Modulation of microtubule interprotofilament interactions by modified taxanes

Biophysical Journal

Volumn 101, Issue 12, 2011, Pages 2970-2980

  Matesanz, Ruth ^a   Rodríguez Salarichs, Javier ^a,b   Pera, Benet ^a   Canales, Ángeles ^a,c   Andreu, José Manuel ^a   Jiménez Barbero, Jesús ^a   Bras, Wim ^d   Nogales, Aurora ^e   Fang, Wei Shuo ^f   Díaz, José Fernando ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b Centro de Estudios Avanzados de Cuba   (Cuba)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^e INSTITUTO DE ESTRUCTURA DE LA MATERIA   (Spain)

^f PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TAXOID;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; MICROTUBULE; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE; X RAY DIFFRACTION;

BINDING SITES; COMPUTER SIMULATION; MICROTUBULES; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; X-RAY DIFFRACTION;

EID: 84055200403     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.11.005     Document Type: Article

References (38)

1. D. Chrétien, and F. Metoz R.H. Wade Lattice defects in microtubules: protofilament numbers vary within individual microtubules J. Cell Biol. 117 1992 1031 1040
2. A. Montero, and F. Fossella V. Valero Docetaxel for treatment of solid tumours: a systematic review of clinical data Lancet Oncol. 6 2005 229 239 (Pubitemid 40450714)
3. R.M. Buey, and I. Barasoain J.F. Díaz Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity Chem. Biol. 12 2005 1269 1279 (Pubitemid 41779467)
4. P.B. Schiff, and S.B. Horwitz Taxol assembles tubulin in the absence of exogenous guanosine 5′-triphosphate or microtubule-associated proteins Biochemistry 20 1981 3247 3252
5. J.F. Díaz, and J.M. Andreu Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition Biochemistry 32 1993 2747 2755 (Pubitemid 23102795)
6. Z. Wu, and H.-W. Wang J. Xing Simulations of tubulin sheet polymers as possible structural intermediates in microtubule assembly PLoS ONE 4 2009 e7291
7. V. VanBuren, L. Cassimeris, and D.J. Odde Mechanochemical model of microtubule structure and self-assembly kinetics Biophys. J. 89 2005 2911 2926 (Pubitemid 41636049)
8. J.F. Díaz, and J.M. Andreu J. Bordas Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering Biophys. J. 70 1996 2408 2420 (Pubitemid 26133736)
9. H.P. Erickson Microtubule surface lattice and subunit structure and observations on reassembly J. Cell Biol. 60 1974 153 167
10. D. Chrétien, S.D. Fuller, and E. Karsenti Structure of growing microtubule ends: two-dimensional sheets close into tubes at variable rates J. Cell Biol. 129 1995 1311 1328
11. B. Vitre, and F.M. Coquelle I. Arnal EB1 regulates microtubule dynamics and tubulin sheet closure in vitro Nat. Cell Biol. 10 2008 415 421
12. J.L. Höög, and S.M. Huisman D. Brunner Electron tomography reveals a flared morphology on growing microtubule ends J. Cell Sci. 124 2011 693 698
13. J.M. Andreu, and J. Bordas E. Towns-Andrews Low resolution structure of microtubules in solution. Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in comparison with glycerol and MAP-induced microtubules J. Mol. Biol. 226 1992 169 184
14. J.M. Andreu, and J.F. Díaz J. Bordas Solution structure of Taxotere-induced microtubules to 3-nm resolution. The change in protofilament number is linked to the binding of the taxol side chain J. Biol. Chem. 269 1994 31785 31792
15. J.F. Díaz, and J.M. Valpuesta J.M. Andreu Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamics J. Biol. Chem. 273 1998 33803 33810
16. J.F. Díaz, and R. Strobe J.M. Andreu Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site J. Biol. Chem. 275 2000 26265 26276
17. E. Nogales, and M. Whittaker K.H. Downing High-resolution model of the microtubule Cell 96 1999 79 88 (Pubitemid 29044155)
18. J.F. Díaz, and I. Barasoain J.M. Andreu Macromolecular accessibility of fluorescent taxoids bound at a paclitaxel binding site in the microtubule surface J. Biol. Chem. 280 2005 3928 3937 (Pubitemid 40223862)
19. R.M. Buey, and E. Calvo J.F. Díaz Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites Nat. Chem. Biol. 3 2007 117 125 (Pubitemid 46134999)
20. I. Barasoain, and A.M. García-Carril J.F. Díaz Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses Chem. Biol. 17 2010 243 253
21. A. Canales, and J. Rodríguez-Salarichs J.F. Díaz Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach ACS Chem. Biol. 6 2011 789 799
22. L.A. Amos, and J. Löwe How Taxol stabilises microtubule structure Chem. Biol. 6 1999 R65 R69
23. R. Matesanz, and I. Barasoain J.F. Díaz Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel Chem. Biol. 15 2008 573 585 (Pubitemid 351815058)
24. A.A. Souto, and A.U. Acuña F. Amat-Guerri New fluorescent water-soluble taxol derivatives Angew. Chem. Int. Ed. Engl. 34 1995 2710 2712
25. J.M. Andreu, and M.J. Gorbunoff S.N. Timasheff Interaction of tubulin with bifunctional colchicine analogues: an equilibrium study Biochemistry 23 1984 1742 1752 (Pubitemid 14139815)
26. M. Abramowitz, and I.A. Stegun Handbook of Mathematical Functions 1965 Dover Publications New York
27. D.A. Case, and T.E. Cheatham III R.J. Woods The Amber biomolecular simulation programs J. Comput. Chem. 26 2005 1668 1688 (Pubitemid 43076180)
28. M.F. Sanner, A.J. Olson, and J.C. Spehner Reduced surface: an efficient way to compute molecular surfaces Biopolymers 38 1996 305 320
29. E.F. Pettersen, and T.D. Goddard T.E. Ferrin UCSF Chimera - a visualization system for exploratory research and analysis J. Comput. Chem. 25 2004 1605 1612
30. V. Jayalakshmi, and N.R. Krishna Complete relaxation and conformational exchange matrix (CORCEMA) analysis of intermolecular saturation transfer effects in reversibly forming ligand-receptor complexes J. Magn. Reson. 155 2002 106 118
31. J.P. Snyder, and J.H. Nettles E. Nogales The binding conformation of Taxol in β-tubulin: a model based on electron crystallographic density Proc. Natl. Acad. Sci. USA 98 2001 5312 5316 (Pubitemid 32397125)
32. M. Magnani, and G. Maccari M. Botta Possible binding site for paclitaxel at microtubule pores FEBS J. 276 2009 2701 2712
33. H. Freedman, and J.T. Huzil J.A. Tuszynski Identification and characterization of an intermediate taxol binding site within microtubule nanopores and a mechanism for tubulin isotype binding selectivity J. Chem. Inf. Model. 49 2009 424 436
34. A. Canales, and R. Matesanz J. Jiménez-Barbero The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin Chemistry 14 2008 7557 7569
35. J.F. Díaz, I. Barasoain, and J.M. Andreu Fast kinetics of Taxol binding to microtubules. Effects of solution variables and microtubule- associated proteins J. Biol. Chem. 278 2003 8407 8419 (Pubitemid 36800591)
36. A. Mitra, and D. Sept Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules Biophys. J. 95 2008 3252 3258
37. A.A. Alcaraz, and A.K. Mehta J.P. Snyder The T-Taxol conformation J. Med. Chem. 49 2006 2478 2488
38. W. Bras, and I.P. Dolbnya E. Heeley Recent experiments on a combined small-angle/wide-angle X-ray scattering beam line at the ESRF J. App. Cryst. 36 2003 791 794