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Volumn 48, Issue 4, 2005, Pages 616-620

Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes

Author keywords

Dipeptidyl peptidase IV; Glucagon like peptide 1; Incretin; Inhibitor; Insulinotropic effect; Novel drug; Side effect; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; CHEMOKINE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GASTRIC INHIBITORY POLYPEPTIDE; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE 1; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; NEUROPEPTIDE; PEPTIDE HORMONE; PROTEINASE;

EID: 17844362518     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1707-5     Document Type: Article
Times cited : (134)

References (20)
  • 1
    • 12744269699 scopus 로고    scopus 로고
    • Therapeutic assessment of GLP-1 agonists compared with dipeptidyl peptidase IV inhibitors as potential anti-diabetic drugs
    • Mentlein R (2005) Therapeutic assessment of GLP-1 agonists compared with dipeptidyl peptidase IV inhibitors as potential anti-diabetic drugs. Expert Opin Investig Drugs 14:57-64
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 57-64
    • Mentlein, R.1
  • 2
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • Ahrén B, Simonsson E, Larsson H et al (2002) Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 25:869-875
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahrén, B.1    Simonsson, E.2    Larsson, H.3
  • 3
    • 9444285818 scopus 로고    scopus 로고
    • Twelve-and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • Ahrén B, Gomis R, Standl E, Mills D, Schweizer A (2004) Twelve-and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care 27:2874-2880
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahrén, B.1    Gomis, R.2    Standl, E.3    Mills, D.4    Schweizer, A.5
  • 4
    • 1342284186 scopus 로고    scopus 로고
    • Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetes db/db mice
    • Brenner MB, Gromada L, Efanov AM, Bokvist K, Mest H-J (2003) Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetes db/db mice. Ann NY Acad Sci 1009:332-340
    • (2003) Ann NY Acad Sci , vol.1009 , pp. 332-340
    • Brenner, M.B.1    Gromada, L.2    Efanov, A.M.3    Bokvist, K.4    Mest, H.-J.5
  • 5
    • 17644409943 scopus 로고    scopus 로고
    • Inhibition of DPP-4 augments insulin secretion in response to exogenously administered GLP-1, GIP, PACAP and GRP in mice
    • in press
    • Ahrén B, Hughes TE (2004) Inhibition of DPP-4 augments insulin secretion in response to exogenously administered GLP-1, GIP, PACAP and GRP in mice. Endocrinology (in press)
    • (2004) Endocrinology
    • Ahrén, B.1    Hughes, T.E.2
  • 6
    • 0037974604 scopus 로고    scopus 로고
    • Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
    • Conarello SL, Li Z, Ronan J et al (2003) Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci U S A 100:6825-6830
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6825-6830
    • Conarello, S.L.1    Li, Z.2    Ronan, J.3
  • 7
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsbøll T, Krarup T, Deacon CF, Madsbad S, Holst JJ (2001) Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50:609-613
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsbøll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 8
    • 17844399596 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
    • DOI 10.1007/s00125-005-1705-7
    • Holst JJ, Deacon CF (2005) Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia DOI 10.1007/s00125-005- 1705-7
    • (2005) Diabetologia
    • Holst, J.J.1    Deacon, C.F.2
  • 9
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA (1995) Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136:3585-3596
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 10
    • 0030607672 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-3 6) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor
    • Knudsen LB, Pridal L (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-3 6) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol 318:429-435
    • (1996) Eur J Pharmacol , vol.318 , pp. 429-435
    • Knudsen, L.B.1    Pridal, L.2
  • 11
    • 1442321740 scopus 로고    scopus 로고
    • Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
    • Gault VA, Parker JC, Harriott P, Flatt PR, O'Harte FP (2002) Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J Endocrinol 175:525-533
    • (2002) J Endocrinol , vol.175 , pp. 525-533
    • Gault, V.A.1    Parker, J.C.2    Harriott, P.3    Flatt, P.R.4    O'Harte, F.P.5
  • 12
    • 0036659179 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (CD26) on T cells cleaves the CXC chemokine CXCL11 (I-TAC) and abolishes the stimulating but not the desensitizing potential of the chemokine
    • Ludwig A, Schiemann F, Mentlein R, Lindner B, Brandt E (2002) Dipeptidyl peptidase IV (CD26) on T cells cleaves the CXC chemokine CXCL11 (I-TAC) and abolishes the stimulating but not the desensitizing potential of the chemokine. J Leukoc Biol 72:183-191
    • (2002) J Leukoc Biol , vol.72 , pp. 183-191
    • Ludwig, A.1    Schiemann, F.2    Mentlein, R.3    Lindner, B.4    Brandt, E.5
  • 13
    • 0035895070 scopus 로고    scopus 로고
    • Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties
    • Proost P, Schutyser E, Menten P et al (2001) Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties. Blood 98:3554-3561
    • (2001) Blood , vol.98 , pp. 3554-3561
    • Proost, P.1    Schutyser, E.2    Menten, P.3
  • 14
    • 0031870418 scopus 로고    scopus 로고
    • Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide
    • Pederson RA, White HA, Schlenzig D, Pauly RP, McIntosh CH, Demuth HU (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47:1253-1258
    • (1998) Diabetes , vol.47 , pp. 1253-1258
    • Pederson, R.A.1    White, H.A.2    Schlenzig, D.3    Pauly, R.P.4    McIntosh, C.H.5    Demuth, H.U.6
  • 15
    • 0036228243 scopus 로고    scopus 로고
    • Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats
    • Pospisilik JA, Stafford SG, Demuth HU et al (2002) Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats. Diabetes 51:943-950
    • (2002) Diabetes , vol.51 , pp. 943-950
    • Pospisilik, J.A.1    Stafford, S.G.2    Demuth, H.U.3
  • 16
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - Role in the inactivation of regulatory peptides
    • Mentlein R (1999) Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regulatory Pept 85:9-24
    • (1999) Regulatory Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 17
    • 3042833899 scopus 로고    scopus 로고
    • Cell surface peptidases
    • Mentlein R (2004) Cell surface peptidases. Int Rev Cyt 235:165-213
    • (2004) Int Rev Cyt , vol.235 , pp. 165-213
    • Mentlein, R.1
  • 18
    • 0043073112 scopus 로고    scopus 로고
    • Prolyl peptidases: A serine protease subfamily with high potential for drug discovery
    • Rosenblum JS, Kozarich JW (2003) Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. Curr Opin Chem Biol 7:496-504
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 496-504
    • Rosenblum, J.S.1    Kozarich, J.W.2
  • 19
    • 4544227213 scopus 로고    scopus 로고
    • Inhibition of DPP8/9 results in toxicity in preclinical studies: Potential importance of selective dipeptidyl peptidase IV inhibition for the treatment of type 2 DM
    • Lankas G, Leiting B, Roy RS et al (2004) Inhibition of DPP8/9 results in toxicity in preclinical studies: potential importance of selective dipeptidyl peptidase IV inhibition for the treatment of type 2 DM. Diabetes 53(Suppl 2):A2
    • (2004) Diabetes , vol.53 , Issue.2 SUPPL.
    • Lankas, G.1    Leiting, B.2    Roy, R.S.3
  • 20
    • 4344713643 scopus 로고    scopus 로고
    • Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycaemia
    • Degn KB, Brock B, Juhl CB et al (2004) Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycaemia. Diabetes 53:2397-2403
    • (2004) Diabetes , vol.53 , pp. 2397-2403
    • Degn, K.B.1    Brock, B.2    Juhl, C.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.