-
1
-
-
33847667443
-
Crohn's disease in patients who fail infliximab therapy: what does the future hold?
-
Abreu, M.T. ( 2007) Crohn's disease in patients who fail infliximab therapy: what does the future hold? Rev Gastroenterol Disord 7(Suppl): S20-S26.
-
(2007)
Rev Gastroenterol Disord
, vol.7
, Issue.Suppl
, pp. S20-S26
-
-
Abreu, M.T.1
-
2
-
-
44849128021
-
Role of β7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease
-
Apostolaki, M., Manoloukos, M., Roulis, M., Wurbel, M.A., Müller, W., Papadakis, K.A. et al. (2008) Role of β7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology 134: 2025-2035.
-
(2008)
Gastroenterology
, vol.134
, pp. 2025-2035
-
-
Apostolaki, M.1
Manoloukos, M.2
Roulis, M.3
Wurbel, M.A.4
Müller, W.5
Papadakis, K.A.6
-
3
-
-
0032923705
-
Tumor necrosis factor α antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
-
Baert, F.J., D'Haens, G.R., Peeters, M., Hiele, M.I., Schaible, T.F., Shealy, D. et al. (1999) Tumor necrosis factor α antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 116: 22-28.
-
(1999)
Gastroenterology
, vol.116
, pp. 22-28
-
-
Baert, F.J.1
D'Haens, G.R.2
Peeters, M.3
Hiele, M.I.4
Schaible, T.F.5
Shealy, D.6
-
4
-
-
34248136828
-
Inflammatory bowel disease: cause and immunobiology
-
Baumgart, D.C. and Carding, S.R. ( 2007) Inflammatory bowel disease: cause and immunobiology. Lancet 369: 1627-1640.
-
(2007)
Lancet
, vol.369
, pp. 1627-1640
-
-
Baumgart, D.C.1
Carding, S.R.2
-
5
-
-
0031802697
-
Osteopontin is a ligand for the α4β1 integrin
-
Bayless, K.J., Meininger, G.A., Scholtz, J.M. and Davis, G.E. ( 1998) Osteopontin is a ligand for the α4β1 integrin. J Cell Sci 111: 1165-1174.
-
(1998)
J Cell Sci
, vol.111
, pp. 1165-1174
-
-
Bayless, K.J.1
Meininger, G.A.2
Scholtz, J.M.3
Davis, G.E.4
-
6
-
-
4243620128
-
The use of pharmacokinetic (PK) modeling and efficacy data to establish optimal dosing of natalizumab (AntegrenTM)
-
(abstract).
-
Bennett, D., Ludden, T., Shah, J., Floren, L. and Beckman, E. ( 2002) The use of pharmacokinetic (PK) modeling and efficacy data to establish optimal dosing of natalizumab (AntegrenTM). Mult Scler 8: P130 (abstract).
-
(2002)
Mult Scler
, vol.8
, pp. P130
-
-
Bennett, D.1
Ludden, T.2
Shah, J.3
Floren, L.4
Beckman, E.5
-
7
-
-
0028984949
-
α4 integrins mediate lymphocyte attachment and rolling under physiologic flow
-
Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R. et al. (1995) α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80: 413-422.
-
(1995)
Cell
, vol.80
, pp. 413-422
-
-
Berlin, C.1
Bargatze, R.F.2
Campbell, J.J.3
von Andrian, U.H.4
Szabo, M.C.5
Hasslen, S.R.6
-
8
-
-
26444529476
-
Course of disease, drug treatment and health-related quality of life in patients with inflammatory bowel disease 5 years after initial diagnosis
-
Bernklev, T., Jahnsen, J., Schulz, T., Sauar, J., Lygren, I., Henriksen, M. et al. (2005) Course of disease, drug treatment and health-related quality of life in patients with inflammatory bowel disease 5 years after initial diagnosis. Eur J Gastroenterol Hepatol 17: 1037-1045.
-
(2005)
Eur J Gastroenterol Hepatol
, vol.17
, pp. 1037-1045
-
-
Bernklev, T.1
Jahnsen, J.2
Schulz, T.3
Sauar, J.4
Lygren, I.5
Henriksen, M.6
-
10
-
-
0027407109
-
Endothelial-leukocyte adhesion molecules
-
Bevilacqua, M.P. ( 1993) Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 11: 767-804.
-
(1993)
Annu Rev Immunol
, vol.11
, pp. 767-804
-
-
Bevilacqua, M.P.1
-
12
-
-
0036479289
-
The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin α4β1
-
Bridges, L.C., Tani, P.H., Hanson, K.R., Roberts, C.M., Judkins, M.B. and Bowditch, R.D. ( 2002) The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin α4β1. J Biol Chem 277: 3784-3792.
-
(2002)
J Biol Chem
, vol.277
, pp. 3784-3792
-
-
Bridges, L.C.1
Tani, P.H.2
Hanson, K.R.3
Roberts, C.M.4
Judkins, M.B.5
Bowditch, R.D.6
-
13
-
-
0030802049
-
Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue
-
Briskin, M., Winsor-Hines, D., Shyjan, A., Cochran, N., Bloom, S., Wilson, J. et al. (1997) Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Path 151: 97-110.
-
(1997)
Am J Path
, vol.151
, pp. 97-110
-
-
Briskin, M.1
Winsor-Hines, D.2
Shyjan, A.3
Cochran, N.4
Bloom, S.5
Wilson, J.6
-
14
-
-
0035214691
-
Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice
-
Burns, R.C., Rivera-Nieves, J., Moskaluk, C.A., Matsumoto, S., Cominelli, F. and Ley, K. ( 2001) Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice. Gastroenterology 121: 1428-1436.
-
(2001)
Gastroenterology
, vol.121
, pp. 1428-1436
-
-
Burns, R.C.1
Rivera-Nieves, J.2
Moskaluk, C.A.3
Matsumoto, S.4
Cominelli, F.5
Ley, K.6
-
15
-
-
0032536046
-
Chemokines and the arrest of lymphocytes rolling under flow conditions
-
Campbell, J.J., Hedrick, J., Zlotnik, A., Siani, M.A., Thompson, D.A. and Butcher, E.C. ( 1998) Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279: 381-384.
-
(1998)
Science
, vol.279
, pp. 381-384
-
-
Campbell, J.J.1
Hedrick, J.2
Zlotnik, A.3
Siani, M.A.4
Thompson, D.A.5
Butcher, E.C.6
-
16
-
-
0029954523
-
Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells
-
Campbell, J.J., Qin, S., Bacon, K.B., Mackay, C.R. and Butcher, E.C. ( 1996) Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells. J Cell Biol 134: 255-266.
-
(1996)
J Cell Biol
, vol.134
, pp. 255-266
-
-
Campbell, J.J.1
Qin, S.2
Bacon, K.B.3
Mackay, C.R.4
Butcher, E.C.5
-
17
-
-
44349124113
-
The genetics and immunopathogenesis of inflammatory bowel disease
-
Cho, J.H. ( 2008) The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 8: 458-466.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 458-466
-
-
Cho, J.H.1
-
18
-
-
34447102570
-
American Gastroenterological Association Consensus Development Conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006
-
Clark, M., Colombel, J.-F., Feagan, B.C., Fedorak, R.N., Hanauer, S.B., Kamm, M.A. et al. (2007) American Gastroenterological Association Consensus Development Conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006. Gastroenterology 133: 312-339.
-
(2007)
Gastroenterology
, vol.133
, pp. 312-339
-
-
Clark, M.1
Colombel, J.-F.2
Feagan, B.C.3
Fedorak, R.N.4
Hanauer, S.B.5
Kamm, M.A.6
-
19
-
-
77950988234
-
Infliximab, azathioprine, or combination therapy for Crohn s disease
-
Colombel, J.F., Sandborn, W.J., Reinisch, W., Mantzaris, G.J., Kornbluth, A., Rachmilewitz, D. et al. (2010) Infliximab, azathioprine, or combination therapy for Crohn s disease. N Engl J Med. 362: 1383-1395.
-
(2010)
N Engl J Med
, vol.362
, pp. 1383-1395
-
-
Colombel, J.F.1
Sandborn, W.J.2
Reinisch, W.3
Mantzaris, G.J.4
Kornbluth, A.5
Rachmilewitz, D.6
-
20
-
-
33846242958
-
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial
-
Colombel, J.F., Sandborn, W.J., Rutgeerts, P., Enns, R., Hanauer, S.B., Panaccione, R. et al. (2007) Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 132: 52-65.
-
(2007)
Gastroenterology
, vol.132
, pp. 52-65
-
-
Colombel, J.F.1
Sandborn, W.J.2
Rutgeerts, P.3
Enns, R.4
Hanauer, S.B.5
Panaccione, R.6
-
22
-
-
12344291265
-
Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
-
Cosnes, J., Nion-Larmurier, I., Beaugerie, L., Afchain, P., Tiret, E. and Gendre, J.P. ( 2005) Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 54: 237-241.
-
(2005)
Gut
, vol.54
, pp. 237-241
-
-
Cosnes, J.1
Nion-Larmurier, I.2
Beaugerie, L.3
Afchain, P.4
Tiret, E.5
Gendre, J.P.6
-
23
-
-
54349115416
-
Lymphocyte homing and its role in the pathogenesis of IBD
-
Eksteen, B., Liaskou, E. and Adams, D.H. ( 2008) Lymphocyte homing and its role in the pathogenesis of IBD. Inflamm Bowel Dis 14: 1298-1312.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 1298-1312
-
-
Eksteen, B.1
Liaskou, E.2
Adams, D.H.3
-
24
-
-
84993794924
-
Elan Pharmaceuticals and Biogen Idec
-
South San Francisco, CA: Elan Pharmaceuticals, Inc. and Cambridge, MA: Biogen Idec Inc
-
Elan Pharmaceuticals and Biogen Idec (2010 ) TYSABRI® (natalizumab) prescribing information. South San Francisco, CA: Elan Pharmaceuticals, Inc., and Cambridge, MA: Biogen Idec Inc.
-
(2010)
TYSABRI® (natalizumab) prescribing information
-
-
-
25
-
-
29244458849
-
Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis
-
Farkas, S., Hornung, M., Sattler, C., Edtinger, K., Steinbauer, M., Anthuber, M. et al. (2006) Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis. Int J Colorectal Dis 21: 71-78.
-
(2006)
Int J Colorectal Dis
, vol.21
, pp. 71-78
-
-
Farkas, S.1
Hornung, M.2
Sattler, C.3
Edtinger, K.4
Steinbauer, M.5
Anthuber, M.6
-
26
-
-
0000788815
-
An ascending dose trial of a humanized α4β7 antibody in ulcerative colitis (UC)
-
(abstract).
-
Feagan, B., McDonald, J.W.D. and Greenberg, G. ( 2000) An ascending dose trial of a humanized α4β7 antibody in ulcerative colitis (UC). Gastroenterology 118: A874 (abstract).
-
(2000)
Gastroenterology
, vol.118
, pp. A874
-
-
Feagan, B.1
McDonald, J.W.D.2
Greenberg, G.3
-
27
-
-
57249089077
-
Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin
-
Feagan, B.G., Greenberg, G.R., Wild, G., Fedorak, R.N., Paré, P., McDonald, J.W. et al. (2008) Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 6: 1370-1377.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 1370-1377
-
-
Feagan, B.G.1
Greenberg, G.R.2
Wild, G.3
Fedorak, R.N.4
Paré, P.5
McDonald, J.W.6
-
28
-
-
20444469332
-
Treatment of ulcerative colitis with a humanized antibody to the α4β7 integrin
-
Feagan, B.G., Greenberg, G.R., Wild, G., Fedorak, R.N., Paré, P., McDonald, J.W. et al. (2005) Treatment of ulcerative colitis with a humanized antibody to the α4β7 integrin. N Engl J Med 352: 2499-2507.
-
(2005)
N Engl J Med
, vol.352
, pp. 2499-2507
-
-
Feagan, B.G.1
Greenberg, G.R.2
Wild, G.3
Fedorak, R.N.4
Paré, P.5
McDonald, J.W.6
-
29
-
-
36549074568
-
Health-related quality of life during natalizumab maintenance therapy for Crohn's disease
-
Feagan, B.G., Sandborn, W.J., Hass, S., Niecko, T. and White, J. ( 2007) Health-related quality of life during natalizumab maintenance therapy for Crohn's disease. Am J Gastroenterol 102: 2737-2746.
-
(2007)
Am J Gastroenterol
, vol.102
, pp. 2737-2746
-
-
Feagan, B.G.1
Sandborn, W.J.2
Hass, S.3
Niecko, T.4
White, J.5
-
30
-
-
37148999955
-
Natalizumab maintains corticosteroid-free remission for 2 years in patients with moderately to severely active Crohn's disease and in those with prior infliximab exposure: results from an open-label extension study
-
(Suppl
-
Ghosh, S. and Panaccione, R. ( 2007) Natalizumab maintains corticosteroid-free remission for 2 years in patients with moderately to severely active Crohn's disease and in those with prior infliximab exposure: results from an open-label extension study. Gut 56(Suppl 2): A22.
-
(2007)
Gut
, vol.56
, Issue.2
, pp. A22
-
-
Ghosh, S.1
Panaccione, R.2
-
31
-
-
0037413468
-
Natalizumab Pan-European Study Group. Natalizumab for active Crohn's disease
-
Ghosh, S., Goldin, E., Gordon, F.H., Malchow, H.A., Rask-Madsen, J., Rutgeerts, P. et al. (2003) Natalizumab Pan-European Study Group. Natalizumab for active Crohn's disease. N Engl J Med 348: 24-32.
-
(2003)
N Engl J Med
, vol.348
, pp. 24-32
-
-
Ghosh, S.1
Goldin, E.2
Gordon, F.H.3
Malchow, H.A.4
Rask-Madsen, J.5
Rutgeerts, P.6
-
32
-
-
33744798761
-
Synthesis and biological evaluation of novel pyridazinone-based α4 integrin receptor antagonists
-
Gong, Y., Barbay, J.K., Dyatkin, A.B., Miskowski, T.A., Kimball, E.S., Prouty, S.M. et al. (2006) Synthesis and biological evaluation of novel pyridazinone-based α4 integrin receptor antagonists. J Med Chem 49: 3402-3411.
-
(2006)
J Med Chem
, vol.49
, pp. 3402-3411
-
-
Gong, Y.1
Barbay, J.K.2
Dyatkin, A.B.3
Miskowski, T.A.4
Kimball, E.S.5
Prouty, S.M.6
-
33
-
-
0034903450
-
A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active Crohn's disease
-
Gordon, F.H., Lai, C.W.Y., Hamilton, M.I., Allison, M.C., Srivastava, E.D., Fouweather, M.G. et al. (2001) A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active Crohn's disease. Gastroenterology 121: 268-274.
-
(2001)
Gastroenterology
, vol.121
, pp. 268-274
-
-
Gordon, F.H.1
Lai, C.W.Y.2
Hamilton, M.I.3
Allison, M.C.4
Srivastava, E.D.5
Fouweather, M.G.6
-
34
-
-
33747396900
-
Antisense therapy of MAdCAM-1 for trinitrobenzenesulfonic acid-induced murine colitis
-
Goto, A., Arimura, Y., Shinomura, Y., Imai, K. and Hinoda, Y. ( 2006) Antisense therapy of MAdCAM-1 for trinitrobenzenesulfonic acid-induced murine colitis. Inflamm Bowel Dis 12: 758-765.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 758-765
-
-
Goto, A.1
Arimura, Y.2
Shinomura, Y.3
Imai, K.4
Hinoda, Y.5
-
35
-
-
0032793928
-
Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1))
-
Hamamoto, N., Maemura, K., Hirata, I., Murano, M., Sasaki, S. and Katsu, K. ( 1999) Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1)). Clin Exp Immunol 117: 462-468.
-
(1999)
Clin Exp Immunol
, vol.117
, pp. 462-468
-
-
Hamamoto, N.1
Maemura, K.2
Hirata, I.3
Murano, M.4
Sasaki, S.5
Katsu, K.6
-
36
-
-
0028181865
-
Role of α4-integrins in lymphocyte homing to mucosal tissues in vivo
-
Hamann, A., Andrew, D.P., Jablonski-Westrich, D., Holzmann, B. and Butcher, E.C. ( 1994) Role of α4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 152: 3282-3293.
-
(1994)
J Immunol
, vol.152
, pp. 3282-3293
-
-
Hamann, A.1
Andrew, D.P.2
Jablonski-Westrich, D.3
Holzmann, B.4
Butcher, E.C.5
-
37
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
-
Hanauer, S.B., Feagan, B.G., Lichtenstein, G.R., Mayer, L.F., Schreiber, S., Colombel, J.F. et al. (2002) Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 359: 1541-1549.
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
Mayer, L.F.4
Schreiber, S.5
Colombel, J.F.6
-
38
-
-
32044451548
-
Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial
-
Hanauer, S.B., Sandborn, W.J., Rutgeerts, P., Fedorak, R.N., Lukas, M., MacIntosh, D. et al. (2006) Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 130: 323-333.
-
(2006)
Gastroenterology
, vol.130
, pp. 323-333
-
-
Hanauer, S.B.1
Sandborn, W.J.2
Rutgeerts, P.3
Fedorak, R.N.4
Lukas, M.5
MacIntosh, D.6
-
39
-
-
0025195762
-
Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions
-
Hemler, M.E., Elices, M.J., Parker, C. and Takada, Y. ( 1990) Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions. Immunol Rev 114: 45-65.
-
(1990)
Immunol Rev
, vol.114
, pp. 45-65
-
-
Hemler, M.E.1
Elices, M.J.2
Parker, C.3
Takada, Y.4
-
40
-
-
0029826678
-
Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin α4β7
-
Hesterberg, P.E., Winsor-Hines, D., Briskin, M.J., Soler-Ferran, D., Merrill, C., Mackay, C.R. et al. (1996) Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin α4β7. Gastroenterology 111: 1373-1380.
-
(1996)
Gastroenterology
, vol.111
, pp. 1373-1380
-
-
Hesterberg, P.E.1
Winsor-Hines, D.2
Briskin, M.J.3
Soler-Ferran, D.4
Merrill, C.5
Mackay, C.R.6
-
41
-
-
0029914865
-
Activation of T lymphocytes by synergeneic murine intestinal smooth muscle cells
-
Hogaboam, C.M., Snider, D.P. and Collins, S.M. ( 1996) Activation of T lymphocytes by synergeneic murine intestinal smooth muscle cells. Gastroenterology 110: 1456-1466.
-
(1996)
Gastroenterology
, vol.110
, pp. 1456-1466
-
-
Hogaboam, C.M.1
Snider, D.P.2
Collins, S.M.3
-
42
-
-
33846634683
-
Natalizumab therapy for moderate to severe Crohn disease in adolescents
-
for the International Natalizumab CD: 305 Trial Group
-
Hyams, J.S., Wilson, D.C., Thomas, A., Heuschkel, R., Mitton, S., Mitchell, B. et al. for the International Natalizumab CD 305 Trial Group (2007) Natalizumab therapy for moderate to severe Crohn disease in adolescents. J Pediatr Gastroenterol Nutr 44: 185-191.
-
(2007)
J Pediatr Gastroenterol Nutr
, vol.44
, pp. 185-191
-
-
Hyams, J.S.1
Wilson, D.C.2
Thomas, A.3
Heuschkel, R.4
Mitton, S.5
Mitchell, B.6
-
43
-
-
0026770377
-
Integrins: versatility, modulation, and signaling in cell adhesion
-
Hynes, R.O. ( 1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25.
-
(1992)
Cell
, vol.69
, pp. 11-25
-
-
Hynes, R.O.1
-
44
-
-
0030813151
-
Quality of life issues in patients with inflammatory bowel disease
-
Irvine, E.J. ( 1997) Quality of life issues in patients with inflammatory bowel disease. Am J Gastroenterol 92: 18S-24S.
-
(1997)
Am J Gastroenterol
, vol.92
, pp. 18S-24S
-
-
Irvine, E.J.1
-
45
-
-
34548490280
-
Crohn's disease patients’ risk-benefit preferences: serious adverse event risks versus treatment efficacy
-
Johnson, F.R., Ozdemir, S., Mansfield, C., Hass, S., Miller, D.W., Siegel, C.A. et al. (2007) Crohn's disease patients’ risk-benefit preferences: serious adverse event risks versus treatment efficacy. Gastroenterology 133: 769-779.
-
(2007)
Gastroenterology
, vol.133
, pp. 769-779
-
-
Johnson, F.R.1
Ozdemir, S.2
Mansfield, C.3
Hass, S.4
Miller, D.W.5
Siegel, C.A.6
-
46
-
-
0033815802
-
Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1
-
Kato, S., Hokari, R., Matsuzaki, K., Iwai, A., Kawaguchi, A., Nagao, S. et al. (2000) Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1. J Pharmacol Exp Ther 295: 183-189.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 183-189
-
-
Kato, S.1
Hokari, R.2
Matsuzaki, K.3
Iwai, A.4
Kawaguchi, A.5
Nagao, S.6
-
47
-
-
61549130275
-
Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function
-
Khatri, B.O., Man, S., Giovannoni, J.C., Koo, A.P., Lee, J.C., Tucky, B. et al. (2009) Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function. Neurology 72: 402-409.
-
(2009)
Neurology
, vol.72
, pp. 402-409
-
-
Khatri, B.O.1
Man, S.2
Giovannoni, J.C.3
Koo, A.P.4
Lee, J.C.5
Tucky, B.6
-
48
-
-
0028987311
-
A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis
-
Kent, S.J., Karlik, S.J., Cannon, C., Hines, D.K., Yednock, T.A., Fritz, L.C. et al. (1995) A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis. J Neuroimmunol 58: 1-10.
-
(1995)
J Neuroimmunol
, vol.58
, pp. 1-10
-
-
Kent, S.J.1
Karlik, S.J.2
Cannon, C.3
Hines, D.K.4
Yednock, T.A.5
Fritz, L.C.6
-
49
-
-
0037378405
-
Comparison of cell culture-grown JC virus (primary human fetal glial cells and the JCI cell line) and recombinant JCV VP 1 as antigen for the detection of anti-JCV antibody by haemagglutination inhibition
-
Knowles, W.A. and Sasnauskas, K. ( 2003) Comparison of cell culture-grown JC virus (primary human fetal glial cells and the JCI cell line) and recombinant JCV VP 1 as antigen for the detection of anti-JCV antibody by haemagglutination inhibition. J Virol Methods 109: 47-54.
-
(2003)
J Virol Methods
, vol.109
, pp. 47-54
-
-
Knowles, W.A.1
Sasnauskas, K.2
-
50
-
-
0141459365
-
Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40
-
Knowles, W.A., Pipkin, P., Andrews, N., Vyse, A., Minor, P., Brown, D.W. et al. (2003) Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol 71: 115-123.
-
(2003)
J Med Virol
, vol.71
, pp. 115-123
-
-
Knowles, W.A.1
Pipkin, P.2
Andrews, N.3
Vyse, A.4
Minor, P.5
Brown, D.W.6
-
51
-
-
0025854524
-
Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
-
Lawrence, M.B. and Springer, T.A. ( 1991) Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins. Cell 65: 859-873.
-
(1991)
Cell
, vol.65
, pp. 859-873
-
-
Lawrence, M.B.1
Springer, T.A.2
-
52
-
-
0030882355
-
Humanization of a mouse antibody against human α-4 integrin: a potential therapeutic for the treatment of multiple sclerosis
-
Leger, O.J.P., Yednock, T.A., Tanner, L., Horner, H.C., Hines, D.K., Keen, S. et al. (1997) Humanization of a mouse antibody against human α-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum Antibodies 8: 3-16.
-
(1997)
Hum Antibodies
, vol.8
, pp. 3-16
-
-
Leger, O.J.P.1
Yednock, T.A.2
Tanner, L.3
Horner, H.C.4
Hines, D.K.5
Keen, S.6
-
53
-
-
0031791231
-
MAdCAM-1 costimulates T cell proliferation exclusively through integrin α4β7, whereas VCAM-1 and CS-1 peptide use α4β1: Evidence for “remote” costimulation and induction of hyperresponsiveness to B 7 molecules
-
Lehnert, K., Print, C.G., Yang, Y. and Krissansen, G.W. ( 1998) MAdCAM-1 costimulates T cell proliferation exclusively through integrin α4β7, whereas VCAM-1 and CS-1 peptide use α4β1: Evidence for “remote” costimulation and induction of hyperresponsiveness to B 7 molecules. Eur J Immunol 28: 3605-3615.
-
(1998)
Eur J Immunol
, vol.28
, pp. 3605-3615
-
-
Lehnert, K.1
Print, C.G.2
Yang, Y.3
Krissansen, G.W.4
-
54
-
-
0037192934
-
Interactions of thrombospondins with α4β1 integrin and CD 47 differentially modulate T cell behavior
-
Li, Z., Calzada, M.J., Sipes, J.M., Cashel, J.A., Krutzsch, H.C., Annis, D.S. et al. (2002) Interactions of thrombospondins with α4β1 integrin and CD 47 differentially modulate T cell behavior. J Cell Biol 157: 509-519.
-
(2002)
J Cell Biol
, vol.157
, pp. 509-519
-
-
Li, Z.1
Calzada, M.J.2
Sipes, J.M.3
Cashel, J.A.4
Krutzsch, H.C.5
Annis, D.S.6
-
55
-
-
70149111495
-
Progressive multifocal leukoencephalopathy after natalizumab monotherapy
-
Linda, H., von Heijne, A., Major, E.O., Ryschkewitsch, C., Berg, J., Olsson, T. et al. (2009) Progressive multifocal leukoencephalopathy after natalizumab monotherapy. New Engl J Med 361: 1081-1087.
-
(2009)
New Engl J Med
, vol.361
, pp. 1081-1087
-
-
Linda, H.1
von Heijne, A.2
Major, E.O.3
Ryschkewitsch, C.4
Berg, J.5
Olsson, T.6
-
56
-
-
0028173015
-
The pathophysiologic role of α4 integrins in vivo
-
Lobb, R.R. and Hemler, M.E. ( 1994) The pathophysiologic role of α4 integrins in vivo. J Clin Invest 94: 1722-1728.
-
(1994)
J Clin Invest
, vol.94
, pp. 1722-1728
-
-
Lobb, R.R.1
Hemler, M.E.2
-
57
-
-
45849130521
-
CCL 25 and CCL 28 promote α4β7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow
-
Miles, A., Liaskou, E., Eksteen, B., Lalor, P.F. and Adams, D.H. ( 2008) CCL 25 and CCL 28 promote α4β7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Am J Physiol Gastrointest Liver Physiol 294: G1257-G1267.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.294
, pp. G1257-G1267
-
-
Miles, A.1
Liaskou, E.2
Eksteen, B.3
Lalor, P.F.4
Adams, D.H.5
-
60
-
-
33646237136
-
Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis
-
Miner Jr, P.B., Geary, R.S., Matson, J., Chuang, E., Xia, S., Baker, B.F. et al. (2006) Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis. Aliment Pharmacol Ther 23: 1427-1434.
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1427-1434
-
-
Miner, P.B.1
Geary, R.S.2
Matson, J.3
Chuang, E.4
Xia, S.5
Baker, B.F.6
-
62
-
-
77954189084
-
Natalizumab maintains remission for 2-years in patients with moderately to severely active Crohn's disease and in those with prior infliximab exposure: results from an open-label extension study
-
Panaccione, R., Colombel, J.F., Enns, R., Feagan, B.G., Hanauer, S., Lawrance, I. et al. (2006) Natalizumab maintains remission for 2-years in patients with moderately to severely active Crohn's disease and in those with prior infliximab exposure: results from an open-label extension study. Abstract presented at United European Gastroenterology Week (UEGW) 2006: OP-G-180.
-
(2006)
Abstract presented at United European Gastroenterology Week (UEGW)
, pp. OP-G-180
-
-
Panaccione, R.1
Colombel, J.F.2
Enns, R.3
Feagan, B.G.4
Hanauer, S.5
Lawrance, I.6
-
63
-
-
35349020929
-
Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis
-
Panés, J., Aceituno, M., Gil, F., Miquel, R., Piqué, J.M., Salas, A. et al. (2007) Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis. Am J Physiol Gastrointest Liver Physiol 293: G739-G748.
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.293
, pp. G739-G748
-
-
Panés, J.1
Aceituno, M.2
Gil, F.3
Miquel, R.4
Piqué, J.M.5
Salas, A.6
-
64
-
-
34848856081
-
Aberrant activation of integrin α4β7 suppresses lymphocyte migration to the gut
-
Park, E.J., Mora, J.R., Carman, C.V., Chen, J., Sasaki, Y., Cheng, G. et al. (2007) Aberrant activation of integrin α4β7 suppresses lymphocyte migration to the gut. J Clin Invest 117: 2526-2538.
-
(2007)
J Clin Invest
, vol.117
, pp. 2526-2538
-
-
Park, E.J.1
Mora, J.R.2
Carman, C.V.3
Chen, J.4
Sasaki, Y.5
Cheng, G.6
-
65
-
-
84993697559
-
Natalizumab use in patients with Crohn's disease and relapsing multiple sclerosis: updated utilization and safety results from the TOUCH TM prescribing program, the pregnancy registry, and the INFORM and TYRIS studies
-
Presented at: American College of Gastroenterology Annual Scientific Meeting and Postgraduate Course; 23-28 October 2009 San Diego CA: Abstract P724.
-
Pepio, A., Taylor, L., Koooijmans, M., Bozic, C., Quinn, G. ( 2009) Natalizumab use in patients with Crohn's disease and relapsing multiple sclerosis: updated utilization and safety results from the TOUCH TM prescribing program, the pregnancy registry, and the INFORM and TYRIS studies. Presented at: American College of Gastroenterology Annual Scientific Meeting and Postgraduate Course; 23-28 October 2009, San Diego CA. Abstract P724.
-
(2009)
-
-
Pepio, A.1
Taylor, L.2
Koooijmans, M.3
Bozic, C.4
Quinn, G.5
-
66
-
-
0027248939
-
Attenuation of colitis in the cotton-top tamarin by anti-α4 integrin monoclonal antibody
-
Podolsky, D.K., Lobb, R., King, N., Benjamin, C.D., Pepinsky, B., Sehgal, P. et al. (1993) Attenuation of colitis in the cotton-top tamarin by anti-α4 integrin monoclonal antibody. J Clin Invest 92: 372-380.
-
(1993)
J Clin Invest
, vol.92
, pp. 372-380
-
-
Podolsky, D.K.1
Lobb, R.2
King, N.3
Benjamin, C.D.4
Pepinsky, B.5
Sehgal, P.6
-
67
-
-
0027768713
-
The α4β1/VCAM-1 adhesion pathway in physiology and disease
-
Postigo, A.A., Teixidó, J. and Sánchez-Madrid, F. ( 1993) The α4β1/VCAM-1 adhesion pathway in physiology and disease. Res Immunol 144: 723-735.
-
(1993)
Res Immunol
, vol.144
, pp. 723-735
-
-
Postigo, A.A.1
Teixidó, J.2
Sánchez-Madrid, F.3
-
68
-
-
84993697551
-
Natalizumab induces sustained response and remission in Crohn's patients after previous infliximab failure: results from the ENCORE trial
-
Presented at: Digestive Disease Week; 19-24 May 2007 Washington, DC
-
Present, D., Feagan, B.G., Fedorak, R.N., Lashner, B., Panaccione, R., Rutgeerts, P. et al. (2007) Natalizumab induces sustained response and remission in Crohn's patients after previous infliximab failure: results from the ENCORE trial. Presented at: Digestive Disease Week; 19-24 May 2007, Washington, DC.
-
(2007)
-
-
Present, D.1
Feagan, B.G.2
Fedorak, R.N.3
Lashner, B.4
Panaccione, R.5
Rutgeerts, P.6
-
69
-
-
0036895062
-
Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS
-
Richardson-Burns, S.M., Kleinschmidt-de Masters, B.K., de Biasi, R.L. and Tyler, K.L. ( 2002) Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS. Arch Neurol 59: 1930-1936.
-
(2002)
Arch Neurol
, vol.59
, pp. 1930-1936
-
-
Richardson-Burns, S.M.1
Kleinschmidt-de Masters, B.K.2
de Biasi, R.L.3
Tyler, K.L.4
-
70
-
-
59849127969
-
Leukocyte adhesion molecules in animal models of inflammatory bowel disease
-
Rivera-Nieves, J., Gorfu, G. and Ley, K. ( 2008) Leukocyte adhesion molecules in animal models of inflammatory bowel disease. Inflamm Bowel Dis 14: 1715-1735.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 1715-1735
-
-
Rivera-Nieves, J.1
Gorfu, G.2
Ley, K.3
-
71
-
-
27644441529
-
Natalizumab induction and maintenance therapy for Crohn's disease
-
for the International Efficacy of Natalizumab as Active Crohn's Therapy (ENACT-1) Trial Group and the Evaluation of Natalizumab as Continuous Therapy (ENACT-2) Trial Group.
-
Sandborn, W.J., Colombel, J.F., Enns, R., Feagan, B.G., Hanauer, S.B., Lawrance, I.C. et al. for the International Efficacy of Natalizumab as Active Crohn's Therapy (ENACT-1) Trial Group and the Evaluation of Natalizumab as Continuous Therapy (ENACT-2) Trial Group. ( 2005) Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 353: 1912-1925.
-
(2005)
N Engl J Med
, vol.353
, pp. 1912-1925
-
-
Sandborn, W.J.1
Colombel, J.F.2
Enns, R.3
Feagan, B.G.4
Hanauer, S.B.5
Lawrance, I.C.6
-
72
-
-
34447523749
-
Certolizumab pegol for the treatment of Crohn's disease
-
Sandborn, W.J., Feagan, B.G., Stoinov, S., Honiball, P.J., Rutgeerts, P., Mason, D. et al. (2007 a) Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 357: 228-238.
-
(2007)
N Engl J Med
, vol.357
, pp. 228-238
-
-
Sandborn, W.J.1
Feagan, B.G.2
Stoinov, S.3
Honiball, P.J.4
Rutgeerts, P.5
Mason, D.6
-
73
-
-
34347402306
-
Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial
-
Sandborn, W.J., Rutgeerts, P., Enns, R., Hanauer, S.B., Colombel, J.F., Panaccione, R. et al. (2007 b) Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med 146: 829-838.
-
(2007)
Ann Intern Med
, vol.146
, pp. 829-838
-
-
Sandborn, W.J.1
Rutgeerts, P.2
Enns, R.3
Hanauer, S.B.4
Colombel, J.F.5
Panaccione, R.6
-
74
-
-
0344496250
-
Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin
-
Sandborn, W.J. and Yednock, T.A. ( 2003) Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin. Am J Gastroenterol 98: 2372-2382.
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 2372-2382
-
-
Sandborn, W.J.1
Yednock, T.A.2
-
75
-
-
33846184129
-
Safety and tolerability of concurrent natalizumab treatment for patients with Crohn's disease not in remission while receiving infliximab
-
Sands, B.E., Kozarek, R., Spainhour, J., Barish, C.F., Becker, S., Goldberg, L. et al. (2007) Safety and tolerability of concurrent natalizumab treatment for patients with Crohn's disease not in remission while receiving infliximab. Inflamm Bowel Dis 13: 2-11.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 2-11
-
-
Sands, B.E.1
Kozarek, R.2
Spainhour, J.3
Barish, C.F.4
Becker, S.5
Goldberg, L.6
-
76
-
-
0035045185
-
Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease
-
the German ICAM-1 Study Group.
-
Schreiber, S., Nikolaus, S., Malchow, H., Kruis, W., Lochs, H., Raedler, A. et al. (2001) and the German ICAM-1 Study Group. Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease. Gastroenterology 120: 1339-1346.
-
(2001)
Gastroenterology
, vol.120
, pp. 1339-1346
-
-
Schreiber, S.1
Nikolaus, S.2
Malchow, H.3
Kruis, W.4
Lochs, H.5
Raedler, A.6
-
77
-
-
0032867984
-
ISIS 2302, an antisense inhibitor of intercellular adhesion molecule 1
-
Shanahan Jr, W.R. ( 1999) ISIS 2302, an antisense inhibitor of intercellular adhesion molecule 1. Expert Opin Investig Drugs 8: 1417-1429.
-
(1999)
Expert Opin Investig Drugs
, vol.8
, pp. 1417-1429
-
-
Shanahan, W.R.1
-
78
-
-
0033783628
-
VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice
-
Soriano, A., Salas, A., Salas, A., Sans, M., Gironella, M., Elena, M. et al. (2000) VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice. Lab Invest 80: 1541-1551.
-
(2000)
Lab Invest
, vol.80
, pp. 1541-1551
-
-
Soriano, A.1
Salas, A.2
Salas, A.3
Sans, M.4
Gironella, M.5
Elena, M.6
-
79
-
-
0027982876
-
Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
-
Springer, T.A. ( 1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301-314.
-
(1994)
Cell
, vol.76
, pp. 301-314
-
-
Springer, T.A.1
-
80
-
-
1842507448
-
Blocking lymphotoxin-β receptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis
-
Stopfer, P., Obermeier, F., Dunger, N., Falk, W., Farkas, S., Janotta, M. et al. (2004) Blocking lymphotoxin-β receptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis. Clin Exp Immunol 136: 21-29.
-
(2004)
Clin Exp Immunol
, vol.136
, pp. 21-29
-
-
Stopfer, P.1
Obermeier, F.2
Dunger, N.3
Falk, W.4
Farkas, S.5
Janotta, M.6
-
81
-
-
0036218221
-
The immunology of mucosal models of inflammation
-
Strober, W., Fuss, I.J. and Blumberg, R.S. ( 2002) The immunology of mucosal models of inflammation. Annu Rev Immunol 20: 495-549
-
(2002)
Annu Rev Immunol
, vol.20
, pp. 495-549
-
-
Strober, W.1
Fuss, I.J.2
Blumberg, R.S.3
-
82
-
-
33846969181
-
Potential risk of progressive multifocal leukoencephalopathy with natalizumab therapy: possible interventions
-
Stüve, O., Marra, C.M., Cravens, P.D., Singh, M.P., Hu, W., Lovett-Racke, A. et al. (2007) Potential risk of progressive multifocal leukoencephalopathy with natalizumab therapy: possible interventions. Arch Neurol 64: 169-176.
-
(2007)
Arch Neurol
, vol.64
, pp. 169-176
-
-
Stüve, O.1
Marra, C.M.2
Cravens, P.D.3
Singh, M.P.4
Hu, W.5
Lovett-Racke, A.6
-
83
-
-
84993775407
-
Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: a randomized, double-blind, placebo-controlled trial
-
Presented at: Digestive Disease Week; 30 May-4 June 2009 Chicago, IL: Abstract S1066.
-
Takazoe, M., Watanabe, M., Kawaguchi, T., Matumoto, T., Oshitani, N., Hiwatashi, N., et al. (2009) Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Presented at: Digestive Disease Week; 30 May-4 June 2009, Chicago, IL. Abstract S1066.
-
(2009)
-
-
Takazoe, M.1
Watanabe, M.2
Kawaguchi, T.3
Matumoto, T.4
Oshitani, N.5
Hiwatashi, N.6
-
84
-
-
34247884424
-
Natalizumab for the treatment of active Crohn's disease: results of the ENCORE trial
-
Targan, S.R., Feagan, B.G., Fedorak, R.N., Lashner, B.A., Panaccione, R., Present, D.H. et al. (2007) Natalizumab for the treatment of active Crohn's disease: results of the ENCORE trial. Gastroenterology 132: 1672-1683.
-
(2007)
Gastroenterology
, vol.132
, pp. 1672-1683
-
-
Targan, S.R.1
Feagan, B.G.2
Fedorak, R.N.3
Lashner, B.A.4
Panaccione, R.5
Present, D.H.6
-
85
-
-
12344278984
-
Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease
-
van Assche, G. and Rutgeerts, P. ( 2005) Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 288: G169-G174.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.288
, pp. G169-G174
-
-
van Assche, G.1
Rutgeerts, P.2
-
86
-
-
33646271377
-
A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis
-
van Deventer, S.J.H., Wedel, M.K., Baker, B.F., Xia, S., Chuang, E. and Miner Jr, P.B. ( 2006) A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative colitis. Aliment Pharmacol Ther 23: 1415-1425.
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1415-1425
-
-
van Deventer, S.J.H.1
Wedel, M.K.2
Baker, B.F.3
Xia, S.4
Chuang, E.5
Miner, P.B.6
-
87
-
-
52649134405
-
JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive multifocal leukoencephalopathy
-
Verbeeck, J., van Assche, G., Ryding, J., Wollants, E., Rans, K., Vermeire, S. et al. (2008) JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive multifocal leukoencephalopathy? Gut 57: 1393-1397.
-
(2008)
Gut
, vol.57
, pp. 1393-1397
-
-
Verbeeck, J.1
van Assche, G.2
Ryding, J.3
Wollants, E.4
Rans, K.5
Vermeire, S.6
-
88
-
-
84993728773
-
Assessment of certolizumab pegol in the treatment of Crohn's disease in patients for whom infliximab treatment was not successful: open-label induction preliminary results from the WELCOME study
-
Presented at: The Congress of European Crohn's and Colitis Organization; 28 February-1 March 2008 Lyon France.
-
Vermeire, S., Abreu, M.T., D'Haens, G., Colombel, J.F., Mitchev, K., Raedler, A. et al. (2008) Assessment of certolizumab pegol in the treatment of Crohn's disease in patients for whom infliximab treatment was not successful: open-label induction preliminary results from the WELCOME study. Presented at: The Congress of European Crohn's and Colitis Organization; 28 February-1 March 2008, Lyon, France.
-
(2008)
-
-
Vermeire, S.1
Abreu, M.T.2
D'Haens, G.3
Colombel, J.F.4
Mitchev, K.5
Raedler, A.6
-
89
-
-
0032904627
-
Mechanisms that regulate the function of the selectins and their ligands
-
Vestweber, D. and Blanks, J.E. ( 1999) Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev 79: 181-213.
-
(1999)
Physiol Rev
, vol.79
, pp. 181-213
-
-
Vestweber, D.1
Blanks, J.E.2
-
90
-
-
0034609968
-
T-cell function and migration. Two sides of the same coin
-
von Adrian, U.H. and Mackay, C.R. ( 2000) T-cell function and migration. Two sides of the same coin. N Engl J Med 343: 1020-1034.
-
(2000)
N Engl J Med
, vol.343
, pp. 1020-1034
-
-
von Adrian, U.H.1
Mackay, C.R.2
-
91
-
-
33645119266
-
Crohn's disease: increased mortality 10 years after diagnosis in a Europe-wide population based cohort
-
for the European Collaborative study group on Inflammatory Bowel Disease (EC-IBD).
-
Wolters, F.L., Russel, M.G., Sijbrandij, J., Schouten, L.J., Odes, S., Riis, L. et al. for the European Collaborative study group on Inflammatory Bowel Disease (EC-IBD). (2006) Crohn's disease: increased mortality 10 years after diagnosis in a Europe-wide population based cohort. Gut 55: 510-518.
-
(2006)
Gut
, vol.55
, pp. 510-518
-
-
Wolters, F.L.1
Russel, M.G.2
Sijbrandij, J.3
Schouten, L.J.4
Odes, S.5
Riis, L.6
-
92
-
-
33846804162
-
A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease
-
Yacyshyn, B., Chey, W.Y., Wedel, M.K., Yu, R.Z., Paul, D. and Chuang, E. ( 2007) A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease. Clin Gastroenterol Hepatol 5: 215-220.
-
(2007)
Clin Gastroenterol Hepatol
, vol.5
, pp. 215-220
-
-
Yacyshyn, B.1
Chey, W.Y.2
Wedel, M.K.3
Yu, R.Z.4
Paul, D.5
Chuang, E.6
-
93
-
-
0031782392
-
A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
-
Yacyshyn, B.R., Bowen-Yacyshyn, M.B., Jewell, L., Tami, J.A., Bennett, C.F., Kisner, D.L. et al. (1998) A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology 114: 1133-1142.
-
(1998)
Gastroenterology
, vol.114
, pp. 1133-1142
-
-
Yacyshyn, B.R.1
Bowen-Yacyshyn, M.B.2
Jewell, L.3
Tami, J.A.4
Bennett, C.F.5
Kisner, D.L.6
-
94
-
-
0036288638
-
Double blind, placebo controlled trial of the remission inducing and steroid sparring properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
-
the ISIS 2302-CS9 Investigators
-
Yacyshyn, B.R., Chey, W.Y., Goff, J., Salzberg, B., Baerg, R., Buchman, A.L. et al. and the ISIS 2302-CS9 Investigators ( 2002) Double blind, placebo controlled trial of the remission inducing and steroid sparring properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease. Gut 51: 30-36.
-
(2002)
Gut
, vol.51
, pp. 30-36
-
-
Yacyshyn, B.R.1
Chey, W.Y.2
Goff, J.3
Salzberg, B.4
Baerg, R.5
Buchman, A.L.6
-
95
-
-
0034634006
-
Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon α4β1-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin
-
Yakubenko, V.P., Lobb, R.R., Plow, E.F. and Ugarova, T.P. ( 2000) Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon α4β1-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Exp Cell Res 260: 73-84.
-
(2000)
Exp Cell Res
, vol.260
, pp. 73-84
-
-
Yakubenko, V.P.1
Lobb, R.R.2
Plow, E.F.3
Ugarova, T.P.4
-
96
-
-
14644391560
-
Targeting leukocyte integrins in human diseases
-
Yonekawa, K. and Harlan, J.M. ( 2005) Targeting leukocyte integrins in human diseases. J Leukoc Biol 77: 129-140.
-
(2005)
J Leukoc Biol
, vol.77
, pp. 129-140
-
-
Yonekawa, K.1
Harlan, J.M.2
-
97
-
-
33644605483
-
Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
-
Yousry, T.A., Major, E.O., Ryschkewitsch, C., Fahle, G., Fischer, S., Hou, J. et al. (2006) Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med 354: 924-933.
-
(2006)
N Engl J Med
, vol.354
, pp. 924-933
-
-
Yousry, T.A.1
Major, E.O.2
Ryschkewitsch, C.3
Fahle, G.4
Fischer, S.5
Hou, J.6
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