The kinase inhibitor imatinib mesylate inhibits TNF-α production in vitro and prevents TNF-dependent acute hepatic inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 38, 2005, Pages 13622-13627

  Wolf, Anna Maria ^a   Wolf, Dominik ^a   Rumpold, Holger ^a   Ludwiczek, Susanne ^b   Enrich, Barbara ^a   Gastl, Guenther ^a   Weiss, Guenter ^b   Tilg, Herbert ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Cytokines; Immunosuppression; Monocytes macrophages

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CONCANAVALIN A; CYTOKINE; DNA; GALACTOSAMINE; I KAPPA B; IMATINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEPATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW CELL; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL; MACROPHAGE; MONOCYTE; MONOCYTE DERIVED MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL DEATH; CELLS, CULTURED; CONCANAVALIN A; FEMALE; HEPATITIS, ANIMAL; HEPATITIS, TOXIC; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MACROPHAGES; NF-KAPPA B; PHOSPHORYLATION; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 26444535295     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501758102     Document Type: Article

References (33)

1. Deininger, M. W. & Druker, B. J. (2003) Pharmacol. Rev. 55, 401-423.
2. Dong, C., Davis, R. J. & Flavell, R. A. (2002) Annu. Rev. Immunol. 20, 55-72.
3. Appel, S., Boehmler, A. M., Grunebach, F., Muller, M. R., Rupf, A., Weck, M. M., Hartmann, U., Reichardt, V. L., Kanz, L., Brummendorf, T. H., et al. (2004) Blood 103, 538-544.
4. Seggewiss, R., Lore, K., Greiner, E., Magnusson, M. K., Price, D. A., Douek, D. C., Dunbar, C. E. & Wiestner, A. (2004) Blood 105, 2473-2479.
5. Dietz, A. B., Souan, L., Knutson, G. J., Bulur, P. A., Litzow, M. R. & Vuk-Pavlovic, S. (2004) Blood 104, 1094-1099.
6. Borg, C., Terme, M., Taieb, J., Menard, C., Flament, C., Robert, C., Maruyama, K., Wakasugi, H., Angevin, E., Thielemans, K., et al. (2004) J. Clin. Invest. 114, 379-388.
7. Vergani, D., Choudhuri, K., Bogdanos, D. P. & Mieli-Vergani, G. (2002) Clin. Liver Dis. 6, 439-449.
8. Tiegs, G., Hentschel, J. & Wendel, A. (1992) J. Clin. Invest. 90, 196-203.
9. Gantner, F., Leist, M., Lohse, A. W., Germann, P. G. & Tiegs, G. (1995) Hepatology 21, 190-198.
10. Kusters, S., Gantner, F., Kunstle, G. & Tiegs, G. (1996) Gastroenterology 111, 462-471.
11. Lehmann, V., Freudenberg, M. A. & Galanos, C. (1987) J. Exp. Med. 165, 657-663.
12. Schreiber, E., Matthias, P., Muller, M. M. & Schaffner, W. (1989) Nucleic Acids Res. 17, 6419.
13. Fritsche, G., Dlaska, M., Barton, H., Theurl, I., Garimorth, K. & Weiss, G. (2003) J. Immunol. 171, 1994-1998.
14. Ghosh, S., May, M. J. & Kopp, E. B. (1998) Annu. Rev. Immunol. 16, 225-260.
15. Buchdunger, E., Zimmermann, J., Mett, H., Meyer, T., Muller, M., Druker, B. J. & Lydon, N. B. (1996) Cancer Res. 56, 100-104.
16. Druker, B. J., Sawyers, C. L., Kantarjian, H., Resta, D. J., Reese, S. F., Ford, J. M., Capdeville, R. & Talpaz, M. (2001) N. Engl. J. Med. 344, 1038-1042.
17. Druker, B. J., Talpaz, M., Resta, D. J., Peng, B., Buchdunger, E., Ford, J. M., Lydon, N. B., Kantarjian, H., Capdeville, R., Ohno-Jones, S., et al. (2001) N. Engl. J. Med. 344, 1031-1037.
18. Cools, J., DeAngelo, D. J., Gotlib, J., Stover, E. H., Legare, R. D., Cortes, J., Kutok, J., Clark, J., Galinsky, I., Griffin, J. D., et al. (2003) N. Engl. J. Med. 348, 1201-1214.
19. van Oosterom, A. T., Judson, I., Verweij, J., Stroobants, S., Donato, D. P., Dimitrijevic, S., Martens, M., Webb, A., Sciot, R., Van Glabbeke, M., et al. (2001) Lancet 358, 1421-1423.
20. Capdeville, R., Buchdunger, E., Zimmermann, J. & Matter, A. (2002) Nat. Rev. Drug Discov. 1, 493-502.
21. Bogdan, C., Vodovotz, Y. & Nathan, C. (1991) J. Exp. Med. 174, 1549-1555.
22. Shakhov, A. N., Collart, M. A., Vassalli, P., Nedospasov, S. A. & Jongeneel, C. V. (1990) J. Exp. Med. 171, 35-47.
23. Appel, S., Rupf, A., Weck, M. M., Schoor, O., Brummendorf, T. H., Weinschenk, T., Grunebach, F. & Brossart, P. (2005) Clin. Cancer Res. 11, 1928-1940.
24. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. & Karin, M. (1997) Nature 388, 548-554.
25. Karin, M. & Ben Neriah, Y. (2000) Annu. Rev. Immunol 18, 621-663.
26. Cwynarski, K., Laylor, R., Macchiarulo, E., Goldman, J., Lombardi, G., Melo, J. V. & Dazzi, F. (2004) Leukemia 18, 1332-1339.
27. Wang, H., Cheng, F., Cuenca, A., Horna, P., Zheng, Z., Bhalla, K. & Sotomayor, E. M. (2004) Blood 105, 1135-1143.
28. Vassalli, P. (1992) Annu. Rev. Immunol. 10, 411-452.
29. Targan, S. R., Hanauer, S. B., van Deventer, S. J., Mayer, L., Present, D. H., Braakman, T., DeWoody, K. L., Schaible, T. F. & Rutgeerts, P. J. (1997) N. Engl. J. Med. 337, 1029-1035.
30. Lipsky, P. E., van der Heijde, D. M., St. Clair, E. W., Furst, D. E., Breedveld, F. C., Kalden, J. R., Smolen, J. S., Weisman, M., Emery, P., Feldmann, M., et al. (2000) N. Engl. J. Med. 343, 1594-1602.
31. Schumann, J., Wolf, D., Pahl, A., Brune, K., Papadopoulos, T., van Rooijen, N. & Tiegs, G. (2000) Am. J. Pathol. 157, 1671-1683.
32. Mizuhara, H., O'Neill, E., Seki, N., Ogawa, T., Kusunoki, C., Otsuka, K., Satoh, S., Niwa, M., Senoh, H. & Fujiwara, H. (1994) J. Exp. Med. 179, 1529-1537.
33. Sass, G., Koerber, K., Bang, R., Guehring, H. & Tiegs, G. (2001) J. Clin. Invest. 107, 439-447.