Drug repurposing and the medicinal chemist

ACS Medicinal Chemistry Letters

Volumn 3, Issue 6, 2012, Pages 442-444

  Aubé, Jeffrey ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DISTRIBUTION; DRUG INDICATION; DRUG METABOLISM; DRUG REPURPOSING; DRUG SCREENING; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 84862281969     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300114c     Document Type: Review

References (8)

1. For an appraisal of the combinatorial chemistry controversy from a contemporary perspective, see: Kennedy, J. P.; Williams, L.; Bridges, T. M.; Daniels, R. N.; Weaver, D.; Lindsley, C. W. Application of Combinatorial Chemistry Science on Modern Drug Discovery J. Comb. Chem. 2008, 10, 345-354
2. Ashburn, T. T.; Thor, K. B. Drug Repositioning: Identifying and Developing New Uses for Existing Drugs Nat. Rev. Drug Discov. 2004, 3, 673-683 (Pubitemid 39173508)
3. O'Connor, K. A.; Roth, B. L. Finding New Tricks for Old Drugs: An Efficient Route for Public-Sector Drug Discovery Nat. Rev. Drug Discov. 2005, 4, 1005-1014
4. Oprea, T. I.; Bauman, J. E.; Bologa, C. G.; Buranda, T.; Chigaev, A.; Edwards, B. S.; Jarvik, J. W.; Gresham, H. D.; Haynes, M. K.; Hjelle, B.; Hromas, R.; Hudson, L.; Mackenzie, D. A.; Muller, C. Y.; Reed, J. C.; Simons, P. C.; Smagley, Y.; Strouse, J.; Surviladze, Z.; Thompson, T.; Ursu, O.; Waller, A.; Wandinger-Ness, A.; Winter, S. S.; Wu, Y.; Young, S. M.; Larson, R. S.; Willman, C.; Sklar, L. A. Drug Repurposing From an Academic Perspective Drug Discov. Today: Ther. Strategies 2011, 8, 61-69
5. Doan, T. L.; Pollastri, M.; Walters, M. A.; Georg, G. I.; Macor, J., E. The Future of Drug Repositioning: Old Drugs, New Opportunities. In Annu. Rep. Med. Chem., Macor, J. E., Ed. Academic Press: Oxford, 2011; Vol. 46, pp 385-401.
6. Huang, R.; Southall, N.; Wang, Y.; Yasgar, A.; Shinn, P.; Jadhav, A.; Nguyen, D.-T.; Austin, C. P. The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics Science Translational Med. 2011, 3, 80ps16
7. Collins, F. S. Mining for therapeutic gold Nat. Rev. Drug Discov. 2011, 10, 397-397
8. The Discovering New Therapeutic Uses for Existing Molecules initiative was announced by NIH on May 3, 2012,: http://www.ncats.nih.gov/research/ reengineering/rescue-repurpose/therapeutic-uses/therapeutic-uses.html.