메뉴 건너뛰기




Volumn 52, Issue 7, 2003, Pages 1683-1688

Poly (ADP-Ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA; GAMMA INTERFERON; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENANTHRIDINE DERIVATIVE;

EID: 0038015663     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.7.1683     Document Type: Article
Times cited : (38)

References (32)
  • 1
    • 0030937468 scopus 로고    scopus 로고
    • Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
    • O'Brien BA, Harmon BV, Cameron DP, Allan DJ: Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46:750-757, 1997
    • (1997) Diabetes , vol.46 , pp. 750-757
    • O'Brien, B.A.1    Harmon, B.V.2    Cameron, D.P.3    Allan, D.J.4
  • 3
    • 0031739726 scopus 로고    scopus 로고
    • Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes
    • Augustein P, Elefanty AG, Allison J, Harrison LC: Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes. Diabetologia 41:1381-1388, 1998
    • (1998) Diabetologia , vol.41 , pp. 1381-1388
    • Augustein, P.1    Elefanty, A.G.2    Allison, J.3    Harrison, L.C.4
  • 4
    • 0032511880 scopus 로고    scopus 로고
    • Cell suicide for beginners
    • Raff M: Cell suicide for beginners. Nature 396:119-122, 1998
    • (1998) Nature , vol.396 , pp. 119-122
    • Raff, M.1
  • 5
  • 6
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of PARP inhibition
    • Virag L, Szabó C: The therapeutic potential of PARP inhibition. Pharmcol Rev 54:375-429, 2002
    • (2002) Pharmcol Rev , vol.54 , pp. 375-429
    • Virag, L.1    Szabó, C.2
  • 8
    • 0032964810 scopus 로고    scopus 로고
    • Nicotinamide protects human beta cells against chemically-induced necrosis but not cytokine-induced apoptosis
    • Hoorens A, Pipeleers D: Nicotinamide protects human beta cells against chemically-induced necrosis but not cytokine-induced apoptosis. Diabetologia 42:55-59, 1999
    • (1999) Diabetologia , vol.42 , pp. 55-59
    • Hoorens, A.1    Pipeleers, D.2
  • 9
    • 0019945886 scopus 로고
    • Preventative and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis: An observation in nonobese diabetic (NOD) mice
    • Yamada K, Nonaka K, Hanafusa T, Miyazaki A, Toyoshima H, Tarui S: Preventative and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis: an observation in nonobese diabetic (NOD) mice. Diabetes 31:740-753, 1982
    • (1982) Diabetes , vol.31 , pp. 740-753
    • Yamada, K.1    Nonaka, K.2    Hanafusa, T.3    Miyazaki, A.4    Toyoshima, H.5    Tarui, S.6
  • 11
    • 0035289536 scopus 로고    scopus 로고
    • Protective effects of PJ34, a novel, potent inhibitor of poly (ADP-ribose) polymerase in vitro and in vivo models of stroke
    • Abdelkarim GE, Gertz K, Harms C, Katchanov J, Dirnagl U, Szabó C, Endres M: Protective effects of PJ34, a novel, potent inhibitor of poly (ADP-ribose) polymerase in vitro and in vivo models of stroke. Int J Mol Med 7:255-260, 2001
    • (2001) Int J Mol Med , vol.7 , pp. 255-260
    • Abdelkarim, G.E.1    Gertz, K.2    Harms, C.3    Katchanov, J.4    Dirnagl, U.5    Szabó, C.6    Endres, M.7
  • 14
    • 0026502893 scopus 로고
    • Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy
    • Wang T, Singh B, Warnock G, Rajotte RV: Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy. Diabetes 41:114-117, 1992
    • (1992) Diabetes , vol.41 , pp. 114-117
    • Wang, T.1    Singh, B.2    Warnock, G.3    Rajotte, R.V.4
  • 15
    • 0029764082 scopus 로고    scopus 로고
    • + T-cells in syngeneic islet grafts in NOD mice produce interferon-γ during β-cell destruction
    • + T-cells in syngeneic islet grafts in NOD mice produce interferon-γ during β-cell destruction. Diabetes 45:1350-1357, 1996
    • (1996) Diabetes , vol.45 , pp. 1350-1357
    • Suarez-Pinzon, W.1    Rajotte, R.V.2    Mosmann, T.R.3    Rabinovitch, A.4
  • 16
    • 0036142055 scopus 로고    scopus 로고
    • Detection of poly (ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate
    • Bakondi E, Bai P, Szabó E, Hunyadi J, Gergely P, Szabó C, Virag L: Detection of poly (ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate. J Histochem Cytochem 50:91-98, 2002
    • (2002) J Histochem Cytochem , vol.50 , pp. 91-98
    • Bakondi, E.1    Bai, P.2    Szabó, E.3    Hunyadi, J.4    Gergely, P.5    Szabó, C.6    Virag, L.7
  • 17
    • 0036314243 scopus 로고    scopus 로고
    • Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice
    • Rabinovitch A, Suarez-Pinzon WL, Shapiro AMJ, Rajotte RV, Power R: Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes 51:638-645, 2002
    • (2002) Diabetes , vol.51 , pp. 638-645
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Shapiro, A.M.J.3    Rajotte, R.V.4    Power, R.5
  • 18
    • 0018639079 scopus 로고
    • Isolation of biologically, active ribonucleic acid from sources enriched in ribonuclease
    • Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter KT: Isolation of biologically, active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979
    • (1979) Biochemistry , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.E.2    MacDonald, R.J.3    Rutter, K.T.4
  • 19
    • 0031573621 scopus 로고    scopus 로고
    • TNF-α down-regulates type 1 cytokines and prolongs survival of syngeneic islet grafts in nonobese diabetic mice
    • Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Rajotte RV, Power RF: TNF-α down-regulates type 1 cytokines and prolongs survival of syngeneic islet grafts in nonobese diabetic mice. J Immunol 159:6298-6303, 1997
    • (1997) J Immunol , vol.159 , pp. 6298-6303
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3    Rajotte, R.V.4    Power, R.F.5
  • 20
    • 0034094769 scopus 로고    scopus 로고
    • Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing β-cell apoptosis
    • O'Brien BA, Harmon BV, Cameron DP, Allan DJ: Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing β-cell apoptosis. J Pathol 191:86-92, 2000
    • (2000) J Pathol , vol.191 , pp. 86-92
    • O'Brien, B.A.1    Harmon, B.V.2    Cameron, D.P.3    Allan, D.J.4
  • 23
    • 0033011114 scopus 로고    scopus 로고
    • Mice lacking the poly (ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin
    • Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, Kolb H: Mice lacking the poly (ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin. Nat Med 5:314-319, 1999
    • (1999) Nat Med , vol.5 , pp. 314-319
    • Burkart, V.1    Wang, Z.Q.2    Radons, J.3    Heller, B.4    Herceg, Z.5    Stingl, L.6    Wagner, E.F.7    Kolb, H.8
  • 26
    • 0034885522 scopus 로고    scopus 로고
    • Inhibitor of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes
    • Mabley JG, Suarez-Pinzon WL, Hasko G, Salzman AL, Rabinovitch A, Kun E, Szabó C: Inhibitor of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes. Br J Pharmacol 133:909-919, 2001
    • (2001) Br J Pharmacol , vol.133 , pp. 909-919
    • Mabley, J.G.1    Suarez-Pinzon, W.L.2    Hasko, G.3    Salzman, A.L.4    Rabinovitch, A.5    Kun, E.6    Szabó, C.7
  • 27
    • 0036312681 scopus 로고    scopus 로고
    • Unexpected sensitivity of nonobese diabetic mice with a disrupted poly (ADP-ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes
    • Gonzalez C, Ménissier de Murcia J, Janiak P, Bidouard JP, Beauvais C, Karray S, Garchon HJ, Levi-Strauss M: Unexpected sensitivity of nonobese diabetic mice with a disrupted poly (ADP-ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes. Diabetes 51:1470-1476, 2002
    • (2002) Diabetes , vol.51 , pp. 1470-1476
    • Gonzalez, C.1    Ménissier de Murcia, J.2    Janiak, P.3    Bidouard, J.P.4    Beauvais, C.5    Karray, S.6    Garchon, H.J.7    Levi-Strauss, M.8
  • 28
    • 0031969160 scopus 로고    scopus 로고
    • Prevention of insulin-dependent diabetes mellitus
    • Pozzilli P: Prevention of insulin-dependent diabetes mellitus. Diabete Metab Rev 14:69-84, 1998
    • (1998) Diabete Metab Rev , vol.14 , pp. 69-84
    • Pozzilli, P.1
  • 29
    • 0033011536 scopus 로고    scopus 로고
    • Nicotinamide in type 1 diabetes: Mechanism of action revisited
    • Kolb H, Burkart V: Nicotinamide in type 1 diabetes: mechanism of action revisited. Diabetes Care 22 (Suppl. 2): B16-B20, 1999
    • (1999) Diabetes Care , vol.22 , Issue.SUPPL. 2
    • Kolb, H.1    Burkart, V.2
  • 32
    • 0029919434 scopus 로고    scopus 로고
    • Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM
    • Greenbaum CJ, Kahn SE, Palmer JP: Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM. Diabetes 45:1631-1634, 1996
    • (1996) Diabetes , vol.45 , pp. 1631-1634
    • Greenbaum, C.J.1    Kahn, S.E.2    Palmer, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.