and immobilized metal affinity chromatography, Food Res. Int. 27(1994)335-348.
62. Garofalo R., Chheda S., Mei F., Palkowetz K.H.,RudloffH.E., Schmalstieg F.C., Rassin O.K., Goldman A.S., Interleudin-10 in human milk, Pediatr. Res. 37 (1995) 444-449.
63. Gilmore W.S., McKelvey-Martin V.J., Rutherford S., Strain J.J., Loane P., Kell M., Millar S., Human milk contains granulocyte colony stimulating factor, Eur. J. Clin. Nutr. 48(1994)222-224.
64. Ginjala V., Pakkanen R., Determination of transforming growth factor-beta 1 (TGF-beta 1) and insulin-like growth factor (IGF-1) in bovine colostrum samples, J. Immunoassay 19(1998) 195-207.
65. Goldenring J.R., Tsunoda Y., Stoch S.A., Coffey R.J., Modlin I.M., Transforming growth factor-alpha (TGF alpha) inhibition of parietal cell secretion: structural requirements for activity, Regul. Pept. 43 (1993) 37-47.
66. Gonnella P.A., Siminoski K., Murphy R.A., Neutra M.R.,Transepithelial transport of epidermal growth factor by absorptive cells of suckling rat ileum, J. Clin. Invest. 80 (1987) 22-32.
67. Goodlad R.A., Boulton R., Playford R.J., Comparison of the mitogenic activity of human epidermal growth factor I-53 and epidermal growth factor I-48 in vitro and in vivo, Clin. Sci. (Lond.)91 (1996)503-507.
68. Gregory H., Thomas C.E., Young J.A., Willshire I.R., Garner A., The contribution of the C-terminal undecapeptide sequence of urogastrone-epidermal growth factor to its biological action, Regul. Pept. 22 (1988) 217-226.
69. Guglietta A., Lesch C.A., Effect of h-EGF and h-EGF 1-48 on histamine-stimulated gastric acid secretion in rats and monkeys, J. Physiol. Paris 87 (1993) 343-347.
70. [70[ Guimont C., Marchall E.,Girardet J.M.,Linden G., Biologically active factors in bovine milk and dairy byproducts: influence on cell culture, Crit. Rev. Food Sci. Nutr. 37 (1997) 393-410.
71. [71 ] Guler H.P., Zapf J., Froesch E.R., Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults, N. Engl. J. Med. 317 (1987) 137-140.
72. Guler H.P., Schmid C., Zapf J., Froesch E.R., Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects, Proc. Natl. Acad. Sci. USA 86 (1989) 2868-2872.
73. Hadsell D.L., Baumrucker C.R., Kensinger R.S., Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase, J. Endocrinol. 137 ( 1993) 223-230.
74. Hagiwara K., Kataoka S., Yamanaka H., Kirisawa R., Iwai H., Detection of cytokines in bovine colostrum, Vet. Immunol. Immunopathol. 76 (2000) 183-190.
75. Hara T., Irie K., Saito S., Ichijo M., Yamada M., Yanai N., Miyazaki S., Identification of macrophage colony-stimulating factor in human milk and mammary gland epithelial cells, Pediatr. Res. 37 (1995) 437-443.
76. Hawkes J.S., Bryan D.L., Gibson R.A., Variations in transforming growth factor beta in human milk are not related to levels in plasma, Cytokine 17 (2002) 182-186.
77. Hawkes J.S., Bryan D.L., James M.J., Gibson R.A., Cytokines (IL-1 beta, IL-6, TNF-alpha, TGF-betal, and TGF-beta2) and prostaglandin E2 in human milk during the first three months postpartum, Pediatr. Res. 46 (1999) 194-199.
78. Heinz-Erian P., Kessler U., Funk B., Gais P., Kiess W., Identification and in situ localization of the insulin-like growth factor-II/man-nose-6- phosphate (1GF-II/M6P) receptor in the rat gastrointestinal tract: comparison with the IGF-I receptor, Endocrinology 129 (1991) 1769-1778.
79. Heldin C.H., Westermark B., Mechanism of action and in vivo role of platelet-derived growth factor, Physiol. Rev. 79 (1999) 1283-1316.
80. Hinck A.P., Archer S.J., Qian S.W., Roberts A.B., Sporn M.B., Weatherbee J.A., Tsang M.L., Lucas R., Zhang B.L., Wenker J., Torchia D.A., Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2, Biochemistry 35(1996)8517-8534.
81. [81 ] Hirado M., Tsunasawa S., Sakiyama F., Niinobe M., Fujii S., Complete amino acid sequence of bovine colostrum low-Mr cysteine proteinase inhibitor, FEBS Lett. 186 ( 1985) 41 -45.
82. Hirano M., Iwakiri R., Fujimoto K., Sakata H., Ohyama T., Sakai T., Joh T., Itoh M., Epidermal growth factor enhances repair of rat intestinal mucosa damaged by oral administration of methotrexate, J. Gastroenterol. 30 (1995)169-176.
83. [831 Hironaka T., Ohishi H., Masaki T., Identification and partial purification of a basic fibroblast growth factor-like growth factor derived from bovine colostrum, J. Dairy Sci. 80(1997)488-495.
84. Hirschberg R., Brunori G., Kopple J.D., Guler H.P., Effects of insulin-like growth factor I on renal function in normal men, Kidney Int. 43 (1993) 387-397.
85. Hollenberg M.D., Gregory H., Epidermal growth factor-urogastrone: biological activity and receptor binding of derivatives, Mol. Pharmacol. 17 (1980) 314-320.
86. Hossner K.L., Yemm R.S., Improved recovery of insulin-like growth factors (IGFs) from bovine colostrum using alkaline diafiltration, Biotechnol. Appl. Biochem. 32 (Pt 3) (2000) 161-166.
87. Howarth G.S., Francis G.L., Cool J.C., Xu X., Byard R.W., Read L.C., Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats, J. Nutr. 126 (1996)2519-2530.
88. Huggett A.C., Hugues A., Schiffrin E., Food composition, European Patent EP 0527283, 1993.
89. lacopetta B.J., Grieu F., Horisberger M., Sunahara G.I., Epidermal growth factor in human and bovine milk, Acta Paediatr. Scand. 81(1992)287-291.
90. Itoh M., Imai S., Joh T., Kawai T., Katsumi K., Yokochi K., Takeuchi T., Protection of gastric mucosa against ethanol-induced injury by intragastric bolus administration of epidermal growth factor combined with hydroxypropylcellulose, J. Clin. Gastroenterol. 14(Suppl. 1) (1992)S127-S130.
91. [91 ] Itoh M., Imai S., Joh T., Yokoyama Y., Yasue N., Iwai A., Matsusako K., Endoh K., Kawai T., Takeuchi T., Effect of epidermal growth factor in combination with sucralfate or omeprazole on the healing of chronic gastric ulcers in the rat, J. Clin. Gastroenterol. 12 (Suppl. 1) (1990)S187-S191.
92. Itoh M., Matsuo Y., Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study, J. Gastroenterol. Hepatol. 9 (Suppl. 1) (1994)878-883.
93. Jansson L., Karlson F.A., Westermark B., Mitogenic activity and epidermal growth factor content in human milk, Acta Paediatr. Scand. 74 (1985) 250-253.
94. [941 Jin Y., Cox D.A., Knecht R., Raschdorf F., Cerletti N., Separation, purification, and sequence identification of TGF-beta 1 and TGF-beta 2 from bovine milk, J. Protein Chem. 10(1991)565-575.
95. [951 Johnson W.S., Playford R.J., Prevention of gastrointestinal damage, PCT WO 98/ 11910A1, 1988.
96. [961 Johnson W.S., Playford R.J., Prevention of gastrointestinal damage, PCT WO 98/ 11904A1, 1998.
97. Jones J.I., Clemmons D.R., Insulin-like growth factors and their binding proteins: biological actions, Endocr. Rev. 16 (1995) 3-34.
98. Junker L., Lewis M., Nelson R., Isolation of purified TGF-βl and TGF-β2 from bone tissue, US Patent 6 492 327, 2002.
99. Juskevich J.C., Guyer C.G., Bovine growth hormone: human food safety evaluation, Science 249 (1990) 875-84.
100. Juul S.E., Joyce A.E., Zhao Y., Ledbetter D.J., Why is erythropoietin present in human milk? Studies of erythropoietin receptors on enterocytes of human and rat neonates, Pediatr. Res. 46 (1999) 263-268.
101. Kalliomaki M., Ouwehand A., Arvilommi H., Kero P., Isolauri E., Transforming growth factor-beta in breast milk: a potential regulator of atopic disease at an early age, J. Allergy Clin. Immunol. 104 (1999) 1251-1257.
102. Kelly O.S., Bovine colostrums: a review of clinical uses, Altern. Med. Rev. 8 (2003) 378-394.
103. Kelly D., McFadyen M., King T.P., Morgan P.J., Characterization and autoradiographic localization of the epidermal growth factor receptor in the jejunum of neonatal and weaned pigs. Reprod. Fertil. Dev. 4 (1992) 183-191.
104. Kirihara O., Ohishi H., Functional proteins in bovine milk, Jap. J. Dairy Food Sci. 44 (1995)9-17.
105. Kishikawa Y., Watanabe T., Watanabe T., Kubo S., Purification and characterization of cell growth factor in bovine colostrum. J. Vet. Med. Sci. 58 (1996) 47-53.
106. Kivits M.G.C., Hendricks A.W.J., Malle L.F., Process for obtaining growth factor preparations (TGF-β and IGF-1) from milk products having low mutual cross-contamination, PCT WO 01725276 A1, 2001.
107. Klagsbrun M., Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts, Proc. Natl. Acad. Sei. USA 75 (1978) 5057-5061.
108. Klagsbrun M., Bovine colostrum supports the serum-free proliferation of epithelial cells but not of fibroblasts in long-term culture, J. Cell Biol. 84 (1980) 808-814.
109. Klagsbrun M., Neumann J., The serum-free growth of Balb/c 3T3 cells in medium supplemented with bovine colostrum, J. Supramol. Struct. 11 (1979) 349-359.
110. Kling P.J., Sullivan T.M., Roberts R.A., Philipps A.E., Koldovsky O., Human milk as a potential enterai source of erythropoietin, Pediatr. Res. 43 (1998) 216-221.
111. Konecny P., Brown, R.J., Scouten, W.H., Chromatographic purification of immunoglobulin G from bovine milk whey, J. Chromatogr. A 673 (1994) 45-53.
112. KonturekS.J.,CieszkowskiM.,JaworekJ., Konturek J., Brzozowski T., Gregory H., Effects of epidermal growth factor on gastrointestinal secretions. Am. J. Physiol. 246 (1984) G580-G586.
113. LaRochelle W.J., Jeffers M., McDonald W.F., Chillakuru R.A., Giese N.A., Lokker N.A., Sullivan C., Boldog F.L., Yang M., Vernet C., Burgess C.E., Fernandes E., Deegler L.L., Rittman B., Shimkets J., Shimkets R.A., Rothberg J.M., Lichenstein H.S., PDGF-D, a new protease-activated growth factor, Nat. Cell Biol. 3 (2001) 517-521.
114. Laskowski M. Jr., Laskowski M., Crystalline trypsin inhibitor from colostrum, J. Biol. Chem. 190(1951)563-573.
115. Lefranc-Milot C., Canivez O., QuinqueB., Fraction sérocolostrale à forte activité anticorps, utilisation et procédé de fabrication d'une telle fraction, European Patent EP 0722952 Al, 1996.
116. Legrand C., Capiaumont J., Belleville F., Nabet P., Comparison of metabolism of hybridoma cells cultured in media supplemented with whey or fetal calf serum, Biotechnol. Prog. 9 (1993) 573-579.
117. [117[ Lessaris K.J.,Forsythe D.W.,Wagner C.L., Effect of human milk fortifier on the immunodetection and molecular mass profile of transforming growth factor-alpha, Biol. Neonate 77 (2000) 156-161.
118. Letterio J.J., Geiser A.G., Kulkarni A.B., Roche N.S., Sporn M.B., Roberts A.B., Maternal rescue of transforming growth factor-beta 1 null mice. Science 264 (1994) 1936-1938.
119. Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., Eriksson U., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor, Nat. Cell. Biol. 2 (2000) 302-309.
120. Lindberg T., Protease inhibitors in human milk, Pediatr. Res. 13 (1979) 969-972.
121. Lindberg T., Ohlsson K., Westrom B., Protease inhibitors and their relation to protease activity in human milk, Pediatr. Res. 16(1982)479-483.
122. Lionetti P., Callegari M.L., Ferrari S., Cavicchi M.C., Pozzi E., de Martino M., Morelli L., Enterai nutrition and microflora in pédiatrie Crohn's disease, J. Parenter. Enterai Nutr. 29 (2005) S173-S178.
123. Liu Q., Ling T.Y., Shieh H.S., Johnson F.E., Huang J.S., Huang S.S., Identification of the high affinity binding site in transforming growth factor-beta involved in complex formation with alpha 2-macroglobulin. Implications regarding the molecular mechanisms of complex formation between alpha 2-macroglobulin and growth factors, cytokines, and hormones, J. Biol. Chem. 276 (2001)46212-46218.
124. Ma L.,Xu R.J., Oral insulinlike growth factor-I stimulates intestinal enzyme maturation in newborn rats, Life Sci. 61 (1997) 51-58.
125. Malven P.V., Head H.H., Collier R.J., Buonomo F.C., Periparturient changes in secretion and mammary uptake of insulin and in concentrations of insulin and insulinlike growth factors in milk of dairy cows, J. Dairy Sci. 70 (1987) 2254-2265.
126. Marcotty C., Frankenne F., Van Beeumen J., Maghuin-Rogister G., Hennen G., Insulin-like growth factor I (IGF-I) from cow colostrum: purification and characterization. Growth Regul. 1 (1991) 56-61.
127. Massague J., The transforming growth factor-beta family, Annu. Rev. Cell Biol. 6 (1990)597-641.
128. Massague J., TGF-beta signal transduction, Annu. Rev. Biochem. 67 (1998) 753-791.
129. Matsuo Y., Gotoh Y., Itoh M., Asaki S., Sugiyama M., Ohshiba S., Nagataki S., Hayakawa A., Ogawa N., Urakawa M., Yamazaki Y., Randomized, double blind comparison of epidermal growth factor from human urine (MG111) with the active placebo in treatment of gastric ulcer, Hellenic J. Gastroenterol. 5 (1992) 217.
130. Matsuoka Y.,Idota T., The concentration of epidermal growth factor in Japanese mother's milk, J. Nutr. Sci. Vitaminol. 41 (1995)241-251.
131. Matsuoka Y., Serizawa A., Yoshioka T., Yamamura J., Morita Y., Kawakami H., Toba Y., Takada Y., Kumegawa M., Cystatin C in milk basic protein (MBP) and its inhibitory effect on bone resorption in vitro, Biosci. Biotechnol. Biochem. 66 (2002) 2531-2536.
132. Maubois J.L., Fauquant J., Jouan P., Bourtourault M., Method for obtaining a TGF-beta enriched protein fraction in activated form, protein fraction and therapeutic applications, PCT/WO 03/006500, 2003.
133. Mero A., Kahkonen J., Nykanen T., Parviainen T., Jokinen I., Takala T., Nikula T., Rasi S., Leppaluoto J., IGF-I, IgA. and IgG responses to bovine colostrum supplementation during training, J. Appl. Physiol. 93 (2002) 732-739.
134. Miell J.P., Taylor A.M., Jones J., Buchanan C.R., Rennie J., Sherwood R., Leicester R., Ross R.J., Administration of human recombinant insulin-like growth factor-I to patients following major gastrointestinal surgery, Clin. Endocrinol. (Oxf.) 37 (1992) 542-551.
135. Moran J.R., Courtney M.E., Orth D.N., Vaughan R., Coy S., Mount C.D., Sherrell B.J., Greene H.L., Epidermal growth factor in human milk: daily production and diurnal variation during early lactation in mothers delivering at term and at premature gestation, J. Pediatr. Gastroent. Nutr. 103 (1983)402-405.
136. Moscatelli D., High and low affinity binding sites for basic fibroblast growth factor on cultured cells: absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells, J. Cell Physiol. 131 (1987) 123-130.
137. Muneta Y., Yoshihara K., Minagawa Y., Nagata R., Yasuyuki M., Yamaguchi T., Takehara K., Bovine IL-18 ELISA: detection of IL-18 in sera of pregnant cow and newborn calf, and in colostrum, J. Immunoassay Immunochem. 26 (2005) 203-213.
138. Munoz C., Endres S., van der Meer J., Schlesinger L., Arevalo M., Dinarello C., Interleukin-1 beta in human colostrum, Res. Immunol. 141 (1990)505-513.
139. Nabet P., Belleville-Nabet F., Linden G., Les peptides du lait à activité physiologique I. Facteurs de croissance dans le lait et le lactosérum. Lait 71 (1991) 225-239.
140. Nagashima K., Itoh K., Kuroume T., Levels of insulin-like growth factor I in full- and preterm human milk in comparison to levels in cow's milk and in milk formulas, Biol. Neonate 58 (1990) 343-346.
141. Nagatomo T., Ohga S., Takada H., Nomura A., Hikino S., Imura M., Ohshima K., Hara T., Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period. Clin. Exp. Immunol. 138 (2004) 47-53.
142. Noda K., Umeda M., Ono T., Transforming growth factor activity in human colostrum. Jap. J. Cancer Res. 75 (1984) 109-112.
143. Oda S., Satoh H., Sugawara T., Matsunaga N., KuharaT., Katoh K., Shoji Y., Nihei A., Ohta M., Sasaki Y., Insulin-like growth factor-I, GH, insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition, Comp. Biochem. Physiol. A 94 (1989) 805-808.
144. Ogawa J., Sasahara A., Yoshida T., Sira M.M., Futatani T., Kanegane H., Miyawaki T., Role of transforming growth factor-beta in breast milk for initiation of IgA production in newborn infants, Early Hum. Dev. 77 (2004) 67-75.
145. Okada M., Ohmura E., Kamiya Y., Murakami H., Onoda N., Iwashita M., Wakai K., Tsushima T., Shizume K., Transforming growth factor (TGF)-alpha in human milk, Life Sci. 48(1991) 1151-1156.
146. Olsen P.S., Poulsen S.S., Therkelsen K., Nexo E., Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats, Gut 27 (1986) 1443-1449.
147. Ontsouka C.E., Bruckmaier R.M., Blum J.W., Fractionized milk composition during removal of colostrum and mature milk, J. Dairy Sci. 86 (2003) 2005-2011.
148. Ornitz D.M., Itoh N., Fibroblast growth factors. Genome Biol. 2 (2001) 1-12.
149. Ornitz D.M., Yayon A., Flanagan J.G., Svahn C.M., Levi E., Leder P., Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells, Mol. Cell Biol. 12 (1992) 240-247.
150. Oz H.S., Ray M., Chen T.S., McClain C.J., Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease, J. Am. Coll. Nutr. 23 (2004) 220-226.
151. Pakkanen R., Determination of transforming growth factor-beta 2 (TGF-beta 2) in bovine colostrum samples, J. Immunoassay 19 (1998) 23-37.
152. Pakkanen R., Kanttinen A., Satama L., Aalto J., Bovine colostrum fraction as a serum substitute for the cultivation of mouse hybridomas, Appl. Microbiol. Biotechnol. 37 (1992) 451-456.
153. Palkowetz K.H., Royer C.L., Garofalo R., Rudioff H.E., Schmalstieg F.C. Jr., Goldman A.S., Production of interleukin-6 and interleukin-8 by human mammary gland epithelial cells, J. Reprod. Immunol. 26 (1994) 57-64.
154. Park H.S., Goodlad R.A., Ahnen D.J., Winnett A., Sasieni P., Lee C.Y., Wright N.A., Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently. Am. J. Pathol. 151 (1997) 843-852.
155. Penttila I.A., Zhang M.F., Bates E., Regester G., Read L.C., Zola H., Immune modulation in suckling rat pups by a growth factor extract derived from milk whey, J. Dairy Res. 68 (2001) 587-599.
156. Pesonen K., Viinikka L., Koskimies A., Banks A.R., Nicolson M., Perheentupa J., Size heterogeneity of epidermal growth factor in human body fluids, Life Sci. 40 (1987) 2489-2494.
157. Philipps A.F., Rao R., Anderson G.G., McCracken D.M., Lake M., Koldovsky O., Fate of insulin-like growth factors I and II administered orogastrically to suckling rats, Pediatr. Res. 37 (1995) 586-592.
158. Philipps A.F., Kling P.J., Grille J.G., Dvorak B., Intestinal transport of insulin-like growth factor-I (IGF-I) in the suckling rat, J. Pediatr. Gastroenterol. Nutr. 35 (2002) 539-544.
159. Phylactos A.C., Fasoula I.N., ArnaudBattandier F., Walker-Smith J.A., Fell J.M., Effect of enteral nutrition on antioxidant enzyme systems and inflammation in paediatric Crohn's disease. Acta Paediatr. 90 (2001) 883-888.
160. Piot M., Fauquant J., Madec M.-N., Maubois J.-L., Preparation of serocolostrum by membrane filtration. Lait 84 (2004) 333-341.
161. Playford R.J., Woodman A.C., Clark P., Watanapa P., Vesey D., Deprez P.H., Williamson R.C., Calam J., Effect of luminal growth factor preservation on intestinal growth. Lancet 341 (1993) 843-848.
162. Playford R.J., Marchbank T., Calnan D.P., Calam J., Royston P., Batten J.J., Hansen H.F., Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice, Gastroenterology 108 (1995) 92-101.
163. Popliker M., Shatz A., Avivi A., Ullrich A., Schlessinger J., Webb C.G., Onset of endogenous synthesis of epidermal growth factor in neonatal mice, Dev. Biol. 119 (1987) 38-44.
164. Prosser C.G., Fleet I.R., Corps A.N., Increased secretion of insulin-like growth factor I into milk of cows treated with recombinantly derived bovine growth hormone, J. Dairy Res. 56 (1989) 17-26.
165. Quinque B., Lesur H., Spick G., Montreuil J., Thomas D., Method for treating colostrum by hydroxyapatite adsorption chromatography, an active fraction of colostrum obtained, and a cellular medium containing the same, PCT WO 92/00014 Al, 1992.
166. Rao R.K., Luminal processing of epidermal growth factor in mouse gastrointestinal tract in vivo, Peptides 16 (1995) 505-513.
167. Rao R.K., Baker R.D., Baker S.S., Bovine milk inhibits proteolytic
168. Rao R.K., Koldovsky O., Kore M., Pollack P.P., Wright S., Davis T.P., Processing and transfer of epidermal growth factor in developing rat jejunum and ileum, Peptides 11 (1990) 1093-1102.
169. Rao R.K., Koldovsky O., Grimes J., Williams C., Davis T.P., Regional differences in gastrointestinal processing and absorption of epidermal growth factor in suckling rats, Am. J. Physiol. 261 (1991) G790-G798.
170. Rao R.K., Lam K., Philipps A.F., Williams C., Lake M., Koldovsky O., Presence of multiple forms of peptidase inhibitors in rat milk, J. Pediatr. Gastroenterol. Nutr. 17 (1993) 414-420.
171. Rayner T.E., Cowin A.J., Robertson J.G., Cooter R.D., Harries R.C., Regester G.O., Smithers G.W., Goddard C., Beiford D.A., Mitogenic whey extract stimulates wound repair activity in vitro and promotes healing of rat incisional wounds, Am. J. Physiol. Regul. Integr. Comp. Physiol. 278 (2000) R1651-R1660.
172. Read L.C., Upton F.M., Francis G.L., Wallace J.C., Dahlenberg G.W., Ballard F.J., Changes in the growth-promoting activity of human milk during lactation, Pediatr. Res. 18 (1984) 133-139.
173. Read L.C., Francis O.L., Wallace J.C., Ballard F.J., Growth factor concentrations and growth-promoting activity in human milk following premature birth, J. Dev. Physiol. 7 (1985) 135-145.
174. [174) Regester G.O., Beiford D.A., West R.J., Goddard C., Development of minor dairy components as therapeutic agents - whey growth factor extract, a case study, Aust. J. Dairy Technol. 58 (2003) 104-106.
175. Rehberger B., Gallmann P., Blum J., Optimized isolation procedure of a crude insulinlike growth factor concentrate, in: Desalination for the 10th Aachener Membran Kolloquium, March 16-17th, Aachen, Germany, 2005, available at http:// www.alp.admin.ch/de/publikationen/docs/ pub_RehbergerB_2005__15726.pdf.
176. Riese D.J. 2nd, Stern D.F., Specificity within the EGF family/ErbB receptor family signaling network, Bioassays 20 (1998) 41-48.
177. Roffler B., Fah A., Sauter S.N., Hammon H.M., Gallmann P., Brem G., Blum J.W., Intestinal morphology, epithelial cell proliferation, and absorptive capacity in neonatal calves fed milk-born insulin-like growth factor-I or a colostrum extract, J. Dairy Sci. 86 (2003) 1797-1806.
178. Rogers M.-L., Beiford D.A., Francis G.L., Ballard F.J., Identification of fibroblast growth factors in bovine cheese whey, J. Dairy Res. 62 (1995) 501-507.
179. Rogers M.-L., Goddard C., Regester G.O., Ballard F.J., Belford D.A., Transforming growth factor β in bovine milk: concentration stability and molecular mass forms, J. Endocrinol. 151 (1996) 77-86.
180. Ronge H., Blum J.W., Somatomecin C and other hormones in dairy cows around parturition in newborn calves and in milk, J. Anim. Physiol. Anim. Nutr. 60 (1988) 168176.
181. Ross M., Francis G.L., Szabo L., Wallace J.C., Ballard F.J., Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des(1-3HGF-1, Biochem. J. 258 (1989) 267-272.
182. Rozengurt E., Woll P., Zachary I., Growth factor receptors, US Patent 5441935, 1992.
183. Rudioff H.E., Schmalstieg F.C. Jr., Palkowetz K.H., Paszkiewicz E.J., Goldman A.S., Interleukin-6 in human milk, J. Reprod. Immunol. 23 (1993) 13-20.
184. Rudloff H.E., Schmalstieg F.C., Mushtaha A.A., Palkowetz K.H., Liu S.K., Goldman A.S., Tumor necrosis factor-α in human milk, Pediatr. Res. 31 (1992) 29-33.
185. Saharinen J., Hyytiainen M., Taipale J., Keski-Oja J., Latent transforming growth factor-beta binding proteins (LTBPs) -structural extracellular matrix proteins for targeting TGF-beta action, Cytokine Growth Factor Rev. 10 (1999) 99-117.
186. Saito S., Maruyama M., Kato Y., Moriyama I., Ichijo M., Detection of IL-6 in human milk and its involvement in IgA production, J. Reprod. Immunol. 20 (1991) 267-276.
187. Saito S.,Yoshida M., Ichijo M., IshizakaS., Tsujii T., Transforming growth factor-beta (TGF-β) in human milk, Clin. Exp. Immunol. 94 (1993) 220-224.
188. Savage C.R. Jr., Inagami T., Cohen S., The primary structure of epidermal growth factor, J. Biol. Chem. 247 (1972) 7612-7621.
189. Schams D., Growth factors in milk, Endocr. Regul. 28 (1994) 3-8.
190. Schams D., Einspanier R., Growth hormone, IGF-I and insulin in mammary gland secretion before and after parturition and possibility of their transfer into the calf, Endocr. Regul. 25 (1991) 139-143.
191. Scheving L.A., Shiurba R.A., Nguyen T.D., Gray G.M, Epidermal growth factor receptor of the intestinal enterocyte. Localization to laterobasal but not brush border membrane. J. Biol. Chem. 264 (1989) 1735-1741.
192. Sejrsen K., Pedersen L.O., Vestergaard M., Purup S., Biological activity of bovine milk. Contribution of IGF-I and IGF binding proteins, Livest. Prod. Sci. 70 (2001) 79-85.
193. Seno M., Tada H., Kosaka M., Sasada R., Igarashi K., Shing Y., Folkman J., Ueda M., Yamada H., Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. Growth Factors 13 (1996) 181-191.
194. Sereni A., Baserga R., Routine growth of cell lines in medium supplemented with milk instead of serum, Cell Biol. Int. Rep. 5 (1981) 339-345.
195. Shen W.H., Xu R.J., Stability of insulinlike growth factor I in the gastrointestinal lumen in neonatal pigs, J. Pediatr. Gastroenterol. Nutr. 30 (2000) 299-304.
196. Shimamoto G.T., Byatt J.C., Jennings M.G., Comens-Keller P.C., Collier R.J., Destripeptide insulin-like growth factor-I in milk from bovine somatotropin-treated cows, Pediatr. Res. 32 (1992) 296-300.
197. Shimizu M., Uryu N., Yamauchi K., Presence of heparan sulfate in the fat globule membrane of bovine and human milk, Agric. Biol. Chem. 45 (1981)741.
198. Shing Y.W., Klagsbrun M., Human and bovine milk contain different set of growth factors, Endocrinology 115 (1984) 273-282.
199. Shing Y., Davidson S., Klagsbrun M., Purification of polypeptide growth factors from milk, Methods Enzymol. 146 (1987) 42-48.
200. Shing Y., Klagsbrun M., Purification and characterization of a bovine colostrumderived growth factor. Mol. Endocrinol. 1 (1987) 335-338.
201. Si X.H., Yang L.J., Extraction and purification of TGFbeta and its effect on the induction of apoptosis of hepatocytes, World J. Gastroenterol. 7 (2001) 527-531.
202. Siafakas C.G., Anatolitou F., Fusunyan R.D., Walker W.A., Sanderson I.R., Vascular endothelial growth factor (VEGF) is present in human breast milk and its receptor is present on intestinal epithelial cells, Pediatr. Res. 45 (1999) 652-657.
203. Simmen F.A., Simmen R.C., Reinhart G., Maternal and neonatal somatomedin C/insulin-like growth factor-I (IGF-I) and IGF binding proteins during early lactation in the pig, Dev. Biol. 130(1988) 16-27.
204. Skaar T.C, Vega J.R., Pyke S.N., Baumrucker C.R., Changes in insulin-like growth factor-binding proteins in bovine mammary secretions associated with pregnancy and parturition, J. Endocrinol. 131 (1991) 127-133.
205. Smithers G. W., Isolation of growth factors from whey and their application in food and biotechnology industries - a brief review, Bull. Int. Dairy Fed. 389 (2004) 16-19.
206. Sparks A.L., Kirkpatrick J.G., Chamberlain C.S., Waldner D., Spicer L.J., Insulin-like growth factor-I and its binding proteins in colostrum compared to measures in serum of Holstein neonates, J. Dairy Sci. 86 (2003) 2022-2029.
207. Srivastava M.D., Srivastava A., Brouhard B., Saneto R., Groh-Wargo S., Kubit J., Cytokines in human milk. Res. Commun. Mol. Pathol. Pharmacol. 93 (1996) 263-287.
208. Starkey R.H., Orth D.N., Radioimmunoassay of human epidermal growth factor (urogastrone). J. Clin. Endocrinol. Metab. 45 (1977) 1144-1153.
209. Steimer K.S., Klagsbrun M., Serum-free growth of normal and transformed fibroblasts in milk: differential requirements for fibronectin. J. Cell Biol. 88 (1981) 294-300.
210. Steimer K.S., Packard R., Holden D., Klagsbrun M., The serum-free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period, J. Cell. Physiol. 109 (1981) 223-234.
211. Stoeck M., Ruegg C., Miescher S., Carrel S., Cox D., Von Fliedner V., Alkan S., Comparison of the immunosuppressive properties of milk growth factor and transforming growth factors beta 1 and beta 2, J. Immunol. Methods 143 (1989) 3258-3265.
212. 2+]i and the activation of protein kinase C, FEBS Lett. 249 (1989) 289-292.
213. Suh D.Y., Hunt T.K., Spencer E.M., Insulin-like growth factor-I reverses the impairment of wound healing induced by corticosteroids in rats, Endocrinol. 131 (1992) 2399-2403.
214. Suikkari A.M., Insulin-like growth factor (IGF-I) and its low molecular weight binding protein in human milk, Eur. J. Obstet. Gynecol. Reprod. Biol. 30 (1989) 19-25.
215. Suzuki S., Yagi H., Kuroume T., Epidermal growth factor in human milk, J. Pediatr. 104 (1984) 962.
216. Takada Y., Kobayashi N., Matsuyama H., Kato K., Yamamura J., Yahiro M., Kumegawa M., Aoe S., Whey protein suppresses the osteoclast-mediated bone resorption and osteoclast cell formation, Int. Dairy J. 7 (1997) 821-825.
217. Tapper D., Klagsbrun M., Neumann J., The identification and clinical implications of human breast milk mitogen, J. Pediatr. Surg. 14 (1979) 803-808.
218. Taylor V.L., Goddard C., Read L.C., A milk growth factor extract reduces chemotherapeutic drug toxicity in epithelial cells in vitro, In Vitro Cell. Dev. Biol. Anim. 37 (2001) 310-318.
219. Thompson J.F., Specific receptors for epidermal growth factor in rat intestinal microvillus membranes, Am. J. Physiol. 254 (1988) G429-G435.
220. Thompson L.D., Pantoliano M.W., Springer B.A., Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domain. Biochemistry 33 (1994) 3831-3840.
221. Thornburg W., Matrisian L., Magun B., Koldovsky O., Gastrointestinal absorption of epidermal growth factor in suckling rats, Am. J. Physiol. 246 (1984) G80-G85.
222. Thornburg W., Rao R.K., Matrisian L.M., Magun B.E., Koldovsky O., Effect of maturation on gastrointestinal absorption of epidermal growth factor in rats, Am. J. Physiol. 253 (1987) G68-G71.
223. Toba Y., Takada Y., Yamamura J., Tanaka M., Matsuoka Y., Kawakami H., Itabashi A., Aoe S., Kumegawa M., Milk basic protein: a novel protective function of milk against osteoporosis, Bone 27 (2000) 403-408.
224. Toba Y., Takada Y., Matsuoka Y., Monta Y., Motouri M., Hirai T., Suguri T., Aoe S., Kawakami H., Kumegawa M., Takeuchi A., Itabashi A., Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men, Biosci. Biotechnol. Biochem. 65 (2001) 1353-1357.
225. Tokuyama H., Tokuyama Y., Bovine colostric transforming growth factor-betalike peptide that induces growth inhibition and changes in morphology of human osteogenic sarcoma cells (MG-63), Cell Biol. Int. Rep. 13 (1989) 251-258.
226. Tokuyama H., Tokuyama Y., Migita S., Isolation of two new proteins from bovine colostrum which stimulate epidermal growth factor-dependent colony formation of NRK-49F cells, Growth Factors 3 (1990) 105-114.
227. Tokuyama Y., Tokuyama H., Purification and identification of TGF-ß2-related growth factor from bovine colostrum, J. Dairy Res. 60 (1993) 99-109.
228. Tran C.D., Howarth G.S., Coyle P., Philcox J.C., Rofe A.M., Butler R.N., Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine, Am. J. Clin. Nutr. 77 (2003) 1296-1303.
229. Vacher P.Y., Blum J.W., Age dependency of insulin like growth factor 1, insulin protein and immunoglobulin concentrations and gamma glutamyl transferase activity in first colostrum of dairy cows, Milchwissenschaft 48 (1993) 423-425.
230. Van den Eijnden-Van Raaij A.J., Koornneef I., Van Zoelen E.J., A new method for high yield purification of type beta transforming growth factor from human platelet, Biochem. Biophys. Res. Comm. 157 (1988) 16-23.
231. Van den Eijnden-Van Raaij A.J., Koornneef I., Van Oostwaard T.M., Feyen A., Kruijer W., De Laat S.W., Van Zoelen E.J., Purification of a growth factor related to platelet-derived growth factor and a type beta transforming growth factor secreted by mouse neuroblastoma cells. A general strategy for the purification of basic polypeptide growth factors, Biochem. J. 257 (1989) 375-382.
232. Vega J.R., Gibson C.A., Skaar T.C., Hadsell D.L., Baumrucker C.R., Insulin-like growth factor (IGF)-I and -II and IGF binding proteins in serum and mammary secretions during the dry period and early lactation in dairy cows, J. Anim. Sci. 69 (1991) 2538-2547.
233. Veselsky L., Cechova D., Jonakova V., Secretion and immunochemical properties of the trypsin inhibitor from bovine colostrum, Hoppe Seylers Z. Physiol. Chem. 359 (1978) 873-878.
234. Wagner C.L., Forsythe D.W., Pittard W.B., Variation in the biochemical forms of transforming growth factor-alpha present in human milk and secreted by human milk macrophages, Biol. Neonate 68 (1995) 325-333.
235. Xian C.J., Shoubridge C.A., Read L.C., Degradation of IGF-I in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein, J. Endocrinol. 146 (1995) 215-225.
236. Xu R.J., Wang T., Gastrointestinal absorption of insulinlike growth factor-I in neonatal pigs, J. Pediatr. Gastroenterol. Nutr. 23 (1996) 430-437.
237. Xu R.J., Mellor D.J., Birtles M.J., Breier B.H., Gluckman P.D., Effects of oral IGFI or IGF-II on digestive organ growth in newborn piglets, Biol. Neonate 66 (1994) 280-287.
238. Yagi H., Suzuki S., Noji T., Nagashima K., Kuroume T., Epidermal growth factor in cow's milk and milk formulas, Acta Paediatr. Scand. 75 (1986) 233-235.
239. Yamamura J., Takada Y., Goto M., Kumegawa M., Aoe S., Bovine milk kininogen fragment 1.2 promotes the proliferation of osteoblastic MC3T3-E1 cells, Biochem. Biophys. Res. Commun. 269 (2000) 628-632.
240. Yamanaka H., Hagiwara K., Kirisawa R., Iwai H., Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression, Microbiol. Immunol. 47 (2003) 461-468.
241. Young O.P., Taranto T.M., Jonas H.A., Cox A.J., Hogg A., Werther G.A., Insulinlike growth factors and the developing and mature rat small intestine: receptors and biological actions. Digestion 46 (Suppl. 2) (1990) 240-252.