메뉴 건너뛰기




Volumn 2, Issue 2, 2008, Pages 75-93

Review: New perspectives in the treatment of idiopathic pulmonary fibrosis

Author keywords

idiopathic interstitial pneumonia; idiopathic pulmonary brosis; treatment

Indexed keywords

ACETYLCYSTEINE; ANTICOAGULANT AGENT; AZATHIOPRINE; BROMHEXINE; CHLORAMBUCIL; COLCHICINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOTOXIC AGENT; ETANERCEPT; GAMMA INTERFERON; GAMMA1B INTERFERON; GC 1008; GLUTATHIONE; IMATINIB; IMMUNOSUPPRESSIVE AGENT; LOW MOLECULAR WEIGHT HEPARIN; METHOTREXATE; METHYLPREDNISOLONE; OCTREOTIDE; PIRFENIDONE; PLACEBO; PREDNISOLONE; PREDNISONE; THALIDOMIDE; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE; WARFARIN;

EID: 57149109880     PISSN: 17534658     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753465808089363     Document Type: Review
Times cited : (26)

References (138)
  • 1
    • 20244364391 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor signaling attenuates pulmonary “brosis
    • Abdollahi, A., Li, M., Ping, G., Plathow, C., Domhan, S., Kiessling, F. et al. (2005) Inhibition of platelet-derived growth factor signaling attenuates pulmonary “brosis. J Exp Med 201: 925-935.
    • (2005) J Exp Med , vol.201 , pp. 925-935
    • Abdollahi, A.1    Li, M.2    Ping, G.3    Plathow, C.4    Domhan, S.5    Kiessling, F.6
  • 2
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood “brocytes: differentiation pathway and migration to wound sites
    • Abe, R., Donnelly, S.C., Peng, T., Bucala, R., Metz, C.N. (2001) Peripheral blood “brocytes: differentiation pathway and migration to wound sites. J Immunol 166: 7556-7562.
    • (2001) J Immunol , vol.166 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3    Bucala, R.4    Metz, C.N.5
  • 3
    • 0034011982 scopus 로고    scopus 로고
    • Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment International Consensus Statement
    • ATS (American Thoracic Society) (2000) Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment International Consensus Statement. Am J Respir Crit Care Med 161: 646-664
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 646-664
    • ATS (American Thoracic Society1
  • 4
  • 5
    • 33749331166 scopus 로고    scopus 로고
    • Long-term clinical effects of interferon gamma-1b and colchicine in idiopathic Pulmonary “brosis
    • Antoniou, K.M., Nicholson, A.G., Dimadi, M. Malagari, K. Latsi1, P. Rapti, A. et al. (2006) Long-term clinical effects of interferon gamma-1b and colchicine in idiopathic Pulmonary “brosis. Eur Respir J 28: 496-504.
    • (2006) Eur Respir J , vol.28 , pp. 496-504
    • Antoniou, K.M.1    Nicholson, A.G.2    Dimadi, M.3    Malagari, K.4    Latsi1, P.5    Rapti, A.6
  • 6
    • 0025053989 scopus 로고
    • Platelet-derived growth factor in idiopathic pulmonary “brosis
    • 1990,:, Nash, J.R., McLaughlin, P.J., Butcher, D., Corrin, B., Expression of tumour necrosis factor- in cryptogenic “brosing alveolitis, Histopathology, 22, 343, 347
    • Antoniades, H.N., Bravo, M.A., Avila, R.E., Galanopoulus, T. Neville, J. Selman, M. et al. (1993) Platelet-derived growth factor in idiopathic pulmonary “brosis. J Clin Invest 1990; 86: 1055-64; Nash, J.R., McLaughlin, P.J., Butcher, D., Corrin, B. Expression of tumour necrosis factor- in cryptogenic “brosing alveolitis. Histopathology 22: 343-347.
    • (1993) J Clin Invest , vol.86 , pp. 1055-1064
    • Antoniades, H.N.1    Bravo, M.A.2    Avila, R.E.3    Galanopoulus, T.4    Neville, J.5    Selman, M.6
  • 7
    • 19644385336 scopus 로고    scopus 로고
    • Imatinib as a novel anti”brotic agent in bleomycin-induced pulmonary “brosis in mice
    • Aono,Y., Nishioka,Y., Inayama, M., Ugai, M., Kishi, J., Uehara, H. et al. (2005) Imatinib as a novel anti”brotic agent in bleomycin-induced pulmonary “brosis in mice. Am J Respir Crit Care Med 171: 1279-1285.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1279-1285
    • AonoY.1    NishiokaY.2    Inayama, M.3    Ugai, M.4    Kishi, J.5    Uehara, H.6
  • 8
    • 20944434994 scopus 로고    scopus 로고
    • Double-blind, Placebo-controlled Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
    • Azuma, A., Nukiwa, T., Tsuboi, E., Suga, M., Abe, S., Nakata, K. et al. (2005) Double-blind, Placebo-controlled Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 171: 1040-1047.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1040-1047
    • Azuma, A.1    Nukiwa, T.2    Tsuboi, E.3    Suga, M.4    Abe, S.5    Nakata, K.6
  • 9
    • 0035991339 scopus 로고    scopus 로고
    • Glutathione de”ciency of the lower respiratory tract in patients with idiopathic pulmonary “brosis
    • Beeh, K.M.J., Beier, I.C., Haas, O., Kornmann, P. and Micke, R. Buhl (2002) Glutathione de”ciency of the lower respiratory tract in patients with idiopathic pulmonary “brosis. Eur Respir J 19: 1119-1123.
    • (2002) Eur Respir J , vol.19 , pp. 1119-1123
    • Beeh, K.M.J.1    Beier, I.C.2    Haas, O.3    Kornmann, P.4    Micke, R.B.5
  • 10
    • 0031449645 scopus 로고    scopus 로고
    • Antioxidative and clinical effects of high-dose N-acetylcysteine in “brosing alveolitis: adjunctive therapy to maintenance immunosuppression
    • Behr, F.A., Maier, K., Degenkolb, B., Krombach, F. and Vogelmeier, C. (1997) Antioxidative and clinical effects of high-dose N-acetylcysteine in “brosing alveolitis: adjunctive therapy to maintenance immunosuppression. Am J Respir Crit Care Med 156: 1897-1901.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1897-1901
    • Behr, F.A.1    Maier, K.2    Degenkolb, B.3    Krombach, F.4    Vogelmeier, C.5
  • 11
    • 0021077452 scopus 로고
    • Mechanisms of pulmonary “brosis: spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders
    • Bitterman, P.B., Adelberg, S. and Crystal, R.G. (1983) Mechanisms of pulmonary “brosis: spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders. J Clin Invest 72: 1801-1813.
    • (1983) J Clin Invest , vol.72 , pp. 1801-1813
    • Bitterman, P.B.1    Adelberg, S.2    Crystal, R.G.3
  • 12
    • 0025886739 scopus 로고
    • Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary “brosis
    • Borok, Z., Buhl, R., Grimes, G.J., Bosker, A.D., Holroyd, K.J., Roum, J.H. et al. (1991) Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary “brosis. Lancet 338: 215-216.
    • (1991) Lancet , vol.338 , pp. 215-216
    • Borok, Z.1    Buhl, R.2    Grimes, G.J.3    Bosker, A.D.4    Holroyd, K.J.5    Roum, J.H.6
  • 13
    • 0015047719 scopus 로고
    • The treatment of cryptogenic “brosing alveolitis with immunosuppressant drugs
    • Brown, C.H. and Turner-Warwick, M. (1971) The treatment of cryptogenic “brosing alveolitis with immunosuppressant drugs. The Quarterly Journal of Medicine 40: 289-302.
    • (1971) The Quarterly Journal of Medicine , vol.40 , pp. 289-302
    • Brown, C.H.1    Turner-Warwick, M.2
  • 14
    • 0028535872 scopus 로고
    • Circulating “brocytes de”ne a new leukocyte subpopulation that mediates tissue repair
    • Bucala, R., Spiegel, L.A., Chesney, J., Hogan, M. and Cerami, A. (1994) Circulating “brocytes de”ne a new leukocyte subpopulation that mediates tissue repair. Mol Med 1: 71-81.
    • (1994) Mol Med , vol.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3    Hogan, M.4    Cerami, A.5
  • 15
    • 0023263236 scopus 로고
    • Oxidant mediated epithelial cell injury in idiopathic pulmonary “brosis
    • Cantin, A.M., North, S.L., Fells, G.A., Hubbard, R.C. and Crystal, R.G. (1987) Oxidant mediated epithelial cell injury in idiopathic pulmonary “brosis. J Clin Invest 79: 1665-1673.
    • (1987) J Clin Invest , vol.79 , pp. 1665-1673
    • Cantin, A.M.1    North, S.L.2    Fells, G.A.3    Hubbard, R.C.4    Crystal, R.G.5
  • 16
    • 0024578662 scopus 로고
    • Glutathione de”ciency in the epithelial lining “uid of the lower respiratory tract in idiopathic pulmonary “brosis
    • Cantin, A.M., Hubbard, R.C. and Crystal, R.G. (1989) Glutathione de”ciency in the epithelial lining “uid of the lower respiratory tract in idiopathic pulmonary “brosis. Am Rev Respir Dis 139: 370-372.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 370-372
    • Cantin, A.M.1    Hubbard, R.C.2    Crystal, R.G.3
  • 17
    • 0141753083 scopus 로고    scopus 로고
    • Role of coagulation cascade proteases in lung repair and “brosis
    • Chambers, R.C. (2003) Role of coagulation cascade proteases in lung repair and “brosis. Eur Respir J 22: Suppl. 44, 33s-35s.
    • (2003) Eur Respir J 22: Suppl , vol.44 , pp. 33s-35s
    • Chambers, R.C.1
  • 19
    • 0036798845 scopus 로고    scopus 로고
    • Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary “brosis: the role of N-p63
    • Chilosi, M., Poletti, V., Murer, B., Lestani, M., Cancellieri, A., Montagna, L. et al. (2002) Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary “brosis: the role of N-p63. Lab Invest 82: 1335-1345.
    • (2002) Lab Invest , vol.82 , pp. 1335-1345
    • Chilosi, M.1    Poletti, V.2    Murer, B.3    Lestani, M.4    Cancellieri, A.5    Montagna, L.6
  • 21
    • 33746977705 scopus 로고    scopus 로고
    • Migratory marker expression in “broblast foci of idiopathic pulmonary “brosis
    • Chilosi, M., Zamò, A., Dogliosi, C., Reghellin, D., Lestani, M., Montagna, L. et al. (2006) Migratory marker expression in “broblast foci of idiopathic pulmonary “brosis. Respir Res 7: 95.
    • (2006) Respir Res , vol.7 , pp. 95
    • Chilosi, M.1    Zamò, A.2    Dogliosi, C.3    Reghellin, D.4    Lestani, M.5    Montagna, L.6
  • 22
    • 34848821215 scopus 로고    scopus 로고
    • with the Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators. Acute Exacerbations of Idiopathic Pulmonary Fibrosis
    • Collard, H.R., Moore, B.B., Flaherty, K.R., Brown, K.K., Kaner, R.J., King Jr,T.E. et al. (2007a). with the Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators. Acute Exacerbations of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 176: 636-643.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 636-643
    • Collard, H.R.1    Moore, B.B.2    Flaherty, K.R.3    Brown, K.K.4    Kaner, R.J.5    King JrT.E.6
  • 23
    • 33947386257 scopus 로고    scopus 로고
    • Sildena”l Improves Walk Distance in Idiopathic Pulmonary Fibrosis
    • Collard, H.R., Anstrom, K.J., Schwarz, M.I. and Zisman, D.A. (2007b) Sildena”l Improves Walk Distance in Idiopathic Pulmonary Fibrosis. Chest 131: 641-643.
    • (2007) Chest , vol.131 , pp. 641-643
    • Collard, H.R.1    Anstrom, K.J.2    Schwarz, M.I.3    Zisman, D.A.4
  • 24
    • 2942699911 scopus 로고    scopus 로고
    • Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary “brosis
    • Collard, H.R., Ryu, J.H., Douglas, W.W., Schwarz, M.I., Curran-Everett, D., King Jr, T.E. et al. (2004) Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary “brosis. Chest 125: 2169-2174.
    • (2004) Chest , vol.125 , pp. 2169-2174
    • Collard, H.R.1    Ryu, J.H.2    Douglas, W.W.3    Schwarz, M.I.4    Curran-Everett, D.5    King, T.E.6
  • 25
    • 33845370466 scopus 로고    scopus 로고
    • Pulmonary vascular lesions in end-stage idiopathic pulmonary “brosis: histopathologic study on lung explant specimens and correlations with pulmonary hemodynamics
    • Colombat, M., Mal, H., Groussard, O., Capron, F., Thabut, G., Jebrak, G. et al. (2007) Pulmonary vascular lesions in end-stage idiopathic pulmonary “brosis: histopathologic study on lung explant specimens and correlations with pulmonary hemodynamics. Human Pathology 38: 60-65.
    • (2007) Human Pathology , vol.38 , pp. 60-65
    • Colombat, M.1    Mal, H.2    Groussard, O.3    Capron, F.4    Thabut, G.5    Jebrak, G.6
  • 26
    • 0017172219 scopus 로고
    • Idiopathic pulmonary “brosis: clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects
    • Crystal, R.G., Fulmer, J.D., Roberts, W.C., Moss, M.L., Line, B.R., Reynolds, H.Y. et al. (1976) Idiopathic pulmonary “brosis: clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects. Ann Intern Med 85: 769-788.
    • (1976) Ann Intern Med , vol.85 , pp. 769-788
    • Crystal, R.G.1    Fulmer, J.D.2    Roberts, W.C.3    Moss, M.L.4    Line, B.R.5    Reynolds, H.Y.6
  • 27
    • 0021288425 scopus 로고
    • Interstitial lung diseases of unknown cause: disorders characterized by chronic in”ammation of the lower respiratory tract
    • Crystal, R.G., Bitterman, P.B., Rennard, S.I., Hance, A.J. and Keogh, B.A. (1984) Interstitial lung diseases of unknown cause: disorders characterized by chronic in”ammation of the lower respiratory tract. N Engl J Med 310: 154-66.
    • (1984) N Engl J Med , vol.310 , pp. 154-166
    • Crystal, R.G.1    Bitterman, P.B.2    Rennard, S.I.3    Hance, A.J.4    Keogh, B.A.5
  • 28
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the pro”brogenic activity of TGF-beta and prevents bleomycin-mediated lung “brosis
    • Daniels, C.E., Wilkes, M.C., Edens, M., Kottom, T.J., Murphy, S.J., Limper, A.H. et al. (2004) Imatinib mesylate inhibits the pro”brogenic activity of TGF-beta and prevents bleomycin-mediated lung “brosis. J Clin Invest 114: 1308-1316.
    • (2004) J Clin Invest , vol.114 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3    Kottom, T.J.4    Murphy, S.J.5    Limper, A.H.6
  • 29
    • 0032851824 scopus 로고    scopus 로고
    • A Histologic Pattern of Nonspeci”c Interstitial Pneumonia Is Associated with a Better Prognosis Than Usual Interstitial Pneumonia in Patients with Cryptogenic Fibrosing Alveolitis
    • Danill, Z.D., Girlchrist, F.C., Nicholson, A.G., Hansell, D.M., Harris, J., Colby, T.V. et al. (1999) A Histologic Pattern of Nonspeci”c Interstitial Pneumonia Is Associated with a Better Prognosis Than Usual Interstitial Pneumonia in Patients with Cryptogenic Fibrosing Alveolitis. AM J Respir Crit Care Med 160: 899-905.
    • (1999) AM J Respir Crit Care Med , vol.160 , pp. 899-905
    • Danill, Z.D.1    Girlchrist, F.C.2    Nicholson, A.G.3    Hansell, D.M.4    Harris, J.5    Colby, T.V.6
  • 31
    • 28144459814 scopus 로고    scopus 로고
    • For the IFIGENIA Study Group*High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis
    • Demedts, M., Behr, J., Buhl, R., Costabel, U., Dekhuijzen, R., Jansen, H.M. et al. (2005) For the IFIGENIA Study Group*High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis. N Engl J Med 353: 2229-2242.
    • (2005) N Engl J Med , vol.353 , pp. 2229-2242
    • Demedts, M.1    Behr, J.2    Buhl, R.3    Costabel, U.4    Dekhuijzen, R.5    Jansen, H.M.6
  • 32
    • 0042090396 scopus 로고    scopus 로고
    • Fibroblast-speci”c expression of a kinase-de”cient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with “brosis in transgenic mice
    • Denton, C.P., Zheng, B., Evans, L.A., Shi-wen, X., Ong, V.H., Fisher, I. et al. (2003) Fibroblast-speci”c expression of a kinase-de”cient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with “brosis in transgenic mice. J Biol Chem 278: 25109-25119.
    • (2003) J Biol Chem , vol.278 , pp. 25109-25119
    • Denton, C.P.1    Zheng, B.2    Evans, L.A.3    Shi-wen, X.4    Ong, V.H.5    Fisher, I.6
  • 33
    • 34250025930 scopus 로고    scopus 로고
    • Etanercept: a review of its use in the management of rheumatoid arthritis
    • Dhillon, S., Lyseng-Williamson, K.A. and Scott, L.J. (2007) Etanercept: a review of its use in the management of rheumatoid arthritis. Drugs 67: 1211-1241.
    • (2007) Drugs , vol.67 , pp. 1211-1241
    • Dhillon, S.1    Lyseng-Williamson, K.A.2    Scott, L.J.3
  • 34
    • 0033930635 scopus 로고    scopus 로고
    • Elevation of anti-cytokeratin 18 antibody and circulating cytokeratin 18: anti-cytokeratin 18 antibody immune complexes in sera of patients with idiopathic pulmonary “brosis
    • Dobashi, N., Fujita, J., Murota, M., Ohtsuki, Y., Yamadori, I., Yoshinouchi, T. et al. (2000) Elevation of anti-cytokeratin 18 antibody and circulating cytokeratin 18: anti-cytokeratin 18 antibody immune complexes in sera of patients with idiopathic pulmonary “brosis. Lung 178: 171-179.
    • (2000) Lung , vol.178 , pp. 171-179
    • Dobashi, N.1    Fujita, J.2    Murota, M.3    Ohtsuki, Y.4    Yamadori, I.5    Yoshinouchi, T.6
  • 37
    • 34548498378 scopus 로고    scopus 로고
    • Inhibition of TGF-β induced lung “broblast to myo”broblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase
    • Dunkern, T.R., Feurstein, D., Rossi, G.A., Sabatini, F. and Hatzelmann, A. (2007) Inhibition of TGF-β induced lung “broblast to myo”broblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase. Eur J Pharmacol 572: 12-22.
    • (2007) Eur J Pharmacol , vol.572 , pp. 12-22
    • Dunkern, T.R.1    Feurstein, D.2    Rossi, G.A.3    Sabatini, F.4    Hatzelmann, A.5
  • 38
    • 0033592759 scopus 로고    scopus 로고
    • Interferon gamma-1b for the treatment of idiopathic pulmonary “brosis
    • Du Bois, R.M. (1999) Interferon gamma-1b for the treatment of idiopathic pulmonary “brosis. New England Journal of Medicine 341: 1302-1304.
    • (1999) New England Journal of Medicine , vol.341 , pp. 1302-1304
    • Du Bois, R.M.1
  • 39
    • 0030054203 scopus 로고    scopus 로고
    • Bleomycininduced pulmonary “brosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    • Eitzman, D.T., McCoy, R.D., Zheng, X., Fay, W.P., Shen, T., Ginsburg, D. et al. (1996) Bleomycininduced pulmonary “brosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97: 232-237.
    • (1996) J Clin Invest , vol.97 , pp. 232-237
    • Eitzman, D.T.1    McCoy, R.D.2    Zheng, X.3    Fay, W.P.4    Shen, T.5    Ginsburg, D.6
  • 40
    • 0025289423 scopus 로고
    • Cytokine networks in the regulation of in”ammation and “brosis in the lung
    • Elias, J.A., Freundlich, B., Kern, J.A. and Rosenbloom, J. (1990) Cytokine networks in the regulation of in”ammation and “brosis in the lung. Chest 97: 1439-1445.
    • (1990) Chest , vol.97 , pp. 1439-1445
    • Elias, J.A.1    Freundlich, B.2    Kern, J.A.3    Rosenbloom, J.4
  • 43
    • 33947396395 scopus 로고    scopus 로고
    • Risk: bene”t pro”le of etanercept in elderly patients with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis
    • Fleischmann, R. and Iqbal, I. (2007) Risk: bene”t pro”le of etanercept in elderly patients with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis. Drugs Aging 24: 239-254.
    • (2007) Drugs Aging , vol.24 , pp. 239-254
    • Fleischmann, R.1    Iqbal, I.2
  • 44
    • 0023109552 scopus 로고
    • The role of intra-alveolar “brosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage
    • Fukuda,Y., Ishizaki, M., Masuda,Y., Kimura, G., Kawanami, O. and Masugi,Y. (1987) The role of intra-alveolar “brosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage. Am J Pathol 126: 171-182.
    • (1987) Am J Pathol , vol.126 , pp. 171-182
    • FukudaY.1    Ishizaki, M.2    MasudaY.3    Kimura, G.4    Kawanami, O.5    MasugiY.6
  • 45
    • 26444534291 scopus 로고    scopus 로고
    • Sildena”l Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildena”l citrate therapy for pulmonary arterial hypertension
    • Galiè, N., Ghofrani, H.A., Torbicki, A., Barst, R.J., Rubin, L.J., Badesch, D. et al. (2005) Sildena”l Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildena”l citrate therapy for pulmonary arterial hypertension. N Engl J Med 353: 2148-2157.
    • (2005) N Engl J Med , vol.353 , pp. 2148-2157
    • Galiè, N.1    Ghofrani, H.A.2    Torbicki, A.3    Barst, R.J.4    Rubin, L.J.5    Badesch, D.6
  • 46
    • 0036558195 scopus 로고    scopus 로고
    • In”ammatory mechanisms are a minor component of the pathogenesis of idiopathic pulmonary “brosis
    • Gauldie, J. (2002) In”ammatory mechanisms are a minor component of the pathogenesis of idiopathic pulmonary “brosis. Am J Respir Crit Care Med 165: 1205-1208.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1205-1208
    • Gauldie, J.1
  • 47
    • 0031766798 scopus 로고    scopus 로고
    • Mapping of topoisomerase II alpha epitopes recognized by autoantibodies in idiopathic pulmonary “brosis
    • Grigolo, B., Mazzetti, I., Borzi, R.M., Hickson, I.D., Fabbri, M., Fasano, L. et al. (1998) Mapping of topoisomerase II alpha epitopes recognized by autoantibodies in idiopathic pulmonary “brosis. Clin Exp Immunol 114: 339-346.
    • (1998) Clin Exp Immunol , vol.114 , pp. 339-346
    • Grigolo, B.1    Mazzetti, I.2    Borzi, R.M.3    Hickson, I.D.4    Fabbri, M.5    Fasano, L.6
  • 48
    • 0035899275 scopus 로고    scopus 로고
    • Idiopathic pulmonary “brosis
    • Gross, T.J. and Hunninghake. G.W. (2001) Idiopathic pulmonary “brosis. N Engl J Med 345: 517-525.
    • (2001) N Engl J Med , vol.345 , pp. 517-525
    • Gross, T.J.1    Hunninghake. G.W.2
  • 49
    • 0022829627 scopus 로고
    • High-dose intravenous methylprednisolone pulse therapy as initial treatment in cryptogenic “brosing alveolitis: a pilot study
    • Gulsvik, A., Kjelsberg, F., Bergmann, A., Froland, S., Rootwelt, K., Vale, I.R. et al. (1986) High-dose intravenous methylprednisolone pulse therapy as initial treatment in cryptogenic “brosing alveolitis: a pilot study. Respiration 50: 252-257.
    • (1986) Respiration , vol.50 , pp. 252-257
    • Gulsvik, A.1    Kjelsberg, F.2    Bergmann, A.3    Froland, S.4    Rootwelt, K.5    Vale, I.R.6
  • 50
    • 34147143526 scopus 로고    scopus 로고
    • Safety and tolerability of bosentan in idiopathic pulmonary “brosis: an open label study
    • Gunther, A., Enke, B., Markart P., Hammerl, P., Morr, H., Behr, J. et al. (2007) Safety and tolerability of bosentan in idiopathic pulmonary “brosis: an open label study. Eur Respir J 29: 713-719.
    • (2007) Eur Respir J , vol.29 , pp. 713-719
    • Gunther, A.1    Enke, B.2    Markart P.3    Hammerl, P.4    Morr, H.5    Behr, J.6
  • 51
  • 52
    • 0029124143 scopus 로고
    • Molecular mechanisms of anti”brotic effect of interferon gamma in bleomycin-mouse model of lung “brosis: downregulation of TGF-b and procollagen I and III gene expression
    • Gurujeyalakshmi, G. and Giri, S.N. (1995) Molecular mechanisms of anti”brotic effect of interferon gamma in bleomycin-mouse model of lung “brosis: downregulation of TGF-b and procollagen I and III gene expression. Exp Lung Res 21: 791-808.
    • (1995) Exp Lung Res , vol.21 , pp. 791-808
    • Gurujeyalakshmi, G.1    Giri, S.N.2
  • 53
    • 0029840755 scopus 로고    scopus 로고
    • Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary “brosis
    • Hayashi, T., Stetler-Stevenson, W.G., Fleming, M.V., Fishback, N., Koss, M.N., Liotta, L.A. et al. (1996) Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary “brosis. Am J Pathol 149: 1241-1256.
    • (1996) Am J Pathol , vol.149 , pp. 1241-1256
    • Hayashi, T.1    Stetler-Stevenson, W.G.2    Fleming, M.V.3    Fishback, N.4    Koss, M.N.5    Liotta, L.A.6
  • 54
    • 40749090043 scopus 로고    scopus 로고
    • PDE5A inhibition attenuates bleomycininduced pulmonary “brosis and pulmonary hypertension through inhibition of ROS Generation and RhoA/Rho kinase Activation
    • 2007, Oct 26; [Epub ahead of print]
    • Hemnes, A.R., Zaiman, A. and Champion, H.C. (2007) PDE5A inhibition attenuates bleomycininduced pulmonary “brosis and pulmonary hypertension through inhibition of ROS Generation and RhoA/Rho kinase Activation. Am J Physiol Lung Cell Mol Physiol 2007 Oct 26; [Epub ahead of print]
    • (2007) Am J Physiol Lung Cell Mol Physiol
    • Hemnes, A.R.1    Zaiman, A.2    Champion, H.C.3
  • 56
    • 0036549805 scopus 로고    scopus 로고
    • Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary “brosis
    • Howell, D.C., Laurent, G.J. and Chambers, R.C. (2002) Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary “brosis. Biochem Soc Trans 30: 211-216.
    • (2002) Biochem Soc Trans , vol.30 , pp. 211-216
    • Howell, D.C.1    Laurent, G.J.2    Chambers, R.C.3
  • 57
    • 0019406326 scopus 로고
    • Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary “brosis
    • Hunninghake, G.W., Gadek, J.E., Lawley, T.J. and Crystal, R.G. (1981) Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary “brosis. J Clin Invest 68: 259-269.
    • (1981) J Clin Invest , vol.68 , pp. 259-269
    • Hunninghake, G.W.1    Gadek, J.E.2    Lawley, T.J.3    Crystal, R.G.4
  • 58
    • 0024344607 scopus 로고
    • Local abnormalities in coagulation and “brinolytic pathways predispose to alveolar “brin deposition in the adult respiratory distress syndrome
    • Idell, S., James, K.K., Levin, E.G., Schwartz, B.S., Manchanda, N., Maunder, R.J. et al. (1989) Local abnormalities in coagulation and “brinolytic pathways predispose to alveolar “brin deposition in the adult respiratory distress syndrome. J Clin Invest 84: 695-705.
    • (1989) J Clin Invest , vol.84 , pp. 695-705
    • Idell, S.1    James, K.K.2    Levin, E.G.3    Schwartz, B.S.4    Manchanda, N.5    Maunder, R.J.6
  • 59
    • 0030791559 scopus 로고    scopus 로고
    • Tissue factor expression and “brin deposition in the lungs of patients with idiopathic pulmonary “brosis and systemic sclerosis
    • Imokawa, S., Sato, A., Hayakawa, H., Kotani, M., Urano, T. and Takada, A. (1997) Tissue factor expression and “brin deposition in the lungs of patients with idiopathic pulmonary “brosis and systemic sclerosis. Am J Respir Crit Care Med 156: 631-636.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 631-636
    • Imokawa, S.1    Sato, A.2    Hayakawa, H.3    Kotani, M.4    Urano, T.5    Takada, A.6
  • 60
    • 0042171665 scopus 로고    scopus 로고
    • Cyclosporin A followed by the treatment of acute exacerbation of idiopathic pulmonary “brosis with corticosteroid
    • Inase, N., Sawada, M., Ohtani,Y., Miyake, S., Isogai, S., Sakashita, H. et al. (2003) Cyclosporin A followed by the treatment of acute exacerbation of idiopathic pulmonary “brosis with corticosteroid. Intern Med 42: 565-570.
    • (2003) Intern Med , vol.42 , pp. 565-570
    • Inase, N.1    Sawada, M.2    OhtaniY.3    Miyake, S.4    Isogai, S.5    Sakashita, H.6
  • 61
    • 0032917960 scopus 로고    scopus 로고
    • Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung “brosis
    • Iyer, S.N., Gurujeyalakshmi, G. and Giri, S.N. (1999) Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung “brosis. J Pharmacol Exp Ther 289: 211-218.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 211-218
    • Iyer, S.N.1    Gurujeyalakshmi, G.2    Giri, S.N.3
  • 62
    • 0036322007 scopus 로고    scopus 로고
    • Evidence that “broblasts derive from epithelium during tissue “brosis
    • Iwano, M., Plieth, D., Danoff, T.M., Xue, C., Okada, H., Neilson, E.G. et al. (2002) Evidence that “broblasts derive from epithelium during tissue “brosis. J Clin Invest 110: 341-350.
    • (2002) J Clin Invest , vol.110 , pp. 341-350
    • Iwano, M.1    Plieth, D.2    Danoff, T.M.3    Xue, C.4    Okada, H.5    Neilson, E.G.6
  • 63
    • 0024547095 scopus 로고
    • Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic “brosing alveolitis
    • Johnson, M.A., Wan, S.K., Snell, N.J.C., Nunn, A.J., Darbyshire, J.H., Turner Warwick, M. et al. (1989) Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic “brosing alveolitis. Thorax 44: 280-288.
    • (1989) Thorax , vol.44 , pp. 280-288
    • Johnson, M.A.1    Wan, S.K.2    Snell, N.J.C.3    Nunn, A.J.4    Darbyshire, J.H.5    Turner Warwick, M.6
  • 64
    • 3543071795 scopus 로고    scopus 로고
    • Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary “brosis
    • Kakugawa, T., Mukae, H., Hayashi, T., Ishii, H., Abe, K., Fujii, T. et al. (2004) Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary “brosis. Eur Respir J 24: 57-65.
    • (2004) Eur Respir J , vol.24 , pp. 57-65
    • Kakugawa, T.1    Mukae, H.2    Hayashi, T.3    Ishii, H.4    Abe, K.5    Fujii, T.6
  • 65
    • 0031965748 scopus 로고    scopus 로고
    • Idiopathic pulmonary “brosis: clinical relevance of pathologic classi”cation
    • Katzenstein, A.L. and Myers, J.L. (1998) Idiopathic pulmonary “brosis: clinical relevance of pathologic classi”cation. Am J Respir Crit Care Med 157: 1301-1315.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1301-1315
    • Katzenstein, A.L.1    Myers, J.L.2
  • 66
    • 0026210618 scopus 로고
    • Increased production and immunohistochemical localization of transforming growth factor-β in idiopathic pulmonary “brosis
    • Khalil, N., O'Connor, R.N., Unruh, H.W., Warren, P.W., Flanders, K.C., Kemp, A. et al. (1991) Increased production and immunohistochemical localization of transforming growth factor-β in idiopathic pulmonary “brosis. Am J Respir Cell Mol Biol 5: 155-162.
    • (1991) Am J Respir Cell Mol Biol , vol.5 , pp. 155-162
    • Khalil, N.1    O'Connor, R.N.2    Unruh, H.W.3    Warren, P.W.4    Flanders, K.C.5    Kemp, A.6
  • 67
    • 33746336263 scopus 로고    scopus 로고
    • Anticoagulant therapy and idiopathic pulmonary “brosis
    • Kinder, B.W., Collard, H.R. and King Jr, T.E. (2006) Anticoagulant therapy and idiopathic pulmonary “brosis. Chest 130: 302-303.
    • (2006) Chest , vol.130 , pp. 302-303
    • Kinder, B.W.1    Collard, H.R.2    King, T.E.3
  • 68
    • 0035883582 scopus 로고    scopus 로고
    • Idiopathic pulmonary “brosis: relationship between histopathologic features and mortality
    • King, T.E. Jr, Schwarz, M.I., Brown, K., Tooze, J.A., Colby, T.V., Waldron Jr, J.A. et al. (2001) Idiopathic pulmonary “brosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med 164: 1025-1032.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1025-1032
    • King, T.E.1    Schwarz, M.I.2    Brown, K.3    Tooze, J.A.4    Colby, T.V.5    Waldron, J.A.6
  • 69
    • 37849012578 scopus 로고    scopus 로고
    • A Randomized Placebo-Controlled Trial of Bosentan in Patients with idiopathic pulmonary “brosis
    • King, T.E. Jr, Behr, J., Brown, K.K., du Bois, R.M., Lancaster, L., de Andrade, J.A. et al. (2007) A Randomized Placebo-Controlled Trial of Bosentan in Patients with idiopathic pulmonary “brosis. Am J Resp Crit Care 177: 75-81.
    • (2007) Am J Resp Crit Care , vol.177 , pp. 75-81
    • King, T.E.1    Behr, J.2    Brown, K.K.3    du Bois, R.M.4    Lancaster, L.5    de Andrade, J.A.6
  • 71
    • 0032424030 scopus 로고    scopus 로고
    • Cyclophosphamide pulse therapy in idiopathic pulmonary “brosis
    • Kolb, M., Kirschner, J., Riedel, W., Wirtz, H. and Schmidt, M. (1998) Cyclophosphamide pulse therapy in idiopathic pulmonary “brosis. Eur Respir J 12: 1409-1414.
    • (1998) Eur Respir J , vol.12 , pp. 1409-1414
    • Kolb, M.1    Kirschner, J.2    Riedel, W.3    Wirtz, H.4    Schmidt, M.5
  • 72
    • 14744285875 scopus 로고    scopus 로고
    • Cyclophosphamide and low-dose prednisolone in idiopathic pulmonary “brosis and “brosing nonspeci”c interstitial pneumonia
    • Kondoh, Y., Taniguchi, H., Yokoi, T., Nishiyama, O., Ohishi, T., Kato, T. et al. (2005) Cyclophosphamide and low-dose prednisolone in idiopathic pulmonary “brosis and “brosing nonspeci”c interstitial pneumonia. Eur Respir J 25: 528-533.
    • (2005) Eur Respir J , vol.25 , pp. 528-533
    • Kondoh, Y.1    Taniguchi, H.2    Yokoi, T.3    Nishiyama, O.4    Ohishi, T.5    Kato, T.6
  • 73
    • 0028929665 scopus 로고
    • Increased procoagulant and anti”brinolytic activities in the lungs with idiopathic pulmonary “brosis
    • Kotani, I., Sato, A., Hayakawa, H., Urano, T., Takada,Y., Takada, A. et al. (1995) Increased procoagulant and anti”brinolytic activities in the lungs with idiopathic pulmonary “brosis. Thromb Res 77: 493-504.
    • (1995) Thromb Res , vol.77 , pp. 493-504
    • Kotani, I.1    Sato, A.2    Hayakawa, H.3    Urano, T.4    TakadaY.5    Takada, A.6
  • 74
    • 24944467299 scopus 로고    scopus 로고
    • Anticoagulant therapy for idiopathic pulmonary “brosis
    • Kubo, H., Nakayama, K., Yanai, M., Suzuki, T., Yamaya, M., Watanabe, M. et al. (2005) Anticoagulant therapy for idiopathic pulmonary “brosis. Chest 128: 1475-1482.
    • (2005) Chest , vol.128 , pp. 1475-1482
    • Kubo, H.1    Nakayama, K.2    Yanai, M.3    Suzuki, T.4    Yamaya, M.5    Watanabe, M.6
  • 75
    • 12244286790 scopus 로고    scopus 로고
    • Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias
    • Kuwano, K., Nakashima, N., Inoshima, I., Hagimoto, N., Fujita, M., Yoshimi, M. et al. (2003) Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias. Eur Respir J 21: 232-240.
    • (2003) Eur Respir J , vol.21 , pp. 232-240
    • Kuwano, K.1    Nakashima, N.2    Inoshima, I.3    Hagimoto, N.4    Fujita, M.5    Yoshimi, M.6
  • 78
    • 33645118315 scopus 로고    scopus 로고
    • Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary “brosis
    • Lettieri, C.J., Nathan, S.D., Barnett, S.D., Ahmad, S. and Shorr, A.F. (2006) Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary “brosis. Chest 129: 746-752.
    • (2006) Chest , vol.129 , pp. 746-752
    • Lettieri, C.J.1    Nathan, S.D.2    Barnett, S.D.3    Ahmad, S.4    Shorr, A.F.5
  • 79
    • 0034921911 scopus 로고    scopus 로고
    • Transforming Growth Factor-β1 Overexpression in Tumor Necrosis Factor-α Receptor Knockout Mice Induces Fibroproliferative Lung Disease
    • Liu, J.-Y., Sime, P.J., Wu, T., Sakuntala Warshamana, G., Pociask, D., Tsai, S.-Y. et al. (2001) Transforming Growth Factor-β1 Overexpression in Tumor Necrosis Factor-α Receptor Knockout Mice Induces Fibroproliferative Lung Disease. Am J Respir Cell Mol Biol 25: 3-7.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 3-7
    • Liu, J.-Y.1    Sime, P.J.2    Wu, T.3    Sakuntala Warshamana, G.4    Pociask, D.5    Tsai, S.-Y.6
  • 81
    • 0031045160 scopus 로고    scopus 로고
    • Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disorders
    • Lynch, J.P. and McCune,W.J. (1997) Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disorders. Am J Respir Crit Care Med 155: 395-420.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 395-420
    • Lynch, J.P.1    McCuneW.J.2
  • 82
    • 68749097993 scopus 로고
    • Effect of cortisone on diffuse pulmonary “brosis; interim report
    • Mackenzie, D.J. (1951) Effect of cortisone on diffuse pulmonary “brosis; interim report. Treat Serv Bull 6: 475-477.
    • (1951) Treat Serv Bull , vol.6 , pp. 475-477
    • Mackenzie, D.J.1
  • 83
    • 38849178850 scopus 로고    scopus 로고
    • Idiopathic pulmonary “brosis: multiple causes and multiple mechanisms?
    • Maher, T.M., Wells, A.U. and Laurent, G.J. (2007) Idiopathic pulmonary “brosis: multiple causes and multiple mechanisms? Eur Respir J 30: 835-839.
    • (2007) Eur Respir J , vol.30 , pp. 835-839
    • Maher, T.M.1    Wells, A.U.2    Laurent, G.J.3
  • 84
    • 0023266217 scopus 로고
    • Exaggerated spontaneous release of platelet derived growth factor by alveolar macrophages from patients with idiopathic pulmonary “brosis
    • Martinet, Y., Rom, W.N., Grotendorst, G.R., Martin, G.R. and Crystal, R.G. (1987) Exaggerated spontaneous release of platelet derived growth factor by alveolar macrophages from patients with idiopathic pulmonary “brosis. New Engl J Med 317: 202-209.
    • (1987) New Engl J Med , vol.317 , pp. 202-209
    • Martinet, Y.1    Rom, W.N.2    Grotendorst, G.R.3    Martin, G.R.4    Crystal, R.G.5
  • 85
    • 0018179492 scopus 로고
    • Early stage of fulminant idiopathic pulmonary “brosis cured by intense combination therapy using cyclophosphamide, vincristine, and prednisone
    • Meuret, G., Fueter, R. and Gloor, F. (1978) Early stage of fulminant idiopathic pulmonary “brosis cured by intense combination therapy using cyclophosphamide, vincristine, and prednisone. Respiration 36: 228-233.
    • (1978) Respiration , vol.36 , pp. 228-233
    • Meuret, G.1    Fueter, R.2    Gloor, F.3
  • 86
    • 0028230612 scopus 로고
    • The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary “brosis
    • Meyer, A., Buhl, R. and Magnussen, H. (1994) The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary “brosis. Eur Respir J 7: 431-436.
    • (1994) Eur Respir J , vol.7 , pp. 431-436
    • Meyer, A.1    Buhl, R.2    Magnussen, H.3
  • 87
    • 0025862370 scopus 로고
    • Cyclosporin as a treatment for interstitial lung disease of unknown aetiology
    • Moolman, J.A., Bardin, P.G., Rossouw, D.J. and Joubert, J.R. (1991) Cyclosporin as a treatment for interstitial lung disease of unknown aetiology. Thorax 46: 592-595.
    • (1991) Thorax , vol.46 , pp. 592-595
    • Moolman, J.A.1    Bardin, P.G.2    Rossouw, D.J.3    Joubert, J.R.4
  • 88
    • 0024271159 scopus 로고
    • Epithelial necrosis and alveolar collapse in the pathogenesis of usual interstitial pneumonia
    • Myers, J.L. and Katzenstein, A.L. (1988) Epithelial necrosis and alveolar collapse in the pathogenesis of usual interstitial pneumonia. Chest 94: 1309-1311.
    • (1988) Chest , vol.94 , pp. 1309-1311
    • Myers, J.L.1    Katzenstein, A.L.2
  • 89
    • 0036967820 scopus 로고    scopus 로고
    • Open-label compassionate use one year-treatment with pirfenidone to patients with chronic pulmonary “brosis
    • Nagai, S., Hamada, K., Shigematsu, M., Taniyama, M., Yamauchi, S., Izumi, T. et al. (2002) Open-label compassionate use one year-treatment with pirfenidone to patients with chronic pulmonary “brosis. Intern Med 41: 1118-1123.
    • (2002) Intern Med , vol.41 , pp. 1118-1123
    • Nagai, S.1    Hamada, K.2    Shigematsu, M.3    Taniyama, M.4    Yamauchi, S.5    Izumi, T.6
  • 90
    • 0033618337 scopus 로고    scopus 로고
    • Matrix metalloproteinases
    • Nagase, H. and Woessner Jr, J.F. (1999) Matrix metalloproteinases. J Biol Chem 274: 21491-21494.
    • (1999) J Biol Chem , vol.274 , pp. 21491-21494
    • Nagase, H.1    Woessner, J.F.2
  • 91
    • 0037141774 scopus 로고    scopus 로고
    • novel anti-”brotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level
    • Nakazato, H., Oku, H., Yamane, S., Tsuruta,Y. and Suzuki, R.A. (2002) novel anti-”brotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol 446: 177-185.
    • (2002) Eur J Pharmacol , vol.446 , pp. 177-185
    • Nakazato, H.1    Oku, H.2    Yamane, S.3    TsurutaY.4    Suzuki, R.A.5
  • 92
    • 0027231698 scopus 로고
    • Expression of tumour necrosis factor-α in cryptogenic “brosing alveolitis
    • Nash, J.R.G., McLaughlin, P.J., Butcher, D. and Corrin, B. (1993) Expression of tumour necrosis factor-α in cryptogenic “brosing alveolitis. Histopathology 22: 343-347.
    • (1993) Histopathology , vol.22 , pp. 343-347
    • Nash, J.R.G.1    McLaughlin, P.J.2    Butcher, D.3    Corrin, B.4
  • 93
    • 0037099161 scopus 로고    scopus 로고
    • The relationship between individual histologic features and disease progression in idiopathic pulmonary “brosis
    • Nicholson, A.G., Fulford, L.G., Colby, T.V. et al. (2002) The relationship between individual histologic features and disease progression in idiopathic pulmonary “brosis. Am J Respir Crit Care Med 166: 173-117.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 173
    • Nicholson, A.G.1    Fulford, L.G.2    Colby, T.V.3
  • 94
    • 0033600396 scopus 로고    scopus 로고
    • Pirfenidone in IPF
    • Nicod, L.P. (1999) Pirfenidone in IPF. Lancet 354: 268-269.
    • (1999) Lancet , vol.354 , pp. 268-269
    • Nicod, L.P.1
  • 95
    • 0035433059 scopus 로고    scopus 로고
    • Autoantibodies to IL-1 alpha in sera from rapidly progressive idiopathic pulmonary “brosis
    • Ogushi, F., Tani, K., Endo, T., Tada, H., Kawano, T., Asano, T. et al. (2001) Autoantibodies to IL-1 alpha in sera from rapidly progressive idiopathic pulmonary “brosis. J Med Invest. 48: 181-189.
    • (2001) J Med Invest , vol.48 , pp. 181-189
    • Ogushi, F.1    Tani, K.2    Endo, T.3    Tada, H.4    Kawano, T.5    Asano, T.6
  • 96
    • 0033646235 scopus 로고    scopus 로고
    • Serum anti-p53 autoantibodies from patients with idiopathic pulmonary “brosis associated with lung cancer
    • Oshikawa, K. and Sugiyama,Y. (2000) Serum anti-p53 autoantibodies from patients with idiopathic pulmonary “brosis associated with lung cancer. Respir Med 94: 1085-1091.
    • (2000) Respir Med , vol.94 , pp. 1085-1091
    • Oshikawa, K.1    SugiyamaY.2
  • 97
    • 0030755489 scopus 로고    scopus 로고
    • Increased endothelin-1 in bleomycin-induced pulmonary “brosis and the effect of an endothelin receptor antagonist
    • Park, S.H., Saleh, D., Giaid, A. and Michel, R.P. (1997) Increased endothelin-1 in bleomycin-induced pulmonary “brosis and the effect of an endothelin receptor antagonist. Am J Respir Crit Care Med 156: 600-608.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 600-608
    • Park, S.H.1    Saleh, D.2    Giaid, A.3    Michel, R.P.4
  • 98
    • 0032780823 scopus 로고    scopus 로고
    • Somatostatin and its receptor family
    • Patel,Y.C. (1999) Somatostatin and its receptor family. Front Neuroendocrinol 20: 157-198.
    • (1999) Front Neuroendocrinol , vol.20 , pp. 157-198
    • PatelY.C.1
  • 99
    • 4043055316 scopus 로고    scopus 로고
    • Circulating “brocytes traf”c to the lungs in response to CXCL12 and mediate “brosis
    • Phillips, R.J., Burdick, M.D., Hong, K., Lutz, M.A., Murray, L.A., Xue,Y.Y. et al. (2004) Circulating “brocytes traf”c to the lungs in response to CXCL12 and mediate “brosis. J Clin Invest 114: 438-446.
    • (2004) J Clin Invest , vol.114 , pp. 438-446
    • Phillips, R.J.1    Burdick, M.D.2    Hong, K.3    Lutz, M.A.4    Murray, L.A.5    XueY.Y.6
  • 100
    • 10244257791 scopus 로고
    • Hamman-Rich syndrome; report of a case diagnosed antemortem by lung biopsy and successfully treated with long-term cortisone therapy
    • Pinney, C.T. and Harris, H.W. (1956) Hamman-Rich syndrome; report of a case diagnosed antemortem by lung biopsy and successfully treated with long-term cortisone therapy. Am J Med 20: 308-313.
    • (1956) Am J Med , vol.20 , pp. 308-313
    • Pinney, C.T.1    Harris, H.W.2
  • 101
    • 0026550854 scopus 로고
    • In vivo levels and in vitro production of interferon-gamma in “brosing interstitial lung diseases
    • Prior, C. and Haslam, P.L. (1992) In vivo levels and in vitro production of interferon-gamma in “brosing interstitial lung diseases. Clin Exp Immunol 88: 280-287.
    • (1992) Clin Exp Immunol , vol.88 , pp. 280-287
    • Prior, C.1    Haslam, P.L.2
  • 102
    • 0026389762 scopus 로고
    • Azathioprine combined with prednisone in the treatment of idiopathic pulmonary “brosis: a prospective double-blind, randomized, placebo-controlled clinical trial
    • Raghu, G., Depaso, W.J., Cain, K., Hammar, S.P., Wetzel, C.E., Dreis, D.F. et al. (1991) Azathioprine combined with prednisone in the treatment of idiopathic pulmonary “brosis: a prospective double-blind, randomized, placebo-controlled clinical trial. Am Rev Respir Dis 144: 291-296.
    • (1991) Am Rev Respir Dis , vol.144 , pp. 291-296
    • Raghu, G.1    Depaso, W.J.2    Cain, K.3    Hammar, S.P.4    Wetzel, C.E.5    Dreis, D.F.6
  • 105
    • 0345824715 scopus 로고    scopus 로고
    • Idiopathic Pulmonary Fibrosis Study Group. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary “brosis
    • Raghu, G., Brown, K.K., Bradford, W.Z., Starko, K., Noble, P.W., Schwartz, D.A. et al. (2004) Idiopathic Pulmonary Fibrosis Study Group. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary “brosis. N Engl J Med 350: 125-133.
    • (2004) N Engl J Med , vol.350 , pp. 125-133
    • Raghu, G.1    Brown, K.K.2    Bradford, W.Z.3    Starko, K.4    Noble, P.W.5    Schwartz, D.A.6
  • 106
    • 55549114541 scopus 로고    scopus 로고
    • Ef”cacy and safety of etanercept in patients with idiopathic pulmonary “brosis (IPF)
    • Suppl
    • Raghu, G., Fatenejad, S., McDermott, L. and the IPF Study Group. (2006) Ef”cacy and safety of etanercept in patients with idiopathic pulmonary “brosis (IPF). Eur Respir J 28: Suppl. 50, 767s.
    • (2006) Eur Respir J , vol.28 , Issue.50 , pp. 767s
    • Raghu, G.1    Fatenejad, S.2    McDermott, L.3    the IPF Study Group.4
  • 107
    • 0035026949 scopus 로고    scopus 로고
    • Fibroblasts from idiopathic pulmonary “brosis and normal lungs differ in growth rate, apoptosis, and TIMPs expression
    • Ramos, C., Montaño, M., García-Alvarez, J., Ruiz, V., Uhal, B.D., Selman, M. et al. (2001) Fibroblasts from idiopathic pulmonary “brosis and normal lungs differ in growth rate, apoptosis, and TIMPs expression. Am J Respir Cell Mol Biol 24: 591-598.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 591-598
    • Ramos, C.1    Montaño, M.2    García-Alvarez, J.3    Ruiz, V.4    Uhal, B.D.5    Selman, M.6
  • 108
    • 0019639461 scopus 로고
    • Production of “bronectin by human alveolar macrophage: mechanism for the recruitment of “broblasts to sites of injury in interstitial lung diseases
    • Rennard, S.I., Hunningake, G.W., Bitterman, P.B. and Crystal, R.G. (1981) Production of “bronectin by human alveolar macrophage: mechanism for the recruitment of “broblasts to sites of injury in interstitial lung diseases. Proc Natl Acad Sci USA 78: 7147-7151.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 7147-7151
    • Rennard, S.I.1    Hunningake, G.W.2    Bitterman, P.B.3    Crystal, R.G.4
  • 110
    • 0031065214 scopus 로고    scopus 로고
    • Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary “brosis: possible involvement of proin”ammatory cytokines
    • Saleh, D., Furukawa, K., Tsao, M.S., Maghazachi, A., Corrin, B., Yanagisawa, M. et al. (1997) Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary “brosis: possible involvement of proin”ammatory cytokines. Am J Respir Cell Mol Biol 16: 187-193.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 187-193
    • Saleh, D.1    Furukawa, K.2    Tsao, M.S.3    Maghazachi, A.4    Corrin, B.5    Yanagisawa, M.6
  • 111
    • 0026080801 scopus 로고
    • Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
    • Sampaio, E.P., Sarno, E.N., Galilly, R., Cohn, Z.A. and Kaplan, G. (1991) Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 173: 699-703.
    • (1991) J Exp Med , vol.173 , pp. 699-703
    • Sampaio, E.P.1    Sarno, E.N.2    Galilly, R.3    Cohn, Z.A.4    Kaplan, G.5
  • 112
    • 0037386288 scopus 로고    scopus 로고
    • A dark side of interferon-gamma in the treatment of idiopathic pulmonary “brosis?
    • Selman, M. (2003) A dark side of interferon-gamma in the treatment of idiopathic pulmonary “brosis? Am J Respir Crit Care Med 167: 945-947.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 945-947
    • Selman, M.1
  • 113
    • 0031842059 scopus 로고    scopus 로고
    • Colchicine, D-penicillamine, and prednisone in the treatment of idiopathic pulmonary “brosis: a controlled clinical trial
    • Selman, M., Carrillo, G., Salas, J., Padilla, R.P., Pérez-Chavira, R., Sansores, R. et al. (1998) Colchicine, D-penicillamine, and prednisone in the treatment of idiopathic pulmonary “brosis: a controlled clinical trial. Chest 114: 507-512.
    • (1998) Chest , vol.114 , pp. 507-512
    • Selman, M.1    Carrillo, G.2    Salas, J.3    Padilla, R.P.4    Pérez-Chavira, R.5    Sansores, R.6
  • 114
    • 0033830350 scopus 로고    scopus 로고
    • TIMP-1-2,-3, and -4 in idiopathic pulmonary “brosis. A prevailing nondegradative lung microenvironment?
    • Selman, M., Ruiz, V., Cabrera, S., Segura, L., Ramirez, R., Barrios, R. et al. (2000) TIMP-1-2,-3, and -4 in idiopathic pulmonary “brosis. A prevailing nondegradative lung microenvironment? Am J Physiol Lung Cell Mol Physiol 279: L562-574.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279 , pp. L562-L574
    • Selman, M.1    Ruiz, V.2    Cabrera, S.3    Segura, L.4    Ramirez, R.5    Barrios, R.6
  • 115
    • 0035895243 scopus 로고    scopus 로고
    • Idiopathic pulmonary “brosis: prevailing and evolving hypothesis about its pathogenesis and implications for therapy
    • Selman, M., King, T.E. and Pardo, A. (2001) Idiopathic pulmonary “brosis: prevailing and evolving hypothesis about its pathogenesis and implications for therapy. Ann Intern Med 134: 136-151.
    • (2001) Ann Intern Med , vol.134 , pp. 136-151
    • Selman, M.1    King, T.E.2    Pardo, A.3
  • 116
    • 25444478849 scopus 로고    scopus 로고
    • Idiopathic pulmonary “brosis: an epithelial/”broblastic cross-talk disorder
    • Selman, M. and Pardo, A. (2002) Idiopathic pulmonary “brosis: an epithelial/”broblastic cross-talk disorder. Respir Res 3: 3
    • (2002) Respir Res , vol.3 , pp. 3
    • Selman, M.1    Pardo, A.2
  • 117
    • 0034972513 scopus 로고    scopus 로고
    • Pulmonary “brosis: a cellular overreaction or a failure of communication?
    • Sheppard, D. (2001) Pulmonary “brosis: a cellular overreaction or a failure of communication? J Clin Invest 107: 1501-1502.
    • (2001) J Clin Invest , vol.107 , pp. 1501-1502
    • Sheppard, D.1
  • 119
    • 0025019279 scopus 로고
    • Oxygen radical production by alveolar in”ammatory cells in idiopathic pulmonary “brosis
    • Strausz, J., Muller-Quernheim, J., Steppling, H. and Ferlinz, R. (1990) Oxygen radical production by alveolar in”ammatory cells in idiopathic pulmonary “brosis. Am Rev Respir Dis 141: 124-128.
    • (1990) Am Rev Respir Dis , vol.141 , pp. 124-128
    • Strausz, J.1    Muller-Quernheim, J.2    Steppling, H.3    Ferlinz, R.4
  • 120
    • 28044447391 scopus 로고    scopus 로고
    • Pathogenesis and Natural History of Usual Interstitial Pneumonia. The Whole Story or the Last Chapter of a Long Novel
    • Strieter, R.M. (2005) Pathogenesis and Natural History of Usual Interstitial Pneumonia. The Whole Story or the Last Chapter of a Long Novel. Chest 128: 526S-532S.
    • (2005) Chest , vol.128 , pp. 526S-532S
    • Strieter, R.M.1
  • 123
    • 34548693221 scopus 로고    scopus 로고
    • Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary “brosis
    • Takahashi, T., Wada, I., Ohtsuka,Y., Munakata, M., Homma,Y., Kuroki,Y. et al. (2007) Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary “brosis. Respirology. 12: 642-653.
    • (2007) Respirology , vol.12 , pp. 642-653
    • Takahashi, T.1    Wada, I.2    OhtsukaY.3    Munakata, M.4    HommaY.5    KurokiY.6
  • 124
    • 0031051039 scopus 로고    scopus 로고
    • Thalidomide reduces tumor necrosis factor-α production by human alveolar macrophages
    • Tavares, J.L., Wangoo, A., Dilworth, P., Marshall, B., Kotecha, S., Shaw, R.J. et al. (1997) Thalidomide reduces tumor necrosis factor-α production by human alveolar macrophages. Respir Med 91: 31-39.
    • (1997) Respir Med , vol.91 , pp. 31-39
    • Tavares, J.L.1    Wangoo, A.2    Dilworth, P.3    Marshall, B.4    Kotecha, S.5    Shaw, R.J.6
  • 125
    • 33644835331 scopus 로고    scopus 로고
    • A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary “brosis
    • Tomioka, H., Kuwata,Y., Imanaka, K., Hashimoto, K., Ohnishi, H., Tada, K. et al. (2005) A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary “brosis Respirology 10: 449-455.
    • (2005) Respirology , vol.10 , pp. 449-455
    • Tomioka, H.1    KuwataY.2    Imanaka, K.3    Hashimoto, K.4    Ohnishi, H.5    Tada, K.6
  • 126
    • 0018823458 scopus 로고
    • Cryptogenic “brosing alveolitis: response to corticosteroid treatment and its effect on survival
    • Turner-Warwick, M., Burrows, B. and Johnson, A. (1980) Cryptogenic “brosing alveolitis: response to corticosteroid treatment and its effect on survival. Thorax 35: 593-599.
    • (1980) Thorax , vol.35 , pp. 593-599
    • Turner-Warwick, M.1    Burrows, B.2    Johnson, A.3
  • 127
    • 0032437815 scopus 로고    scopus 로고
    • Alveolar epithelial cell death adjacent to underlying myo”broblasts in advanced “brotic human lung
    • Uhal, B.D., Joshi, I., Hughes, W.F., Ramos, C., Pardo, A., Selman, M. et al. (1998) Alveolar epithelial cell death adjacent to underlying myo”broblasts in advanced “brotic human lung. Am J Physiol 275: L1192-L1199.
    • (1998) Am J Physiol , vol.275 , pp. L1192-L1199
    • Uhal, B.D.1    Joshi, I.2    Hughes, W.F.3    Ramos, C.4    Pardo, A.5    Selman, M.6
  • 128
    • 0027731993 scopus 로고
    • Ef”cacy of cyclosporine to reduce steroids in patients with idiopathic pulmonary “brosis before lung transplantation
    • Venuta, F., Rendina, E.A., Ciriaco, P., De Giacomo, T., Pompeo, E., Bachetoni, A. et al. (1993) Ef”cacy of cyclosporine to reduce steroids in patients with idiopathic pulmonary “brosis before lung transplantation. J Heart Lung Transplant 12(6Pt1): 909-914.
    • (1993) J Heart Lung Transplant , vol.12 , Issue.6Pt1 , pp. 909-914
    • Venuta, F.1    Rendina, E.A.2    Ciriaco, P.3    De Giacomo, T.4    Pompeo, E.5    Bachetoni, A.6
  • 129
    • 18144371956 scopus 로고    scopus 로고
    • Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myo”broblasts
    • Waghray, M., Cui, Z., Horowitz, J.C., Subramanian, I.M., Martinez, F.J., Toews, G.B. et al. (2005) Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myo”broblasts. FASEB J 19: 854-856.
    • (2005) FASEB J , vol.19 , pp. 854-856
    • Waghray, M.1    Cui, Z.2    Horowitz, J.C.3    Subramanian, I.M.4    Martinez, F.J.5    Toews, G.B.6
  • 130
    • 0033021135 scopus 로고    scopus 로고
    • Immunoreactive interleukin 4 and interferon-gamma expression by type II alveolar epithelial cells in interstitial lung disease
    • Wallace, W.A. and Howie, S.E. (1999) Immunoreactive interleukin 4 and interferon-gamma expression by type II alveolar epithelial cells in interstitial lung disease. J Pathol 187(4): 475-480.
    • (1999) J Pathol , vol.187 , Issue.4 , pp. 475-480
    • Wallace, W.A.1    Howie, S.E.2
  • 131
    • 0029113474 scopus 로고
    • A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic “brosing alveolitis (CFA)
    • Wallace, W.A., Ramage, E.A., Lamb, D. and Howie, S.E. (1995) A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic “brosing alveolitis (CFA). Clin Exp Immunol 101(3): 436-441.
    • (1995) Clin Exp Immunol , vol.101 , Issue.3 , pp. 436-441
    • Wallace, W.A.1    Ramage, E.A.2    Lamb, D.3    Howie, S.E.4
  • 132
    • 33744901434 scopus 로고    scopus 로고
    • Current perspectives on the treatment of idiopathic pulmonary “brosis
    • E
    • Walter, N., Collard, H.R. and King Jr., T. E. (2006) Current perspectives on the treatment of idiopathic pulmonary “brosis. Proc Am Thorac Soc 3: 330-338.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 330-338
    • Walter, N.1    Collard, H.R.2    King, T.3
  • 133
    • 0036248415 scopus 로고    scopus 로고
    • Detection of antivimentin antibody in sera of patients with idiopathic pulmonary “brosis and non-speci”c interstitial pneumonia
    • Yang,Y., Fujita, J., Bandoh, S., Ohtsuki, Y., Yamadori, I., Yoshinouchi, T. et al. (2002) Detection of antivimentin antibody in sera of patients with idiopathic pulmonary “brosis and non-speci”c interstitial pneumonia. Clin Exp Immunol 128: 169-174.
    • (2002) Clin Exp Immunol , vol.128 , pp. 169-174
    • YangY.1    Fujita, J.2    Bandoh, S.3    Ohtsuki, Y.4    Yamadori, I.5    Yoshinouchi, T.6
  • 134
    • 33847402332 scopus 로고    scopus 로고
    • Thalidomide reduces IL-18, IL-8 and TNF-a release from alveolar macrophages in interstitial lung disease
    • Ye, Q., Chen, B., Tong, Z., Nakamura, S., Sarria, R., Costabel, U. and Guzman, J. (2006) Thalidomide reduces IL-18, IL-8 and TNF-a release from alveolar macrophages in interstitial lung disease. Eur Respir J 28: 824-831.
    • (2006) Eur Respir J , vol.28 , pp. 824-831
    • Ye, Q.1    Chen, B.2    Tong, Z.3    Nakamura, S.4    Sarria, R.5    Costabel, U.6    Guzman, J.7
  • 135
    • 0033258047 scopus 로고    scopus 로고
    • Inhibition of myo”broblast apoptosis by transforming growth factor beta(1)
    • Zhang, H.Y. and Phan, S.H. (1999) Inhibition of myo”broblast apoptosis by transforming growth factor beta(1). Am J Respir Cell Mol Biol 21: 658-665.
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 658-665
    • Zhang, H.Y.1    Phan, S.H.2
  • 136
    • 33750268741 scopus 로고    scopus 로고
    • Therapy of chronic interstitial lung disease with a combination of interferon-gamma and low-dose prednisolone
    • Suppl:
    • Ziesche, R., Kink, E., Herold, C., Podolsky, A. and Block, L.H. (1996) Therapy of chronic interstitial lung disease with a combination of interferon-gamma and low-dose prednisolone. Chest 110: Suppl: 25S.
    • (1996) Chest , vol.110 , Issue.25S
    • Ziesche, R.1    Kink, E.2    Herold, C.3    Podolsky, A.4    Block, L.H.5
  • 137
    • 0033592753 scopus 로고    scopus 로고
    • A pre liminary study of long-term treatment with interferon gamma 1b and low-dose prednisolone in patients with idiopathic pulmonary “brosis
    • Ziesche, R., Hofbauer, E., Wittmann, K., Petkov, V. and Block, L.H. (1999) A pre liminary study of long-term treatment with interferon gamma 1b and low-dose prednisolone in patients with idiopathic pulmonary “brosis. The New England Journal of Medicine 341: 1264-1269.
    • (1999) The New England Journal of Medicine , vol.341 , pp. 1264-1269
    • Ziesche, R.1    Hofbauer, E.2    Wittmann, K.3    Petkov, V.4    Block, L.H.5
  • 138
    • 0034047115 scopus 로고    scopus 로고
    • Cyclophosphamide in the treatment of idiopathic pulmonary “brosis: a prospective study in patients who failed to respond to corticosteroids
    • Zisman, D.A., Lynch, J.P. 3rd, Toews, G.B., Kazerooni, E.A., Flint, A., Martinez, F.J. et al. (2000) Cyclophosphamide in the treatment of idiopathic pulmonary “brosis: a prospective study in patients who failed to respond to corticosteroids. Chest 117: 1619-1626.
    • (2000) Chest , vol.117 , pp. 1619-1626
    • Zisman, D.A.1    Lynch, J.P.2    Toews, G.B.3    Kazerooni, E.A.4    Flint, A.5    Martinez, F.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.