Osteopontin

Critical Reviews in Oral Biology and Medicine

Volumn 11, Issue 3, 2000, Pages 279-303

  Sodek, J ^a,b   Ganss, B ^a   McKee, M D ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Bone remodeling; Cell attachment; Cell signaling; Sialoprotein; Tooth

Indexed keywords

CALCIUM PHOSPHATE; CYTOKINE; HERMES ANTIGEN; INTEGRIN; OSTEOPONTIN; OXALIC ACID; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN SERINE THREONINE KINASE;

AMINO ACID SEQUENCE; ARTICLE; BONE REMODELING; CALCIFICATION; CARCINOGENESIS; CELL ADHESION; EXTRACELLULAR MATRIX; GENETIC CONSERVATION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION; WOUND HEALING;

EID: 0033810657     PISSN: 10454411     EISSN: None     Source Type: Journal    
DOI: 10.1177/10454411000110030101     Document Type: Article

References (224)

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4. Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity
5. Contribution of human osteopontin to inhibition of calcium oxalate crystallization
6. Coordinate expression of OPN and associated receptors during monocyte/macrophage differentiation of HL-60 cells
7. Cellular and molecular biology of the osteoclast
8. Quantification of osteopontin in human plasma with an ELISA: Basal levels in pre- and postmenopausal women
9. Osteopontin is a ligand for the alpha4 beta1 integrin
10. Expression of bone sialoprotein, a bone matrix protein, in human breast cancer
11. Osteopontin: Its transglutaminase-catalyzed post-translational modifications and cross-linking to fibronectin
12. Agonist-activated alphav beta3 on platelets and lymphocytes binds to the matrix protein osteopontin
13. Developmental appearance and distribution of bone sialoprotein and osteopontin in human and rat cementurn
14. Osteopontin-hydroxyapatite interactions in vitro. Inhibition of hydroxyapatite formation and growth in a gelatin gel
15. New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
16. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
17. Osteopontin
18. Osteopontin localization in the Holstein bull reproductive tract
19. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
20. Osteopontin is strongly expressed by histocytes in granulomas of diverse etiology
21. Osteoblasts induce osteopontin expression in response to attachment on fibronectin: Demonstration of a common role for integrin receptors in the signal transduction processes of cell attachment and mechanical stimulation
22. Cells in vivo and in vitro from osteopetrotic mice homozygous for c-src disruption show suppression of synthesis of osteopontin, a multifunctional extracellular matrix protein
23. Induction of expression of osteopontin (OPN: Secreted phosphoprotein) in metastatic, ras-transformed N1H3T3 cells
24. Osteopontin expression in lung cancer
25. Effects of okadaic acid on calcitriol- and phorbol ester-induced expression and phosphorylation of osteopontin in mouse JB6 epidermal cells
26. Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase
27. c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase
28. Regulation of bone sialoprotein and osteopontin mRNA expression by dexamethasone and 1,25-dihydroxyvitamin D3 in rat bone organ cultures
29. Altered expression of bone sialoproteins in vitamin D-deficient rBSP2.7Luc transgenic mice
30. Calreticuiin is essential for calcium-mediated calcium signaling and cell adhesion
31. Dissociation between bone resorption and bone formation in osteopenic transgenic mice
32. Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis
33. Assembly of focal adhesions: Progress, paradigms, and portents
34. Distinct roles of osteopontin in host defence activity and tumor survival during squamous cell carcinoma progression in vivo
35. Cell differentiation and endogenous cyclic adenosine 3' 5'-monophosphate regulate osteopontin expression in human trophoblasts
36. In vitro modelling of the bone/implant interface
37. Expression of bone associated markers by tooth root lining cells, in situ and in vitro
38. Inhibition of nuclear hormone receptor activity by calreticulin
39. Identification of osteopontin as a novel ligand for the integrin alpha8 beta 1 and potential roles for this integrin-ligand interaction in kidney morphogenesis
40. Overcoming obstacles to metastasis-defenses against host defenses: Osteopontin (OPN) as a shield against attack by cytotoxic host cells
41. Osteopontin: A protein with diverse functions
42. Osteopontin expression and function: Role in bone remodeling
43. Osteopontin-induced modifications of cellular functions
44. Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cells
45. Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling bone
46. Osteopontin deposition in remodeling bone: An osteoclast mediated event
47. The role of integrins in osteoclast function
48. PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase
49. Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase: Modulation of osteoclast adhesion in vitro
50. Osteopontin stimulates a subpopulation of quiescent human prostate epithelial cells with high proliferative potential to divide in vitro
51. Osteopontin and its integrin receptor alpha(v)beta3 are upregulated during formation of the glial scar after focal stroke
52. Activation of alphav beta3 integrin on human osteoclast-like cells stimulates adhesion and migration in response to osteopontin
53. Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack
54. Localization of the mouse gene for secreted phosphoprotein 1 (Spp-1) (2ar, osteopontin, bone sialoprotein 1, 44-kDa bone phosphoprotein, tumor-secreted phosphoprotein) to chromosome 5, closely linked to Ric (Rickettsia resistance)
55. Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone
56. Isolation and characterization of two sialoproteins present only in bone calcified matrix
57. Requirement for NF-kappaB in osteoclast and B-cell development
58. Control of adhesion-dependent cell survival by focal adhesion kinase
59. Preferential adsorption of dentin and bone acidic proteins on the (100) face of hydroxyapatite crystals
60. Interactions of matrix proteins from mineralized tissues with octacalcium phosphate
61. Bone siaioprotein
62. Osteopontin in skeletal homeostasis: An emerging picture of the autocrine/paracrine functions of the extracellular matrix
63. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosderotic plaques
64. Osteopontin expression in cardiovascular diseases
65. Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo
66. The inhibitory activity of osteopontin on hydroxyapatite formation in vitro
67. Myocardial osteopontin expression is associated with left ventricular hypertrophy
68. Identification of a ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cell
69. Beta 1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption
70. Cloning and characterization of the human osteopontin gene and its promoter
71. Interaction of osteopontin with osteoclast integrins
72. Osteopontin in urinary stone formation
73. Modulation of crystal formation by bone phosphoproteins: Structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation
74. Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins
75. Age and development-related changes in osteopontin and nitric oxide synthase mRNA levels in human kidney proximal tubule epithelial cells: Contrasting responses to hypoxia and reoxygenation
76. Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies
77. Effect of ATP on actin filament stiffness
78. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
79. Transglutaminase-catalyzed cross-linking of osteopontin is inhibited by osteocalcin
80. Cross-linking of osteopontin by tissue transglutaminase increases its collagen binding properties
81. Calcitonin inhibits osteopontin mRNA expression in isolated rabbit osteoclasts
82. Differential regulation of the 55 kDa and rat bone cells by osteotropic hormones, growth factors and a tumor promoter
83. Non-RGD-domains of osteopontin promote cell adhesion without involving alphav-integrins
84. CD44 variants but not CD44s cooperate with beta 1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
85. Casein kinase 2 phosphorylation of recombinant rat osteopontin enhances adhesion of osteoclasts but not osteoblasts
86. The cDNA cloning and RNA distribution of bovine osteopontin
87. Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells
88. The cDNA and derived amino acid sequence for human osteopontin
89. Transcription of the bone sialoprotein gene is stimulated by v-Src acting through an inverted CCAAT box
90. Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures
91. Expression of osteopontin, a urinary inhibitor of stone mineral crystal growth, in rat kidney
92. Structure and expression of the mRNA encoding urinary stone protein (osteopontin)
93. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
94. Differential screening identifies genetic markers of monocyte to macrophage maturation
95. Multiple forms of SPP1 (secreted phosphoprotein 1, osteopontin) synthesized by normal and transformed rat bone cell populations: Regulation by TGF-β
96. Influence of an intermittent compressive force on matrix protein expression by ROS 17/2.8 cells. Selective stimulation of osteopontin
97. Phosphorylation of osteopontin by Golgi apparatus casein kinase
98. Relationship of cellular proliferation to expression of osteopontin and bone sialoprotein in regenerating rat periodontium
99. Characteristics of vitamin D3 receptor (VDR) binding to the vitamin D response element (VDRE) in rat bone sialoprotein gene promoter
100. The adhesive and migratory effects of osteopontin are mediated by distinct cell surface integrins
101. Altered wound healing in mice lacking a functional osteopontin gene (sppl)
102. Activation of a signal transduction pathway by osteopontin
103. Rho-and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: An essential role for ezrin/radixin/moesin proteins
104. Osteopontin in chronic puromycin aminonucleoside nephrosis
105. Transcriptional and posttranscriptional regulation of osteopontin gene expression in preosteoblasts by retinoic acid
106. Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1alpha, osteopontin and CD14 in a monocytic leukemia cell line
107. Ultrastructural, cytochemical and immunocytochemical studies on bone and its interfaces
108. Osteopontin and the bone remodeling sequence. Colloidal-gold immunocytochemistry of an interfacial extracellular matrix protein
109. Postembedding colloidal-gold immunocytochemistry of noncollagenous extracellular matrix proteins in mineralized tissues
110. Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair
111. Secretion of osteopontin by macrophages and its accumulation at tissue surfaces during wound healing in mineralized tissues: A potential requirement for macrophage adhesion and phagocytosis
112. Osteopontin: An interfacial extracellular matrix protein in mineralized tissues
113. Osteopontin deposition in remodeling bone: An osteoblast mediated event
114. Ultrastructural immunodetection of osteopontin and osteocalcin as major matrix components of renal calculi
115. Extracellular matrix in tooth cementum and mantle dentin: Localization of osteopontin and other noncollagenous proteins, plasma proteins and glycoconjugates by electron microscopy
116. Expression of osteopontin mRNA by osteoclasts and osteoblasts in modelling adult human bone
117. Matrix mineralization and the differentiation of osteocyte-like cells in culture
118. Analysis of differential gene expression in rat tibia after an osteogenic stimulus in vivo: Mechanical loading regulates osteopontin and myeloperoxidase
119. Quantitative studies of human urinary excretion of uropontin
120. 3 integrin stimulates immediate cell signals in osteoclasts
121. Nucleotide sequence of cDNA for mouse osteopontin-like protein
122. Detection of osteopontin in calcified human aortic valves
123. Characterization of a cDNA for chicken osteopontin: Expression during bone development, osteoblast differentiation, and tissue distribution
124. Sulphation of secreted phosphoprotein 1 (SPP1, osteopontin) is associated with mineralillzed tissue formation
125. Biosynthesis of bone proteins [SPP-1 (secreted phosphoprotein-1, osteopontin). BSP (bone sialoprotein) and SPARC (osteonectin)] in association with mineralized-tissue formation by fetal-rat calvarial cells in culture
126. Immunolocalization of CD44 and the ERM family in bone cells of mouse tibiae
127. Localization of CD44, the hyaluronate receptor, on the plasma membrane of osteocytes an osteoclasts in rat tibiae
128. Tissue response to titanium implants in the rat tibia: Ultrastructural, immunocytochemical and lectin-cytochemical characterization of the bone-titanium interface
129. CD44 structure, function, and association with malignant process
130. A chemoattractant cytokine associated with granulomas in tuberculosis and silicosis
131. Posttranslational modification in rat bone osteopontin
132. Normal rat kidney cells secrete both phosphorylated and nonphosphorylated forms of osteopontin showing different physiological properties
133. Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin)gene expression
134. Osteopontin-deficient mice (OD-) cells exhibit enhanced actin fiber formation and spreading while OD-osteoclasts are less efficient in removing hydroxyapatite coated on glass and in recruitment to ectopically implanted bone matrix
135. Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine like properties in vitro
136. The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model
137. The role of osteopontin in tumorigenesis and metastasis
138. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an arg-gly-asp cell-binding sequence
139. Potential roles of osteopontin and alphaVbeta3 integrin in the development of coronary artery restenosis after angioplasty
140. Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone
141. Structural and functional studies of the early T-lymphocyte activation (Eta-1) gene
142. Molecular and cellular basis of genetic resistance to bacterial infection: The role of the early T-lymphocyte activation-1/osteopontin gene
143. 3 regulates the biosynthesis of osteopontin, a bone-derived cell attachment protein, in clonal osteoblast-like osteosarcoma cells
144. Isolation, characterization and biosynthesis of a phosphorylated glycoprotein from rat bone
145. Osteopontin, a substrate for transglutaminase and factor XIII activity
146. Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain
147. Ultrastructural immunogold localization of osteopontin in human gastric mucosa
148. Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney
149. Characterization of the chicken osteopontin-encoding gene
150. Characterization of the rat osteopontin gene. Evidence for two vitamin D response elements
151. Osteopontin function in pathology: Lessons from osteopontin-deficient mice
152. Detection of mouse osteopontin by Western blotting
153. Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro
154. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
155. Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages
156. 3 potentiate bone resorption
157. Gene expression and phosphorylation of mouse osteopontin
158. 2+ influx
159. Expression of osteopontin in human glioma. Its correlation with the malignancy
160. Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases
161. Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues
162. NF-kappaB mediates alphav beta3 integrin-induced endothelial cell survival
163. Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissue
164. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin
165. Transformed mammalian cells secrete specific proteins and phosphoproteins
166. Purification of a human milk protein closely similar to tumor secreted phosphoprotein and osteopontin
167. Elevated expression of secreted phosphoprotein 1 (osteopontin, 2ar) as a consequence of neoplastic transformation
168. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin
169. Altered sialylation of osteopontin prevents its receptor-mediated binding on the surface of oncogenically transformed tsB77 cells
170. Osteopontin is associated with bioprosthetic heart valve calcification in humans
171. Inhibition of calcium oxalate crystal growth in vitro by uropontin: Another member of the aspartic acid-rich protein superfamily
172. Upregulated renal tubular CD44, hyaluronan, and osteopontin in kdkd mice with interstitial nephritis
173. Physiological properties and glycosylation of phosphorylated and non-phosphorylated forms of osteopontin secreted by normal rat kidney
174. Differential processing of osteopontin transcripts in rat kidney- and osteoblast-derived cell lines
175. Calcium-binding properties of osteopontin derived from non-osteogenic sources
176. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival
177. Structural requirements for alpha9 beta1-mediated adhesion and migration to thrombin-cleaved osteopontin
178. Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9 beta1 integrin
179. Elucidating the functions of bone sialoprotein and osteopontin in bone formation
180. Regulation of osteopontin expression in osteoblasts
181. Expression of attachment proteins during cementogenesis
182. Localization of transglutaminase-reactive glutamine residues in bovine osteopontin
183. Posttranslational modifications of bovine osteopontin: Identification of twenty-eight phosphorylation and three O-glycosylation sites
184. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
185. JavaShade: Multiple sequence alignment box-and-shading on the World Wide Web
186. Selective alphavbeta3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury: Evidence for the functional importance of alphavbeta3 and osteopontin expression during neointima formation
187. CD44 occupancy prevents macrophage multinucleation
188. Suppression of p53 activity and p21WAF1/C1P1 expression by vascular cell integrin alphaVbeta3 during angiogenesis
189. The LCC15-MB human breast cancer cell line expresses osteopontin and exhibits an invasive and metastatic phenotype
190. The carboxyl terminal fragment of osteopontin suppresses arginine glycine asparatic acid dependent cell adhesion
191. Interleukin-1-induced bone resorption does not occur in osteopontin-deficient mice
192. Osteopontin antisense deoxyoligonucleotides inhibit bone resorption in mouse osteoclasts in vitro
193. Activation of MMP-2 by human GCT23 giant cell tumour cells induced by osteopontin, bone sialoprotein and GRGDSP peptides is RGD and cell shape change dependent
194. Identification of osteopontin in isolated rabbit osteoclasts
195. Stimulation of mouse osteopontin promoter by v-Src is mediated by a CCAAT box-binding factor
196. Early expression of osteopontin in the chick is restricted to rhombomeres 5 and 6 and to a subpopulation of neural crest cells that arise from these segments
197. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap-penalties and weight matrix choice
198. Signal transduction of mechanical stimuli is dependent on microfilament integrity: Identification of osteopontin as a mechanically induced gene in osteoblasts
199. TPA-mediated regulation of osteopontin in human malignant glioma cells
200. Co-expression of osteopontin and CD44v9 in gastric cancer
201. Evidence that a non-RGD domain in rat osteopontin is involved in cell attachment
202. Calcification of vascular smooth muscle cell cultures: Inhibition by osteopontin
203. The immunology of Eta-1/osteopontin
204. Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
205. Osteopontin production by cultured kidney cells
206. Full-length cDNA sequence of porcine secreted phosphoprotein-I (SPP-I, osteopontin)
207. Recombinant GST-human osteopontin fusion protein is functional in RGD-dependent cell adhesion
208. The effect of osteopontin on the adhesion of calcium oxalate crystals to Madin-Darby canine kidney cells
209. Alendronate inhibits osteopontin expression enhanced by parathyroid hormone-related peptide (PTHrP) in the rat kidney
210. Promotion of angiogenesis and enhancement of breast cancer metastasis to bone
211. Osteopontin-deficient mice reveal increase in osteoclast number, enhanced TRANCE/RANKL/ODF expression in bone but are resistant to bone resorption that follows bone formation after bone marrow ablation
212. Osteopontin-deficient mice are resistant to ovariectomy-induced bone loss
213. cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)
214. Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts
215. Characterization of fetal porcine bone sialoproteins: Secreted phosphoprotein 1 (SPP1, osteopontin), bone sialoprotein, and a 23 kDa glycoprotein. Demonstration that the 23 kDa glycoprotein is derived from the carboxy-terminus of SPP1
216. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
217. Deposition of cement at reversal lines in rat femoral bone
218. Evidence of ectokinase-mediated phosphorylation of osteopontin and bone sialoprotein by osteoblasts during bone formation in vitro
219. Soluble alpha v beta 3-integrin ligands raise [Ca2+]i in rat osteoclasts and mouse-derived osteoclast-like cells
220. Single cell analysis of intracellular osteopontin in osteogenic cultures of fetal rat calvarial cells
221. Characterization of stromal progenitor cells enriched by flow cytometry
222. Analysis of intracellular osteopontin as a marker of osteoblastic cell differentiation and mesenchymal cell migration
223. Flow cytometric analysis of recombinant human osteogenic protein-1 (BMP-7) responsive subpopulations from fetal rat calvaria based on intracellular osteopontin content
224. Intracellular OPN is an integral component of the CD44-ERM complex involved in cell migration