Function and interactions of integrins

Cell and Tissue Research

Volumn 305, Issue 3, 2001, Pages 285-298

  Van der Flier, Arjan ^a   Sonnenberg, Arnoud ^a  

^a NONE   (Netherlands)

Author keywords

Cell adhesion; Extracellular matrix; Focal adhesion; Integrin; Signaling

Indexed keywords

ALPHA4 INTEGRIN; ALPHA6 INTEGRIN; BETA1 INTEGRIN; BETA3 INTEGRIN; BETA4 INTEGRIN; CELL ADHESION MOLECULE; CYTOPLASM PROTEIN; INTEGRIN; INTEGRIN RECEPTOR; LIGAND; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN SUBUNIT;

APOPTOSIS; CANCER; CELL ADHESION; CELL ANCHORAGE; CELL MIGRATION; CELL PROLIFERATION; CYTOSKELETON; EXTRACELLULAR MATRIX; GENETIC DISORDER; HEMIDESMOSOME; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; RNA SPLICING; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

ANIMALS; CELL ADHESION; HUMANS; INTEGRINS; SIGNAL TRANSDUCTION;

EID: 0035724579     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410100417     Document Type: Review

References (198)

1. 5-subunit and inhibits cell migration
2. 1 functions as a sperm receptor
3. Cell adhesion molecules, signal transduction and cell growth
4. 6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
5. 1 integrin subunit
6. Genomic organization of the mouse β1 gene: Conservation of the β1D but not of the β1B and β1C integrin splice variants
7. Knockout and knockin of the β1 exon D define distinct roles for integrin splice variants in heart function and embryonic development
8. β1D integrin inhibits cell cycle progression in normal myoblasts and fibroblasts
9. β1D integrin displaces the β1A isoform in striated muscles: Localization at junctional structures and signaling potential in nonmuscle cells
10. Muscle β1D integrin reinforces the cytoskeleton-matrix link: Modulation of integrin adhesive function by alternative splicing
11. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that α3β1 complexes with EMMPRIN/basigin/OX47/M6
12. Role of endoproteolytic processing in the adhesive and signaling functions of αVβ5 integrin
13. Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity
14. Requirement of integrin β3 tyrosine 747 for β3 tyrosine phosphorylation and regulation of αVβ3 avidity
15. A molecular mechanism of integrin crosstalk: αVβ3 suppression of calcium/calmodulin-dependent protein kinase II regulates α5β1 function
16. PDGF-receptor-β and EGF-receptor-2 bind to the β3 integrin through its extracellular domain
17. Structure and function of hemidesmosomes: More than simple adhesion complexes
18. Extracellular matrix signaling: Integration of form and function in normal and malignant cells
19. Genetic analysis of β1 integrin function: Confirmed, new and revised roles for a crucial family of cell adhesion molecules
20. Melusin is a new muscle-specific interactor for β1 integrin cytoplasmic domain
21. Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs
22. Circulating integrins: α5β1, α6β4 and Mac-1, but not α3β1, α4β1 or LFA-1
23. Integrin-associated protein: A 50-kD plasma membrane antigen physically and functionally associated with integrins
24. Invertebrate integrins: Structure, function, and evolution
25. Focal adhesion assembly
26. The talin head domain binds to integrin β-subunit cytoplasmic tails and regulates integrin activation
27. Urokinase receptor interacts with αVβ5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer
28. ICAP-1, a novel β1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of β1 integrin
29. Association of β1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells
30. Secondary reduction of α7B integrin in laminin α2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle
31. Inducible interaction of integrin αE2β1 with calreticulin - Dependence on the activation state of the integrin
32. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
33. Syndecan-4 and integrins: Combinatorial signaling in cell adhesion
34. Identification of SHC as the primary protein binding to the tyrosine phosphorylated β3-subunit of αlIbβ3 during outside-in integrin platelet signaling
35. Functional partitioning of β1 integrins revealed by activating and inhibitory mAbs
36. Integrins: Regulators of embryogenesis
37. Integrins and signal transduction
38. Integrin-linked kinase (ILK): A regulator of integrin and growth-factor signalling
39. Expression and function of the cytoplasmic variants of the integin α6-subunit in transfected K562 cells. Activation-dependent adhesion and interaction with isoforms of laminin
40. An alternatively spliced exon in the extracellular domain of the human α6 integrin subunit: Functional analysis of the α6 integrin variants
41. Cleavage of the α6A subunit is essential for activation of the α6Aβ1 integrin by phorbol 12-myristate 13-acetate
42. The dynamic regulation of integrin adhesiveness
43. Integrin-mediated muscle cell spreading. The role of protein kinase C in outside-in and inside-out signaling and evidence of integrin cross-talk
44. A new alternative transcript encodes a 60 kDa truncated form of integrin α3
45. CD36 is spatially associated with glycoprotein IIb-IIIa (αIIbβ3) on the surface of resting platelets
46. Calpain cleavage of the cytoplasmic domain of the integrin α3-subunit
47. A conserved sequence motif in the integrin β3 cytoplasmic domain is required for its specific interaction with β3-endonexin
48. Sperm disintegrins, egg integrins, and other cell adhesion molecules of mammalian gamete plasma membrane interactions
49. α6β4 and α6β1 integrins associate with ErbB-2 in human carcinoma cell lines
50. Perturbation of β1-integrin function alters the development of murine mammary gland
51. 4-subunit bind to ERBIN
52. Complementation of dominant suppression implicates CD98 in integrin activation
53. Differential role of β1C and β1A integrin cytoplasmic variants in modulating focal adhesion kinase, protein kinase B/AKT, and Ras/Mitogen-activated protein kinase pathways
54. Cooperative signaling between α6β4 integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion
55. Binding of integrin α6β4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding
56. Cytohesin-1 regulates β2 integrin-mediated adhesion through ARF-GEF function and interaction with LFA-1
57. Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice
58. Essential role of α6 integrins in cortical and retinal lamination
59. Integrin signaling: Specificity and control of cell survival and cell cycle progression
60. Cre-loxP-mediated inactivation of the α6A integrin splice variant in vivo: Evidence for a specific functional role of α6A in lymphocyte migration but not in heart development
61. Induction of cell scattering by expression of β1 integrins in β1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function
62. Splice variants of the Drosophila PS2 integrins differentially interact with RGD-containing fragments of the extra-cellular proteins tiggrin, ten-m, and D-laminin 2
63. Rho GTPases and the actin cytoskeleton
64. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase
65. Mutations in the integrin α7 gene cause congenital myopathy
66. Integrin associated proteins
67. Altered expression of the α7β1 integrin in human and murine muscular dystrophies
68. Novel roles for α3β1 integrin as a regulator of cyto-skeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes
69. Biochemical characterization and tissue distribution of the A and B variants of the integrin α6-subunit
70. Genetic analysis of integrin function in man: LAD-1 and other syndromes
71. The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome
72. Interaction of BP180 (type XVII collagen) and α6 integrin is necessary for stabilization of hemidesmosome structure
73. Integrin affinity modulation
74. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling
75. Integrin structure
76. Targeted mutations in cell adhesion genes: What have we learned from them?
77. Cell adhesion: Old and new questions
78. Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons
79. The evolution of cell adhesion
80. Expression of GIRK (Kir3.1/Kir3.4) channels in mouse fibroblast cells with and without β1 integrins
81. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
82. Tyrosine phosphorylation of the β3 cytoplasmic domain mediates integrin-cytoskeletal interactions
83. Adhesion molecules in cancer: The role of integrins
84. Effect of mutagenesis of GPIIb amino acid 273 on the expression and conformation of the platelet integrin GPIIb-IIIa
85. The gamete fusion process is defective in eggs of CD9-deficient mice
86. Integrin-ligand interactions: Scratching the surface
87. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
88. Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions
89. Cell adhesion molecules in the pathogenesis of and host defence against microbial infection
90. Serine 752 in the cytoplasmic domain of the β3 integrin subunit is not required for αVβ3 postreceptor signaling events
91. Threonine phosphorylation of the β3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding
92. αLβ2 Integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule
93. Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family
94. Cloning and characterization of a novel integrin β3-subunit
95. Cell migration: A physically integrated molecular process
96. Outside-in integrin signal transduction: αIIbβ3-(GPIIb-IIIa) tyrosine phosphorylation induced by platelet aggregation
97. 2+ and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils
98. The composition and dynamics of cell-substratum adhesions in locomoting fish keratocytes
99. Severely reduced female fertility in CD9-deficient mice
100. The integrin chains β1 and α6 associate with the chaperone calnexin prior to integrin assembly
101. Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin αsubunit binding protein
102. Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: Physical and functional association between Kv1.3 channels and β1 integrins
103. A novel muscle-specific β1 integrin binding protein (MIBP) that modulates myogenic differentiation
104. Rack1, a receptor for activated protein kinase C, interacts with integrin β-subunit
105. Cell anchorage permits efficient signal transduction between ras and its downstream kinases
106. Paxillin binding to a conserved sequence motif in the α4 integrin cytoplasmic domain
107. Binding of paxillin to α4 integrins modifies integrin-dependent biological responses
108. Integrin cytoplasmic domain-binding proteins
109. New insights into integrin-ligand interaction
110. Filamin binds to the cytoplasmic domain of the β1-integrin. Identification of amino acids responsible for this interaction
111. CD46 (membrane cofactor protein) associates with multiple β1 integrins and tetraspans
112. The tetraspanin superfamily: Molecular facilitators
113. Intracellular signals direct integrin localization to sites of function in embryonic muscles
114. Amino acid motifs required for isolated β cytoplasmic domains to regulate 'in trans' β1 integrin conformation and function in cell attachment
115. Absence of integrin α7 causes a novel form of muscular dystrophy
116. Evidence for a functional interaction between integrins and G protein-activated inward rectifier K+ channels
117. Integrins: Alternative splicing as a mechanism to regulate ligand binding and integrin signaling events
118. Actin binds to the cytoplasmic tail of α1-subunit of integrin in hepatocytes
119. Mutational analysis of cell cycle inhibition by integrin β1C
120. Requirement of CD9 on the egg plasma membrane for fertilization
121. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
122. Cross talk between adhesion molecules: Control of N- cadherin activity by intracellular signals elicited by β1 and β3 integrins in migrating neural crest cells
123. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival
124. Phosphoinositide 3-OH kinase activates the β2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1
125. Identification of a novel calcium-binding protein that interacts with the integrin αIIb cytoplasmic domain
126. Deficiency of the integrin β4-subunit in junctional epidermolysis bullosa with pyloric atresia: Consequences for hemidesmosome formation and adhesion properties
127. Biology and function of hemidesmosomes
128. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways
129. Mapping of the α-actinin binding site within the β1 integrin cytoplasmic domain
130. Physical and biochemical regulation of integrin release during rear detachment of migrating cells
131. Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement
132. Identification of a talin-binding site in the integrin β3-subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin N-terminal head domain interacts with the membrane-proximal region of the β3 cytoplasmic tail
133. Integrins as promiscuous signal trans-duction devices
134. Integrin-β cytoplasmic domains differentially bind to cytoskeletal proteins
135. Ligand binding to integrins
136. Integrins take partners: Cross-talk between integrins and other membrane receptors
137. Activation of Rac and Cdc42 by integrins mediates cell spreading
138. The ADAM gene family: Surface proteins with adhesion and protease activity
139. Identification of an interaction between the M-band protein skelemin and β-integrin subunits. Colocalization of a skelemin-like protein with β1- and β3-integrins in nonmuscle cells
140. The small GTPase, Rap1, mediate CD31-induced integrin adhesion
141. Dynamics of β1 integrin-mediated adhesive contacts in motile fibroblasts
142. Activation of the MAP kinase pathway by growth factors requires integrin-mediated cell adhesion
143. β1-Integrin cytoplasmic subdomains involved in dominant negative function
144. Linking integrin α6β4-based cell adhesion to the intermediate filament cytoskeleton: Direct interaction between the β4-subunit and plectin at multiple molecular sites
145. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of β7-integrins
146. Integrating the MAP kinase signal into the G1 phase cell cycle machinery
147. A homozygous mutation in the integrin α6 gene in junctional epidermolysis bullosa with pyloric atresia
148. Protein complexes involving αVβ3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells
149. Cytoskeletal interactions with the leukocyte integrin β2 cytoplasmic tail. Activation-dependent regulation of associations with talin and α-actinin
150. The β4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly
151. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers
152. Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domains
153. Integrin signalling and tyrosine phosphorylation: Just the FAKs?
154. αVβ3 integrins associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF
155. The role of extracellular and cytoplasmic splice domains of α7-integrin in cell adhesion and migration on laminins
156. Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin αIIbβ3 (platelet glyco-protein IIb/IIIa) and the cellular retraction of fibrin clots
157. Interactions between mitogenic stimuli, or, a thousand and one connections
158. β3-Endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin β3-subunit
159. Regulation of cellular interactions with laminin by integrin cytoplasmic domains: The A and B structural variants of the α6β1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages
160. Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion
161. Calcium-dependent properties of CIB binding to the integrin αIIb cytoplasmic domain and translocation to the platelet cytoskeleton
162. β1-Integrin binds the 16-kDa subunit of vacuolar H+-ATPase at a site important for human papillomavirus E5 and platelet-derived growth factor signaling
163. Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
164. Identification of β1C-2, a novel variant of the integrin β1-subunit generated by utilization of an alternative splice acceptor site in exon C
165. Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel β5 integrin-modulating, PKC τ-dependent protein
166. The integrins α3β1 and α6β1 physically and functionally associate with CD36 in human melanoma cells: Requirement for the extracellular domain of CD36
167. Macromolecular organization of basement membranes
168. The muscle-specific laminin receptor α7β1 integrin negatively regulates α5β1 fibronectin receptor function
169. Integrins α7β1 in muscle function and survival: Disrupted expression in merosin-deficient congenital muscular dystrophy
170. Divalent cations differentially regulate integrin αIIb cytoplasmic tail binding to β3 and to calcium- and integrin-binding protein
171. The cyto-skeletal association of CD11/CD18 leukocyte integrins in phorbol ester-activated cells correlates with CD18 phosphorylation
172. Integrins and cancer
173. The sequence of the human genome
174. Integrin β4 mutations associated with junctional epidermolysis bullosa with pyloric atresia
175. NPXY motifs control the recruitment of the α5β1 integrin in focal adhesions independently of the association of talin with the β1 chain
176. The Pl(A2) polymorphism of integrin β3 enhances outside-in signaling and adhesive functions
177. A structural basis for integrin activation by the cytoplasmic tail of the αIIb-subunit
178. Cleavage of β4 integrin by matrilysin
179. Association of insulin receptor substrate-1 with integrins
180. The thrombospondin receptor CD47 (IAP) modulates and associates with α2β1 integrin in vascular smooth muscle cells
181. α3β1-Integrin regulates epithelial cytoskeletal organization
182. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
183. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
184. Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the α6 integrin subunit
185. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
186. Identification of novel interaction partners for the conserved membrane proximal region of α-integrin cytoplasmic domains
187. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several α and β integrin chains and is recruited to adhesion complexes
188. Urokinase-type plasminogen activator receptors associate with β1 and β3 integrins of fibrosarcoma cells: Dependence on extracellular matrix components
189. Molecular interactions in cell adhesion complexes
190. Integrin transmembrane signaling and cytoskeletal control
191. Mutation of the cytoplasmic domain of the integrin β3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis
192. Integrin α3β1-dependent EGF receptor activation at cell-cell contact sites
193. Molecular diversity of cell-matrix adhesions
194. Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts
195. Class- and splice variant-specific association of CD98 with integrin-β cytoplasmic domains
196. Interaction of the integrin β1 cytoplasmic domain with ICAP-1 protein
197. Integrin activation by R-ras
198. The laminin-binding activity of the α7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain