Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

Breast Cancer Research and Treatment

Volumn 132, Issue 1, 2012, Pages 175-187

  Agyeman, Abena S ^a   Chaerkady, Raghothama ^b,c   Shaw, Patrick G ^a   Davidson, Nancy E ^d,e   Visvanathan, Kala ^a   Pandey, Akhilesh ^b,c   Kensler, Thomas W ^a,d,e  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Institute of Bioinformatics   (India)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Biomarker discovery; Keap1 Nrf2 pathway; Microarray; Prevention; SILAC; Sulforaphane

Indexed keywords

ALDO KETO REDUCTASE; GLUTATHIONE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA; SULFORAPHANE; UNCLASSIFIED DRUG;

AKR1B10 GENE; AKR1C1 GENE; AKR1C2 GENE; AKR1C3 GENE; ALDH3A1 GENE; AMINO ACID ANALYSIS; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARBOHYDRATE METABOLISM; CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; DRUG TARGETING; EPITHELIUM CELL; GENE; GENE EXPRESSION PROFILING; GENETIC CORRELATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; ISOTOPE LABELING; KEAP1 GENE; MARKER GENE; MICROARRAY ANALYSIS; NQO1 GENE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEOMICS; TRANSCRIPTOMICS; UPREGULATION; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

ALCOHOL OXIDOREDUCTASES; ALDEHYDE DEHYDROGENASE; ANTICARCINOGENIC AGENTS; BREAST; CELL LINE; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NAD(P)H DEHYDROGENASE (QUINONE); OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOME; RNA INTERFERENCE; THIOCYANATES; TRANSCRIPTOME; UP-REGULATION;

EID: 84857918033     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1536-9     Document Type: Article

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