Lipopolysaccharide inhibits transforming growth factor-beta1-stimulated Smad6 expression by inducing phosphorylation of the linker region of Smad3 through a TLR4-IRAK1-ERK1/2 pathway

FEBS Letters

Volumn 585, Issue 5, 2011, Pages 779-785

  Kim, Eun Ye ^a   Kim, Byung Chul ^a  

^a Kangwon National University   (South Korea)

Author keywords

ERK1 2; IRAK1; LPS; Smad3 linker phosphorylation; Smad6; TGF 1

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMAD3 PROTEIN; SMAD6 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA STRUCTURE; LINKER REGION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD6 PROTEIN; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1;

BACTERIA (MICROORGANISMS);

EID: 79952310317     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.01.044     Document Type: Article

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