Role of Epidermal Growth Factor and Other Growth Factors in the Prevention of Necrotizing Enterocolitis

Seminars in Perinatology

Volumn 32, Issue 2, 2008, Pages 107-113

  Nair, Rajalakshmi R ^a   Warner, Barbara B ^a   Warner, Brad W ^a  

^a ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

EGF; EPO; G CSF; HB CSF; NEC; prematurity

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR;

AMNION FLUID; BREAST MILK; CELL MATURATION; CELL PROLIFERATION; GASTROINTESTINAL TRACT; HUMAN; INTESTINE CELL; NECROTIZING ENTEROCOLITIS; NEWBORN DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SALIVA;

ENTEROCOLITIS, NECROTIZING; EPIDERMAL GROWTH FACTOR; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INTESTINAL MUCOSA;

EID: 40749150576     PISSN: 01460005     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semperi.2008.01.007     Document Type: Review

References (92)

1. Lee J.S., and Polin R.A. Treatment and prevention of necrotizing enterocolitis. Semin Neonatol 8 (2003) 449-459
2. Kosloske A.M. Epidemiology of necrotizing enerocolitis. Acta Pediatr Suppl 396 (1994) 2-7
3. Dvorak B. Epidermal growth factor and necrotizing enterocolitis. Clin Perinatol 31 (2004) 183-192
4. Kafetzis D., Skevaki C., and Costalos C. Neonatal necrotizing enterocolitis: an overview. Curr Opin Infect Dis 16 (2003) 349-355
5. Duh G., Mouri N., Warburton D., et al. EGF regulates early embryonic mouse gut development in chemically defined organ culture. Pediatr Res 48 (2000) 794-802
6. Dvorak B., Philips A.F., and Koldovsky O. Milk-borne growth factors and gut Development. In: Zeigler E., Lucas A., and Moro G. (Eds). Nutrition of the Very Low Birthweight Infant (1999), Williams & Wilkins, Philadelphia, PA 245-255
7. Pollack P.F., Goda T., Colony P.C., et al. Effects of enterally fed epidermal growth factor on the small and large intestinal of the suckling rat. Regul Pept 17 (1987) 121-132
8. Clark J., Doelle S., Halpern M., et al. Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol 291 (2006) 938-949
9. Hirai C., Ichiba H., Saito M., et al. Trophic effect of multiple growth factors in amniotic fluid or human milk on cultured human fetal small intestinal cells. J Pediatr Gastroenterol Nutr 34 (2002) 524-528
10. Barnard J., Beauchamp D., Russel W., et al. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology 108 (1995) 564-580
11. Playford R., and Wright N. Why is epidermal growth factor present in the gut lumen. Gut 38 (1996) 303-305
12. Li A., Schattenkerk M., Huffman R., et al. Hypersecretion of submandibular saliva in male mice: trophic response in small intestine. Gastroenterology 84 (1983) 949-955
13. Buchmiller T., Shaw K., Chopourian H., et al. Effect of transamniotic administration of epidermal growth factor on fetal rabbit small intestinal nutrient transport and disacchardase production. J Pediatr Surg 28 (1993) 1239-1244
14. Playford R., Hanby A., Gschmeissner S., et al. The epidermal growth factor receptor is present on the basolateral, but not the apical surface of enterocytes in the human gastrointestinal tract. Gut 39 (1996) 262-266
15. Thompson J. Specific receptor for epidermal growth factor in rat intestinal microvillus membranes. Am J Physiol 254 (1988) 235-429
16. Kelly D., McFadyen M., King, et al. Characterization and autoradiographic localization of the EGFR in the jejunum of neonatal and weaned pigs. Reprod Fertil Dev 4 (1992) 183-191
17. Wong W., and Wright N. Epidermal growth factor: EGFR, intestinal growth and adaptation. J Parenter Enteral Nutr 23 (1999) S83-S88
18. Miettinen P.J., Berger J.E., Meneses J., et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376 (1995) 337-341
19. Egger B., Buchler M., Laskhmanan J., et al. Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis. Scand J Gastroenterol 35 (2000) 1181-1187
20. Ichiba H., Fujimura M., and Takeuchi T. Levels of epidermal growth factor in human cord blood. Biol Neonate 61 (1992) 302-307
21. Scott S.M., Buenaflor G.G., and Orth D.N. Immunoreactive human epidermal growth factor concentrations in amniotic fluid, umbilical artery and vein serum, and placenta in full-term and preterm infants. Biol Neonate 56 (1989) 246-251
22. Tsau Y.K., Teng R.J., and Chen C.H. Correlation between urinary epidermal growth factor excretion and serum thyroid hormone in premature and term neonates. Nephron 78 (1998) 168-171
23. Evans N.J., Rutter N., and Gregory H. Urinary excretion of epidermal growth factor in the newborn. Early Hum Dev 14 (1986) 277-282
24. Scott S.M., Guardian C.M., Angelus P., et al. Developmental pattern of urinary epidermal growth factor in the premature infant and the influence of gender. J Clin Endocrinol Metab 72 (1991) 588-593
25. Warner B., Ryan A., Seeger K., et al. Ontogeny of salivery epidermal growth factor and necrotizing enterocolitis. J Pediatr 150 (2007) 358-363
26. Shin C., Falcone R., Duane K., et al. The distribution of endogenous epidermal growth factor after small bowel resection suggests increased intestinal utilization during adaptation. J Pediatr Surg 34 (1999) 22-26
27. Feng J., and Besner G. Heparin-binding EGF like factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis. J Pediatr Surg 42 (2007) 214-220
28. Wright N., Pike C., and Elia G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human intestinal stem cells. Nature 343 (1990) 82-85
29. Ohumura E., Emoto N., Tsushima T., et al. Salivary immunoreactive human epidermal growth factor (IR-HEGF) in patients with peptic ulcer disease. Hepatogastroenterology 102 (1987) 695-698
30. Zandomeneghi R., Serra L., Baumgartl U., et al. The role of epidermal growth factor in the pathogenesis of peptic ulcer disease. Am J Gastroenterol 86 (1991) 1150-1153
31. Tarnawski A., Stachura J., Durbin T., et al. Increased expression of epidermal growth factor receptor during the gastric ulcer healing in rats. Gastroenterology 102 (1992) 695-698
32. Itoh M., and Matsuo Y. Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blinded controlled clinical study. J Gastroenterol Hepatol 9 (1994) 78-83
33. Haedo W., Gonzalez T., Mas J.A., et al. Oral human recombinant epidermal growth factor in the treatment of patients with duodenal ulcer. Rev Esp Enferm Dig 88 (1996) 409-418
34. Juhl C.O., Jensen L.S., Steiniche T., et al. Recombinant human epidermal growth factor prevents sclerotherapy-induced esophageal ulcer and stricture formations in pigs. Dig Dis Sci 39 (1994) 393-401
35. Stepankova R., Kofronova O., Tuckova L., et al. Experimentally induced gluten enteropathy and protective effect of epidermal growth factor in artificially fed neonatal rats. J Pediatr Gastroenterol Nutr 36 (2004) 96-104
36. Abud H., Watson N., and Heath J. Growth of epithelial cells in culture is dependent on EGF signaling. Exp Cell Res 303 (2005) 252-262
37. Warner B., and Erwin C. Critical roles for EGF receptor signaling during resection -induced small bowel adaptation. J Pediatr Gastroenterol Nutr 43 (2006) 63-73
38. Williamson R. Intestinal adaptation: structural, functional and cytokinetic changes. N Engl J Med 298 (1978) 1393-1402
39. Knott A., Erwin C., Profitt S., et al. Localization of post-resection EGF receptor expression using laser capture microdissection. J Pediatr Surg 38 (2003) 440-445
40. Helmrath M., Shin C., Fow J., et al. Adaptation after small bowel resection is attenuated by sialoadenectomy: the role for endogenous epidermal growth factor. Surgery 124 (1998) 848-854
41. Helmrath M., Erwin C., and Warner B. A defective EGF receptor in waved-2 mice attenuates intestinal adaptation. J Surg Res 69 (1997) 76-80
42. Obrien D., Nelson L., Williams J., et al. Selective inhibition of the epidermal growth factor receptor impairs intestinal adaptation after small bowel resection. J Surg Res 105 (2002) 25-30
43. Chaet M., Arya G., Ziegler N., et al. Epidermal growth factor enhances intestinal adaptation after massive small bowel resection. J Pediatr Surg 29 (1994) 1035-1039
44. Erwin C., Helmrath M., Shin C., et al. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol 277 (1999) 533-540
45. Falcone R., Stern L., Kemp C., et al. Intestinal adaptation occurs independent of transforming growth factor-alpha. J Pediatr Surg 35 (2000) 365-370
46. Ribbons K.A., Howarth G.S., Ford W.D., et al. Effects of epidermal growth factor administration on repair of acetic acid-induced colonic ulcerations in rats. Growth Fact 14 (1989) 89-101
47. Sinha A., Nightingale J., West K.P., et al. Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis. N Engl J Med 349 (2003) 350-357
48. Sullivan P., Brueton M., Taaara Z., et al. Epidermal growth factor in necrotizing enteritis. Lancet 145 (1991) 804-807
49. Fagbemi A., Wright N., Lakhoo K., et al. Immunoreactive epidermal growth factor receptors are present in the gastrointestinal epithelial cells of preterm infants with necrotizing enterocolitis. Early Hum Dev 65 (2001) 1-9
50. Shin C.E., Falcone Jr. R.A., Stuart L., et al. Diminished epidermal growth factor levels in infants with necrotizing enterocolitis. J Pediatr Surg 35 (2000) 173-176
51. Scott S.M., Rogers C., Angelus P., et al. Effect of necrotizing enterocolitis on urinary epidermal growth factor levels. Am J Dis Child 145 (1991) 804-807
52. Anderson D., and Kliegaman R. The relationship of neonatal alimentation practice to the occurrence of endemic necrotizing enterocolitis. Am J Perinatol 8 (1991) 62-67
53. Dvorak B., Halpern M., Holubec H., et al. Epidermal growth factor reduces the development of necrotizng enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 282 (2002) 1560-1564
54. Lucas A., and Cole T. Breast milk and neonatal necrotizing enterocolitis. Lancet 336 (1990) 1519-1523
55. Carpenter G. Epidermal growth factor is a major growth-promoting agent in human milk. Science 210 (1980) 198-199
56. Connolly J., and Rose D. Epidermal growth factor-like proteins in breast fluid and human milk. Life Sci 42 (1988) 1751-1756
57. Dvorak B., Fituch C., and Williams C. Concentrations of EGF and TGF alpha in preterm milk. Adv Exp Med Biol 554 (2004) 407-409
58. Sullivan P., Lewindon P., Cheng C., et al. Intestinal mucosal remodeling by recombinant human EGF in neonates with severe necrotizing enterocolitis. J Pediatr Surg 42 (2007) 462-469
59. Nanthakumar N., Fusunyan R., Sanderson I., et al. Inflammation in the developing human intestine; a possible pathophysiology contributing to necrotizing enterocolitis. Proc Natl Acad Sci U S A 97 (2000) 6043-6048
60. Clark J., Lane R., Maclennan N., et al. Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 288 (2005) 755-762
61. Ford H., Watkins S., Reblock K., et al. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg 32 (1997) 275-282
62. Edelson M., Bagwell C., and Rozyxki H. Circulating pro-and counter inflammatory cytokine levels and severity in necrotizing enterocolitis. Pediatrics 103 (1991) 766-771
63. Caplan M., Sun X., Hseuh W., et al. Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis. J Pediatr 116 (1990) 960-964
64. Kuhn R., Lohler J., Rennick D., et al. Interleukin-10 deficient mice develop chronic enterocolitis. Cell 75 (1993) 263-274
65. Halpern M., Domingueq J., Dvorakova K., et al. Ileal cytokine dysregulation in experimental necrotizing is reduced by epidermal growth factor. J Pediatr Gastroenterol Nutr 36 (2003) 126-133
66. Rouwet E., Heineman E., Burman W., et al. Intestinal permeability and carrier-mediated monosaccharide absorption in preterm neonates during the early postnatal period. Pediatr Res 51 (2002) 64-70
67. Pacha J. Development of intestinal transport function in mammals. Physiol Rev 80 (2000) 1633-1667
68. Piena-Spoel M., Albers M., and Ten Kate J. Intestinal permeability in newborn with necrotizing enterocolitis and controls: does the sugar absorption test provide guideline for the time to (re)introduce enteral nutrition?. J Pediatr Surg 36 (2001) 587-592
69. Okuyama H., Urao M., Lee D., et al. The effect of epidermal growth factor on bacterial translocation in newborn rabbits. J Pediatr Surg 33 (1998) 225-228
70. Zapata-Sirvent R.L., Hansbrough J.F., Wolf P., et al. Epidermal growth factor limits structural alterations in gastrointestinal tissues and decreases bacterial translocation in burned mice. Surgery 113 (1993) 564-573
71. McAndrew H.F., Lloyd D.A., Rintala R., et al. The effects of intravenous epidermal growth factor on bacterial translocation and central venous catheter infection in the rat total parenteral nutrition model. Pediatr Surg Int 16 (2000) 169-173
72. Jarboe M., Juno R., Stehr W., et al. Epidermal growth factor receptor signaling regulates goblet cell production after small bowel resection. J Pediatr Surg 40 (2005) 92-97
73. Jilling T., Lu J., Jackson M., et al. Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis. Pediatr Res 55 (2004) 622-629
74. Warner B.W., and Warner B.B. Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis. Semin Pediatr Surg 14 (2005) 175-180
75. Feng J., El-Assal O., and Besner G. Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis. Semin Pediatr Surg 14 (2005) 167-174
76. Jin K., Mao X., Sun Y., et al. Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo. J Neurosci 22 (2002) 5365-5673
77. Cribbs R., Harding R., Luquette M., et al. Endogenous production of heparin-binding EGF-like growth factor during murine partial thickness burn wound healing. J Burn Care Rehab 23 (2002) 116-125
78. Marikovsky M., Breuing K., Liu P., et al. Appearance of heparin-binding EGF-like growth factor in wound fluid as response to injury. Proc Natl Acad Sci U S A 90 (1993) 3889-3893
79. Barlow B., Santulli T., Heird W., et al. An experimental study of acute neonatal enterocolitis; the importance of breast milk. J Pediatr Surg 14 (1994) 587-595
80. El-Assal O., Radulescu A., and Besner G. Heparin-binding EGF-like growth factor preserves mesenteric microcirculatory blood flow and protects against intestinal injury in rats subjected to hemorrhagic shock and resuscitation. Surgery 142 (2007) 234-242
81. Calhoun D., and Christense R. Human developmental biology of granulocyte colony-stimulating factor. Clin Perinatal 27 (2000) 559-576
82. Calhoun D., Lunoe M., Du Y., et al. Granulocyte colony-stimulating factor is present in human milk and its receptor is present in human fetal intestine. Pediatrics 105 (2000) E1-E6
83. Calhoun D., Lunoe M., Du Y., et al. Concentrations of granulocyte colony-stimulating factor in human milk after in vitro simulations of digestion. Pediatr Res 46 (1999) 767-771
84. Canpolat F., Yurdakik M., Ozsoy S., et al. Protective effects of recombinant human granulocyte colony stimulation factor in a rat model of necrotizing enterocolits. Pediatr Surg Int 22 (2006) 719-723
85. Kling P., Sullivan T., Roberts R., et al. Human milk as a potential enteral source of erythropoietin. Pediatr Res 43 (1998) 216-221
86. Juul S., Yachnis A., Rojiana A., et al. Tissue distribution of Epo and Epo-R in the developing human fetus. Early Hum Dev 52 (1998) 235-249
87. McCole D.F., Rogler G., Varki N., et al. Epidermal growth factor partially restores colonic ion transport in mouse models of chronic colitis. Gastroenterology 129 (2005) 591-608
88. Sinha A., Nightingale J., West K., et al. Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis. New Engl J Med 394 (2003) 350-357
89. Stern L., Erwin C., O'Brien D., et al. Epidermal growth factor is critical for intestinal adaptation following small bowel resection. Microsc Res Tech 51 (2000) 138-148
90. Clark J.A., Clark A.T., Hotchkiss R.S., et al. Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis. Shock (2007) (abstr)
91. Tsujikawa T., Bamba T., and Hosoda S. The trophic effect of epidermal growth factor on morphological changes and polyamine metabolism in the small intestine in rats. Gastroenterol Jpn 25 (1990) 328-334
92. Sasaki M., Fitzgerald A., Mandir N., et al. Keratinocyte growth factor and epidermal growth factor can reverse the intestinal atrophy associated with elemental diets in mice. Exp Physiol 88 (2003) 261-267