Lactoferrin targets T cells in the small intestine

Journal of Gastroenterology

Volumn 45, Issue 11, 2010, Pages 1121-1128

  Nielsen, Sanne Mie ^a   Hansen, Gert H ^a   Danielsen, E Michael ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Brush border; Enterocytes; Lactoferrin; Small intestine; T lymphocytes

Indexed keywords

CD3 ANTIGEN; IMMUNOGLOBULIN; LACTOFERRIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LABELING; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENDOSOME; EXPLANT; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOGLOBULIN PRODUCTION; IMMUNOGOLD ELECTRON MICROSCOPY; INCUBATION TIME; INTERNALIZATION; INTESTINE BRUSH BORDER; INTESTINE CELL; LAMINA PROPRIA; MUCOSAL IMMUNITY; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SEROSA; SMALL INTESTINE MUCOSA; SWINE; T LYMPHOCYTE;

ANIMALS; CELL NUCLEUS; CYTOSOL; INTESTINAL MUCOSA; INTESTINE, SMALL; LACTOFERRIN; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; SWINE; T-LYMPHOCYTES;

EID: 78651310429     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0271-z     Document Type: Article

References (39)

1. Baker EN, Baker HM, Kidd RD. Lactoferrin and transferrin: functional variations on a common structural framework. Biochem Cell Biol. 2002;80:27-34.
2. Gonzalez-Chavez SA, Revalo-Gallegos S, Rascon-Cruz Q. Lactoferrin: structure, function and applications. Int J Antimicrob Agents. 2009;33:301-308.
3. Baker EN, Baker HM. Molecular structure, binding properties and dynamics of lactoferrin. Cell Mol Life Sci. 2005;62: 2531-2539.
4. Brines RD, Brock JH. The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum. Unusual resistance of human apolactoferrin to proteolytic digestion. Biochim Biophys Acta. 1983;759:229-235.
5. Baggiolini M, De DC, Masson PL, Heremans JF. Association of lactoferrin with specific granules in rabbit heterophil leukocytes. J Exp Med. 1970;131:559-570.
6. Jenssen H, Hancock RE. Antimicrobial properties of lactoferrin. Biochimie. 2009;91:19-29.
7. Ellison RT III, Giehl TJ, LaForce FM. Damage of the outer membrane of enteric Gram-negative bacteria by lactoferrin and transferrin. Infect Immun. 1988;56:2774-2781.
8. Hendrixson DR, Qiu J, Shewry SC, Fink DL, Petty S, Baker EN, et al. Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites. Mol Microbiol. 2003;47:607-617.
9. Suzuki YA, Lopez V, Lonnerdal B. Mammalian lactoferrin receptors: structure and function. Cell Mol Life Sci. 2005;62: 2560-2575.
10. Cox TM, Mazurier J, Spik G, Montreuil J, Peters TJ. Iron binding proteins and influx of iron across the duodenal brush border. Evidence for specific lactotransferrin receptors in the human intestine. Biochim Biophys Acta. 1979;588:120-128.
11. Roiron-Lagroux D, Figarella C. Evidence for a different mechanism of lactoferrin and transferrin translocation on HT 29-D4 cells. Biochem Biophys Res Commun. 1990;170:837-842.
12. Mikogami T, Heyman M, Spik G, Desjeux JF. Apical-to-basolateral transepithelial transport of human lactoferrin in the intestinal cell line HT-29 cl.19A. Am J Physiol. 1994;267: G308-G315.
13. Ashida K, Sasaki H, Suzuki YA, Lonnerdal B. Cellular internalization of lactoferrin in intestinal epithelial cells. Biometals. 2004;17:311-315.
14. Suzuki YA, Shin K, Lonnerdal B. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Biochemistry. 2001;40:15771-15779.
15. Wang WP, Iigo M, Sato J, Sekine K, Adachi I, Tsuda H. Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn J Cancer Res. 2000;91:1022-1027.
16. Danielsen EM, Sjostrom H, Noren O, Bro B, Dabelsteen E. Biosynthesis of intestinal microvillar proteins. Characterization of intestinal explants in organ culture and evidence for the existence of pro-forms of the microvillar enzymes. Biochem J. 1982;202:647-654.
17. Hansen GH, Rasmussen K, Niels-Christiansen LL, Danielsen EM. Endocytic trafficking from the small intestinal brush border probed with FM dye. Am J Physiol Gastrointest Liver Physiol. 2009;297:708-715.
18. Hansen GH, Niels-Christiansen LL, Immerdal L, Hunziker W, Kenny AJ, Danielsen EM. Transcytosis of immunoglobulin A in the mouse enterocyte occurs through glycolipid raft- and rab17-containing compartments. Gastroenterology. 1999;116: 610-622.
19. Anderson GJ, Frazer DM, McLaren GD. Iron absorption and metabolism. Curr Opin Gastroenterol. 2009;25:129-135.
20. Wrackmeyer U, Hansen GH, Seya T, Danielsen EM. Intelectin: a novel lipid raft-associated protein in the enterocyte brush border. Biochemistry. 2006;45:9188-9197.
21. Danielsen EM, Hansen GH. Lipid raft organization and function in brush borders of epithelial cells. Mol Membr Biol. 2006;23:71-79.
22. Rodewald R, Kraehenbuhl JP. Receptor-mediated transport of IgG. J Cell Biol. 1984;99:159s-164s.
23. Kraehenbuhl JP, Neutra MR. Transepithelial transport and mucosal defence II: secretion of IgA. Trends Cell Biol. 1992;2: 170-174.
24. Green I, Kirkpatrick CH, Dale DC. Lactoferrin-specific localization in the nuclei of human polymorphonuclear neutrophilic leukocytes. Proc Soc Exp Biol Med. 1971;137:1311-1317.
25. Bennett RM, Kokocinski T. Lactoferrin content of peripheral blood cells. Br J Haematol. 1978;39:509-521.
26. He J, Furmanski P. Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA. Nature. 1995;373:721-724.
27. Mariller C, Benaissa M, Hardiville S, Breton M, Pradelle G, Mazurier J, et al. Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression. FEBS J. 2007;274:2038-2053.
28. Rubartelli A, Sitia R. Entry of exogenous polypeptides into the nucleus of living cells: facts and speculations. Trends Cell Biol. 1995;5:409-412.
29. Suzuki YA, Wong H, Ashida KY, Schryvers AB, Lonnerdal B. The N1 domain of human lactoferrin is required for internalization by caco-2 cells and targeting to the nucleus. Biochemistry. 2008;47:10915-10920.
30. Bi BY, Liu JL, Legrand D, Roche AC, Capron M, Spik G, et al. Internalization of human lactoferrin by the Jurkat human lymphoblastic T-cell line. Eur J Cell Biol. 1996;69:288-296.
31. Dhennin-Duthille I, Masson M, Damiens E, Fillebeen C, Spik G, Mazurier J. Lactoferrin upregulates the expression of CD4 antigen through the stimulation of the mitogen-activated protein kinase in the human lymphoblastic T Jurkat cell line. J Cell Biochem. 2000;79:583-593.
32. Bennett RM, Davis J. Lactoferrin binding to human peripheral blood cells: an interaction with a B-enriched population of lymphocytes and a subpopulation of adherent mononuclear cells. J Immunol. 1981;127:1211-1216.
33. Zimecki M, Mazurier J, Spik G, Kapp JA. Human lactoferrin induces phenotypic and functional changes in murine splenic B cells. Immunology. 1995;86:122-127.
34. Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des. 2009;15:1956-1973.
35. Agace WW. T-cell recruitment to the intestinal mucosa. Trends Immunol. 2008;29:514-522.
36. Cheroutre H. Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu Rev Immunol. 2004;22:217-246.
37. Lonnerdal B. Nutritional roles of lactoferrin. Curr Opin Clin Nutr Metab Care. 2009;12:293-297.
38. Tsuda H, Kozu T, Iinuma G, Ohashi Y, Saito Y, Saito D, et al. Cancer prevention by bovine lactoferrin: from animal studies to human trial. Biometals. 2010;23:399-409.
39. Tang Z, Yin Y, Zhang Y, Huang R, Sun Z, Li T, et al. Effects of dietary supplementation with an expressed fusion peptide bovine lactoferricin- lactoferrampin on performance, immune function and intestinal mucosal morphology in piglets weaned at age 21 d. Br J Nutr. 2009;101:998-1005.