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Volumn , Issue , 2013, Pages

Enhanced 4-hydroxynonenal resistance in keap1 silenced human colon cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

4-HYDROXY-NONENAL; ADDUCT FORMATION; ALDO-KETO REDUCTASE; CELLULAR TOXICITIES; CONFORMATIONAL CHANGE; HUMAN COLON CANCER CELLS; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; TARGET GENE EXPRESSION;

EID: 84878692259     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/423965     Document Type: Article
Times cited : (23)

References (64)
  • 2
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • 2-s2.0-33847050801 10.1146/annurev.pharmtox.46.120604.141046
    • Kensler T. W., Wakabayashi N., Biswal S., Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology 2007 47 89 116 2-s2.0-33847050801 10.1146/annurev.pharmtox.46.120604.141046
    • (2007) Annual Review of Pharmacology and Toxicology , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 3
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • 2-s2.0-63549121490 10.1016/j.tibs.2008.12.008
    • Hayes J. D., McMahon M., NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends in Biochemical Sciences 2009 34 4 176 188 2-s2.0-63549121490 10.1016/j.tibs.2008.12.008
    • (2009) Trends in Biochemical Sciences , vol.34 , Issue.4 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 4
    • 78149434112 scopus 로고    scopus 로고
    • The Nrf2 system as a potential target for the development of indirect antioxidants
    • 2-s2.0-78149434112 10.3390/molecules15107266
    • Jung K. A., Kwak M. K., The Nrf2 system as a potential target for the development of indirect antioxidants. Molecules 2010 15 10 7266 7291 2-s2.0-78149434112 10.3390/molecules15107266
    • (2010) Molecules , vol.15 , Issue.10 , pp. 7266-7291
    • Jung, K.A.1    Kwak, M.K.2
  • 5
    • 13644268144 scopus 로고    scopus 로고
    • Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
    • DOI 10.1093/toxsci/kfi027
    • Li J., Johnson D., Calkins M., Wright L., Svendsen C., Johnson J., Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicological Sciences 2005 83 2 313 328 2-s2.0-13644268144 10.1093/toxsci/kfi027 (Pubitemid 40227901)
    • (2005) Toxicological Sciences , vol.83 , Issue.2 , pp. 313-328
    • Li, J.1    Johnson, D.2    Calkins, M.3    Wright, L.4    Svendsen, C.5    Johnson, J.6
  • 6
    • 43349098881 scopus 로고    scopus 로고
    • Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression
    • DOI 10.1007/s11095-007-9370-9
    • Prawan A., Keum Y. S., Khor T. O., Yu S., Nair S., Li W., Hu L., Kong A. N., Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression. Pharmaceutical Research 2008 25 4 836 844 10.1007/s11095-007-9370-9 (Pubitemid 351661826)
    • (2008) Pharmaceutical Research , vol.25 , Issue.4 , pp. 836-844
    • Prawan, A.1    Keum, Y.-S.2    Khor, T.O.3    Yu, S.4    Nair, S.5    Li, W.6    Hu, L.7    Kong, A.-N.T.8
  • 7
    • 84873443918 scopus 로고    scopus 로고
    • Identification of aldo-keto reductases as NRF2-target marker genes in human cells
    • 10.1016/j.toxlet.2012.12.026
    • Jung K. A., Choi B. H., Nam C. W., Song M., Kim S. T., Lee J. Y., Kwak M. K., Identification of aldo-keto reductases as NRF2-target marker genes in human cells. Toxicology Letters 2013 218 1 39 49 10.1016/j.toxlet.2012.12.026
    • (2013) Toxicology Letters , vol.218 , Issue.1 , pp. 39-49
    • Jung, K.A.1    Choi, B.H.2    Nam, C.W.3    Song, M.4    Kim, S.T.5    Lee, J.Y.6    Kwak, M.K.7
  • 8
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J. D., Yamamoto M., Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes and Development 1999 13 1 76 86 2-s2.0-0032953192 (Pubitemid 29045117)
    • (1999) Genes and Development , vol.13 , Issue.1 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 9
    • 77958115724 scopus 로고    scopus 로고
    • Regulation of the Nrf2-keap1 antioxidant response by the ubiquitin proteasome system: An insight into cullin-ring ubiquitin ligases
    • 2-s2.0-77958115724 10.1089/ars.2010.3211
    • Villeneuve N. F., Lau A., Zhang D. D., Regulation of the Nrf2-keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxidants and Redox Signaling 2010 13 11 1699 1712 2-s2.0-77958115724 10.1089/ars.2010.3211
    • (2010) Antioxidants and Redox Signaling , vol.13 , Issue.11 , pp. 1699-1712
    • Villeneuve, N.F.1    Lau, A.2    Zhang, D.D.3
  • 12
    • 28144445947 scopus 로고    scopus 로고
    • Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
    • DOI 10.1016/j.bbrc.2005.10.185, PII S0006291X05024733
    • Okawa H., Motohashi H., Kobayashi A., Aburatani H., Kensler T. W., Yamamoto M., Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochemical and Biophysical Research Communications 2006 339 1 79 88 2-s2.0-28144445947 10.1016/j.bbrc.2005.10.185 (Pubitemid 41697517)
    • (2006) Biochemical and Biophysical Research Communications , vol.339 , Issue.1 , pp. 79-88
    • Okawa, H.1    Motohashi, H.2    Kobayashi, A.3    Aburatani, H.4    Kensler, T.W.5    Yamamoto, M.6
  • 15
    • 84857918033 scopus 로고    scopus 로고
    • Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
    • 2-s2.0-79955946590 10.1007/s10549-011-1536-9
    • Agyeman A. S., Chaerkady R., Shaw P. G., Davidson N. E., Visvanathan K., Pandey A., Kensler T. W., Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Research and Treatment 2012 132 1 175 187 2-s2.0-79955946590 10.1007/s10549-011-1536-9
    • (2012) Breast Cancer Research and Treatment , vol.132 , Issue.1 , pp. 175-187
    • Agyeman, A.S.1    Chaerkady, R.2    Shaw, P.G.3    Davidson, N.E.4    Visvanathan, K.5    Pandey, A.6    Kensler, T.W.7
  • 17
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer H., Schaur R. J., Zollner H., Chemistry and Biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radical Biology and Medicine 1991 11 1 81 128 2-s2.0-0025814980 10.1016/0891-5849(91)90192-6 (Pubitemid 121003917)
    • (1991) Free Radical Biology and Medicine , vol.11 , Issue.1 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 18
    • 79952965423 scopus 로고    scopus 로고
    • Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues
    • 2-s2.0-79952965423 10.1021/tx100323m
    • McGrath C. E., Tallman K. A., Porter N. A., Marnett L. J., Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues. Chemical Research in Toxicology 2011 24 3 357 370 2-s2.0-79952965423 10.1021/tx100323m
    • (2011) Chemical Research in Toxicology , vol.24 , Issue.3 , pp. 357-370
    • McGrath, C.E.1    Tallman, K.A.2    Porter, N.A.3    Marnett, L.J.4
  • 19
    • 0037411282 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal: A product and mediator of oxidative stress
    • DOI 10.1016/S0163-7827(03)00014-6
    • Uchida K., 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Progress in Lipid Research 2003 42 4 318 343 2-s2.0-0037411282 10.1016/S0163-7827(03)00014-6 (Pubitemid 36411689)
    • (2003) Progress in Lipid Research , vol.42 , Issue.4 , pp. 318-343
    • Uchida, K.1
  • 20
    • 78650147789 scopus 로고    scopus 로고
    • Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease
    • 2-s2.0-78650147789 10.3109/10715762.2010.520014
    • Butterfield D. A., Reed T., Sultana R., Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease. Free Radical Research 2011 45 1 59 72 2-s2.0-78650147789 10.3109/10715762.2010.520014
    • (2011) Free Radical Research , vol.45 , Issue.1 , pp. 59-72
    • Butterfield, D.A.1    Reed, T.2    Sultana, R.3
  • 21
    • 79956122656 scopus 로고    scopus 로고
    • Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis
    • 2-s2.0-79956122656 10.1111/j.1365-2559.2011.03835.x
    • Karihtala P., Kauppila S., Puistola U., Jukkola-Vuorinen A., Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis. Histopathology 2011 58 6 854 862 2-s2.0-79956122656 10.1111/j.1365-2559.2011.03835.x
    • (2011) Histopathology , vol.58 , Issue.6 , pp. 854-862
    • Karihtala, P.1    Kauppila, S.2    Puistola, U.3    Jukkola-Vuorinen, A.4
  • 23
    • 0035951825 scopus 로고    scopus 로고
    • The reactive oxygen species- and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α, β -unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene
    • 2-s2.0-0035951825 10.1074/jbc.M006655200
    • Burczynski M. E., Sridhar G. R., Palackal N. T., Penning T. M., The reactive oxygen species- and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α β -unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. The Journal of Biological Chemistry 2001 276 4 2890 2897 2-s2.0-0035951825 10.1074/jbc.M006655200
    • (2001) The Journal of Biological Chemistry , vol.276 , Issue.4 , pp. 2890-2897
    • Burczynski, M.E.1    Sridhar, G.R.2    Palackal, N.T.3    Penning, T.M.4
  • 24
    • 33846818874 scopus 로고    scopus 로고
    • 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes
    • DOI 10.1016/j.exer.2006.10.020, PII S0014483506004234
    • Malone P. E., Hernandez M. R., 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes. Experimental Eye Research 2007 84 3 444 454 2-s2.0-33846818874 10.1016/j.exer.2006.10.020 (Pubitemid 46210058)
    • (2007) Experimental Eye Research , vol.84 , Issue.3 , pp. 444-454
    • Malone, P.E.1    Hernandez, M.R.2
  • 25
    • 84871716357 scopus 로고    scopus 로고
    • Aldo-keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells
    • 10.1016/j.neuint.2012.10.007
    • Lyon R. C., Li D., McGarvie G., Ellis E. M., Aldo-keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells. Neurochemistry International 2013 62 1 113 121 10.1016/j.neuint.2012.10.007
    • (2013) Neurochemistry International , vol.62 , Issue.1 , pp. 113-121
    • Lyon, R.C.1    Li, D.2    McGarvie, G.3    Ellis, E.M.4
  • 26
    • 33845962827 scopus 로고    scopus 로고
    • Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages
    • DOI 10.1074/jbc.M603819200
    • Ramana K. V., Fadl A. A., Tammali R., Reddy A. B. M., Chopra A. K., Srivastava S. K., Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. The Journal of Biological Chemistry 2006 281 44 33019 33029 2-s2.0-33845962827 10.1074/jbc.M603819200 (Pubitemid 46036684)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.44 , pp. 33019-33029
    • Ramana, K.V.1    Fadl, A.A.2    Tammali, R.3    Reddy, A.B.M.4    Chopra, A.K.5    Srivastava, S.K.6
  • 27
    • 0035881570 scopus 로고    scopus 로고
    • Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines
    • Bonnesen C., Eggleston I. M., Hayes J. D., Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Research 2001 61 16 6120 6130 2-s2.0-0035881570 (Pubitemid 32762548)
    • (2001) Cancer Research , vol.61 , Issue.16 , pp. 6120-6130
    • Bonnesen, C.1    Eggleston, I.M.2    Hayes, J.D.3
  • 28
    • 79955051623 scopus 로고    scopus 로고
    • Involvement of the aldo-keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms
    • 2-s2.0-79955051623 10.1097/CAD.0b013e3283448df0
    • Matsunaga T., Yamane Y., Iida K., Endo S., Banno Y., El-Kabbani O., Hara A., Involvement of the aldo-keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms. Anti-Cancer Drugs 2011 22 5 402 408 2-s2.0-79955051623 10.1097/CAD.0b013e3283448df0
    • (2011) Anti-Cancer Drugs , vol.22 , Issue.5 , pp. 402-408
    • Matsunaga, T.1    Yamane, Y.2    Iida, K.3    Endo, S.4    Banno, Y.5    El-Kabbani, O.6    Hara, A.7
  • 29
    • 79952749190 scopus 로고    scopus 로고
    • NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1 α
    • 10.1158/0008-5472.CAN-10-3007
    • Kim T. H., Hur E. G., Kang S. J., Kim J. A., Thapa D., Lee Y. M., Ku S. K., Jung Y., Kwak M. K., NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1 α Cancer Research 2011 71 6 2260 2275 10.1158/0008-5472.CAN-10-3007
    • (2011) Cancer Research , vol.71 , Issue.6 , pp. 2260-2275
    • Kim, T.H.1    Hur, E.G.2    Kang, S.J.3    Kim, J.A.4    Thapa, D.5    Lee, Y.M.6    Ku, S.K.7    Jung, Y.8    Kwak, M.K.9
  • 30
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: Identification of novel gene clusters for cell survival
    • DOI 10.1074/jbc.M211898200
    • Kwak M. K., Wakabayashi N., Itoh K., Motohashi H., Yamamoto M., Kensler T. W., Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival. The Journal of Biological Chemistry 2003 278 10 8135 8145 2-s2.0-0037424262 10.1074/jbc.M211898200 (Pubitemid 36800555)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8135-8145
    • Kwak, M.-K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 31
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa R. K., Mai K. H., Srisuma S., Kensler T. W., Yamamoto M., Biswal S., Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Research 2002 62 18 5196 5203 2-s2.0-0037106099 (Pubitemid 35033454)
    • (2002) Cancer Research , vol.62 , Issue.18 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 32
    • 0038146898 scopus 로고    scopus 로고
    • Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    • DOI 10.1074/jbc.M211558200
    • Lee J. M., Calkins M. J., Chan K., Kan Y. W., Johnson J. A., Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. The Journal of Biological Chemistry 2003 278 14 12029 12038 2-s2.0-0038146898 10.1074/jbc.M211558200 (Pubitemid 36800179)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.14 , pp. 12029-12038
    • Lee, J.-M.1    Calkins, M.J.2    Chan, K.3    Kan, Y.W.4    Johnson, J.A.5
  • 33
    • 0842304134 scopus 로고    scopus 로고
    • Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by tert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult
    • DOI 10.1523/JNEUROSCI.3817-03.2004
    • Kraft A. D., Johnson D. A., Johnson J. A., Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. Journal of Neuroscience 2004 24 5 1101 1112 2-s2.0-0842304134 10.1523/JNEUROSCI.3817-03.2004 (Pubitemid 38177017)
    • (2004) Journal of Neuroscience , vol.24 , Issue.5 , pp. 1101-1112
    • Kraft, A.D.1    Johnson, D.A.2    Johnson, J.A.3
  • 34
    • 67349247003 scopus 로고    scopus 로고
    • Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
    • 2-s2.0-67349247003 10.1016/j.taap.2009.03.005
    • Higgins L. G., Kelleher M. O., Eggleston I. M., Itoh K., Yamamoto M., Hayes J. D., Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicology and Applied Pharmacology 2009 237 3 267 280 2-s2.0-67349247003 10.1016/j.taap.2009.03.005
    • (2009) Toxicology and Applied Pharmacology , vol.237 , Issue.3 , pp. 267-280
    • Higgins, L.G.1    Kelleher, M.O.2    Eggleston, I.M.3    Itoh, K.4    Yamamoto, M.5    Hayes, J.D.6
  • 37
    • 0031417633 scopus 로고    scopus 로고
    • Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells
    • DOI 10.1093/carcin/18.6.1195
    • Redman C., Xu M. J., Peng Y. M., Scott J. A., Payne C., Clark L. C., Nelson M. A., Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells. Carcinogenesis 1997 18 6 1195 1202 2-s2.0-0031417633 10.1093/carcin/18.6.1195 (Pubitemid 28132511)
    • (1997) Carcinogenesis , vol.18 , Issue.6 , pp. 1195-1202
    • Redman, C.1    Xu, M.J.2    Peng, Y.-M.3    Scott, J.A.4    Payne, C.5    Clark, L.C.6    Nelson, M.A.7
  • 38
    • 0033531262 scopus 로고    scopus 로고
    • Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras
    • DOI 10.1038/sj.onc.1202280
    • Lorentz O., Cadoret A., Duluc I., Capeau J., Gespach C., Cherqui G., Freund J. N., Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene 1999 18 1 87 92 2-s2.0-0033531262 10.1038/sj.onc.1202280 (Pubitemid 29060582)
    • (1999) Oncogene , vol.18 , Issue.1 , pp. 87-92
    • Lorentz, O.1    Cadoret, A.2    Duluc, I.3    Capeau, J.4    Gespach, C.5    Cherqui, G.6    Freund, J.-N.7
  • 42
    • 0030722195 scopus 로고    scopus 로고
    • Activation of adenomatous polyposis coli (APC) gene expression by the DNA-alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine requires p53
    • DOI 10.1074/jbc.272.49.30619
    • Narayan S., Jaiswal A. S., Activation of adenomatous polyposis coli (APC) gene expression by the DNA-alkylating agent N-methyl-N′-nitro-N- nitrosoguanidine requires p53. The Journal of Biological Chemistry 1997 272 49 30619 30622 2-s2.0-0030722195 10.1074/jbc.272.49.30619 (Pubitemid 27527492)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.49 , pp. 30619-30622
    • Narayan, S.1    Jaiswal, A.S.2
  • 43
    • 0034602188 scopus 로고    scopus 로고
    • Role of BAX in the apoptotic response to anticancer agents
    • 2-s2.0-0034602188 10.1126/science.290.5493.989
    • Zhang L., Yu J., Park B. H., Kinzler K. W., Vogelstein B., Role of BAX in the apoptotic response to anticancer agents. Science 2000 290 5493 989 992 2-s2.0-0034602188 10.1126/science.290.5493.989
    • (2000) Science , vol.290 , Issue.5493 , pp. 989-992
    • Zhang, L.1    Yu, J.2    Park, B.H.3    Kinzler, K.W.4    Vogelstein, B.5
  • 44
    • 33847021147 scopus 로고    scopus 로고
    • Aldo-keto reductases and bioactivation/detoxication
    • 10.1146/annurev.pharmtox.47.120505.105337
    • Jin Y., Penning T. M., Aldo-keto reductases and bioactivation/ detoxication. Annual Review of Pharmacology and Toxicology 2007 47 263 292 10.1146/annurev.pharmtox.47.120505.105337
    • (2007) Annual Review of Pharmacology and Toxicology , vol.47 , pp. 263-292
    • Jin, Y.1    Penning, T.M.2
  • 45
    • 0037324845 scopus 로고    scopus 로고
    • Selective and potent inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone
    • DOI 10.1016/S0009-2797(02)00206-5, PII S0009279702002065
    • Higaki Y., Usami N., Shintani S., Ishikura S., El-Kabbani O., Hara A., Selective and potent inhibitors of human 20 α -hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. Chemico-Biological Interactions 2003 143-144 503 513 2-s2.0-0037324845 10.1016/S0009-2797(02)00206-5 (Pubitemid 36253599)
    • (2003) Chemico-Biological Interactions , vol.143-144 , pp. 503-513
    • Higaki, Y.1    Usami, N.2    Shintani, S.3    Ishikura, S.4    El-Kabbani, O.5    Hara, A.6
  • 46
    • 33644749351 scopus 로고    scopus 로고
    • Tibolone metabolism in human liver is catalyzed by 3α/3β- hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily
    • DOI 10.1124/jpet.105.091587
    • Steckelbroeck S., Oyesanmi B., Jin Y., Lee S. H., Kloosterboer H. J., Penning T. M., Tibolone metabolism in human liver is catalyzed by 3 α /3 β -hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. Journal of Pharmacology and Experimental Therapeutics 2006 316 3 1300 1309 2-s2.0-33644749351 10.1124/jpet.105.091587 (Pubitemid 43345306)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.316 , Issue.3 , pp. 1300-1309
    • Steckelbroeck, S.1    Oyesanmi, B.2    Jin, Y.3    Lee, S.-H.4    Kloosterboer, H.J.5    Penning, T.M.6
  • 48
    • 61349117533 scopus 로고    scopus 로고
    • Increased Nrf2 activation in livers from keap1-knockdown mice Increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species
    • 2-s2.0-61349117533 10.1093/toxsci/kfn267
    • Reisman S. A., Yeager R. L., Yamamoto M., Klaassen C. D., Increased Nrf2 activation in livers from keap1-knockdown mice Increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicological Sciences 2009 108 1 35 47 2-s2.0-61349117533 10.1093/toxsci/kfn267
    • (2009) Toxicological Sciences , vol.108 , Issue.1 , pp. 35-47
    • Reisman, S.A.1    Yeager, R.L.2    Yamamoto, M.3    Klaassen, C.D.4
  • 49
    • 77958125017 scopus 로고    scopus 로고
    • Discovery of the negative regulator of Nrf2, keap1: A historical overview
    • 2-s2.0-77958125017 10.1089/ars.2010.3222
    • Itoh K., Mimura J., Yamamoto M., Discovery of the negative regulator of Nrf2, keap1: a historical overview. Antioxidants and Redox Signaling 2010 13 11 1665 1678 2-s2.0-77958125017 10.1089/ars.2010.3222
    • (2010) Antioxidants and Redox Signaling , vol.13 , Issue.11 , pp. 1665-1678
    • Itoh, K.1    Mimura, J.2    Yamamoto, M.3
  • 52
    • 0242580049 scopus 로고    scopus 로고
    • Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
    • DOI 10.1128/MCB.23.22.8137-8151.2003
    • Zhang D. D., Hannink M., Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Molecular and Cellular Biology 2003 23 22 8137 8151 2-s2.0-0242580049 10.1128/MCB.23.22.8137-8151.2003 (Pubitemid 37377505)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.22 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 53
    • 22544464124 scopus 로고    scopus 로고
    • Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
    • DOI 10.1073/pnas.0502402102
    • Eggler A. L., Liu G., Pezzuto J. M., van Breemen R. B., Mesecar A. D., Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proceedings of the National Academy of Sciences of the United States of America 2005 102 29 10070 10075 2-s2.0-22544464124 10.1073/pnas.0502402102 (Pubitemid 41023327)
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.29 , pp. 10070-10075
    • Eggler, A.L.1    Liu, G.2    Pezzuto, J.M.3    Van Breemen, R.B.4    Mesecar, A.D.5
  • 54
    • 36349019109 scopus 로고    scopus 로고
    • Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent
    • 2-s2.0-36349019109 10.1021/tx700217c
    • Eggler A. L., Luo Y., van Breemen R. B., Mesecar A. D., Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. Chemical Research in Toxicology 2007 20 12 1878 1884 2-s2.0-36349019109 10.1021/tx700217c
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.12 , pp. 1878-1884
    • Eggler, A.L.1    Luo, Y.2    Van Breemen, R.B.3    Mesecar, A.D.4
  • 55
    • 70350787143 scopus 로고    scopus 로고
    • Aldo-keto reductase (AKR) superfamily: Genomics and annotation
    • 2-s2.0-70350787143
    • Mindnich R. D., Penning T. M., Aldo-keto reductase (AKR) superfamily: genomics and annotation. Human Genomics 2009 3 4 362 370 2-s2.0-70350787143
    • (2009) Human Genomics , vol.3 , Issue.4 , pp. 362-370
    • Mindnich, R.D.1    Penning, T.M.2
  • 56
    • 59049089110 scopus 로고    scopus 로고
    • Type 5 17 β -hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): Role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs
    • 2-s2.0-59049089110 10.1016/j.cbi.2008.10.024
    • Byrns M. C., Penning T. M., Type 5 17 β -hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chemico-Biological Interactions 2009 178 1-3 221 227 2-s2.0-59049089110 10.1016/j.cbi.2008.10.024
    • (2009) Chemico-Biological Interactions , vol.178 , Issue.1-3 , pp. 221-227
    • Byrns, M.C.1    Penning, T.M.2
  • 57
    • 34547692874 scopus 로고    scopus 로고
    • Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms
    • DOI 10.1016/j.abb.2007.04.024, PII S0003986107002226
    • Penning T. M., Drury J. E., Human aldo-keto reductases: function, gene regulation, and single nucleotide polymorphisms. Archives of Biochemistry and Biophysics 2007 464 2 241 250 2-s2.0-34547692874 10.1016/j.abb.2007.04.024 (Pubitemid 47214569)
    • (2007) Archives of Biochemistry and Biophysics , vol.464 , Issue.2 , pp. 241-250
    • Penning, T.M.1    Drury, J.E.2
  • 58
    • 67349161804 scopus 로고    scopus 로고
    • The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells
    • 10.1016/j.cbi.2009.03.011
    • Vondracek J., Krcmar P., Prochazkova J., The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells. Chemico-Biological Interactions 2009 180 2 226 237 10.1016/j.cbi.2009.03.011
    • (2009) Chemico-Biological Interactions , vol.180 , Issue.2 , pp. 226-237
    • Vondracek, J.1    Krcmar, P.2    Prochazkova, J.3
  • 59
    • 33645893202 scopus 로고    scopus 로고
    • Induction of AKR1C2 by phase II inducers: Identification of a distal consensus antioxidant response element regulated by NRF2
    • 2-s2.0-33645893202 10.1124/mol.105.019794
    • Lou H., Du S., Ji Q., Stolz A., Induction of AKR1C2 by phase II inducers: identification of a distal consensus antioxidant response element regulated by NRF2. Molecular Pharmacology 2006 69 5 1662 1672 2-s2.0-33645893202 10.1124/mol.105.019794
    • (2006) Molecular Pharmacology , vol.69 , Issue.5 , pp. 1662-1672
    • Lou, H.1    Du, S.2    Ji, Q.3    Stolz, A.4
  • 60
    • 70249138697 scopus 로고    scopus 로고
    • Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: Demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
    • 2-s2.0-70249138697 10.1093/carcin/bgp176
    • Macleod A. K., Mcmahon M., Plummer S. M., Higgins L. G., Penning T. M., Igarashi K., Hayes J. D., Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis 2009 30 9 1571 1580 2-s2.0-70249138697 10.1093/carcin/bgp176
    • (2009) Carcinogenesis , vol.30 , Issue.9 , pp. 1571-1580
    • Macleod, A.K.1    McMahon, M.2    Plummer, S.M.3    Higgins, L.G.4    Penning, T.M.5    Igarashi, K.6    Hayes, J.D.7
  • 62
    • 84874633349 scopus 로고    scopus 로고
    • Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo
    • 10.1016/j.freeradbiomed.2012.12.011
    • Miller D. M., Singh I. N., Wang J. A., Hall E. D., Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo. Free Radical Biology and Medicine 2012 57 1 9 10.1016/j.freeradbiomed.2012.12.011
    • (2012) Free Radical Biology and Medicine , vol.57 , pp. 1-9
    • Miller, D.M.1    Singh, I.N.2    Wang, J.A.3    Hall, E.D.4
  • 63
    • 0034633980 scopus 로고    scopus 로고
    • Selective recognition of glutathiolated aldehydes by aldose reductase
    • 2-s2.0-0034633980 10.1021/bi000796e
    • Ramana K. V., Dixit B. L., Srivastava S., Balendiran G. K., Srivastava S. K., Bhatnagar A., Selective recognition of glutathiolated aldehydes by aldose reductase. Biochemistry 2000 39 40 12172 12180 2-s2.0-0034633980 10.1021/bi000796e
    • (2000) Biochemistry , vol.39 , Issue.40 , pp. 12172-12180
    • Ramana, K.V.1    Dixit, B.L.2    Srivastava, S.3    Balendiran, G.K.4    Srivastava, S.K.5    Bhatnagar, A.6
  • 64
    • 2942567694 scopus 로고    scopus 로고
    • Trans-4-hydroxy-2-nonenial inhibits nucleotide excision repair human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis
    • DOI 10.1073/pnas.0402794101
    • Feng Z., Hu W., Tang M. S., Trans-4-hydroxy-2-nonenial inhibits nucleotide excision repair human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America 2004 101 23 8598 8602 2-s2.0-2942567694 10.1073/pnas.0402794101 (Pubitemid 38745816)
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , Issue.23 , pp. 8598-8602
    • Feng, Z.1    Hu, W.2    Tang, M.-S.3


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