Selective and potent inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone

Chemico-Biological Interactions

Volumn 143-144, Issue , 2003, Pages 503-513

  Higaki, Yu ^a   Usami, Noriyuki ^a   Shintani, Syunichi ^a   Ishikura, Shuhei ^a   El Kabbani, Ossama ^b   Hara, Akira ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b NONE

Author keywords

20 Hydroxysteroid dehydrogenase; 3 Hydroxysteroid dehydrogenase; Aldo keto reductase family; Chemical inhibitor; Neurosteroid

Indexed keywords

1,10 PHENANTHROLINE; 2 CRESOLPHTHALEIN; 20ALPHA HYDROXYSTEROID DEHYDROGENASE; 3',3'',5',5'' TETRABROMOPHENOLPHTHALEIN; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA,5ALPHA TETRAHYDRODEOXYCORTICOSTERONE; BENZBROMARONE; BETAMETHASONE; CLOXAZOLAM; DIAZEPAM; ETACRYNIC ACID; FLUFENAMIC ACID; GLYCYRRHETINIC ACID; HEXESTROL; INDOMETACIN; LITHOCHOLIC ACID; MEDAZEPAM; MEDROXYPROGESTERONE ACETATE; NEUROSTEROID; OXIDOREDUCTASE INHIBITOR; PHENOLPHTHALEIN; PROGESTERONE; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

CATALYSIS; CATALYST; CELL STRAIN HEPG2; CONFERENCE PAPER; CONTROLLED STUDY; DRUG INHIBITION; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOMERISM; KINETICS; OXIDATION REDUCTION REACTION; PRECURSOR; REDUCTION;

20-HYDROXYSTEROID DEHYDROGENASES; BENZBROMARONE; BINDING SITES; ENZYME INHIBITORS; HUMANS; PHENOLPHTHALEINS; PROGESTERONE;

ANIMALIA;

EID: 0037324845     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(02)00206-5     Document Type: Conference Paper

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