-
1
-
-
77951089891
-
-
International Federation of Diabetes. Accessed January 2011
-
International Federation of Diabetes. IDF diabetes atlas. http://www.diabetesatlas.org/ (Accessed January 2011).
-
IDF Diabetes Atlas
-
-
-
2
-
-
19944426903
-
Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes
-
Lyssenko V, Almgren P, Anevski D, Perfekt R, Lahti K, Nissen M, et al. Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 2005;54:166-74.
-
(2005)
Diabetes
, vol.54
, pp. 166-174
-
-
Lyssenko, V.1
Almgren, P.2
Anevski, D.3
Perfekt, R.4
Lahti, K.5
Nissen, M.6
-
3
-
-
0002872316
-
Empirical risk figures for first-degree relatives of non-insulin dependent diabetics
-
Köbberling J, Tattersall R, eds. London: Academic Press;
-
Köbberling J, Tillil H. Empirical risk figures for first-degree relatives of non-insulin dependent diabetics. In: Köbberling J, Tattersall R, eds. The genetics of diabetes mellitus. London: Academic Press; 1982:201-9.
-
(1982)
The Genetics of Diabetes Mellitus
, pp. 201-209
-
-
Köbberling, J.1
Tillil, H.2
-
4
-
-
0003014882
-
Metabolic consequences of a family history of NIDDM (the Botnia study): Evidence for sex-specific parental effects
-
Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, Nissen M, et al. Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 1996;45:1585-93.
-
(1996)
Diabetes
, vol.45
, pp. 1585-1593
-
-
Groop, L.1
Forsblom, C.2
Lehtovirta, M.3
Tuomi, T.4
Karanko, S.5
Nissen, M.6
-
5
-
-
0026641354
-
Concordance for type 1 (insulin-dependent) and type 2 (noninsulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
-
Kaprio J, Tuomilehto J, Koskenvuo M, Romanov K, Reunanen A, Eriksson J, et al. Concordance for type 1 (insulin-dependent) and type 2 (noninsulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 1992;35:1060-7.
-
(1992)
Diabetologia
, vol.35
, pp. 1060-1067
-
-
Kaprio, J.1
Tuomilehto, J.2
Koskenvuo, M.3
Romanov, K.4
Reunanen, A.5
Eriksson, J.6
-
6
-
-
0023201498
-
Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins
-
Newman B, Selby JV, King MC, Slemenda C, Fabsitz R, Friedman GD. Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 1987;30:763-8.
-
(1987)
Diabetologia
, vol.30
, pp. 763-768
-
-
Newman, B.1
Selby, J.V.2
King, M.C.3
Slemenda, C.4
Fabsitz, R.5
Friedman, G.D.6
-
7
-
-
40049088818
-
Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients
-
Glans F, Elgzyri T, Shaat N, Lindholm E, Apelqvist J, Groop L. Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients. Diabet Med 2008;25:303-7.
-
(2008)
Diabet Med
, vol.25
, pp. 303-307
-
-
Glans, F.1
Elgzyri, T.2
Shaat, N.3
Lindholm, E.4
Apelqvist, J.5
Groop, L.6
-
8
-
-
79551491840
-
-
Accessed January 2011
-
WHO. Obesity. http://www.who.int/topics/obesity/ (Accessed January 2011).
-
Obesity
-
-
-
9
-
-
70349566593
-
Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"?
-
Neel JV. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 1962;14:353-62.
-
(1962)
Am J Hum Genet
, vol.14
, pp. 353-362
-
-
Neel, J.V.1
-
10
-
-
0033365057
-
Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans
-
Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, et al. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 1999;64:1127-40.
-
(1999)
Am J Hum Genet
, vol.64
, pp. 1127-1140
-
-
Duggirala, R.1
Blangero, J.2
Almasy, L.3
Dyer, T.D.4
Williams, K.L.5
Leach, R.J.6
-
11
-
-
0042666793
-
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2
-
Reynisdottir I, Thorleifsson G, Benediktsson R, Sigurdsson G, Emilsson V, Einarsdottir AS, et al. Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am J Hum Genet 2003;73:323-35.
-
(2003)
Am J Hum Genet
, vol.73
, pp. 323-335
-
-
Reynisdottir, I.1
Thorleifsson, G.2
Benediktsson, R.3
Sigurdsson, G.4
Emilsson, V.5
Einarsdottir, A.S.6
-
12
-
-
32544451924
-
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
-
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006;38:320-3.
-
(2006)
Nat Genet
, vol.38
, pp. 320-323
-
-
Grant, S.F.1
Thorleifsson, G.2
Reynisdottir, I.3
Benediktsson, R.4
Manolescu, A.5
Sainz, J.6
-
13
-
-
61849101938
-
Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: A large Human Genome Epidemiology (HuGE) review and meta-analysis
-
Tong Y, Lin Y, Zhang Y, Yang J, Liu H, Zhang B. Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis. BMC Med Genet 2009;10:15.
-
(2009)
BMC Med Genet
, vol.10
, pp. 15
-
-
Tong, Y.1
Lin, Y.2
Zhang, Y.3
Yang, J.4
Liu, H.5
Zhang, B.6
-
14
-
-
34547702501
-
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
-
Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007;117:2155-63.
-
(2007)
J Clin Invest
, vol.117
, pp. 2155-2163
-
-
Lyssenko, V.1
Lupi, R.2
Marchetti, P.3
Del Guerra, S.4
Orho-Melander, M.5
Almgren, P.6
-
15
-
-
12544254474
-
TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
-
Yi F, Brubaker PL, Jin T. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 2005;280:1457-64.
-
(2005)
J Biol Chem
, vol.280
, pp. 1457-1464
-
-
Yi, F.1
Brubaker, P.L.2
Jin, T.3
-
16
-
-
35848942800
-
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
-
Schafer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, et al. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 2007;50:2443-50.
-
(2007)
Diabetologia
, vol.50
, pp. 2443-2450
-
-
Schafer, S.A.1
Tschritter, O.2
Machicao, F.3
Thamer, C.4
Stefan, N.5
Gallwitz, B.6
-
17
-
-
9044243415
-
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
-
Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, Stirling B, et al. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet 1996;13:161-6.
-
(1996)
Nat Genet
, vol.13
, pp. 161-166
-
-
Hanis, C.L.1
Boerwinkle, E.2
Chakraborty, R.3
Ellsworth, D.L.4
Concannon, P.5
Stirling, B.6
-
18
-
-
0033772073
-
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
-
Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 2000;26:163-75.
-
(2000)
Nat Genet
, vol.26
, pp. 163-175
-
-
Horikawa, Y.1
Oda, N.2
Cox, N.J.3
Li, X.4
Orho-Melander, M.5
Hara, M.6
-
19
-
-
0842285701
-
Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies
-
Song Y, Niu T, Manson JE, Kwiatkowski DJ, Liu S. Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies. Am J Hum Genet 2004;74:208-22.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 208-222
-
-
Song, Y.1
Niu, T.2
Manson, J.E.3
Kwiatkowski, D.J.4
Liu, S.5
-
20
-
-
0242607158
-
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility
-
Weedon MN, Schwarz PE, Horikawa Y, Iwasaki N, Illig T, Holle R, et al. Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet 2003;73:1208-12.
-
(2003)
Am J Hum Genet
, vol.73
, pp. 1208-1212
-
-
Weedon, M.N.1
Schwarz, P.E.2
Horikawa, Y.3
Iwasaki, N.4
Illig, T.5
Holle, R.6
-
21
-
-
0031595923
-
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J, et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998;20:284-7.
-
(1998)
Nat Genet
, vol.20
, pp. 284-287
-
-
Deeb, S.S.1
Fajas, L.2
Nemoto, M.3
Pihlajamaki, J.4
Mykkanen, L.5
Kuusisto, J.6
-
22
-
-
0033624575
-
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000;26:76-80.
-
(2000)
Nat Genet
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
Hirschhorn, J.N.2
Klannemark, M.3
Lindgren, C.M.4
Vohl, M.C.5
Nemesh, J.6
-
23
-
-
33845472305
-
Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with pre-diabetic phenotypes: Meta-analysis of 57 studies on nondiabetic individuals
-
Tonjes A, Scholz M, Loeffler M, Stumvoll M. Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care 2006;29:2489-97.
-
(2006)
Diabetes Care
, vol.29
, pp. 2489-2497
-
-
Tonjes, A.1
Scholz, M.2
Loeffler, M.3
Stumvoll, M.4
-
24
-
-
77949397703
-
The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: A HuGE review and meta-analysis
-
Gouda HN, Sagoo GS, Harding AH, Yates J, Sandhu MS, Higgins JP. The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol 2010;171:645-55.
-
(2010)
Am J Epidemiol
, vol.171
, pp. 645-655
-
-
Gouda, H.N.1
Sagoo, G.S.2
Harding, A.H.3
Yates, J.4
Sandhu, M.S.5
Higgins, J.P.6
-
25
-
-
0027367546
-
Aminoacid polymorphisms of insulin receptor substrate-1 in noninsulin-dependent diabetes mellitus
-
Almind K, Bjorbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O. Aminoacid polymorphisms of insulin receptor substrate-1 in noninsulin-dependent diabetes mellitus. Lancet 1993;342:828-32.
-
(1993)
Lancet
, vol.342
, pp. 828-832
-
-
Almind, K.1
Bjorbaek, C.2
Vestergaard, H.3
Hansen, T.4
Echwald, S.5
Pedersen, O.6
-
26
-
-
70349557826
-
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
-
Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proenca C, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009;41:1110-5.
-
(2009)
Nat Genet
, vol.41
, pp. 1110-1115
-
-
Rung, J.1
Cauchi, S.2
Albrechtsen, A.3
Shen, L.4
Rocheleau, G.5
Cavalcanti-Proenca, C.6
-
27
-
-
2342633204
-
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes
-
Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, et al. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004;350:1838-49.
-
(2004)
N Engl J Med
, vol.350
, pp. 1838-1849
-
-
Gloyn, A.L.1
Pearson, E.R.2
Antcliff, J.F.3
Proks, P.4
Bruining, G.J.5
Slingerland, A.S.6
-
28
-
-
0031773333
-
Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians
-
Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, Froguel P. Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians. Diabetologia 1998;41:1511-5.
-
(1998)
Diabetologia
, vol.41
, pp. 1511-1515
-
-
Hani, E.H.1
Boutin, P.2
Durand, E.3
Inoue, H.4
Permutt, M.A.5
Velho, G.6
Froguel, P.7
-
29
-
-
0037317981
-
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
-
Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003;52:568-72.
-
(2003)
Diabetes
, vol.52
, pp. 568-572
-
-
Gloyn, A.L.1
Weedon, M.N.2
Owen, K.R.3
Turner, M.J.4
Knight, B.A.5
Hitman, G.6
-
30
-
-
2342561802
-
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region
-
Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, et al. Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes 2004;53:1360-8.
-
(2004)
Diabetes
, vol.53
, pp. 1360-1368
-
-
Florez, J.C.1
Burtt, N.2
De Bakker, P.I.3
Almgren, P.4
Tuomi, T.5
Holmkvist, J.6
-
31
-
-
17844410419
-
Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: Population-based studies and metaanalyses
-
van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ. Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and metaanalyses. Diabet Med 2005;22:590-8.
-
(2005)
Diabet Med
, vol.22
, pp. 590-598
-
-
Van Dam, R.M.1
Hoebee, B.2
Seidell, J.C.3
Schaap, M.M.4
De Bruin, T.W.5
Feskens, E.J.6
-
32
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
Wash DC
-
Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (Wash DC) 2007;316:1331-6.
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
Burtt, N.P.4
De Bakker, P.I.5
Chen, H.6
-
33
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
-
Wash DC
-
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (Wash DC) 2007;316:1341-5.
-
(2007)
Science
, vol.316
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
Duren, W.L.6
-
34
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
Wash DC
-
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (Wash DC) 2007;316:1336-41.
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
Frayling, T.M.4
Elliott, K.S.5
Lango, H.6
-
35
-
-
0036227462
-
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations
-
Minton JA, Hattersley AT, Owen K, McCarthy MI, Walker M, Latif F, et al. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes 2002;51:1287-90.
-
(2002)
Diabetes
, vol.51
, pp. 1287-1290
-
-
Minton, J.A.1
Hattersley, A.T.2
Owen, K.3
McCarthy, M.I.4
Walker, M.5
Latif, F.6
-
36
-
-
34547536393
-
Common variants in WFS1 confer risk of type 2 diabetes
-
Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, et al. Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 2007;39:951-3.
-
(2007)
Nat Genet
, vol.39
, pp. 951-953
-
-
Sandhu, M.S.1
Weedon, M.N.2
Fawcett, K.A.3
Wasson, J.4
Debenham, S.L.5
Daly, A.6
-
37
-
-
39049146958
-
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
-
Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, et al. Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia 2008;51:458-63.
-
(2008)
Diabetologia
, vol.51
, pp. 458-463
-
-
Franks, P.W.1
Rolandsson, O.2
Debenham, S.L.3
Fawcett, K.A.4
Payne, F.5
Dina, C.6
-
38
-
-
33847361938
-
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
-
Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, Almgren P, et al. Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 2007;56:685-93.
-
(2007)
Diabetes
, vol.56
, pp. 685-693
-
-
Winckler, W.1
Weedon, M.N.2
Graham, R.R.3
McCarroll, S.A.4
Purcell, S.5
Almgren, P.6
-
39
-
-
33750954749
-
Common variants in HNF-1 alpha and risk of type 2 diabetes
-
Holmkvist J, Cervin C, Lyssenko V, Winckler W, Anevski D, Cilio C, et al. Common variants in HNF-1 alpha and risk of type 2 diabetes. Diabetologia 2006;49:2882-91.
-
(2006)
Diabetologia
, vol.49
, pp. 2882-2891
-
-
Holmkvist, J.1
Cervin, C.2
Lyssenko, V.3
Winckler, W.4
Anevski, D.5
Cilio, C.6
-
40
-
-
48249139502
-
Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
-
Holmkvist J, Almgren P, Lyssenko V, Lindgren CM, Eriksson KF, Isomaa B, et al. Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes. Diabetes 2008;57:1738-44.
-
(2008)
Diabetes
, vol.57
, pp. 1738-1744
-
-
Holmkvist, J.1
Almgren, P.2
Lyssenko, V.3
Lindgren, C.M.4
Eriksson, K.F.5
Isomaa, B.6
-
41
-
-
77954143522
-
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
-
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579-89.
-
(2010)
Nat Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
Morris, A.P.4
Dina, C.5
Welch, R.P.6
-
42
-
-
34547510624
-
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
-
Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 2007;39:977-83.
-
(2007)
Nat Genet
, vol.39
, pp. 977-983
-
-
Gudmundsson, J.1
Sulem, P.2
Steinthorsdottir, V.3
Bergthorsson, J.T.4
Thorleifsson, G.5
Manolescu, A.6
-
43
-
-
33847176604
-
A genome-wide association study identifies novel risk loci for type 2 diabetes
-
Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007;445:881-5.
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
Rocheleau, G.2
Rung, J.3
Dina, C.4
Shen, L.5
Serre, D.6
-
44
-
-
34249828965
-
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
-
Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 2007;39:770-5.
-
(2007)
Nat Genet
, vol.39
, pp. 770-775
-
-
Steinthorsdottir, V.1
Thorleifsson, G.2
Reynisdottir, I.3
Benediktsson, R.4
Jonsdottir, T.5
Walters, G.B.6
-
45
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
The Wellcome Trust Case Control Consortium
-
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
46
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-6.
-
(2007)
Nat Genet
, vol.39
, pp. 724-726
-
-
Dina, C.1
Meyre, D.2
Gallina, S.3
Durand, E.4
Korner, A.5
Jacobson, P.6
-
47
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Wash DC
-
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (Wash DC) 2007;316:889-94.
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
Lindgren, C.M.6
-
48
-
-
50449085212
-
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
-
Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008;40:1098-102.
-
(2008)
Nat Genet
, vol.40
, pp. 1098-1102
-
-
Unoki, H.1
Takahashi, A.2
Kawaguchi, T.3
Hara, K.4
Horikoshi, M.5
Andersen, G.6
-
49
-
-
50449085998
-
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
-
Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008;40:1092-7.
-
(2008)
Nat Genet
, vol.40
, pp. 1092-1097
-
-
Yasuda, K.1
Miyake, K.2
Horikawa, Y.3
Hara, K.4
Osawa, H.5
Furuta, H.6
-
50
-
-
70349640785
-
A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion
-
Jonsson A, Isomaa B, Tuomi T, Taneera J, Salehi A, Nilsson P, et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes 2009;58:2409-13.
-
(2009)
Diabetes
, vol.58
, pp. 2409-2413
-
-
Jonsson, A.1
Isomaa, B.2
Tuomi, T.3
Taneera, J.4
Salehi, A.5
Nilsson, P.6
-
51
-
-
77649214654
-
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese
-
Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, Chang CT, et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 6:e1000847.
-
PLoS Genet.
, vol.6
-
-
Tsai, F.J.1
Yang, C.F.2
Chen, C.C.3
Chuang, L.M.4
Lu, C.H.5
Chang, C.T.6
-
52
-
-
72449122779
-
Parental origin of sequence variants associated with complex diseases
-
Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S, et al. Parental origin of sequence variants associated with complex diseases. Nature 2009;462:868-74.
-
(2009)
Nature
, vol.462
, pp. 868-874
-
-
Kong, A.1
Steinthorsdottir, V.2
Masson, G.3
Thorleifsson, G.4
Sulem, P.5
Besenbacher, S.6
-
53
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008;40:638-45.
-
(2008)
Nat Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
Voight, B.F.4
Marchini, J.L.5
Hu, T.6
-
54
-
-
77954172286
-
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
-
Qi L, Cornelis MC, Kraft P, Stanya KJ, Linda Kao WH, Pankow JS, et al. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet. 19:2706-15.
-
Hum Mol Genet
, vol.19
, pp. 2706-2715
-
-
Qi, L.1
Cornelis, M.C.2
Kraft, P.3
Stanya, K.J.4
Linda Kao, W.H.5
Pankow, J.S.6
-
55
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105-16.
-
(2010)
Nat Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
Langenberg, C.2
Prokopenko, I.3
Saxena, R.4
Soranzo, N.5
Jackson, A.U.6
-
56
-
-
58149175669
-
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
-
Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 2009;41:82-8.
-
(2009)
Nat Genet
, vol.41
, pp. 82-88
-
-
Lyssenko, V.1
Nagorny, C.L.2
Erdos, M.R.3
Wierup, N.4
Jonsson, A.5
Spegel, P.6
-
57
-
-
58149175143
-
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
-
Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, Sparso T, Holmkvist J, Marchand M, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 2009;41:89-94.
-
(2009)
Nat Genet
, vol.41
, pp. 89-94
-
-
Bouatia-Naji, N.1
Bonnefond, A.2
Cavalcanti-Proenca, C.3
Sparso, T.4
Holmkvist, J.5
Marchand, M.6
-
58
-
-
58149156287
-
Variants in MTNR1B influence fasting glucose levels
-
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, et al. Variants in MTNR1B influence fasting glucose levels. Nat Genet 2009;41:77-81.
-
(2009)
Nat Genet
, vol.41
, pp. 77-81
-
-
Prokopenko, I.1
Langenberg, C.2
Florez, J.C.3
Saxena, R.4
Soranzo, N.5
Thorleifsson, G.6
-
59
-
-
11844293488
-
Melatonin as a chronobiotic
-
Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Med Rev 2005;9:25-39.
-
(2005)
Sleep Med Rev
, vol.9
, pp. 25-39
-
-
Arendt, J.1
Skene, D.J.2
-
60
-
-
0035991404
-
Mammalian melatonin receptors: Molecular biology and signal transduction
-
von Gall C, Stehle JH, Weaver DR. Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res 2002;309:151-62.
-
(2002)
Cell Tissue Res
, vol.309
, pp. 151-162
-
-
Von Gall, C.1
Stehle, J.H.2
Weaver, D.R.3
-
61
-
-
67349224047
-
Melatonin receptors in pancreatic islets: Good morning to a novel type 2 diabetes gene
-
Mulder H, Nagorny CL, Lyssenko V, Groop L. Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene. Diabetologia 2009;52:1240-9.
-
(2009)
Diabetologia
, vol.52
, pp. 1240-1249
-
-
Mulder, H.1
Nagorny, C.L.2
Lyssenko, V.3
Groop, L.4
-
62
-
-
55649105963
-
Clinical risk factors, DNA variants, and the development of type 2 diabetes
-
Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008;359:2220-32.
-
(2008)
N Engl J Med
, vol.359
, pp. 2220-2232
-
-
Lyssenko, V.1
Jonsson, A.2
Almgren, P.3
Pulizzi, N.4
Isomaa, B.5
Tuomi, T.6
-
63
-
-
50049119989
-
Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
-
Grarup N, Andersen G, Krarup NT, Albrechtsen A, Schmitz O, Jorgensen T, et al. Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes. Diabetes 2008;57:2534-40.
-
(2008)
Diabetes
, vol.57
, pp. 2534-2540
-
-
Grarup, N.1
Andersen, G.2
Krarup, N.T.3
Albrechtsen, A.4
Schmitz, O.5
Jorgensen, T.6
-
64
-
-
77951858557
-
Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans
-
Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes 2010;59:1266-75.
-
(2010)
Diabetes
, vol.59
, pp. 1266-1275
-
-
Ingelsson, E.1
Langenberg, C.2
Hivert, M.F.3
Prokopenko, I.4
Lyssenko, V.5
Dupuis, J.6
-
65
-
-
74249123937
-
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
-
Wash DC
-
Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, et al. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science (Wash DC) 2010;327:217-20.
-
(2010)
Science
, vol.327
, pp. 217-220
-
-
Rosengren, A.H.1
Jokubka, R.2
Tojjar, D.3
Granhall, C.4
Hansson, O.5
Li, D.Q.6
-
66
-
-
54249088172
-
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
-
Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella D, Roos C, et al. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 2008;57:3112-21.
-
(2008)
Diabetes
, vol.57
, pp. 3112-3121
-
-
Orho-Melander, M.1
Melander, O.2
Guiducci, C.3
Perez-Martinez, P.4
Corella, D.5
Roos, C.6
-
67
-
-
17244369621
-
Role of insulin-like growth factor in maintaining normal glucose homeostasis
-
Clemmons DR. Role of insulin-like growth factor in maintaining normal glucose homeostasis. Horm Res 2004;62(Suppl 1):77-82.
-
(2004)
Horm Res
, vol.62
, Issue.SUPPL. 1
, pp. 77-82
-
-
Clemmons, D.R.1
-
68
-
-
34249724529
-
Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution
-
Parker-Katiraee L, Carson AR, Yamada T, Arnaud P, Feil R, Abu-Amero SN, et al. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. PLoS Genet 2007;3:e65.
-
(2007)
PLoS Genet
, vol.3
-
-
Parker-Katiraee, L.1
Carson, A.R.2
Yamada, T.3
Arnaud, P.4
Feil, R.5
Abu-Amero, S.N.6
-
69
-
-
50549202600
-
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-9.
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Garland, P.B.2
Hales, C.N.3
Newsholme, E.A.4
-
70
-
-
0032934826
-
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
-
Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 1999;42:113-6.
-
(1999)
Diabetologia
, vol.42
, pp. 113-116
-
-
Krssak, M.1
Falk Petersen, K.2
Dresner, A.3
DiPietro, L.4
Vogel, S.M.5
Rothman, D.L.6
-
71
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999;48:1270-4.
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
Bell, K.4
Barucci, N.5
Lee, D.6
-
72
-
-
0035125917
-
Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spill-over
-
Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spill-over. Diabetes 2001;50 Suppl 1:S118-21.
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Unger, R.H.1
Zhou, Y.T.2
-
73
-
-
34548480442
-
Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: Heritabilities
-
Souren NY, Paulussen AD, Loos RJ, Gielen M, Beunen G, Fagard R, et al. Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities. Diabetologia 2007;50:2107-16.
-
(2007)
Diabetologia
, vol.50
, pp. 2107-2116
-
-
Souren, N.Y.1
Paulussen, A.D.2
Loos, R.J.3
Gielen, M.4
Beunen, G.5
Fagard, R.6
-
74
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009;41:18-24.
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
Steinthorsdottir, V.4
Sulem, P.5
Helgadottir, A.6
-
75
-
-
59149097625
-
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
-
Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, Gallina S, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009;41:157-9.
-
(2009)
Nat Genet
, vol.41
, pp. 157-159
-
-
Meyre, D.1
Delplanque, J.2
Chevre, J.C.3
Lecoeur, C.4
Lobbens, S.5
Gallina, S.6
-
76
-
-
70849120493
-
Recent progress in the genetics of common obesity
-
Loos RJ. Recent progress in the genetics of common obesity. Br J Clin Pharmacol 2009;68:811-29.
-
(2009)
Br J Clin Pharmacol
, vol.68
, pp. 811-829
-
-
Loos, R.J.1
-
77
-
-
77952405825
-
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
-
Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI, et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet 2010;6:e1000916.
-
(2010)
PLoS Genet
, vol.6
-
-
Scherag, A.1
Dina, C.2
Hinney, A.3
Vatin, V.4
Scherag, S.5
Vogel, C.I.6
-
78
-
-
67651236725
-
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
-
Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009;5:e1000508.
-
(2009)
PLoS Genet
, vol.5
-
-
Lindgren, C.M.1
Heid, I.M.2
Randall, J.C.3
Lamina, C.4
Steinthorsdottir, V.5
Qi, L.6
-
79
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115.
-
(2007)
PLoS Genet
, vol.3
-
-
Scuteri, A.1
Sanna, S.2
Chen, W.M.3
Uda, M.4
Albai, G.5
Strait, J.6
-
80
-
-
50949104331
-
Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population
-
Chang YC, Liu PH, Lee WJ, Chang TJ, Jiang YD, Li HY, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes 2008;57:2245-52.
-
(2008)
Diabetes
, vol.57
, pp. 2245-2252
-
-
Chang, Y.C.1
Liu, P.H.2
Lee, W.J.3
Chang, T.J.4
Jiang, Y.D.5
Li, H.Y.6
-
81
-
-
77956283111
-
Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study
-
Bressler J, Kao WH, Pankow JS, Boerwinkle E. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. PLoS One 2010;5:e10521.
-
(2010)
PLoS One
, vol.5
-
-
Bressler, J.1
Kao, W.H.2
Pankow, J.S.3
Boerwinkle, E.4
-
82
-
-
33645891676
-
Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins
-
Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem 2006;100:644-69.
-
(2006)
J Inorg Biochem
, vol.100
, pp. 644-669
-
-
Clifton, I.J.1
McDonough, M.A.2
Ehrismann, D.3
Kershaw, N.J.4
Granatino, N.5
Schofield, C.J.6
-
83
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
Wash DC
-
Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (Wash DC) 2007;318:1469-72.
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
Girard, C.A.2
Tung, Y.C.3
Webby, C.J.4
Saudek, V.5
Hewitson, K.S.6
-
84
-
-
67349211789
-
Inactivation of the Fto gene protects from obesity
-
Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Bruning JC, Ruther U. Inactivation of the Fto gene protects from obesity. Nature 2009;458:894-8.
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
Koch, L.2
Emmerling, C.3
Vierkotten, J.4
Peters, T.5
Bruning, J.C.6
Ruther, U.7
-
85
-
-
70549105941
-
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
-
Olszewski PK, Fredriksson R, Olszewska AM, Stephansson O, Alsio J, Radomska KJ, et al. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci 2009;10:129.
-
(2009)
BMC Neurosci
, vol.10
, pp. 129
-
-
Olszewski, P.K.1
Fredriksson, R.2
Olszewska, A.M.3
Stephansson, O.4
Alsio, J.5
Radomska, K.J.6
-
86
-
-
33845295812
-
The role of the central melanocortin system in the regulation of food intake and energy homeostasis: Lessons from mouse models
-
Ellacott KL, Cone RD. The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philos Trans R Soc Lond B Biol Sci 2006;361:1265-74.
-
(2006)
Philos Trans R Soc Lond B Biol Sci
, vol.361
, pp. 1265-1274
-
-
Ellacott, K.L.1
Cone, R.D.2
-
87
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40:768-75.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
Wheeler, E.4
Zhao, J.H.5
Prokopenko, I.6
-
88
-
-
44349166252
-
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
-
Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 2008;40:716-8.
-
(2008)
Nat Genet
, vol.40
, pp. 716-718
-
-
Chambers, J.C.1
Elliott, P.2
Zabaneh, D.3
Zhang, W.4
Li, Y.5
Froguel, P.6
-
89
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
Li, S.4
Lindgren, C.M.5
Heid, I.M.6
-
90
-
-
77952574849
-
Uncovering the roles of rare variants in common disease through whole-genome sequencing
-
Cirulli ET, Goldstein DB. Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet 2010;11:415-25.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 415-425
-
-
Cirulli, E.T.1
Goldstein, D.B.2
-
91
-
-
67349169201
-
Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction
-
Sparso T, Grarup N, Andreasen C, Albrechtsen A, Holmkvist J, Andersen G, et al. Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction. Diabetologia 2009;52:1308-14.
-
(2009)
Diabetologia
, vol.52
, pp. 1308-1314
-
-
Sparso, T.1
Grarup, N.2
Andreasen, C.3
Albrechtsen, A.4
Holmkvist, J.5
Andersen, G.6
-
92
-
-
47749124258
-
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
-
Cauchi S, Meyre D, Durand E, Proenca C, Marre M, Hadjadj S, et al. Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS One 2008;3:e2031.
-
(2008)
PLoS One
, vol.3
-
-
Cauchi, S.1
Meyre, D.2
Durand, E.3
Proenca, C.4
Marre, M.5
Hadjadj, S.6
-
93
-
-
33750876203
-
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
-
Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E, et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 2006;3:e374.
-
(2006)
PLoS Med
, vol.3
-
-
Weedon, M.N.1
McCarthy, M.I.2
Hitman, G.3
Walker, M.4
Groves, C.J.5
Zeggini, E.6
-
94
-
-
58149396842
-
Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis
-
Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W, et al. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci U S A 2008;105:19910-4.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19910-19914
-
-
Shao, H.1
Burrage, L.C.2
Sinasac, D.S.3
Hill, A.E.4
Ernest, S.R.5
O'Brien, W.6
-
95
-
-
0036499241
-
Sample size requirements for association studies of gene-gene interaction
-
Gauderman WJ. Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 2002;155:478-84.
-
(2002)
Am J Epidemiol
, vol.155
, pp. 478-484
-
-
Gauderman, W.J.1
-
96
-
-
2642583283
-
Mapping complex disease loci in wholegenome association studies
-
Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in wholegenome association studies. Nature 2004;429:446-52.
-
(2004)
Nature
, vol.429
, pp. 446-452
-
-
Carlson, C.S.1
Eberle, M.A.2
Kruglyak, L.3
Nickerson, D.A.4
-
97
-
-
33645381715
-
Epistasis and the release of genetic variation during long-term selection
-
Carlborg O, Jacobsson L, Ahgren P, Siegel P, Andersson L. Epistasis and the release of genetic variation during long-term selection. Nat Genet 2006;38:418-20.
-
(2006)
Nat Genet
, vol.38
, pp. 418-420
-
-
Carlborg, O.1
Jacobsson, L.2
Ahgren, P.3
Siegel, P.4
Andersson, L.5
-
98
-
-
18444416834
-
Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice
-
Johannesson M, Karlsson J, Wernhoff P, Nandakumar KS, Lindqvist AK, Olsson L, et al. Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice. Genes Immun 2005;6:175-85.
-
(2005)
Genes Immun
, vol.6
, pp. 175-185
-
-
Johannesson, M.1
Karlsson, J.2
Wernhoff, P.3
Nandakumar, K.S.4
Lindqvist, A.K.5
Olsson, L.6
-
99
-
-
30744473697
-
Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci
-
Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA. Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome 2006;17:22-36.
-
(2006)
Mamm Genome
, vol.17
, pp. 22-36
-
-
Stylianou, I.M.1
Korstanje, R.2
Li, R.3
Sheehan, S.4
Paigen, B.5
Churchill, G.A.6
-
100
-
-
77958596171
-
Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring
-
Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature. 467:963-6.
-
Nature
, vol.467
, pp. 963-966
-
-
Ng, S.F.1
Lin, R.C.2
Laybutt, D.R.3
Barres, R.4
Owens, J.A.5
Morris, M.J.6
-
101
-
-
33847367675
-
Nongenomic transgenerational inheritance of disease risk
-
Gluckman PD, Hanson MA, Beedle AS. Nongenomic transgenerational inheritance of disease risk. Bioessays 2007;29:145-54.
-
(2007)
Bioessays
, vol.29
, pp. 145-154
-
-
Gluckman, P.D.1
Hanson, M.A.2
Beedle, A.S.3
-
102
-
-
77649086970
-
A map of open chromatin in human pancreatic islets
-
Gaulton KJ, Nammo T, Pasquali L, Simon JM, Giresi PG, Fogarty MP, et al. A map of open chromatin in human pancreatic islets. Nat Genet 2010;42:255-9.
-
(2010)
Nat Genet
, vol.42
, pp. 255-259
-
-
Gaulton, K.J.1
Nammo, T.2
Pasquali, L.3
Simon, J.M.4
Giresi, P.G.5
Fogarty, M.P.6
-
103
-
-
34247498697
-
Developmental origins of beta-cell failure in type 2 diabetes: The role of epigenetic mechanisms
-
Simmons RA. Developmental origins of beta-cell failure in type 2 diabetes: the role of epigenetic mechanisms. Pediatr Res 2007;61:64R-7R.
-
(2007)
Pediatr Res
, vol.61
-
-
Simmons, R.A.1
-
104
-
-
0033645241
-
Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: A study of discordant sibships
-
Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 2000;49:2208-11.
-
(2000)
Diabetes
, vol.49
, pp. 2208-2211
-
-
Dabelea, D.1
Hanson, R.L.2
Lindsay, R.S.3
Pettitt, D.J.4
Imperatore, G.5
Gabir, M.M.6
-
105
-
-
45549097738
-
Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
-
Park JH, Stoffers DA, Nicholls RD, Simmons RA. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest 2008;118:2316-24.
-
(2008)
J Clin Invest
, vol.118
, pp. 2316-2324
-
-
Park, J.H.1
Stoffers, D.A.2
Nicholls, R.D.3
Simmons, R.A.4
-
106
-
-
41149172495
-
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
-
Ling C, Del Guerra S, Lupi R, Ronn T, Granhall C, Luthman H, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008;51:615-22.
-
(2008)
Diabetologia
, vol.51
, pp. 615-622
-
-
Ling, C.1
Del Guerra, S.2
Lupi, R.3
Ronn, T.4
Granhall, C.5
Luthman, H.6
-
107
-
-
36049002392
-
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
-
Ling C, Poulsen P, Simonsson S, Ronn T, Holmkvist J, Almgren P, et al. Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J Clin Invest 2007;117:3427-35.
-
(2007)
J Clin Invest
, vol.117
, pp. 3427-3435
-
-
Ling, C.1
Poulsen, P.2
Simonsson, S.3
Ronn, T.4
Holmkvist, J.5
Almgren, P.6
-
108
-
-
44749089106
-
Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
-
Ronn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, Nilsson P, et al. Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia 2008;51:1159-68.
-
(2008)
Diabetologia
, vol.51
, pp. 1159-1168
-
-
Ronn, T.1
Poulsen, P.2
Hansson, O.3
Holmkvist, J.4
Almgren, P.5
Nilsson, P.6
-
109
-
-
70349138460
-
Insulin gene expression is regulated by DNA methylation
-
Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel F, et al. Insulin gene expression is regulated by DNA methylation. PLoS One 2009;4:e6953.
-
(2009)
PLoS One
, vol.4
-
-
Kuroda, A.1
Rauch, T.A.2
Todorov, I.3
Ku, H.T.4
Al-Abdullah, I.H.5
Kandeel, F.6
-
110
-
-
64749111074
-
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
-
Tateishi K, Okada Y, Kallin EM, Zhang Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009;458:757-61.
-
(2009)
Nature
, vol.458
, pp. 757-761
-
-
Tateishi, K.1
Okada, Y.2
Kallin, E.M.3
Zhang, Y.4
-
111
-
-
67249155691
-
High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats
-
Milagro FI, Campion J, Garcia-Diaz DF, Goyenechea E, Paternain L, Martinez JA. High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J Physiol Biochem 2009;65:1-9.
-
(2009)
J Physiol Biochem
, vol.65
, pp. 1-9
-
-
Milagro, F.I.1
Campion, J.2
Garcia-Diaz, D.F.3
Goyenechea, E.4
Paternain, L.5
Martinez, J.A.6
-
112
-
-
56349096931
-
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
-
Lango H, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, et al. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008;57:3129-35.
-
(2008)
Diabetes
, vol.57
, pp. 3129-3135
-
-
Lango, H.1
Palmer, C.N.2
Morris, A.D.3
Zeggini, E.4
Hattersley, A.T.5
McCarthy, M.I.6
-
113
-
-
56749101779
-
Genotype score in addition to common risk factors for prediction of type 2 diabetes
-
Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 2008;359:2208-19.
-
(2008)
N Engl J Med
, vol.359
, pp. 2208-2219
-
-
Meigs, J.B.1
Shrader, P.2
Sullivan, L.M.3
McAteer, J.B.4
Fox, C.S.5
Dupuis, J.6
-
114
-
-
58149333712
-
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: A population-based study
-
van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, Oostra BA, et al. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 2008;57:3122-8.
-
(2008)
Diabetes
, vol.57
, pp. 3122-3128
-
-
Van Hoek, M.1
Dehghan, A.2
Witteman, J.C.3
Van Duijn, C.M.4
Uitterlinden, A.G.5
Oostra, B.A.6
-
115
-
-
23644442564
-
Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes
-
Winckler W, Burtt NP, Holmkvist J, Cervin C, de Bakker PI, Sun M, et al. Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes. Diabetes 2005;54:2336-42.
-
(2005)
Diabetes
, vol.54
, pp. 2336-2342
-
-
Winckler, W.1
Burtt, N.P.2
Holmkvist, J.3
Cervin, C.4
De Bakker, P.I.5
Sun, M.6
-
116
-
-
64549158008
-
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
-
Renstrom F, Payne F, Nordstrom A, Brito EC, Rolandsson O, Hallmans G, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 2009;18:1489-96.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1489-1496
-
-
Renstrom, F.1
Payne, F.2
Nordstrom, A.3
Brito, E.C.4
Rolandsson, O.5
Hallmans, G.6
|