메뉴 건너뛰기




Volumn 33, Issue 3, 2013, Pages 245-281

Immunotherapeutic treatment of autoimmune diabetes

Author keywords

Autoantigen; Autoimmune diabetes; Prevention; Treatment

Indexed keywords

ABATACEPT; ALPHA 1 ANTITRYPSIN; BCG VACCINE; BHT 3021; CANAKINUMAB; DIAMYD; DIAPEP277; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DNA VACCINE; ETANERCEPT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUTAMATE DECARBOXYLASE 65; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOSUPPRESSIVE AGENT; INSULIN; INTERLEUKIN 2; LANSOPRAZOLE; NBI 6024; NICOTINAMIDE; OTELIXIZUMAB; PLACEBO; PROINSULIN; RAPAMYCIN; RECOMBINANT ALPHA INTERFERON; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; SITAGLIPTIN; SYNTHETIC PEPTIDE; TEPLIZUMAB; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIBODY; AUTOANTIGEN;

EID: 84878702238     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevImmunol.2013006913     Document Type: Article
Times cited : (3)

References (242)
  • 3
    • 70449412682 scopus 로고    scopus 로고
    • No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes
    • Walter M, Philotheou A, Bonnici F, Ziegler AG, Jimenez R. No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes. Diabetes Care. 2009;32:2036-40.
    • (2009) Diabetes Care , vol.32 , pp. 2036-2040
    • Walter, M.1    Philotheou, A.2    Bonnici, F.3    Ziegler, A.G.4    Jimenez, R.5
  • 6
    • 80054692681 scopus 로고    scopus 로고
    • Long-term outcome of individuals treated with oral insulin: Diabetes prevention trial-type 1 (DPT-1) oral insulin trial
    • Vehik K, Cuthbertson D, Ruhlig H, Schatz DA, Peakman M, Krischer JP. Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial. Diabetes Care. 2011;34:1585-90.
    • (2011) Diabetes Care , vol.34 , pp. 1585-1590
    • Vehik, K.1    Cuthbertson, D.2    Ruhlig, H.3    Schatz, D.A.4    Peakman, M.5    Krischer, J.P.6
  • 7
    • 52749085098 scopus 로고    scopus 로고
    • Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)
    • Butty V, Campbell C, Mathis D, Benoist C. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes. 2008;57:2348-59.
    • (2008) Diabetes , vol.57 , pp. 2348-2359
    • Butty, V.1    Campbell, C.2    Mathis, D.3    Benoist, C.4
  • 8
    • 4644230843 scopus 로고    scopus 로고
    • Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    • Harrison LC, Honeyman MC, Steele CE, Stone NL, Sarugeri E, Bonifacio E, Couper JJ, Colman PG. Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care. 2004;27:2348-55.
    • (2004) Diabetes Care , vol.27 , pp. 2348-2355
    • Harrison, L.C.1    Honeyman, M.C.2    Steele, C.E.3    Stone, N.L.4    Sarugeri, E.5    Bonifacio, E.6    Couper, J.J.7    Colman, P.G.8
  • 14
    • 0026322837 scopus 로고
    • Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein
    • Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA. 1991;88:3088-91.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3088-3091
    • Elias, D.1    Reshef, T.2    Birk, O.S.3    van der Zee, R.4    Walker, M.D.5    Cohen, I.R.6
  • 15
    • 33845687082 scopus 로고    scopus 로고
    • DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes
    • Elias D, Avron A, Tamir M, Raz I. DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes. Ann N Y Acad Sci. 2006;1079:340-4.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 340-344
    • Elias, D.1    Avron, A.2    Tamir, M.3    Raz, I.4
  • 18
    • 80755168854 scopus 로고    scopus 로고
    • C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277: An exploratory study
    • Buzzetti R, Cernea S, Petrone A, Capizzi M, Spoletini M, Zampetti S, Guglielmi C, Venditti C, Pozzilli P. C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277: an exploratory study. Diabetes. 2011;60: 3067-72.
    • (2011) Diabetes , vol.60 , pp. 3067-3072
    • Buzzetti, R.1    Cernea, S.2    Petrone, A.3    Capizzi, M.4    Spoletini, M.5    Zampetti, S.6    Guglielmi, C.7    Venditti, C.8    Pozzilli, P.9
  • 19
    • 0141593569 scopus 로고    scopus 로고
    • Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies
    • Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA. 2003;290:1721-8.
    • (2003) JAMA , vol.290 , pp. 1721-1728
    • Ziegler, A.G.1    Schmid, S.2    Huber, D.3    Hummel, M.4    Bonifacio, E.5
  • 20
    • 80051982382 scopus 로고    scopus 로고
    • Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: The BABYDIET study
    • Hummel S, Pflüger M, Hummel M, Bonifacio E, Ziegler AG. Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care. 2011;34:1301-5.
    • (2011) Diabetes Care , vol.34 , pp. 1301-1305
    • Hummel, S.1    Pflüger, M.2    Hummel, M.3    Bonifacio, E.4    Ziegler, A.G.5
  • 22
    • 0033816148 scopus 로고    scopus 로고
    • Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group
    • Paronen J, Knip M, Savilahti E, Virtanen SM, Ilonen J, Akerblom HK, Vaarala O. Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group. Diabetes. 2000;49:1657-65.
    • (2000) Diabetes , vol.49 , pp. 1657-1665
    • Paronen, J.1    Knip, M.2    Savilahti, E.3    Virtanen, S.M.4    Ilonen, J.5    Akerblom, H.K.6    Vaarala, O.7
  • 24
    • 0035802695 scopus 로고    scopus 로고
    • Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study
    • Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500-3.
    • (2001) Lancet , vol.358 , pp. 1500-1503
    • Hypponen, E.1    Laara, E.2    Reunanen, A.3    Jarvelin, M.R.4    Virtanen, S.M.5
  • 26
    • 77957147196 scopus 로고    scopus 로고
    • Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody require TNF
    • Ablamunits V, Bisikirska B, Herold K. Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody require TNF. Eur J Immunol. 2010;40:2891-901.
    • (2010) Eur J Immunol , vol.40 , pp. 2891-2901
    • Ablamunits, V.1    Bisikirska, B.2    Herold, K.3
  • 27
    • 80051931752 scopus 로고    scopus 로고
    • Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells
    • Penaranda C, Tang Q, Bluestone JA. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol. 2011;187:2015-22.
    • (2011) J Immunol , vol.187 , pp. 2015-2022
    • Penaranda, C.1    Tang, Q.2    Bluestone, J.A.3
  • 29
    • 20444445931 scopus 로고    scopus 로고
    • Regulatory T cells and type 1 diabetes
    • Bisikirska BC, Herold KC. Regulatory T cells and type 1 diabetes. Curr Diab Rep. 2005;5:104-9.
    • (2005) Curr Diab Rep , vol.5 , pp. 104-109
    • Bisikirska, B.C.1    Herold, K.C.2
  • 30
    • 73349105249 scopus 로고    scopus 로고
    • Monitoring of antigenspecific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies
    • Cernea S, Herold KC. Monitoring of antigenspecific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies. Clin Immunol. 2010;134:121-9.
    • (2010) Clin Immunol , vol.134 , pp. 121-129
    • Cernea, S.1    Herold, K.C.2
  • 34
    • 84858013882 scopus 로고    scopus 로고
    • New and future immunomodulatory therapy in type 1 diabetes
    • Tooley JE, Waldron-Lynch F, Herold KC. New and future immunomodulatory therapy in type 1 diabetes. Trends Mol Med. 2012;18:173-81.
    • (2012) Trends Mol Med , vol.18 , pp. 173-181
    • Tooley, J.E.1    Waldron-Lynch, F.2    Herold, K.C.3
  • 35
    • 84255199280 scopus 로고    scopus 로고
    • Making progress: Preserving beta cells in type 1 diabetes
    • Gallagher MP, Goland RS, Greenbaum CJ. Making progress: preserving beta cells in type 1 diabetes. Ann N Y Acad Sci. 2011;1243:119-34.
    • (2011) Ann N Y Acad Sci , vol.1243 , pp. 119-134
    • Gallagher, M.P.1    Goland, R.S.2    Greenbaum, C.J.3
  • 38
    • 80051940031 scopus 로고    scopus 로고
    • Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes
    • Herold KC, Pescovitz MD, McGee P, Krause-Steinrauf H, Spain LM, Boucier K, Asare A, Liu Z, Lachin JM, Dosch HM. Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes. J Immunol. 2011;187:1998-2005.
    • (2011) J Immunol , vol.187 , pp. 1998-2005
    • Herold, K.C.1    Pescovitz, M.D.2    McGee, P.3    Krause-Steinrauf, H.4    Spain, L.M.5    Boucier, K.6    Asare, A.7    Liu, Z.8    Lachin, J.M.9    Dosch, H.M.10
  • 40
    • 80055084799 scopus 로고    scopus 로고
    • Preliminary studies related to antiinterleukin-1beta therapy in children with newly diagnosed type 1 diabetes
    • Sumpter KM, Adhikari S, Grishman EK, White PC. Preliminary studies related to antiinterleukin-1beta therapy in children with newly diagnosed type 1 diabetes. Pediatr Diabetes. 2011;12:656-67.
    • (2011) Pediatr Diabetes , vol.12 , pp. 656-667
    • Sumpter, K.M.1    Adhikari, S.2    Grishman, E.K.3    White, P.C.4
  • 43
    • 0035313059 scopus 로고    scopus 로고
    • IFNg/TNFa synergism as the final effector in autoimmune diabetes: A key role for STAT1/IRF-1 in pancreatic b-cell death
    • Suk K, Kim S, Kim Y-H, Kim K-A, Chang I, Yagita H, Shong M, Lee M-S. IFNg/TNFa synergism as the final effector in autoimmune diabetes: A key role for STAT1/IRF-1 in pancreatic b-cell death. J Immunol. 2001;166:4481-9.
    • (2001) J Immunol , vol.166 , pp. 4481-4489
    • Suk, K.1    Kim, S.2    Kim, Y.-H.3    Kim, K.-A.4    Chang, I.5    Yagita, H.6    Shong, M.7    Lee, M.-S.8
  • 45
    • 84878623453 scopus 로고    scopus 로고
    • Biologic therapies in the treatment of psoriasis: A comprehensive evidence-based basic science and clinical review and a practical guide to tuberculosis monitoring
    • Sivamani RK, Goodarzi H, Garcia MS, Raychaudhuri SP, Wehrli LN, Ono Y, Maverakis E. Biologic therapies in the treatment of psoriasis: a comprehensive evidence-based basic science and clinical review and a practical guide to tuberculosis monitoring. Clin Rev Allergy Immunol. 2012;44:121-40.
    • (2012) Clin Rev Allergy Immunol , vol.44 , pp. 121-140
    • Sivamani, R.K.1    Goodarzi, H.2    Garcia, M.S.3    Raychaudhuri, S.P.4    Wehrli, L.N.5    Ono, Y.6    Maverakis, E.7
  • 47
    • 0031782993 scopus 로고    scopus 로고
    • Ingested interferon alpha suppresses type I diabetes in non-obese diabetic mice
    • Brod SA, Malone M, Darcan S, Papolla M, Nelson L. Ingested interferon alpha suppresses type I diabetes in non-obese diabetic mice. Diabetologia. 1998;41:1227-32.
    • (1998) Diabetologia , vol.41 , pp. 1227-1232
    • Brod, S.A.1    Malone, M.2    Darcan, S.3    Papolla, M.4    Nelson, L.5
  • 50
    • 17844362518 scopus 로고    scopus 로고
    • Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes
    • Mest HJ, Mentlein R. Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes. Diabetologia. 2005;48:616-20.
    • (2005) Diabetologia , vol.48 , pp. 616-620
    • Mest, H.J.1    Mentlein, R.2
  • 51
    • 67650685905 scopus 로고    scopus 로고
    • Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycemia in non-obese diabetic mice
    • Suarez-Pinzon WL, Cembrowski GS, Rabinovitch A. Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycemia in non-obese diabetic mice. Diabetologia. 2009;52:1680-2.
    • (2009) Diabetologia , vol.52 , pp. 1680-1682
    • Suarez-Pinzon, W.L.1    Cembrowski, G.S.2    Rabinovitch, A.3
  • 52
    • 53749089728 scopus 로고    scopus 로고
    • Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice
    • Suarez-Pinzon WL, Lakey JR, Rabinovitch A. Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice. Cell Transplantation. 2008;17:631-40.
    • (2008) Cell Transplantation , vol.17 , pp. 631-640
    • Suarez-Pinzon, W.L.1    Lakey, J.R.2    Rabinovitch, A.3
  • 53
    • 80053003537 scopus 로고    scopus 로고
    • Effect of sitagliptin on glucose control in adult patients with Type 1 diabetes: A pilot, doubleblind, randomized, crossover trial
    • Ellis SL, Moser EG, Snell-Bergeon JK, Rodionova AS, Hazenfield RM, Garg SK. Effect of sitagliptin on glucose control in adult patients with Type 1 diabetes: a pilot, doubleblind, randomized, crossover trial. Diabetic Med. 2011;28:1176-81.
    • (2011) Diabetic Med , vol.28 , pp. 1176-1181
    • Ellis, S.L.1    Moser, E.G.2    Snell-Bergeon, J.K.3    Rodionova, A.S.4    Hazenfield, R.M.5    Garg, S.K.6
  • 62
    • 48249144864 scopus 로고    scopus 로고
    • Immunomodulation by mesenchymal stem cells: A potential therapeutic strategy for type 1 diabetes
    • Abdi R, Fiorina P, Adra CN, Atkinson M, Sayegh MH. Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes. 2008;57:1759-67.
    • (2008) Diabetes , vol.57 , pp. 1759-1767
    • Abdi, R.1    Fiorina, P.2    Adra, C.N.3    Atkinson, M.4    Sayegh, M.H.5
  • 63
    • 59649086980 scopus 로고    scopus 로고
    • Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI
    • Li N, Chen Y, He W, Yi T, Zhao D, Zhang C, Lin CL, Todorov I, Kandeel F, Forman S, Zeng D. Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI. Blood. 2009;113:953-62.
    • (2009) Blood , vol.113 , pp. 953-962
    • Li, N.1    Chen, Y.2    He, W.3    Yi, T.4    Zhao, D.5    Zhang, C.6    Lin, C.L.7    Todorov, I.8    Kandeel, F.9    Forman, S.10    Zeng, D.11
  • 64
    • 8544253255 scopus 로고    scopus 로고
    • Effect of human umbilical cord blood cells on glycemia and insulitis in type 1 diabetic mice
    • Ende N, Chen R, Reddi AS. Effect of human umbilical cord blood cells on glycemia and insulitis in type 1 diabetic mice. Biochem Biophys Res Com. 2004;325:665-9.
    • (2004) Biochem Biophys Res Com , vol.325 , pp. 665-669
    • Ende, N.1    Chen, R.2    Reddi, A.S.3
  • 65
    • 84861669648 scopus 로고    scopus 로고
    • Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells
    • Bassi EJ, de Almeida DC, Moraes-Vieira PM, Camara NO. Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells. Stem Cell Reviews. 2012; 8:329-42.
    • (2012) Stem Cell Reviews , vol.8 , pp. 329-342
    • Bassi, E.J.1    de Almeida, D.C.2    Moraes-Vieira, P.M.3    Camara, N.O.4
  • 71
    • 0019945886 scopus 로고
    • Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice
    • Yamada K, Nonaka K, Hanafusa T, Miyazaki A, Toyoshima H, Tarui S. Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice. Diabetes. 1982;31:740-53.
    • (1982) Diabetes , vol.31 , pp. 740-753
    • Yamada, K.1    Nonaka, K.2    Hanafusa, T.3    Miyazaki, A.4    Toyoshima, H.5    Tarui, S.6
  • 72
    • 1642277657 scopus 로고    scopus 로고
    • European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes
    • European Nicotinamide Diabetes Intervention Trial (ENDIT) Group
    • Gale EA, Bingley PJ, Emmett CL, Collier T. European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet. 2004;363:925-31.
    • (2004) Lancet , vol.363 , pp. 925-931
    • Gale, E.A.1    Bingley, P.J.2    Emmett, C.L.3    Collier, T.4
  • 73
    • 44649165790 scopus 로고    scopus 로고
    • Effects of b-cell rest on b-cell function: A review of clinical and preclinical data
    • Brown RJ, Rother KI. Effects of b-cell rest on b-cell function: a review of clinical and preclinical data. Pediatr Diabetes. 2008;9:14-22.
    • (2008) Pediatr Diabetes , vol.9 , pp. 14-22
    • Brown, R.J.1    Rother, K.I.2
  • 74
    • 0025837184 scopus 로고
    • Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
    • Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci U S A. 1991;88:10252-6.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10252-10256
    • Zhang, Z.J.1    Davidson, L.2    Eisenbarth, G.3    Weiner, H.L.4
  • 75
    • 0035746917 scopus 로고    scopus 로고
    • Expression of a dominant-negative inhibitor of NF-kB protects MIN6 beta-cells from cytokineinduced apoptosis
    • Baker MS, Chen X, Cao XC, Kaufman DB. Expression of a dominant-negative inhibitor of NF-kB protects MIN6 beta-cells from cytokineinduced apoptosis. J Surg Res. 2001;97:117-22.
    • (2001) J Surg Res , vol.97 , pp. 117-122
    • Baker, M.S.1    Chen, X.2    Cao, X.C.3    Kaufman, D.B.4
  • 76
    • 0029872093 scopus 로고    scopus 로고
    • Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes
    • Daniel D, Wegmann DR. Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes. Ann N Y Acad Sci. 1996;778:371-2.
    • (1996) Ann N Y Acad Sci , vol.778 , pp. 371-372
    • Daniel, D.1    Wegmann, D.R.2
  • 77
    • 0033981213 scopus 로고    scopus 로고
    • Gamma delta T cells as mediators of mucosal tolerance: The autoimmune diabetes model
    • Hanninen A, Harrison LC. Gamma delta T cells as mediators of mucosal tolerance: the autoimmune diabetes model. Immunol Rev. 2000;173:109-19.
    • (2000) Immunol Rev , vol.173 , pp. 109-119
    • Hanninen, A.1    Harrison, L.C.2
  • 78
    • 1842847412 scopus 로고    scopus 로고
    • Diabetes and Nutrition Study Group of the EASD (DNSG). Minutes of the General Assembly held at Samos on 29 June 2002. European Association for the Study of Diabetes
    • Julius U, Hermansen K. Diabetes and Nutrition Study Group of the EASD (DNSG). Minutes of the General Assembly held at Samos on 29 June 2002. European Association for the Study of Diabetes. Diabetologia. 2002;45:R68-69.
    • (2002) Diabetologia , vol.45
    • Julius, U.1    Hermansen, K.2
  • 79
    • 0036408394 scopus 로고    scopus 로고
    • Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice
    • Aspord C, Thivolet C. Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol. 2002;130: 204-11.
    • (2002) Clin Exp Immunol , vol.130 , pp. 204-211
    • Aspord, C.1    Thivolet, C.2
  • 80
    • 0030456670 scopus 로고    scopus 로고
    • Aerosol insulin induces regulatory CD8 gamma delta Tcells that prevent murine insulin-dependent diabetes
    • Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K. Aerosol insulin induces regulatory CD8 gamma delta Tcells that prevent murine insulin-dependent diabetes. J Exp Med.1996;184:2167-74.
    • (1996) J Exp Med , vol.184 , pp. 2167-2174
    • Harrison, L.C.1    Dempsey-Collier, M.2    Kramer, D.R.3    Takahashi, K.4
  • 81
    • 0027999706 scopus 로고
    • Administering glutamic acid decarboxylase to NOD mice prevents diabetes
    • Tisch R, Yang XD, Liblau RS, McDevitt HO. Administering glutamic acid decarboxylase to NOD mice prevents diabetes. J Autoimmun. 1994;7:845-50.
    • (1994) J Autoimmun , vol.7 , pp. 845-850
    • Tisch, R.1    Yang, X.D.2    Liblau, R.S.3    McDevitt, H.O.4
  • 82
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med. 1996;183:1561-7.
    • (1996) J Exp Med , vol.183 , pp. 1561-1567
    • Tian, J.1    Atkinson, M.A.2    Clare-Salzler, M.3    Herschenfeld, A.4    Forsthuber, T.5    Lehmann, P.V.6    Kaufman, D.L.7
  • 83
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature. 1993;366:72-5.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 84
    • 0028099535 scopus 로고
    • Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes
    • Bergerot I, Fabien N, Maguer V, Thivolet C. Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes. J Autoimmun. 1994;7:655-63.
    • (1994) J Autoimmun , vol.7 , pp. 655-663
    • Bergerot, I.1    Fabien, N.2    Maguer, V.3    Thivolet, C.4
  • 85
    • 79952193175 scopus 로고    scopus 로고
    • Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit
    • Odumosu O, Payne K, Baez I, Jutzy J, Wall N, Langridge W. Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit. Immunobiology. 2011;216: 447-56.
    • (2011) Immunobiology , vol.216 , pp. 447-456
    • Odumosu, O.1    Payne, K.2    Baez, I.3    Jutzy, J.4    Wall, N.5    Langridge, W.6
  • 86
    • 0031831753 scopus 로고    scopus 로고
    • Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice
    • Tisch R, Liblau RS, Yang XD, Liblau P, McDevitt HO. Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. Diabetes. 1998;47:894-9.
    • (1998) Diabetes , vol.47 , pp. 894-899
    • Tisch, R.1    Liblau, R.S.2    Yang, X.D.3    Liblau, P.4    McDevitt, H.O.5
  • 88
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von Herrath M. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest. 2006;116:1371-81.
    • (2006) J Clin Invest , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3    Chen, Y.4    Bluestone, J.A.5    Herold, K.C.6    von Herrath, M.7
  • 91
    • 0027958044 scopus 로고
    • Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
    • Chatenoud L, Thervet E, Primo J, Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci U S A. 1994;91:123-7.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 123-127
    • Chatenoud, L.1    Thervet, E.2    Primo, J.3    Bach, J.F.4
  • 92
    • 0031569177 scopus 로고    scopus 로고
    • CD3 antibodyinduced dominant self tolerance in overtly diabetic NOD mice
    • Chatenoud L, Primo J, Bach JF. CD3 antibodyinduced dominant self tolerance in overtly diabetic NOD mice. J Immunol. 1997;158:2947-54.
    • (1997) J Immunol , vol.158 , pp. 2947-2954
    • Chatenoud, L.1    Primo, J.2    Bach, J.F.3
  • 93
    • 0141796312 scopus 로고    scopus 로고
    • TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med. 2003;9:1202-8.
    • (2003) Nat Med , vol.9 , pp. 1202-1208
    • Belghith, M.1    Bluestone, J.A.2    Barriot, S.3    Megret, J.4    Bach, J.F.5    Chatenoud, L.6
  • 97
    • 84868019779 scopus 로고    scopus 로고
    • Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies
    • Yi Z, Diz R, Martin AJ, Morillon YM, Kline DE, Li L, Wang B, Tisch R. Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes. 2012;61:2871-80.
    • (2012) Diabetes , vol.61 , pp. 2871-2880
    • Yi, Z.1    Diz, R.2    Martin, A.J.3    Morillon, Y.M.4    Kline, D.E.5    Li, L.6    Wang, B.7    Tisch, R.8
  • 98
    • 0029841157 scopus 로고    scopus 로고
    • The role of CD8+ T cells in the initiation of insulindependent diabetes mellitus
    • Wang B, Gonzalez A, Benoist C, Mathis D. The role of CD8+ T cells in the initiation of insulindependent diabetes mellitus. Eur J Immunol. 1996;26:1762-9.
    • (1996) Eur J Immunol , vol.26 , pp. 1762-1769
    • Wang, B.1    Gonzalez, A.2    Benoist, C.3    Mathis, D.4
  • 99
    • 0023903295 scopus 로고
    • Immunotherapy of the nonobese diabetic mouse: Treatment with an antibody to T-helper lymphocytes
    • Shizuru JA, Taylor-Edwards C, Banks BA, Gregory AK, Fathman CG. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science. 1988;240:659-62.
    • (1988) Science , vol.240 , pp. 659-662
    • Shizuru, J.A.1    Taylor-Edwards, C.2    Banks, B.A.3    Gregory, A.K.4    Fathman, C.G.5
  • 100
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways:Application to autoimmune disease therapy
    • Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways:application to autoimmune disease therapy. Cell. 1995;80:707-18.
    • (1995) Cell , vol.80 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3    Ranger, A.M.4    Zamvil, S.S.5    Sobel, R.A.6    Weiner, H.L.7    Nabavi, N.8    Glimcher, L.H.9
  • 101
    • 0028900297 scopus 로고
    • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
    • Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med. 1995;181:1145-55.
    • (1995) J Exp Med , vol.181 , pp. 1145-1155
    • Lenschow, D.J.1    Ho, S.C.2    Sattar, H.3    Rhee, L.4    Gray, G.5    Nabavi, N.6    Herold, K.C.7    Bluestone, J.A.8
  • 102
    • 0031279105 scopus 로고    scopus 로고
    • CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice
    • Balasa B, Krahl T, Patstone G, Lee J, Tisch R, McDevitt HO, Sarvetnick N. CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J Immunol. 1997;159:4620-7.
    • (1997) J Immunol , vol.159 , pp. 4620-4627
    • Balasa, B.1    Krahl, T.2    Patstone, G.3    Lee, J.4    Tisch, R.5    McDevitt, H.O.6    Sarvetnick, N.7
  • 103
    • 49149112185 scopus 로고    scopus 로고
    • ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice
    • Hawiger D, Tran E, Du W, Booth CJ, Wen L, Dong C, Flavell RA. ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice. J Immunol. 2008;180:3140-7.
    • (2008) J Immunol , vol.180 , pp. 3140-3147
    • Hawiger, D.1    Tran, E.2    Du, W.3    Booth, C.J.4    Wen, L.5    Dong, C.6    Flavell, R.A.7
  • 104
    • 33644666732 scopus 로고    scopus 로고
    • Antigen processing by autoreactive B cells promotes determinant spreading
    • Dai YD, Carayanniotis G, Sercarz E. Antigen processing by autoreactive B cells promotes determinant spreading. Cell Moll Immunol. 2005;2:169-75.
    • (2005) Cell Moll Immunol , vol.2 , pp. 169-175
    • Dai, Y.D.1    Carayanniotis, G.2    Sercarz, E.3
  • 105
    • 84861133472 scopus 로고    scopus 로고
    • The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice
    • Xiang Y, Peng J, Tai N, Hu C, Zhou Z, Wong FS, Wen L. The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice. J Immunol. 2012;188:4747-58.
    • (2012) J Immunol , vol.188 , pp. 4747-4758
    • Xiang, Y.1    Peng, J.2    Tai, N.3    Hu, C.4    Zhou, Z.5    Wong, F.S.6    Wen, L.7
  • 107
    • 82955247641 scopus 로고    scopus 로고
    • Antigen-specific prevention of type 1 diabetes of NOD mice is ameliorated by OX40 agonist treatment
    • Bresson D, Fousteri G, Manenkova Y, Croft M, von Herrath M. Antigen-specific prevention of type 1 diabetes of NOD mice is ameliorated by OX40 agonist treatment. J Autoimmunity. 2011;37:342-51.
    • (2011) J Autoimmunity , vol.37 , pp. 342-351
    • Bresson, D.1    Fousteri, G.2    Manenkova, Y.3    Croft, M.4    von Herrath, M.5
  • 108
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12:431-40.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6    Bluestone, J.A.7
  • 109
    • 33749259809 scopus 로고    scopus 로고
    • A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells
    • Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N. A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol. 2006;17:2844-53.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2844-2853
    • Lopez, M.1    Clarkson, M.R.2    Albin, M.3    Sayegh, M.H.4    Najafian, N.5
  • 114
    • 26444535295 scopus 로고    scopus 로고
    • The kinase inhibitor imatinib mesylate inhibits TNF-a production in vitro and prevents TNF-dependent acute hepatic inflammation
    • Wolf AM, Wolf D, Rumpold H, Ludwiczek S, Enrich B, Gastl G, Weiss G, Tilg H. The kinase inhibitor imatinib mesylate inhibits TNF-a production in vitro and prevents TNF-dependent acute hepatic inflammation. Proc Natl Acad Sci USA. 2005;102:13622-7.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13622-13627
    • Wolf, A.M.1    Wolf, D.2    Rumpold, H.3    Ludwiczek, S.4    Enrich, B.5    Gastl, G.6    Weiss, G.7    Tilg, H.8
  • 117
    • 18644366150 scopus 로고    scopus 로고
    • Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720
    • Maki T, Gottschalk R, Ogawa N, Monaco AP. Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720. Transplantation. 2005;79: 1051-5.
    • (2005) Transplantation , vol.79 , pp. 1051-1055
    • Maki, T.1    Gottschalk, R.2    Ogawa, N.3    Monaco, A.P.4
  • 118
    • 79958205590 scopus 로고    scopus 로고
    • Fingolimod: An oral disease-modifying therapy for relapsing multiple sclerosis
    • Ann Yeh E, Weinstock-Guttman B. Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis. AdvTherapeut. 2011;28:270-8.
    • (2011) AdvTherapeut , vol.28 , pp. 270-278
    • Ann, Y.E.1    Weinstock-Guttman, B.2
  • 120
    • 1642483061 scopus 로고    scopus 로고
    • A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice
    • Davoodi-Semiromi A, Laloraya, M., Kumar GP, Purohit S, Jha RK, She JX. A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice. J Biol Chem. 2004;279:11553-61.
    • (2004) J Biol Chem , vol.279 , pp. 11553-11561
    • Davoodi-Semiromi, A.1    Laloraya, M.2    Kumar, G.P.3    Purohit, S.4    Jha, R.K.5    She, J.X.6
  • 122
    • 84866730597 scopus 로고    scopus 로고
    • Tyrphostin AG-490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor
    • Davoodi-Semiromi A, Hassanzadeh A, Wasserfall CH, Droney A, Atkinson M. Tyrphostin AG-490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor. J Clin Immunol. 2012;32:1038-47.
    • (2012) J Clin Immunol , vol.32 , pp. 1038-1047
    • Davoodi-Semiromi, A.1    Hassanzadeh, A.2    Wasserfall, C.H.3    Droney, A.4    Atkinson, M.5
  • 125
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130:1071-82.
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 127
    • 84868214942 scopus 로고    scopus 로고
    • Treatment of autoimmune diabetes by toll-like receptor 2 tolerance in conjunction with dipeptidyl peptidase 4 inhibition
    • Kim DH, Lee J-C, Lee M-K., Kim K-W, Lee M-S. Treatment of autoimmune diabetes by toll-like receptor 2 tolerance in conjunction with dipeptidyl peptidase 4 inhibition. Diabetologia. 2012;55:3308-17.
    • (2012) Diabetologia , vol.55 , pp. 3308-3317
    • Kim, D.H.1    Lee, J.-C.2    Lee, M.-K.3    Kim, K.-W.4    Lee, M.-S.5
  • 129
    • 57749177662 scopus 로고    scopus 로고
    • The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice
    • Wong FS, Hu C, Zhang L, Du W, Alexopoulou L, Flavell RA, Wen L. The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice. Ann N Y Acad Sci. 2008;1150:146-8.
    • (2008) Ann N Y Acad Sci , vol.1150 , pp. 146-148
    • Wong, F.S.1    Hu, C.2    Zhang, L.3    Du, W.4    Alexopoulou, L.5    Flavell, R.A.6    Wen, L.7
  • 130
    • 0024795364 scopus 로고
    • Immunostimulation circumvents diabetes in NOD/Lt mice
    • Serreze DV, Hamaguchi K, Leiter EH. Immunostimulation circumvents diabetes in NOD/Lt mice. J Autoimmunity. 1989;2:759-76.
    • (1989) J Autoimmunity , vol.2 , pp. 759-776
    • Serreze, D.V.1    Hamaguchi, K.2    Leiter, E.H.3
  • 131
    • 0034548005 scopus 로고    scopus 로고
    • Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity
    • Quintana FJ, Rotem A, Carmi P, Cohen IR. Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity. J Immunol. 2000;165:6148-55.
    • (2000) J Immunol , vol.165 , pp. 6148-6155
    • Quintana, F.J.1    Rotem, A.2    Carmi, P.3    Cohen, I.R.4
  • 134
    • 0038558249 scopus 로고    scopus 로고
    • Collaborative induction of inflammatory responses by dectin-1 and Toll-like Receptor 2
    • Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like Receptor 2. J Exp Med. 2003;197:1107-17.
    • (2003) J Exp Med , vol.197 , pp. 1107-1117
    • Gantner, B.N.1    Simmons, R.M.2    Canavera, S.J.3    Akira, S.4    Underhill, D.M.5
  • 135
    • 58849145188 scopus 로고    scopus 로고
    • Induction of innate immune response through TLR2 and dectin-1 prevents type 1 diabetes
    • Karumuthil-Melethil S, Perez N, Li R, Vasu C. Induction of innate immune response through TLR2 and dectin-1 prevents type 1 diabetes. J Immunol. 2008;181:8323-34.
    • (2008) J Immunol , vol.181 , pp. 8323-8334
    • Karumuthil-Melethil, S.1    Perez, N.2    Li, R.3    Vasu, C.4
  • 136
    • 78049369030 scopus 로고    scopus 로고
    • Roles for TGF-b and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice
    • Burton OT, Zaccone P, Phillips JM, De La Peña H, Fehérvári Z, Azuma M, Gibbs S, Stockinger B, Cooke A. Roles for TGF-b and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice. J Immunol. 2010;185:2754-62.
    • (2010) J Immunol , vol.185 , pp. 2754-2762
    • Burton, O.T.1    Zaccone, P.2    Phillips, J.M.3    de la Peña, H.4    Fehérvári, Z.5    Azuma, M.6    Gibbs, S.7    Stockinger, B.8    Cooke, A.9
  • 137
    • 68949092245 scopus 로고    scopus 로고
    • Fungal zymosan and mannan activate the cryopyrin inflammasome
    • Lamkanfi M, Malireddi RK, Kanneganti TD. Fungal zymosan and mannan activate the cryopyrin inflammasome. J Biol Chem. 2009;284:20574-81.
    • (2009) J Biol Chem , vol.284 , pp. 20574-20581
    • Lamkanfi, M.1    Malireddi, R.K.2    Kanneganti, T.D.3
  • 138
    • 70249096015 scopus 로고    scopus 로고
    • Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model
    • Mizuno M, Ito Y, Hepburn N, Mizuno T, Noda Y, Yuzawa Y, Harris CL, Morgan BP, Matsuo S. Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model. J Immunol. 2009;183:1403-12.
    • (2009) J Immunol , vol.183 , pp. 1403-1412
    • Mizuno, M.1    Ito, Y.2    Hepburn, N.3    Mizuno, T.4    Noda, Y.5    Yuzawa, Y.6    Harris, C.L.7    Morgan, B.P.8    Matsuo, S.9
  • 140
    • 0027314785 scopus 로고
    • Complete Freund's adjuvant-induced T cells prevents the development and adoptive transfer of diabetes in nonobese diabetic mice
    • Qin H-Y, Sadelain WJ, Hitchon C, Lauzon J, Singh B. Complete Freund's adjuvant-induced T cells prevents the development and adoptive transfer of diabetes in nonobese diabetic mice. J Immunol. 1993;150:2072-80.
    • (1993) J Immunol , vol.150 , pp. 2072-2080
    • Qin, H.-Y.1    Sadelain, W.J.2    Hitchon, C.3    Lauzon, J.4    Singh, B.5
  • 141
    • 80053076885 scopus 로고    scopus 로고
    • NKT cells are required for complete Freund's adjuvantmediated protection from autoimmune diabetes
    • Lee I, van den Elzen P, Tan R, Priatel JJ. NKT cells are required for complete Freund's adjuvantmediated protection from autoimmune diabetes. J Immunol. 2011;187:2898-904.
    • (2011) J Immunol , vol.187 , pp. 2898-2904
    • Lee, I.1    van den Elzen, P.2    Tan, R.3    Priatel, J.J.4
  • 142
    • 1642454721 scopus 로고    scopus 로고
    • Regulation of autoimmune diabetes by complete Freund's adjuvant is mediated by NK cells
    • Lee IF, Qin H, Trudeau J, Dutz J R. T. Regulation of autoimmune diabetes by complete Freund's adjuvant is mediated by NK cells. J Immunol. 2004;272:937-42.
    • (2004) J Immunol , vol.272 , pp. 937-942
    • Lee, I.F.1    Qin, H.2    Trudeau, J.3    Dutz, J.R.T.4
  • 143
    • 77954518232 scopus 로고    scopus 로고
    • Th17 polarized cells from nonobese diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes
    • Nikoopour E, Schwartz JA, Huszarik K, Sandrock C, Krougly O, Lee-Chan E, Singh B. Th17 polarized cells from nonobese diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes. J Immunol. 2010;184:4779-88.
    • (2010) J Immunol , vol.184 , pp. 4779-4788
    • Nikoopour, E.1    Schwartz, J.A.2    Huszarik, K.3    Sandrock, C.4    Krougly, O.5    Lee-Chan, E.6    Singh, B.7
  • 144
  • 145
    • 33645221626 scopus 로고    scopus 로고
    • Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution
    • Nishio J, Gaglia JL., Turvey SE, Campbell C, Benoist C, Mathis D. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science. 2006;311: 1775-8.
    • (2006) Science , vol.311 , pp. 1775-1778
    • Nishio, J.1    Gaglia, J.L.2    Turvey, S.E.3    Campbell, C.4    Benoist, C.5    Mathis, D.6
  • 146
    • 33645223082 scopus 로고    scopus 로고
    • Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells
    • Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, Unanue ER. Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science. 2006;311: 1778-80.
    • (2006) Science , vol.311 , pp. 1778-1780
    • Suri, A.1    Calderon, B.2    Esparza, T.J.3    Frederick, K.4    Bittner, P.5    Unanue, E.R.6
  • 149
    • 0023855229 scopus 로고
    • Casein, a prohormone with an immunomodulating role for the newborn?
    • Migliore-Samour D, Jolles P. Casein, a prohormone with an immunomodulating role for the newborn? Experientia. 1988;44:188-93.
    • (1988) Experientia , vol.44 , pp. 188-193
    • Migliore-Samour, D.1    Jolles, P.2
  • 150
    • 0030999981 scopus 로고    scopus 로고
    • Immunological aspects of nutritional diabetes prevention in NOD mice: A pilot study for the cow's milk-based IDDM prevention trial
    • Karges W, Hammond-McKibben D, Cheung RK, Visconti M, Shibuya N, Kemp D, Dosch HM. Immunological aspects of nutritional diabetes prevention in NOD mice: a pilot study for the cow's milk-based IDDM prevention trial. Diabetes. 1997;46:557-64.
    • (1997) Diabetes , vol.46 , pp. 557-564
    • Karges, W.1    Hammond-McKibben, D.2    Cheung, R.K.3    Visconti, M.4    Shibuya, N.5    Kemp, D.6    Dosch, H.M.7
  • 151
    • 0036381993 scopus 로고    scopus 로고
    • A multi-centre, blinded international trial of the effect of A(1) and A(2) beta-casein variants on diabetes incidence in two rodent models of spontaneous Type I diabetes
    • Beales PE, Elliott RB, Flohe S, Hill JP, Kolb H, Pozzilli P, Wang GS, Wasmuth H, Scott FW. A multi-centre, blinded international trial of the effect of A(1) and A(2) beta-casein variants on diabetes incidence in two rodent models of spontaneous Type I diabetes. Diabetologia. 2002;45:1240-6.
    • (2002) Diabetologia , vol.45 , pp. 1240-1246
    • Beales, P.E.1    Elliott, R.B.2    Flohe, S.3    Hill, J.P.4    Kolb, H.5    Pozzilli, P.6    Wang, G.S.7    Wasmuth, H.8    Scott, F.W.9
  • 152
    • 58149348476 scopus 로고    scopus 로고
    • Beta-cell mass and type 1 diabetes: Going, going, gone?
    • Akirav E, Kushner JA, Herold KC. Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes. 2008;57:2883-8.
    • (2008) Diabetes , vol.57 , pp. 2883-2888
    • Akirav, E.1    Kushner, J.A.2    Herold, K.C.3
  • 156
    • 33744498935 scopus 로고    scopus 로고
    • Diabetes preventive gluten-free diet decreases the number of caecal bacteria in non-obese diabetic mice
    • Hansen AK, Ling F, Kaas A, Funda DP, Farlov H, Buschard K. Diabetes preventive gluten-free diet decreases the number of caecal bacteria in non-obese diabetic mice. Diabetes Metab Res Rev. 2006;22:220-5.
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 220-225
    • Hansen, A.K.1    Ling, F.2    Kaas, A.3    Funda, D.P.4    Farlov, H.5    Buschard, K.6
  • 159
    • 0028215907 scopus 로고
    • Peptide therapy for diabetes in NOD mice
    • Elias D, Cohen IR. Peptide therapy for diabetes in NOD mice. Lancet. 1994;343:704-6.
    • (1994) Lancet , vol.343 , pp. 704-706
    • Elias, D.1    Cohen, I.R.2
  • 160
    • 1842854683 scopus 로고    scopus 로고
    • Immune modulation with highdose heat-shock protein gp96: Therapy of murine autoimmune diabetes and encephalomyelitis
    • Chandawarkar RY, Wagh MS, Kovalchin JT, Srivastava P. Immune modulation with highdose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitis. Int Immunol. 2004;16:615-24.
    • (2004) Int Immunol , vol.16 , pp. 615-624
    • Chandawarkar, R.Y.1    Wagh, M.S.2    Kovalchin, J.T.3    Srivastava, P.4
  • 162
    • 0027990811 scopus 로고
    • Effect of tumor necrosis factor a on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
    • Yang X-D, Tisch R, Singer SM, Cao ZA., Effect of tumor necrosis factor a on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med. 1994;180:995-1004.
    • (1994) J Exp Med , vol.180 , pp. 995-1004
    • Yang, X.-D.1    Tisch, R.2    Singer, S.M.3    Cao, Z.A.4
  • 163
    • 0035877181 scopus 로고    scopus 로고
    • A dual role for TNF-alpha in type 1 diabetes: Islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis
    • Christen U, Wolfe T, Möhrle U, Hughes AC, Rodrigo E, Green EA, Flavell RA, von Herrath MG. A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis. J Immunol. 2001;166:7023-32.
    • (2001) J Immunol , vol.166 , pp. 7023-7032
    • Christen, U.1    Wolfe, T.2    Möhrle, U.3    Hughes, A.C.4    Rodrigo, E.5    Green, E.A.6    Flavell, R.A.7    von Herrath, M.G.8
  • 164
    • 0038407295 scopus 로고    scopus 로고
    • Cellular and molecular changes accompanying the progression from insulitis to diabetes
    • Andre-Schmutz I, Hindelang C, Benoist C, Mathis D. Cellular and molecular changes accompanying the progression from insulitis to diabetes. Eur J Immunol. 1999;29:245-55.
    • (1999) Eur J Immunol , vol.29 , pp. 245-255
    • Andre-Schmutz, I.1    Hindelang, C.2    Benoist, C.3    Mathis, D.4
  • 165
    • 0031593867 scopus 로고    scopus 로고
    • Lymphoid hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD-->NOD-scid adoptive T cell transfer
    • Brown GR, Silva MD, Thompson PA, Beutler B. Lymphoid hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD-->NOD-scid adoptive T cell transfer. Diabetologia. 1998;41:1502-10.
    • (1998) Diabetologia , vol.41 , pp. 1502-1510
    • Brown, G.R.1    Silva, M.D.2    Thompson, P.A.3    Beutler, B.4
  • 167
    • 0035806277 scopus 로고    scopus 로고
    • Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor
    • Wu Q, Salomon B, Chen M, Wang Y, Hoffman LM, Bluestone JA, Fu Y-X. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor. J Exp Med. 2001;193:1327-32.
    • (2001) J Exp Med , vol.193 , pp. 1327-1332
    • Wu, Q.1    Salomon, B.2    Chen, M.3    Wang, Y.4    Hoffman, L.M.5    Bluestone, J.A.6    Fu, Y.-X.7
  • 168
    • 0028501432 scopus 로고
    • Islet expression of interferon-a precedes diabetes in both the BB rats and streptozotocin-treated mice
    • Huang X, Hultgren B, Dybdal N, Stewart TA. Islet expression of interferon-a precedes diabetes in both the BB rats and streptozotocin-treated mice. Immunity. 1994;1:469-78.
    • (1994) Immunity , vol.1 , pp. 469-478
    • Huang, X.1    Hultgren, B.2    Dybdal, N.3    Stewart, T.A.4
  • 169
    • 79958769172 scopus 로고    scopus 로고
    • The role of interferon alpha in initiation of type I diabetes in the NOD mouse
    • Li Q, McDevitt HO. The role of interferon alpha in initiation of type I diabetes in the NOD mouse. Clin Immunol. 2011;140:3-7.
    • (2011) Clin Immunol , vol.140 , pp. 3-7
    • Li, Q.1    McDevitt, H.O.2
  • 172
    • 0025020303 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNF-a and interleukin 1
    • Jacob CO, Aiso S, Michie SA, McDevitt HO, Acha-Orbea H. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNF-a and interleukin 1. Proc Natl Acad Sci USA. 1990;87:968-72.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 968-972
    • Jacob, C.O.1    Aiso, S.2    Michie, S.A.3    McDevitt, H.O.4    Acha-Orbea, H.5
  • 174
    • 22544482621 scopus 로고    scopus 로고
    • Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen activated protein kinase/STAT1/reactive oxygen species pathway
    • Kim HS, Lee M-S. Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen activated protein kinase/STAT1/reactive oxygen species pathway. Mol Cell Biol. 2005;25:6821-33.
    • (2005) Mol Cell Biol , vol.25 , pp. 6821-6833
    • Kim, H.S.1    Lee, M.-S.2
  • 175
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia. 1996;39:1005-29.
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 178
    • 0029896602 scopus 로고    scopus 로고
    • IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity
    • Lee M-S, Mueller R, Wicker LS, Peterson LB, Sarvetnick N. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med. 1996;183:2663-8.
    • (1996) J Exp Med , vol.183 , pp. 2663-2668
    • Lee, M.-S.1    Mueller, R.2    Wicker, L.S.3    Peterson, L.B.4    Sarvetnick, N.5
  • 179
    • 0028346888 scopus 로고
    • Production of interleukin 10 by islet cells accelerates immunemediated destruction of b cells in nonobese diabetic mice
    • Wogensen L, Lee M-S, Sarvetnick N. Production of interleukin 10 by islet cells accelerates immunemediated destruction of b cells in nonobese diabetic mice. J Exp Med. 1994;179:1379-84.
    • (1994) J Exp Med , vol.179 , pp. 1379-1384
    • Wogensen, L.1    Lee, M.-S.2    Sarvetnick, N.3
  • 182
    • 84856669229 scopus 로고    scopus 로고
    • IFN-γ induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice
    • Zhang J, Huang Z, Sun R, Tian Z, Wei H. IFN-γ induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice. J Autoimmunity. 2011;38:20-8.
    • (2011) J Autoimmunity , vol.38 , pp. 20-28
    • Zhang, J.1    Huang, Z.2    Sun, R.3    Tian, Z.4    Wei, H.5
  • 183
    • 0027948090 scopus 로고
    • Resistance alleles at two non-major histocompability complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes
    • Wicker LS, Todd JA, Prins J-B, Podolin PL, Renjilian RJ, Peterson LB. Resistance alleles at two non-major histocompability complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J Exp Med. 1994;180:1705-13.
    • (1994) J Exp Med , vol.180 , pp. 1705-1713
    • Wicker, L.S.1    Todd, J.A.2    Prins, J.-B.3    Podolin, P.L.4    Renjilian, R.J.5    Peterson, L.B.6
  • 186
    • 0033178614 scopus 로고    scopus 로고
    • IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis
    • Rothe H, Hausmann A, Casteels K, Okamura H, Kurimoto M, Burkart V, Mathieu C, Kolb H. IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis. J Immunol. 1999;163:1230-6.
    • (1999) J Immunol , vol.163 , pp. 1230-1236
    • Rothe, H.1    Hausmann, A.2    Casteels, K.3    Okamura, H.4    Kurimoto, M.5    Burkart, V.6    Mathieu, C.7    Kolb, H.8
  • 188
    • 12144270876 scopus 로고    scopus 로고
    • Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cells
    • Kared H, Masson A, Adle-Biassette H, Bach JF, Chatenoud L, Zavala F. Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cells. Diabetes. 2005;54:78-84.
    • (2005) Diabetes , vol.54 , pp. 78-84
    • Kared, H.1    Masson, A.2    Adle-Biassette, H.3    Bach, J.F.4    Chatenoud, L.5    Zavala, F.6
  • 191
    • 0029742924 scopus 로고    scopus 로고
    • Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic GotoKakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis
    • Avignon A, Yamada K, Zhou X, Spencer B, Cardona O, Saba-Siddique S, Galloway L, Standaert ML, Farese RV. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic GotoKakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Diabetes. 1996;45:1396-404.
    • (1996) Diabetes , vol.45 , pp. 1396-1404
    • Avignon, A.1    Yamada, K.2    Zhou, X.3    Spencer, B.4    Cardona, O.5    Saba-Siddique, S.6    Galloway, L.7    Standaert, M.L.8    Farese, R.V.9
  • 193
    • 77954611378 scopus 로고    scopus 로고
    • Reversal of newonset diabetes through modulating inflammation and stimulating β-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor
    • Tian L, Gao J, Hao J, Zhang Y, Yi H, O'Brien TD, Sorenson R, Luo J, Guo Z. Reversal of newonset diabetes through modulating inflammation and stimulating β-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor. Endocrinology. 2010;151:3049-60.
    • (2010) Endocrinology , vol.151 , pp. 3049-3060
    • Tian, L.1    Gao, J.2    Hao, J.3    Zhang, Y.4    Yi, H.5    O'Brien, T.D.6    Sorenson, R.7    Luo, J.8    Guo, Z.9
  • 194
    • 62749133510 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation
    • Kim S-J, Nian C, Doudet DJ, McIntosh CH. Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes. 2009;58:641-51.
    • (2009) Diabetes , vol.58 , pp. 641-651
    • Kim, S.-J.1    Nian, C.2    Doudet, D.J.3    McIntosh, C.H.4
  • 196
    • 65149091474 scopus 로고    scopus 로고
    • Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses
    • Vora KA, Porter G, Peng R, Cui Y, Pryor K, Eiermann G, Zaller DM. Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses. BMC Immunol. 2009;10:1-11.
    • (2009) BMC Immunol , vol.10 , pp. 1-11
    • Vora, K.A.1    Porter, G.2    Peng, R.3    Cui, Y.4    Pryor, K.5    Eiermann, G.6    Zaller, D.M.7
  • 197
  • 198
    • 58149357117 scopus 로고    scopus 로고
    • Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice
    • Suarez-Pinzon WL, Power RF, Yan Y, Wasserfall C, Atkinson M, Rabinovitch A. Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice. Diabetes. 2008;57:3281-8.
    • (2008) Diabetes , vol.57 , pp. 3281-3288
    • Suarez-Pinzon, W.L.1    Power, R.F.2    Yan, Y.3    Wasserfall, C.4    Atkinson, M.5    Rabinovitch, A.6
  • 199
    • 14944346879 scopus 로고    scopus 로고
    • Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development
    • O'Keeffe M, C. BT, Fancke B, Vremec D, Morahan G, Maraskovsky E, Steptoe R, Harrison LC, Shortman K. Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development. Int Immunol. 2005;17:307-14.
    • (2005) Int Immunol , vol.17 , pp. 307-314
    • O'Keeffe, M.1    Bt, C.2    Fancke, B.3    Vremec, D.4    Morahan, G.5    Maraskovsky, E.6    Steptoe, R.7    Harrison, L.C.8    Shortman, K.9
  • 202
    • 78650912749 scopus 로고    scopus 로고
    • A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice
    • Creusot RJ, Chang P, Healey DG, Tcherepanova IY, Nicolette CA, Fathman CG. A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice. Mol Ther. 2010;18:2112-20.
    • (2010) Mol Ther , vol.18 , pp. 2112-2120
    • Creusot, R.J.1    Chang, P.2    Healey, D.G.3    Tcherepanova, I.Y.4    Nicolette, C.A.5    Fathman, C.G.6
  • 203
    • 77952242738 scopus 로고    scopus 로고
    • Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment
    • Van Belle TL, Juntti T, Liao J, von Herrath MG. Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment. J Autoimmunity. 2010;34:445-52.
    • (2010) J Autoimmunity , vol.34 , pp. 445-452
    • van Belle, T.L.1    Juntti, T.2    Liao, J.3    von Herrath, M.G.4
  • 207
    • 2942692039 scopus 로고    scopus 로고
    • CD25+CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM. CD25+CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004;199:1467-77.
    • (2004) J Exp Med , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 209
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    • Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science. 2006;311:1924-7.
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3    Surh, C.D.4    Sprent, J.5
  • 211
    • 49649095420 scopus 로고    scopus 로고
    • Polyclonal adaptive regulatory CD4 cells that can reverse type 1 diabetes become oligoclonal long-term protective memory cells
    • Godebu E, Summers-Torres D, Lin MM, Baaten BJG, Bradley L. Polyclonal adaptive regulatory CD4 cells that can reverse type 1 diabetes become oligoclonal long-term protective memory cells. J Immunol. 2008;181:1798-805.
    • (2008) J Immunol , vol.181 , pp. 1798-1805
    • Godebu, E.1    Summers-Torres, D.2    Lin, M.M.3    Baaten, B.J.G.4    Bradley, L.5
  • 212
    • 79958022977 scopus 로고    scopus 로고
    • Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice
    • Kaminitz A, Yolcu ES, Stein J, Yaniv I, Shirwin H, Askenasy N. Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice. J Autoimmunity. 2011;37:39-47.
    • (2011) J Autoimmunity , vol.37 , pp. 39-47
    • Kaminitz, A.1    Yolcu, E.S.2    Stein, J.3    Yaniv, I.4    Shirwin, H.5    Askenasy, N.6
  • 217
    • 2542513931 scopus 로고    scopus 로고
    • Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity
    • Poirot L, Benoist C, Mathis D. Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity. Proc Natl Acad Sci USA. 2004;101:8102-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8102-8107
    • Poirot, L.1    Benoist, C.2    Mathis, D.3
  • 220
    • 38349022508 scopus 로고    scopus 로고
    • Critical role for IFN-gamma in natural killer cell-mediated protection from diabetes
    • Lee IF, Qin H, Priatel JJ, Tan R. Critical role for IFN-gamma in natural killer cell-mediated protection from diabetes. Eur J Immunol. 2008;38:82-9.
    • (2008) Eur J Immunol , vol.38 , pp. 82-89
    • Lee, I.F.1    Qin, H.2    Priatel, J.J.3    Tan, R.4
  • 221
    • 33846934465 scopus 로고    scopus 로고
    • NK3-like NK cells are involved in protective effect of polyinosinicpolycytidylic acid on type 1 diabetes in nonobese diabetic mice
    • Zhou R, Wei H, Tian Z. NK3-like NK cells are involved in protective effect of polyinosinicpolycytidylic acid on type 1 diabetes in nonobese diabetic mice. J Immunol. 2007;178:2141-7.
    • (2007) J Immunol , vol.178 , pp. 2141-2147
    • Zhou, R.1    Wei, H.2    Tian, Z.3
  • 222
    • 0032538904 scopus 로고    scopus 로고
    • Overexpression of natural killer T cells protects Valpha14-Jalpha281 transgenic nonobese diabetic mice against diabetes
    • Lehuen A, Lantz O, Beaudoin L, Laloux V, Carnaud C, Bendelac A, Bach JF, Monteiro RC. Overexpression of natural killer T cells protects Valpha14-Jalpha281 transgenic nonobese diabetic mice against diabetes. J Exp Med. 1998;188:1831-9.
    • (1998) J Exp Med , vol.188 , pp. 1831-1839
    • Lehuen, A.1    Lantz, O.2    Beaudoin, L.3    Laloux, V.4    Carnaud, C.5    Bendelac, A.6    Bach, J.F.7    Monteiro, R.C.8
  • 223
    • 0035817251 scopus 로고    scopus 로고
    • Cd1-Restricted NKT cells protect nonobese diabetic mice from developing diabetes
    • Wang B, Geng YB, Wang CR. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J Exp Med. 2001;194:313-20.
    • (2001) J Exp Med , vol.194 , pp. 313-320
    • Wang, B.1    Geng, Y.B.2    Wang, C.R.3
  • 230
    • 0030801225 scopus 로고    scopus 로고
    • Prevention of onset in an insulin-dependent diabetes mellitus model, NOD mice, by oral feeding of Lactobacillus casei
    • Matsuzaki T, Nagata Y, Kado S, Uchida K, Kato I, Hashimoto S, Yokokura T. Prevention of onset in an insulin-dependent diabetes mellitus model, NOD mice, by oral feeding of Lactobacillus casei. APMIS. 1997;105:643-9.
    • (1997) APMIS , vol.105 , pp. 643-649
    • Matsuzaki, T.1    Nagata, Y.2    Kado, S.3    Uchida, K.4    Kato, I.5    Hashimoto, S.6    Yokokura, T.7
  • 231
    • 84861712541 scopus 로고    scopus 로고
    • Making b cells from adult tissues
    • Efrat S, Russ HA. Making b cells from adult tissues. Trends Endocrinol Metab. 2012;23:278-285.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 278-285
    • Efrat, S.1    Russ, H.A.2
  • 233
    • 47949111842 scopus 로고    scopus 로고
    • A comparison of protocols used to generate insulinproducing cell clusters from mouse embryonic stem cells
    • Boyld AS, Wu DC, Higashi Y, Wood KJ. A comparison of protocols used to generate insulinproducing cell clusters from mouse embryonic stem cells. Stem Cells. 2008;26:1128-37.
    • (2008) Stem Cells , vol.26 , pp. 1128-1137
    • Boyld, A.S.1    Wu, D.C.2    Higashi, Y.3    Wood, K.J.4
  • 235
    • 34247898958 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
    • Shim JH, Kim SE, Woo DH, Kim SK, Oh CH, McKay R, Kim JH. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia. 2007;50:1228-38.
    • (2007) Diabetologia , vol.50 , pp. 1228-1238
    • Shim, J.H.1    Kim, S.E.2    Woo, D.H.3    Kim, S.K.4    Oh, C.H.5    McKay, R.6    Kim, J.H.7
  • 236
    • 77955814966 scopus 로고    scopus 로고
    • Reversal of hyperglycemia in diabetic mouse models using induced-pleuripotent stem (iPS)-derived pancreatic b-like cells
    • Alipio Z, Liao W, Roemer EJ, Waner M, Fink LM, Ward DC, Ma Y. Reversal of hyperglycemia in diabetic mouse models using induced-pleuripotent stem (iPS)-derived pancreatic b-like cells. Proc Natl Acad Sci USA. 2010;107:13426-31.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13426-13431
    • Alipio, Z.1    Liao, W.2    Roemer, E.J.3    Waner, M.4    Fink, L.M.5    Ward, D.C.6    Ma, Y.7
  • 239
  • 240
    • 84866239774 scopus 로고    scopus 로고
    • Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model
    • Jeon K, Lim H, Kim JH, Thuan NV, Park SH, Lim YM, Choi HY, Lee ER, Kim JH, Lee MS, Cho SG. Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model. Stem Cells Dev. 2012;21:2642-2655.
    • (2012) Stem Cells Dev , vol.21 , pp. 2642-2655
    • Jeon, K.1    Lim, H.2    Kim, J.H.3    Thuan, N.V.4    Park, S.H.5    Lim, Y.M.6    Choi, H.Y.7    Lee, E.R.8    Kim, J.H.9    Lee, M.S.10    Cho, S.G.11
  • 241
    • 0032964810 scopus 로고    scopus 로고
    • Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis
    • Hoorens A, Pipeleers D. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis. Diabetologia. 1999;42:55-9.
    • (1999) Diabetologia , vol.42 , pp. 55-59
    • Hoorens, A.1    Pipeleers, D.2
  • 242
    • 0038015663 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes
    • Suarez-Pinzon WL, Mabley JG, Power R, Szabó C, Rabinovitch A. Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Diabetes. 2003;52:1683-8.
    • (2003) Diabetes , vol.52 , pp. 1683-1688
    • Suarez-Pinzon, W.L.1    Mabley, J.G.2    Power, R.3    Szabó, C.4    Rabinovitch, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.