Breast milk-transforming growth factor-β2 specifically attenuates IL-1β-induced inflammatory responses in the immature human intestine via an SMAD6-and ERK-dependent mechanism

Neonatology

Volumn 99, Issue 3, 2011, Pages 192-201

  Rautava, Samuli ^a,b   Nanthakumar, N Nanda ^a   Dubert Ferrandon, Alix ^a   Lu, Lei ^a   Rautava, Jaana ^a   Walker, W Allan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Immature intestinal epithelium; Modulation of immune response; Transforming growth factor

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SMAD6 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; BREAST MILK; CELL CULTURE; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE; INTESTINE EPITHELIUM CELL; NEWBORN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE CULTURE;

CELL LINE; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FETUS; FLAVONOIDS; HUMANS; INFANT, NEWBORN; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; INTESTINE, SMALL; MILK, HUMAN; PROTEIN KINASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SMAD6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2;

EID: 77957136025     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000314109     Document Type: Article

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