메뉴 건너뛰기




Volumn 20, Issue 13, 2013, Pages 1623-1634

Human disease and drug pharmacology, complex as real life

Author keywords

Multitarget drugs; Multitarget therapies; Network pharmacology; Polypharmacology; Protein interaction networks

Indexed keywords

BRIVARACETAM; CLORAZIL; CLOZAPINE; DASATINIB; DOPAMINE RECEPTOR; ERLOTINIB; ETIRACETAM; G PROTEIN COUPLED RECEPTOR; GEFITINIB; HALOPERIDOL; IMATINIB; LAPATINIB; MUSCARINIC RECEPTOR; OLANZAPINE; SEROTONIN RECEPTOR; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG;

EID: 84877947846     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867311320130002     Document Type: Article
Times cited : (33)

References (140)
  • 1
    • 84861490509 scopus 로고    scopus 로고
    • Modern phenotypic drug discovery is a viable, neoclassic pharma strategy
    • Lee, J.A.; Uhlik, M.T.; Moxham, C.M.; Tomandl, D.; Sall, D.J. Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. J. Med. Chem., 2012, 55, 4527-4538.
    • (2012) J. Med. Chem. , vol.55 , pp. 4527-4538
    • Lee, J.A.1    Uhlik, M.T.2    Moxham, C.M.3    Tomandl, D.4    Sall, D.J.5
  • 3
    • 0037108001 scopus 로고    scopus 로고
    • Rational drug discovery: What can we learn from regulatory networks?
    • Huang, S. Rational drug discovery: What can we learn from regulatory networks? Drug Discov. Today, 2002, 7, S163-169.
    • (2002) Drug Discov. Today , vol.7
    • Huang, S.1
  • 4
    • 72949101438 scopus 로고    scopus 로고
    • Structure and organization of drug-target networks: Insights from genomic approaches for drug discovery
    • Janga, S.C.; Tzakos, A. Structure and organization of drug-target networks: Insights from genomic approaches for drug discovery. Mol. BioSyst., 2009, 5, 1536-1548.
    • (2009) Mol. BioSyst. , vol.5 , pp. 1536-1548
    • Janga, S.C.1    Tzakos, A.2
  • 5
    • 35148824614 scopus 로고    scopus 로고
    • Network pharmacology
    • Hopkins, A.L. Network pharmacology. Nat. Biotechnol., 2007, 25, 1110-1111.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1110-1111
    • Hopkins, A.L.1
  • 6
    • 42949175085 scopus 로고    scopus 로고
    • Paul Ehrlich: Founder of chemotherapy
    • Kaufmann, S.H. Paul Ehrlich: Founder of chemotherapy. Nat. Rev. Drug Discov., 2008, 7, 373.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 373
    • Kaufmann, S.H.1
  • 7
    • 84863751896 scopus 로고    scopus 로고
    • Designed multiple ligands: Basic research vs clinical outcomes
    • Costantino, L.; Barlocco, D. Designed multiple ligands: Basic research vs clinical outcomes. Curr. Med. Chem., 2012, 19, 3353-3387.
    • (2012) Curr. Med. Chem. , vol.19 , pp. 3353-3387
    • Costantino, L.1    Barlocco, D.2
  • 8
    • 23044504046 scopus 로고    scopus 로고
    • How many genomics targets can a portfolio afford?
    • Betz, U.A.K. How many genomics targets can a portfolio afford? Drug Discov. Today, 2005, 10, 1057-1063.
    • (2005) Drug Discov. Today , vol.10 , pp. 1057-1063
    • Betz, U.A.K.1
  • 9
    • 12244297116 scopus 로고    scopus 로고
    • Drug industry in "depression"
    • Almog, D. Drug industry in "depression". Med. Sci. Monit., 2005, 11, SR1-SR4.
    • (2005) Med. Sci. Monit. , vol.11
    • Almog, D.1
  • 14
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I.; Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov., 2004, 3, 711-716.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 711-716
    • Kola, I.1    Landis, J.2
  • 15
    • 12144268237 scopus 로고    scopus 로고
    • Macro trends in pharmaceutical innovation
    • Cohen, F.J. Macro trends in pharmaceutical innovation. Nat. Rev. Drug Discov., 2005, 4, 78-84.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 78-84
    • Cohen, F.J.1
  • 16
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: Is something wrong?
    • Sams-Dodd, F. Target-based drug discovery: Is something wrong? Drug Discov. Today, 2005, 10, 139-147.
    • (2005) Drug Discov. Today , vol.10 , pp. 139-147
    • Sams-Dodd, F.1
  • 17
    • 84856454917 scopus 로고    scopus 로고
    • Systems biology impact on antiepileptic drug discovery
    • Margineanu, D.G. Systems biology impact on antiepileptic drug discovery. Epilepsy Res., 2012, 98, 104-115.
    • (2012) Epilepsy Res. , vol.98 , pp. 104-115
    • Margineanu, D.G.1
  • 18
    • 31144438390 scopus 로고    scopus 로고
    • Rescuing drug discovery: In vivo systems pathology and systems pharmacology
    • van der Greef, J.; McBurney, R.N. Rescuing drug discovery: In vivo systems pathology and systems pharmacology. Nat. Rev. Drug Discov., 2005, 4, 961-967.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 961-967
    • Van Der Greef, J.1    McBurney, R.N.2
  • 19
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • Hopkins, A.L. Network pharmacology: The next paradigm in drug discovery. Nat. Chem. Biol., 2008, 4, 682-690.
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 20
    • 77649182705 scopus 로고    scopus 로고
    • Unveiling the role of network and systems biology in drug discovery
    • Pujol, A.; Mosca, R.; Farrés, J.; Aloy, P. Unveiling the role of network and systems biology in drug discovery. Trends Pharmacol. Sci., 2010, 31, 115-123.
    • (2010) Trends Pharmacol. Sci. , vol.31 , pp. 115-123
    • Pujol, A.1    Mosca, R.2    Farrés, J.3    Aloy, P.4
  • 21
    • 27144449695 scopus 로고    scopus 로고
    • Designed multiple ligands. An emerging drug discovery paradigm
    • Morphy, R.; Rankovic, Z. Designed multiple ligands. An emerging drug discovery paradigm. J. Med. Chem., 2005, 48, 6523-6543.
    • (2005) J. Med. Chem. , vol.48 , pp. 6523-6543
    • Morphy, R.1    Rankovic, Z.2
  • 22
    • 3142512451 scopus 로고    scopus 로고
    • Back To The Future: The "old-fashioned" way to new medications for neurodegeneration
    • Lansbury, P.T., Jr. Back to the future: The "old-fashioned" way to new medications for neurodegeneration. Nat. Med., 2004, 10, S51-S57.
    • (2004) Nat. Med. , vol.10
    • Lansbury Jr., P.T.1
  • 23
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: Understanding the cell's functional organization
    • Barabási, A.L.; Oltvai, Z.N. Network biology: Understanding the cell's functional organization. Nat. Rev. Genet., 2004, 5, 101-113.
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 101-113
    • Barabási, A.L.1    Oltvai, Z.N.2
  • 24
    • 14844311241 scopus 로고    scopus 로고
    • Interactome modeling
    • Vidal, M. Interactome modeling. FEBS Lett., 2005, 579, 1834-1838.
    • (2005) FEBS Lett. , vol.579 , pp. 1834-1838
    • Vidal, M.1
  • 25
    • 79953071469 scopus 로고    scopus 로고
    • Three-dimensional modeling of protein interactions and complexes is going 'omics
    • Stein, A.; Mosca, R.; Aloy, P. Three-dimensional modeling of protein interactions and complexes is going 'omics. Curr. Opin. Struct. Biol., 2011, 21, 200-208.
    • (2011) Curr. Opin. Struct. Biol. , vol.21 , pp. 200-208
    • Stein, A.1    Mosca, R.2    Aloy, P.3
  • 26
    • 0041822089 scopus 로고    scopus 로고
    • Join the crowd
    • Ellis, R.J.; Minton, A.P. Join the crowd. Nature, 2003, 425, 27-28.
    • (2003) Nature , vol.425 , pp. 27-28
    • Ellis, R.J.1    Minton, A.P.2
  • 27
    • 0035478585 scopus 로고    scopus 로고
    • Macromolecular crowding: Obvious but underappreciated
    • Ellis, R.J. Macromolecular crowding: Obvious but underappreciated. Trends Biochem. Sci., 2001, 26, 597-604.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 597-604
    • Ellis, R.J.1
  • 28
    • 0041931122 scopus 로고    scopus 로고
    • Macromolecular crowding: Qualitative and semiquantitative successes, quantitative challenges
    • Hall, D.; Minton, A.P. Macromolecular crowding: Qualitative and semiquantitative successes, quantitative challenges. Biochim. Biophys. Acta, 2003, 1649, 127-139.
    • (2003) Biochim. Biophys. Acta , vol.1649 , pp. 127-139
    • Hall, D.1    Minton, A.P.2
  • 29
    • 15044349115 scopus 로고    scopus 로고
    • The efficiency of multitarget drugs: The network approach might help drug design
    • Csermely, P.; Agoston, V.; Pongor, S. The efficiency of multitarget drugs: The network approach might help drug design. Trends Pharmacol. Sci., 2005, 26, 178-182.
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 178-182
    • Csermely, P.1    Agoston, V.2    Pongor, S.3
  • 31
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • Kitano, H. Systems biology: A brief overview. Science, 2002, 295, 1662-1664.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 32
    • 67349276056 scopus 로고    scopus 로고
    • A network medicine approach to human disease
    • Zanzoni, A.; Soler-López, M.; Aloy, P. A network medicine approach to human disease. FEBS Lett., 2009, 583, 1759-1765.
    • (2009) FEBS Lett. , vol.583 , pp. 1759-1765
    • Zanzoni, A.1    Soler-López, M.2    Aloy, P.3
  • 33
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • Kitano, H. Biological robustness. Nat. Rev. Genet., 2004, 5, 826-837.
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 826-837
    • Kitano, H.1
  • 34
    • 33847377573 scopus 로고    scopus 로고
    • A robustness-based approach to systems-oriented drug design
    • Kitano, H. A robustness-based approach to systems-oriented drug design. Nat. Rev. Drug Discov., 2007, 6, 202-210.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 202-210
    • Kitano, H.1
  • 35
  • 36
    • 0034721164 scopus 로고    scopus 로고
    • Error and attack tolerance of complex networks
    • Albert, R.; Jeong, H.; Barabasi, A.L. Error and attack tolerance of complex networks. Nature, 2000, 406, 378-382.
    • (2000) Nature , vol.406 , pp. 378-382
    • Albert, R.1    Jeong, H.2    Barabasi, A.L.3
  • 37
    • 34548825690 scopus 로고    scopus 로고
    • Towards a theory of biological robustness
    • Kitano, H. Towards a theory of biological robustness. Mol. Syst. Biol., 2007, 3, 137.
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 137
    • Kitano, H.1
  • 39
    • 27544446579 scopus 로고    scopus 로고
    • Promiscuous drugs compared to selective drugs (promiscuity can be a virtue
    • Mencher, S.K.; Wang, L.G. Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clin. Pharmacol., 2005, 5, 3.
    • (2005) BMC Clin. Pharmacol. , vol.5 , pp. 3
    • Mencher, S.K.1    Wang, L.G.2
  • 40
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
    • Roth, B.L.; Scheffler, D.J.; Kroeze, W.K. Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia. Nat. Rev. Drug Discov., 2004, 3, 353-359.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 353-359
    • Roth, B.L.1    Scheffler, D.J.2    Kroeze, W.K.3
  • 41
    • 59249102753 scopus 로고    scopus 로고
    • From ion channels to complex networks: Magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy
    • Bianchi, M.T.; Pathmanathan, J.; Cash, S.S. From ion channels to complex networks: Magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy. Med. Hypotheses, 2009, 72, 297-305.
    • (2009) Med. Hypotheses , vol.72 , pp. 297-305
    • Bianchi, M.T.1    Pathmanathan, J.2    Cash, S.S.3
  • 42
    • 59349083179 scopus 로고    scopus 로고
    • Mechanisms of drug combinations: Interaction and network perspectives
    • Jia, J.; Zhu, F.; Ma, X.; Cao, Z.W.; Li, Y.X.; Chen, Y.Z. Mechanisms of drug combinations: Interaction and network perspectives. Nat. Rev. Drug Discov., 2009, 8, 111-128.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 111-128
    • Jia, J.1    Zhu, F.2    Ma, X.3    Cao, Z.W.4    Li, Y.X.5    Chen, Y.Z.6
  • 43
    • 0032143073 scopus 로고    scopus 로고
    • From "magic bullet" to "specially engineered shotgun loads": The new genetics and the need for individualized pharmacotherapy
    • Erickson, R.P. From "magic bullet" to "specially engineered shotgun loads": The new genetics and the need for individualized pharmacotherapy. Bioessays, 1998, 20, 683-685.
    • (1998) Bioessays , vol.20 , pp. 683-685
    • Erickson, R.P.1
  • 44
    • 14244255403 scopus 로고    scopus 로고
    • The promiscuous drug concept with applications to Alzheimer's disease
    • Stephenson, V.C.; Heyding, R.A.; Weaver, D.F. "The promiscuous drug concept" with applications to Alzheimer's disease. FEBS Lett., 2005, 579, 1338-1342.
    • (2005) FEBS Lett. , vol.579 , pp. 1338-1342
    • Stephenson, V.C.1    Heyding, R.A.2    Weaver, D.F.3
  • 45
    • 77950510228 scopus 로고    scopus 로고
    • Targeting ligand-gated ion channels in neurology and psychiatry: Is pharmacological promiscuity an obstacle or an opportunity?
    • Bianchi, M.T.; Botzolakis, E.J. Targeting ligand-gated ion channels in neurology and psychiatry: Is pharmacological promiscuity an obstacle or an opportunity? BMC Pharmacol., 2010, 10, 3.
    • (2010) BMC Pharmacol. , vol.10 , pp. 3
    • Bianchi, M.T.1    Botzolakis, E.J.2
  • 46
    • 0024406857 scopus 로고
    • A novel genetic system to detect protein-protein interactions
    • Fields, S.; Song, O. A novel genetic system to detect protein-protein interactions. Nature, 1989, 340, 245-246.
    • (1989) Nature , vol.340 , pp. 245-246
    • Fields, S.1    Song, O.2
  • 48
    • 34147167177 scopus 로고    scopus 로고
    • Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split ubiquitin membrane yeast two-hybrid analysis
    • Paumi, C.M.; Menendez, J.; Arnoldo, A.; Engels, K.; Iyer, K.R.; Thaminy, S.; Georgiev, O.; Barral, Y.; Michaelis, S.; Stagljar, I. Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split ubiquitin membrane yeast two-hybrid analysis. Mol. Cell, 2007, 26, 15-25.
    • (2007) Mol. Cell , vol.26 , pp. 15-25
    • Paumi, C.M.1    Menendez, J.2    Arnoldo, A.3    Engels, K.4    Iyer, K.R.5    Thaminy, S.6    Georgiev, O.7    Barral, Y.8    Michaelis, S.9    Stagljar, I.10
  • 53
    • 84864259146 scopus 로고    scopus 로고
    • Prediction and analysis of the protein interactome in Pseudomonas aeruginosa to enable network-based drug target selection
    • Zhang, M.; Su, S.; Bhatnagar, R.K.; Hassett, D.J.; Lu, L.J. Prediction and analysis of the protein interactome in Pseudomonas aeruginosa to enable network-based drug target selection. PLOS ONE, 2012, 7, e41202.
    • (2012) PLOS ONE , vol.7
    • Zhang, M.1    Su, S.2    Bhatnagar, R.K.3    Hassett, D.J.4    Lu, L.J.5
  • 64
    • 79952267533 scopus 로고    scopus 로고
    • Interactome mapping suggests new mechanistic details underlying Alzheimer's disease
    • Soler-López, M.; Zanzoni, A.; Lluís, R.; Stelzl, U.; Aloy, P. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. Genome Res., 2011, 21, 364-376.
    • (2011) Genome Res. , vol.21 , pp. 364-376
    • Soler-López, M.1    Zanzoni, A.2    Lluís, R.3    Stelzl, U.4    Aloy, P.5
  • 65
    • 46349091971 scopus 로고    scopus 로고
    • The social network of a cell: Recent advances in interactome mapping
    • Charbonnier, S.; Gallego, O.; Gavin, A.C. The social network of a cell: Recent advances in interactome mapping. Biotechnol. Annu. Rev., 2008, 14, 1-28.
    • (2008) Biotechnol. Annu. Rev. , vol.14 , pp. 1-28
    • Charbonnier, S.1    Gallego, O.2    Gavin, A.C.3
  • 66
    • 84862323532 scopus 로고    scopus 로고
    • Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction
    • Soler-López, M.; Badiola, N.; Zanzoni, A.; Aloy, P. Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Bioessays, 2012, 34, 532-541.
    • (2012) Bioessays , vol.34 , pp. 532-541
    • Soler-López, M.1    Badiola, N.2    Zanzoni, A.3    Aloy, P.4
  • 70
    • 42349096647 scopus 로고    scopus 로고
    • A global view of drug-therapy interactions
    • Nacher, J.C.; Schwartz, J.-M. A global view of drug-therapy interactions. BMC Pharmacol., 2008, 8, 5.
    • (2008) BMC Pharmacol. , vol.8 , pp. 5
    • Nacher, J.C.1    Schwartz, J.-M.2
  • 71
    • 84861610134 scopus 로고    scopus 로고
    • A systematic prediction of multiple drugtarget interactions from chemical, genomic, and pharmacological data
    • Yu, H.; Chen, J.; Xu, X.; Li, Y.; Zhao, H.; Fang, Y.; Li, X.; Zhou, W.; Wang, W.; Wang, Y. A systematic prediction of multiple drugtarget interactions from chemical, genomic, and pharmacological data. PLoS One, 2012, 7, 1-14.
    • (2012) PLoS One , vol.7 , pp. 1-14
    • Yu, H.1    Chen, J.2    Xu, X.3    Li, Y.4    Zhao, H.5    Fang, Y.6    Li, X.7    Zhou, W.8    Wang, W.9    Wang, Y.10
  • 72
    • 77949760141 scopus 로고    scopus 로고
    • Identifying unexpected therapeutic targets via chemical-protein interactome
    • Yang, L.; Chen, J.; Shi, L.; Hudock, M.P.; Wang, K.; He, L. Identifying unexpected therapeutic targets via chemical-protein interactome. PLoS One, 2010, 5, 1-11.
    • (2010) PLoS One , vol.5 , pp. 1-11
    • Yang, L.1    Chen, J.2    Shi, L.3    Hudock, M.P.4    Wang, K.5    He, L.6
  • 73
    • 68949119585 scopus 로고    scopus 로고
    • The topology of drug-target interaction networks: Implicit dependence on drug properties and target families
    • Mestres, J.; Gregori-Puigjané, E.; Valverde, S.; Solé, R.V. The topology of drug-target interaction networks: Implicit dependence on drug properties and target families. J. Mol. BioSyst., 2009, 5, 1051-1057.
    • (2009) J. Mol. BioSyst. , vol.5 , pp. 1051-1057
    • Mestres, J.1    Gregori-Puigjané, E.2    Valverde, S.3    Solé, R.V.4
  • 75
    • 70449673534 scopus 로고    scopus 로고
    • Predicting promiscuity
    • Hopkins, A.L. Predicting promiscuity. Nature, 2009, 462, 167-168.
    • (2009) Nature , vol.462 , pp. 167-168
    • Hopkins, A.L.1
  • 77
    • 27144443099 scopus 로고    scopus 로고
    • Drug discovery: Playing dirty
    • Frantz, S. Drug discovery: Playing dirty. Nature, 2005, 437, 942-943.
    • (2005) Nature , vol.437 , pp. 942-943
    • Frantz, S.1
  • 78
    • 3242802116 scopus 로고    scopus 로고
    • Promiscuous anticancer drugs that hit multiple targets may thwart resistance
    • Hampton, T. "Promiscuous" anticancer drugs that hit multiple targets may thwart resistance. JAMA, 2004, 292, 419-422.
    • (2004) JAMA , vol.292 , pp. 419-422
    • Hampton, T.1
  • 79
  • 80
    • 70350103708 scopus 로고    scopus 로고
    • Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia
    • Giles, F.J.; O'Dwyer, M.; Swords, R. Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia, 2009, 23, 1698-1707.
    • (2009) Leukemia , vol.23 , pp. 1698-1707
    • Giles, F.J.1    O'Dwyer, M.2    Swords, R.3
  • 81
    • 33746628593 scopus 로고    scopus 로고
    • Case histories, magic bullets and the state of drug discovery
    • Drews, J. Case histories, magic bullets and the state of drug discovery. Nat. Rev. Drug. Discov., 2006, 5, 635-640.
    • (2006) Nat. Rev. Drug. Discov. , vol.5 , pp. 635-640
    • Drews, J.1
  • 83
    • 75149130051 scopus 로고    scopus 로고
    • Targeting the cancer kinome through polypharmacology
    • Knight, Z.A.; Lin, H.; Shokat, K.M. Targeting the cancer kinome through polypharmacology. Nat. Rev. Cancer, 2010, 10, 130-137.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 130-137
    • Knight, Z.A.1    Lin, H.2    Shokat, K.M.3
  • 84
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre, S.; Demetri, G.; Sargent, W.; Raymond, E. Molecular basis for sunitinib efficacy and future clinical development. Nat. Rev. Drug Discov., 2007, 6, 734-745.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 90
    • 0037161362 scopus 로고    scopus 로고
    • Staged approach to epilepsy management
    • Brodie, M.J.; Kwan, P. Staged approach to epilepsy management. Neurology, 2002, 58, S2-S8.
    • (2002) Neurology , vol.58
    • Brodie, M.J.1    Kwan, P.2
  • 91
    • 49549119738 scopus 로고    scopus 로고
    • Brivaracetam: A rational drug discovery success story
    • Rogawski, M.A. Brivaracetam: A rational drug discovery success story. Br. J. Pharmacol., 2008, 154, 1555-1557.
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 1555-1557
    • Rogawski, M.A.1
  • 92
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski, M.A.; Löscher, W. The neurobiology of antiepileptic drugs. Nat. Rev. Neurosci., 2004, 5, 553-564.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 553-564
    • Rogawski, M.A.1    Löscher, W.2
  • 93
    • 72449198911 scopus 로고    scopus 로고
    • Promiscuous modification of ion channels by antipsychotic and anti-dementia medications
    • Bianchi, M.T. Promiscuous modification of ion channels by antipsychotic and anti-dementia medications. Med. Hypotheses, 2010, 74, 297-300.
    • (2010) Med. Hypotheses , vol.74 , pp. 297-300
    • Bianchi, M.T.1
  • 94
    • 84877948208 scopus 로고    scopus 로고
    • The economics of polypharmacology: Fixed dose combinations and drug cocktails
    • in press
    • Wertheimer, A.I. The economics of polypharmacology: Fixed dose combinations and drug cocktails. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Wertheimer, A.I.1
  • 95
    • 84877931785 scopus 로고    scopus 로고
    • Polypharmacology in a single drug: Multitarget drugs
    • in press
    • Bolognesi, M.L. Polypharmacology in a single drug: Multitarget drugs. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Bolognesi, M.L.1
  • 96
    • 84877972616 scopus 로고    scopus 로고
    • Predicting targeted polypharmacology for drug repositioning and multi-target drug discovery
    • in press
    • Liu, X.; Zhu, F.; Ma, X.H.; Shi, Z.; Yang, S.Y.; Wei, Y.Q.; Chen, Y.Z. Predicting targeted polypharmacology for drug repositioning and multi-target drug discovery. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Liu, X.1    Zhu, F.2    Ma, X.H.3    Shi, Z.4    Yang, S.Y.5    Wei, Y.Q.6    Chen, Y.Z.7
  • 97
    • 84877948856 scopus 로고    scopus 로고
    • Rationally designed multitargeted agents against neurodegenerative diseases
    • in press
    • Geldenhuys, W.J.; Van der Schyf, C.J. Rationally designed multitargeted agents against neurodegenerative diseases. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Geldenhuys, W.J.1    Van Der Schyf, C.J.2
  • 98
    • 84877982789 scopus 로고    scopus 로고
    • Multi-target compounds acting in the central nervous system designed from natural products
    • in press
    • Chen, X.; Decker, M. Multi-target compounds acting in the central nervous system designed from natural products. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Chen, X.1    Decker, M.2
  • 99
    • 84877962244 scopus 로고    scopus 로고
    • Multitarget drugs of plants origin acting on Alzheimer's disease
    • in press
    • Russo, P.; Frustaci, A.; Fini, M.; Cesario, A. Multitarget drugs of plants origin acting on Alzheimer's disease. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Russo, P.1    Frustaci, A.2    Fini, M.3    Cesario, A.4
  • 100
    • 84877941156 scopus 로고    scopus 로고
    • Rationally designed multitarget anticancer agents
    • in press
    • Chen, Z.; Han, L.; Xu, M.; Xu, Y.; Qian, X. Rationally designed multitarget anticancer agents. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Chen, Z.1    Han, L.2    Xu, M.3    Xu, Y.4    Qian, X.5
  • 101
    • 84877986822 scopus 로고    scopus 로고
    • Recent developments in rationally designed multitarget antiprotozoan agents
    • in press
    • Njogu, P.M.; Chibale, K. Recent developments in rationally designed multitarget antiprotozoan agents. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Njogu, P.M.1    Chibale, K.2
  • 102
    • 84877959151 scopus 로고    scopus 로고
    • Rationally designed multitarget anti-HIV agents
    • in press
    • Zhan, P.; Liu, X. Rationally designed multitarget anti-HIV agents. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Zhan, P.1    Liu, X.2
  • 103
    • 84877957415 scopus 로고    scopus 로고
    • Design of multifunctional compounds for cardiovascular disease: From natural scaffolds to "classical" multitarget approach
    • in press
    • Bisi, A.; Gobbi, S.; Belluti, F.; Rampa, A. Design of multifunctional compounds for cardiovascular disease: From natural scaffolds to "classical" multitarget approach. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Bisi, A.1    Gobbi, S.2    Belluti, F.3    Rampa, A.4
  • 104
    • 84877948851 scopus 로고    scopus 로고
    • Rationally designed multitarget agents against inflammation and pain
    • in press
    • Hwang, S.H.; Wecksler, A.T.; Wagner, K.; Hammock, B.D. Rationally designed multitarget agents against inflammation and pain. Curr. Med. Chem., 2013, 20, in press.
    • (2013) Curr. Med. Chem. , pp. 20
    • Hwang, S.H.1    Wecksler, A.T.2    Wagner, K.3    Hammock, B.D.4
  • 105
    • 33644668387 scopus 로고    scopus 로고
    • Finding new tricks for old drugs: An efficient route for public-sector drug discovery
    • O'Connor, K.A.; Roth, B.L. Finding new tricks for old drugs: An efficient route for public-sector drug discovery. Nat. Rev. Drug Discov., 2005, 4, 1005-1014.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 1005-1014
    • O'Connor, K.A.1    Roth, B.L.2
  • 106
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn, T.T.; Thor, K.B. Drug repositioning: Identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov., 2004, 3, 673-683.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 109
    • 84862281969 scopus 로고    scopus 로고
    • Drug repurposing and the medicinal chemist
    • Aubé, J. Drug repurposing and the medicinal chemist. ACS Med. Chem. Lett., 2012, 3, 442-444.
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 442-444
    • Aubé, J.1
  • 110
    • 67649619336 scopus 로고    scopus 로고
    • 970 Million druglike small molecules for virtual screening in the chemical universe database GDB-13
    • Blum, L.C.; Reymond, J.L. 970 Million druglike small molecules for virtual screening in the chemical universe database GDB-13. J. Am. Chem. Soc., 2009, 131, 8732-8733.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 8732-8733
    • Blum, L.C.1    Reymond, J.L.2
  • 111
    • 34548304745 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: Methods for virtual ligand screening and profiling
    • Ekins, S.; Mestres, J.; Testa, B. In silico pharmacology for drug discovery: Methods for virtual ligand screening and profiling Br. J. Pharmacol., 2007, 152, 9-20.
    • (2007) Br. J. Pharmacol. , vol.152 , pp. 9-20
    • Ekins, S.1    Mestres, J.2    Testa, B.3
  • 112
    • 79958774039 scopus 로고    scopus 로고
    • In silico target profiling of one billion molecules
    • Nonell-Canals, A.; Mestres, J. In silico target profiling of one billion molecules. Mol. Inf., 2011, 30, 405-409.
    • (2011) Mol. Inf. , vol.30 , pp. 405-409
    • Nonell-Canals, A.1    Mestres, J.2
  • 113
    • 83755163958 scopus 로고    scopus 로고
    • Systematic drug repositioning based on clinical side-effects
    • Yang, L; Agarwal, P. Systematic drug repositioning based on clinical side-effects. PLoS ONE, 2011, 6, e28025.
    • (2011) PLoS ONE , vol.6
    • Yang, L.1    Agarwal, P.2
  • 115
    • 84856055845 scopus 로고    scopus 로고
    • Recycling side-effects into clinical makers for drug repositioning
    • Duran-Frigola, M.; Aloy, P. Recycling side-effects into clinical makers for drug repositioning. Genome Med., 2012, 4, 3.
    • (2012) Genome Med. , vol.4 , pp. 3
    • Duran-Frigola, M.1    Aloy, P.2
  • 116
    • 67149130229 scopus 로고    scopus 로고
    • Drug discovery. Repurposing with a difference
    • Boguski, K.S.; Mandl, K.D.; Sukhatme, V.P. Drug discovery. Repurposing with a difference. Science, 2009, 324, 1394-1395.
    • (2009) Science , vol.324 , pp. 1394-1395
    • Boguski, K.S.1    Mandl, K.D.2    Sukhatme, V.P.3
  • 117
    • 1542268206 scopus 로고    scopus 로고
    • Selective optimization of side activities: Another way for drug discovery
    • Wermuth, C.G. Selective optimization of side activities: Another way for drug discovery. J. Med. Chem., 2004, 47, 1303-1314.
    • (2004) J. Med. Chem. , vol.47 , pp. 1303-1314
    • Wermuth, C.G.1
  • 118
    • 0035695149 scopus 로고    scopus 로고
    • The SOSA approach: An alternative to highthroughput screening
    • Wermuth, C.G. The "SOSA" approach: An alternative to highthroughput screening. Med. Chem. Res., 2001, 10, 431-439.
    • (2001) Med. Chem. Res. , vol.10 , pp. 431-439
    • Wermuth, C.G.1
  • 119
    • 4644289587 scopus 로고    scopus 로고
    • Multitargeted drugs: The end of the "one-targetone-disease" philosophy?
    • Wermuth, C.G. Multitargeted drugs: The end of the "one-targetone- disease" philosophy? Drug Discov. Today, 2004, 9, 826-827.
    • (2004) Drug Discov. Today , vol.9 , pp. 826-827
    • Wermuth, C.G.1
  • 120
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: When the whole is greater than the sum of the parts
    • Zimmermann, G.R.; Lehár, J.; Keith, C.T. Multi-target therapeutics: When the whole is greater than the sum of the parts. Drug Discov. Today, 2007, 12, 34-42.
    • (2007) Drug Discov. Today , vol.12 , pp. 34-42
    • Zimmermann, G.R.1    Lehár, J.2    Keith, C.T.3
  • 122
    • 80051629593 scopus 로고    scopus 로고
    • Combination drugs-hype, harm and hope
    • Podolsky, S.H.; Greene, J.A. Combination drugs-hype, harm and hope. N. Engl. J. Med., 2011, 365, 488-491.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 488-491
    • Podolsky, S.H.1    Greene, J.A.2
  • 123
    • 74049100437 scopus 로고    scopus 로고
    • The challenge of polypharmacy in cardiovascular medicine
    • Volpe, M.; Chin, D.; Paneni, F. The challenge of polypharmacy in cardiovascular medicine. Fundament. Clin. Pharmacol., 2010, 24, 9-17.
    • (2010) Fundament. Clin. Pharmacol. , vol.24 , pp. 9-17
    • Volpe, M.1    Chin, D.2    Paneni, F.3
  • 124
    • 1642494659 scopus 로고    scopus 로고
    • Cocktail approaches and strategies in drug development: Valuable tool or flawed science?
    • Zhou, H.; Tong, Z.; McLeod, J.F. "Cocktail" approaches and strategies in drug development: Valuable tool or flawed science? J. Clin. Pharmacol., 2004, 44, 120-134.
    • (2004) J. Clin. Pharmacol. , vol.44 , pp. 120-134
    • Zhou, H.1    Tong, Z.2    McLeod, J.F.3
  • 125
    • 45749135146 scopus 로고    scopus 로고
    • Optimal drug cocktail design: Methods for targeting molecular ensembles and insights from theoretical model systems
    • Radhakrishnan, M.L.; Tidor, B. Optimal drug cocktail design: Methods for targeting molecular ensembles and insights from theoretical model systems. J. Chem. Inf. Model., 2008, 48, 1055-1073.
    • (2008) J. Chem. Inf. Model. , vol.48 , pp. 1055-1073
    • Radhakrishnan, M.L.1    Tidor, B.2
  • 127
    • 14644403608 scopus 로고    scopus 로고
    • A mathematical model of combination therapy using the EGFR signalling network
    • Araujo, R.P.; Petricoin, E.F.; Liotta, L.A. A mathematical model of combination therapy using the EGFR signalling network. Biosystems, 2005, 80, 57-69.
    • (2005) Biosystems , vol.80 , pp. 57-69
    • Araujo, R.P.1    Petricoin, E.F.2    Liotta, L.A.3
  • 129
    • 34250179723 scopus 로고    scopus 로고
    • Fixed-dose combinations improve medication compliance: A metaanalysis
    • Bangalore, S.; Kamalakkannan, G.; Parkar, S.; Messerli, F.H. Fixed-dose combinations improve medication compliance: A metaanalysis. Am. J. Med., 2007, 120, 713-719.
    • (2007) Am. J. Med. , vol.120 , pp. 713-719
    • Bangalore, S.1    Kamalakkannan, G.2    Parkar, S.3    Messerli, F.H.4
  • 133
    • 84857709982 scopus 로고    scopus 로고
    • Ladostigil: A novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment
    • Weinreb, O.; Amit, T.; Bar-Am, O.; Youdim, M.B.H. Ladostigil: A novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr. Drug Targets, 2012, 13, 483-494.
    • (2012) Curr. Drug Targets , vol.13 , pp. 483-494
    • Weinreb, O.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.H.4
  • 134
    • 33746862160 scopus 로고    scopus 로고
    • The physicochemical challenges of designing multiple ligands
    • Morphy, R.; Rankovic, Z. The physicochemical challenges of designing multiple ligands. J. Med. Chem., 2006, 49, 4961-4970.
    • (2006) J. Med. Chem. , vol.49 , pp. 4961-4970
    • Morphy, R.1    Rankovic, Z.2
  • 135
    • 65549171659 scopus 로고    scopus 로고
    • Designing multiple-ligands-medicinal chemistry strategies and challenges
    • Morphy, R.; Rankovic, Z. Designing multiple-ligands-medicinal chemistry strategies and challenges. Curr. Pharm. Des., 2009, 15, 587-600.
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 587-600
    • Morphy, R.1    Rankovic, Z.2
  • 136
    • 33846574259 scopus 로고    scopus 로고
    • Fragments network biology and designing multiple ligands
    • Morphy, R.; Rankovic, Z. Fragments, network biology and designing multiple ligands. Drug Discov. Today, 2007, 12, 156-160.
    • (2007) Drug Discov. Today , vol.12 , pp. 156-160
    • Morphy, R.1    Rankovic, Z.2
  • 137
    • 3242794178 scopus 로고    scopus 로고
    • From magic bullets to designed multiple ligands
    • Morphy, R.; Kay, C.; Rankovic, Z. From magic bullets to designed multiple ligands. Drug Discov. Today, 2004, 9, 641-651.
    • (2004) Drug Discov. Today , vol.9 , pp. 641-651
    • Morphy, R.1    Kay, C.2    Rankovic, Z.3
  • 138
    • 0035324944 scopus 로고    scopus 로고
    • Molecular complexity and its impact on the probability of finding leads for drug discovery
    • Hann, M.M.; Leach, A.R.; Harper, G. Molecular complexity and its impact on the probability of finding leads for drug discovery. J. Chem. Inf. Comput. Sci., 2001, 41, 856-864.
    • (2001) J. Chem. Inf. Comput. Sci. , vol.41 , pp. 856-864
    • Hann, M.M.1    Leach, A.R.2    Harper, G.3
  • 140
    • 84857380650 scopus 로고    scopus 로고
    • Rational approaches to improving selectivity in drug design
    • Huggins, D.J.; Sherman, W.; Tidor, B. Rational approaches to improving selectivity in drug design. J. Med. Chem., 2012, 55, 1424-1444.
    • (2012) J. Med. Chem. , vol.55 , pp. 1424-1444
    • Huggins, D.J.1    Sherman, W.2    Tidor, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.