-
1
-
-
0036500993
-
Systems biology: A brief overview
-
Kitano, H. Systems biology: a brief overview. Science 295, 1662-1664 (2002).
-
(2002)
Science
, vol.295
, pp. 1662-1664
-
-
Kitano, H.1
-
2
-
-
0037079054
-
Computational systems biology
-
Kitano, H. Computational systems biology. Nature 420, 206-210 (2002).
-
(2002)
Nature
, vol.420
, pp. 206-210
-
-
Kitano, H.1
-
3
-
-
0033517148
-
Robustness of a gene regulatory circuit
-
Little, J. W., Shepley, D. P. & Wert, D. W. Robustness of a gene regulatory circuit. EMBO J. 18, 4299-4307 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 4299-4307
-
-
Little, J.W.1
Shepley, D.P.2
Wert, D.W.3
-
5
-
-
7644234438
-
Calculating biological behaviors of epigenetic states in the phage λ life cycle
-
Zhu, X. M., Yin, L., Hood, L. & Ao, P. Calculating biological behaviors of epigenetic states in the phage λ life cycle. Funct. Integr. Genomics 4, 188-195 (2004).
-
(2004)
Funct. Integr. Genomics
, vol.4
, pp. 188-195
-
-
Zhu, X.M.1
Yin, L.2
Hood, L.3
Ao, P.4
-
6
-
-
0346688719
-
Why the lysogenic state of phage λ is so stable: A mathematical modeling approach
-
Santillan, M. & Mackey, M. C. Why the lysogenic state of phage λ is so stable: a mathematical modeling approach. Biophys. J. 86, 75-84 (2004).
-
(2004)
Biophys. J.
, vol.86
, pp. 75-84
-
-
Santillan, M.1
Mackey, M.C.2
-
7
-
-
0033552946
-
Robustness in bacterial chemotaxis
-
Alon, U., Surette, M. G., Barkai, N. & Leibler, S. Robustness in bacterial chemotaxis. Nature 397, 168-171 (1999). A seminal research paper on the robust adaptation observed in bacterial chemotaxis.
-
(1999)
Nature
, vol.397
, pp. 168-171
-
-
Alon, U.1
Surette, M.G.2
Barkai, N.3
Leibler, S.4
-
8
-
-
0030797355
-
Robustness in simple biochemical networks
-
Barkai, N. & Leibler, S. Robustness in simple biochemical networks. Nature 387, 913-917 (1997).
-
(1997)
Nature
, vol.387
, pp. 913-917
-
-
Barkai, N.1
Leibler, S.2
-
9
-
-
0034712843
-
Robust perfect adaptation in bacterial chemotaxis through integral feedback control
-
Yi, T. M., Huang, Y., Simon, M. I. & Doyle, J. Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc. Natl Acad. Sci. USA 97, 4649-4653 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4649-4653
-
-
Yi, T.M.1
Huang, Y.2
Simon, M.I.3
Doyle, J.4
-
10
-
-
0034644270
-
The segment polarity network is a robust developmental module
-
von Dassow, G., Meir, E., Munro, E. M. & Odell, G. M. The segment polarity network is a robust developmental module. Nature 406, 188-192 (2000). A study that suggests that the modular robust network contributes to pattern formation during embryogenesis in D. melanogaster.
-
(2000)
Nature
, vol.406
, pp. 188-192
-
-
Von Dassow, G.1
Meir, E.2
Munro, E.M.3
Odell, G.M.4
-
11
-
-
3142517462
-
Topology and robustness in the Drosophila segment polarity network
-
Ingolia, N. T. Topology and robustness in the Drosophila segment polarity network. PLoS Biol. 2, e123 (2004).
-
(2004)
PLoS Biol.
, vol.2
-
-
Ingolia, N.T.1
-
12
-
-
0037162399
-
Modeling pattern formation: Counting to two in the Drosophila egg
-
Barkai, N. & Shilo, B. Modeling pattern formation: counting to two in the Drosophila egg. Curr. Biol. 12, R493 (2002).
-
(2002)
Curr. Biol.
, vol.12
-
-
Barkai, N.1
Shilo, B.2
-
13
-
-
0037075022
-
Establishment of developmental precision and proportions in the early Drosophila embryo
-
Houchmandzadeh, B., Wieschaus, F. & Leibler, S. Establishment of developmental precision and proportions in the early Drosophila embryo. Nature 415, 798-802 (2002).
-
(2002)
Nature
, vol.415
, pp. 798-802
-
-
Houchmandzadeh, B.1
Wieschaus, F.2
Leibler, S.3
-
14
-
-
0344010691
-
Cancer robustness: Tumour tactics
-
Kitano, H. Cancer robustness: tumour tactics. Nature 426, 125 (2003).
-
(2003)
Nature
, vol.426
, pp. 125
-
-
Kitano, H.1
-
15
-
-
1542619848
-
Cancer as a robust system: Implications for anticancer therapy
-
Kitano, H. Cancer as a robust system: implications for anticancer therapy. Nature Rev. Cancer 4, 227-235 (2004). A theoretical proposal to approach cancer treatment from the aspect of robustness.
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 227-235
-
-
Kitano, H.1
-
16
-
-
7644241654
-
Metabolic syndrome and robustness trade-offs
-
Kitano, H. et al. Metabolic syndrome and robustness trade-offs. Diabetes 53, (Suppl. 3), 1-10 (2004).
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
, pp. 1-10
-
-
Kitano, H.1
-
17
-
-
0036301511
-
Robustness as a measure of plausibility in models of biochemical networks
-
Morohashi, M. et al. Robustness as a measure of plausibility in models of biochemical networks. J. Theor. Biol. 216, 19-30 (2002).
-
(2002)
J. Theor. Biol.
, vol.216
, pp. 19-30
-
-
Morohashi, M.1
-
18
-
-
0032494690
-
Bifurcation analysis of a model of mitotic control in frog eggs
-
Borisuk, M. T. & Tyson, J. J. Bifurcation analysis of a model of mitotic control in frog eggs. J. Theor. Biol. 195, 69-85 (1998).
-
(1998)
J. Theor. Biol.
, vol.195
, pp. 69-85
-
-
Borisuk, M.T.1
Tyson, J.J.2
-
19
-
-
19344376625
-
Design and diversity in bacterial chemotaxis: A comparative study in Escherichia coli and Bacillus subtilis
-
Rao, C. V., Kirby, J. R. & Arkin, A. P. Design and diversity in bacterial chemotaxis: a comparative study in Escherichia coli and Bacillus subtilis. PLoS Biol. 2, e49 (2004).
-
(2004)
PLoS Biol.
, vol.2
-
-
Rao, C.V.1
Kirby, J.R.2
Arkin, A.P.3
-
20
-
-
0033083733
-
It's a noisy business! Genetic regulation at the nanomolar scale
-
McAdams, H. H. & Arkin, A. It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet. 15, 65-69 (1999).
-
(1999)
Trends Genet.
, vol.15
, pp. 65-69
-
-
McAdams, H.H.1
Arkin, A.2
-
21
-
-
0037078982
-
Control, exploitation and tolerance of intracellular noise
-
Rao, C. V., Wolf, D. M. & Arkin, A. P. Control, exploitation and tolerance of intracellular noise. Nature 420, 231-237 (2002).
-
(2002)
Nature
, vol.420
, pp. 231-237
-
-
Rao, C.V.1
Wolf, D.M.2
Arkin, A.P.3
-
22
-
-
0029028963
-
Circuit simulation of genetic networks
-
McAdams, H. H. & Shapiro, L. Circuit simulation of genetic networks. Science 269, 650-656 (1995).
-
(1995)
Science
, vol.269
, pp. 650-656
-
-
McAdams, H.H.1
Shapiro, L.2
-
23
-
-
0031879114
-
Stochastic kinetic analysis of developmental pathway bifurcation in phage λ-infected Escherichia coli cells
-
Arkin, A., Ross, J. & McAdams, H. H. Stochastic kinetic analysis of developmental pathway bifurcation in phage λ-infected Escherichia coli cells. Genetics 149, 1633-1648 (1998).
-
(1998)
Genetics
, vol.149
, pp. 1633-1648
-
-
Arkin, A.1
Ross, J.2
McAdams, H.H.3
-
25
-
-
0242515913
-
The JNK cascade as a biochemical switch in mammalian cells: Ultrasensitive and all-or-none responses
-
Bagowski, C. P., Besser, J., Frey, C. R. & Ferrell, J. E. Jr. The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses. Curr Biol. 13, 315-320 (2003).
-
(2003)
Curr Biol.
, vol.13
, pp. 315-320
-
-
Bagowski, C.P.1
Besser, J.2
Frey, C.R.3
Ferrell Jr., J.E.4
-
26
-
-
0036532226
-
Self-perpetuating states in signal transduction: Positive feedback, double-negative feedback and bistability
-
Ferrell, J. E. Jr. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr. Opin. Cell. Biol. 14, 140-148 (2002).
-
(2002)
Curr. Opin. Cell. Biol.
, vol.14
, pp. 140-148
-
-
Ferrell Jr., J.E.1
-
27
-
-
0035656416
-
Network dynamics and cell physiology
-
Tyson, J. J., Chen, K. & Novak, B. Network dynamics and cell physiology. Nature Rev. Mol. Cell Biol. 2, 908-916 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol.
, vol.2
, pp. 908-916
-
-
Tyson, J.J.1
Chen, K.2
Novak, B.3
-
28
-
-
0034676456
-
Feedback control of intercellular signalling in development
-
Freeman, M. Feedback control of intercellular signalling in development. Nature 408, 313-319 (2000). A comprehensive review of how feedback control contributes to robustness and pattern formation during development.
-
(2000)
Nature
, vol.408
, pp. 313-319
-
-
Freeman, M.1
-
29
-
-
0035850895
-
Phenotypic plasticity in the interactions and evolution of species
-
Agrawal, A. A. Phenotypic plasticity in the interactions and evolution of species. Science 294, 321-326 (2001).
-
(2001)
Science
, vol.294
, pp. 321-326
-
-
Agrawal, A.A.1
-
32
-
-
0027220020
-
CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae
-
Schwob, E. & Nasmyth, K. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev. 7, 1160-1175 (1993).
-
(1993)
Genes Dev.
, vol.7
, pp. 1160-1175
-
-
Schwob, E.1
Nasmyth, K.2
-
33
-
-
1942452749
-
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
-
Kellis, M., Birren, B. W. & Lander, E. S. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature 428, 617-624 (2004).
-
(2004)
Nature
, vol.428
, pp. 617-624
-
-
Kellis, M.1
Birren, B.W.2
Lander, E.S.3
-
34
-
-
0037456380
-
Yeast genome duplication was followed by asynchronous differentiation of duplicated genes
-
Langkjaer, R. B., Cliften, P. F., Johnston, M. & Piskur, J. Yeast genome duplication was followed by asynchronous differentiation of duplicated genes. Nature 421, 848-852 (2003).
-
(2003)
Nature
, vol.421
, pp. 848-852
-
-
Langkjaer, R.B.1
Cliften, P.F.2
Johnston, M.3
Piskur, J.4
-
36
-
-
0038353717
-
Evolution of duplicate genes versus genetic robustness against null mutations
-
Gu, X. Evolution of duplicate genes versus genetic robustness against null mutations. Trends Genet. 19, 354-356 (2003).
-
(2003)
Trends Genet.
, vol.19
, pp. 354-356
-
-
Gu, X.1
-
37
-
-
0347033256
-
Role of duplicate genes in genetic robustness against null mutations
-
Gu, Z. et al. Role of duplicate genes in genetic robustness against null mutations. Nature 421, 63-66 (2003).
-
(2003)
Nature
, vol.421
, pp. 63-66
-
-
Gu, Z.1
-
38
-
-
0030836756
-
Evolution of genetic redundancy
-
Nowak, M. A., Boerlijst, M. C., Cooke, J. & Smith, J. M. Evolution of genetic redundancy. Nature 388, 167-171 (1997).
-
(1997)
Nature
, vol.388
, pp. 167-171
-
-
Nowak, M.A.1
Boerlijst, M.C.2
Cooke, J.3
Smith, J.M.4
-
40
-
-
0030669030
-
Exploring the metabolic and genetic control of gene expression on a genomic scale
-
DeRisi, J. L., Iyer, V. R. & Brown, P. O. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278, 680-686 (1997).
-
(1997)
Science
, vol.278
, pp. 680-686
-
-
DeRisi, J.L.1
Iyer, V.R.2
Brown, P.O.3
-
41
-
-
0034519221
-
Robustness analysis of the Escherichia coli metabolic network
-
Edwards, J. S. & Palsson, B. O. Robustness analysis of the Escherichia coli metabolic network. Biotechnol. Prog. 16, 927-939 (2000).
-
(2000)
Biotechnol. Prog.
, vol.16
, pp. 927-939
-
-
Edwards, J.S.1
Palsson, B.O.2
-
42
-
-
0035125986
-
In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
-
Edwards, J. S., Ibarra, R. U. & Palsson, B. O. In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nature Biotechnol. 19, 125-130 (2001).
-
(2001)
Nature Biotechnol.
, vol.19
, pp. 125-130
-
-
Edwards, J.S.1
Ibarra, R.U.2
Palsson, B.O.3
-
43
-
-
0037743679
-
Convergent evolution of gene circuits
-
Conant, G. C. & Wagner, A. Convergent evolution of gene circuits. Nature Genet. 34, 264-266 (2003).
-
(2003)
Nature Genet.
, vol.34
, pp. 264-266
-
-
Conant, G.C.1
Wagner, A.2
-
44
-
-
2442537233
-
Gene regulatory network growth by duplication
-
Teichmann, S. A. & Babu, M. M. Gene regulatory network growth by duplication. Nature Genet. 36, 492-496 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 492-496
-
-
Teichmann, S.A.1
Babu, M.M.2
-
45
-
-
0033518234
-
From molecular to modular cell biology
-
Hartwell, L. H., Hopfield, J. J., Leibler, S. & Murray, A. W. From molecular to modular cell biology. Nature 402, 47-52 (1999). An influential article that stresses the importance of a system-based approach in biology, with particular emphasis on modularity.
-
(1999)
Nature
, vol.402
, pp. 47-52
-
-
Hartwell, L.H.1
Hopfield, J.J.2
Leibler, S.3
Murray, A.W.4
-
46
-
-
0004319914
-
-
Univ. Chicago Press, Chicago
-
Schlosser, G, & Wagner, G. (eds.) Modularity in Development and Evolution (Univ. Chicago Press, Chicago, 2004). An edited collection of papers on modularity in biological systems that provides up-to-date discussions of the issue.
-
(2004)
Modularity in Development and Evolution
-
-
Schlosser, G.1
Wagner, G.2
-
47
-
-
0003501595
-
-
MIT Press, Cambridge, Massachusetts
-
Baldwin, C. & Clark, K. Design Rules, Vol. 1: The Power of Modularity (MIT Press, Cambridge, Massachusetts, 2000).
-
(2000)
Design Rules, Vol. 1: The Power of Modularity
, vol.1
-
-
Baldwin, C.1
Clark, K.2
-
49
-
-
1542380403
-
The evolution of genetic regulatory systems in bacteria
-
McAdams, H. H., Srinivasan, B. & Arkin, A. P. The evolution of genetic regulatory systems in bacteria. Nature Rev. Genet. 5, 169-178 (2004).
-
(2004)
Nature Rev. Genet.
, vol.5
, pp. 169-178
-
-
McAdams, H.H.1
Srinivasan, B.2
Arkin, A.P.3
-
50
-
-
0142059836
-
Protein complexes and functional modules in molecular networks
-
Spirin, V. & Mirny, L. A. Protein complexes and functional modules in molecular networks. Proc. Natl Acad. Sci. USA 100, 12123-12128 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12123-12128
-
-
Spirin, V.1
Mirny, L.A.2
-
51
-
-
0032569851
-
Hsp90 as a capacitor for morphological evolution
-
Rutherford, S. L. & Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 396, 336-342 (1998).
-
(1998)
Nature
, vol.396
, pp. 336-342
-
-
Rutherford, S.L.1
Lindquist, S.2
-
52
-
-
0037030713
-
Hsp90 as a capacitor of phenotypic variation
-
Queitsch, C., Sangster, T. A. & Lindquist, S. Hsp90 as a capacitor of phenotypic variation. Nature 417, 616-624 (2002).
-
(2002)
Nature
, vol.417
, pp. 616-624
-
-
Queitsch, C.1
Sangster, T.A.2
Lindquist, S.3
-
53
-
-
0037379626
-
Between genotype and phenotype: Protein chaperones and evolvability
-
Rutherford, S. L. Between genotype and phenotype: protein chaperones and evolvability. Nature Rev. Genet. 4, 263-274 (2003). This article describes issues to do with genetic buffering, particularly involving hsp90, and outlines the implications of such phenomena.
-
(2003)
Nature Rev. Genet.
, vol.4
, pp. 263-274
-
-
Rutherford, S.L.1
-
55
-
-
0017368336
-
Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution
-
Kimura, M. Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature 267, 275-276 (1977).
-
(1977)
Nature
, vol.267
, pp. 275-276
-
-
Kimura, M.1
-
56
-
-
0018544480
-
The neutral theory of molecular evolution
-
108 passim
-
Kimura, M. The neutral theory of molecular evolution. Sci. Am. 241, 98-100, 102, 108 passim (1979).
-
(1979)
Sci. Am.
, vol.241
, pp. 98-100
-
-
Kimura, M.1
-
57
-
-
0035830860
-
Principles for the buffering of genetic variation
-
Hartman, J. L. 4th, Garvik, B. & Hartwell, L. Principles for the buffering of genetic variation. Science 291, 1001-1004 (2001).
-
(2001)
Science
, vol.291
, pp. 1001-1004
-
-
Hartman IV, J.L.1
Garvik, B.2
Hartwell, L.3
-
58
-
-
0042154192
-
Evolutionary capacitance as a general feature of complex gene networks
-
Bergman, A. & Siegal, M. L. Evolutionary capacitance as a general feature of complex gene networks. Nature 424, 549-552 (2003).
-
(2003)
Nature
, vol.424
, pp. 549-552
-
-
Bergman, A.1
Siegal, M.L.2
-
59
-
-
0036724987
-
Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication
-
Kitami, T. & Nadeau, J. H. Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication. Nature Genet. 32, 191-194 (2002).
-
(2002)
Nature Genet.
, vol.32
, pp. 191-194
-
-
Kitami, T.1
Nadeau, J.H.2
-
60
-
-
0036678862
-
Waddington's canalization revisited: Developmental stability and evolution
-
Siegal, M. L. & Bergman, A. Waddington's canalization revisited: developmental stability and evolution. Proc. Natl. Acad. Sci. USA 99, 10528-10532 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10528-10532
-
-
Siegal, M.L.1
Bergman, A.2
-
61
-
-
0034633702
-
Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
-
Lev Bar-Or, R. et al. Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc. Natl Acad. Sci. USA 97, 11250-11255 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11250-11255
-
-
Lev Bar-Or, R.1
-
62
-
-
0842332406
-
Dynamics of the p53-Mdm2 feedback loop in individual cells
-
Lahav, G. et al. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nature Genet. 36, 147-150 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 147-150
-
-
Lahav, G.1
-
63
-
-
0032555135
-
Evolvability
-
Kirschner, M. & Gerhart, J. Evolvability. Proc. Natl Acad. Sci. USA 95, 8420-8427 (1998). An influential article that discusses the various molecular and system mechanisms that contribute to the evolvability of organisms. Together with their book (reference 64), basic issues and perspectives are presented.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8420-8427
-
-
Kirschner, M.1
Gerhart, J.2
-
64
-
-
0004068679
-
-
Blackwell Science, Malden, Massachusetts
-
Gerhart, J. & Kirschner, M. Cells, Embryos, and Evolution: Toward a Cellular and Developmental Understanding of Phenotypic Variation and Evolutionary Adaptability (Blackwell Science, Malden, Massachusetts, 1997).
-
(1997)
Cells, Embryos, and Evolution: Toward a Cellular and Developmental Understanding of Phenotypic Variation and Evolutionary Adaptability
-
-
Gerhart, J.1
Kirschner, M.2
-
66
-
-
4344670936
-
Bow ties, metabolism and disease
-
Csete, M. E. & Doyle, J. Bow ties, metabolism and disease. Trends Biotechnol. 22, 446-450 (2004).
-
(2004)
Trends Biotechnol.
, vol.22
, pp. 446-450
-
-
Csete, M.E.1
Doyle, J.2
-
67
-
-
10744228524
-
Evolution and detection of genetics robustness
-
de Visser, J. et al. Evolution and detection of genetics robustness. Evolution 57, 1959-1972 (2003). A summary of workshop discussions on evolvability and robustness, which are relevant to current discussions.
-
(2003)
Evolution
, vol.57
, pp. 1959-1972
-
-
De Visser, J.1
-
68
-
-
0037136555
-
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
-
Elder, A. et al. Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419, 304-308 (2002).
-
(2002)
Nature
, vol.419
, pp. 304-308
-
-
Elder, A.1
-
69
-
-
0000573339
-
Pattern formation in artificially activated ectoderm (Rana pipiens and Ambystoma punctatum)
-
Niewukoop, P. D. Pattern formation in artificially activated ectoderm (Rana pipiens and Ambystoma punctatum). Dev. Biol. 7, 255-279 (1963).
-
(1963)
Dev. Biol.
, vol.7
, pp. 255-279
-
-
Niewukoop, P.D.1
-
70
-
-
0022369196
-
Inductive interactions in early amphibian development and their general nature
-
Nieuwkoop, P. D. Inductive interactions in early amphibian development and their general nature. J. Embryol. Exp. Morphol. 89, S333-S347 (1985).
-
(1985)
J. Embryol. Exp. Morphol.
, vol.89
-
-
Nieuwkoop, P.D.1
-
71
-
-
0037223971
-
The evolution of signaling pathways in animal development
-
Pires-daSilva, A. & Sommer, R. J. The evolution of signaling pathways in animal development. Nature Rev. Genet. 4, 39-49 (2003).
-
(2003)
Nature Rev. Genet.
, vol.4
, pp. 39-49
-
-
Pires-DaSilva, A.1
Sommer, R.J.2
-
72
-
-
0003851228
-
-
Blackwell, Oxford
-
Carroll, S., Grenier, J. & Weatherbee, S. From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design (Blackwell, Oxford, 2001). This book describes the role of toolkit and co-option in development.
-
(2001)
From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design
-
-
Carroll, S.1
Grenier, J.2
Weatherbee, S.3
-
73
-
-
0344736730
-
Hox cluster duplications and the opportunity for evolutionary novelties
-
Wagner, G. P., Amemiya, C. & Ruddle, F. Hox cluster duplications and the opportunity for evolutionary novelties. Proc. Natl Acad. Sci. USA 100, 14603-14606 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14603-14606
-
-
Wagner, G.P.1
Amemiya, C.2
Ruddle, F.3
-
75
-
-
0018240421
-
A gene complex controlling segmentation in Drosophila
-
Lewis, E. B. A gene complex controlling segmentation in Drosophila. Nature 276, 565-570 (1976).
-
(1976)
Nature
, vol.276
, pp. 565-570
-
-
Lewis, E.B.1
-
76
-
-
0025116879
-
Molecular and genetic organization of the antennapedia gene complex of Drosophila melanogaster
-
Kaufman, T. C., Seeger, M. A. & Olsen, G. Molecular and genetic organization of the antennapedia gene complex of Drosophila melanogaster. Adv. Genet. 27, 309-362 (1990).
-
(1990)
Adv. Genet.
, vol.27
, pp. 309-362
-
-
Kaufman, T.C.1
Seeger, M.A.2
Olsen, G.3
-
77
-
-
0019796926
-
A homoeotic mutation transforming leg to antenna in Drosophila
-
Struhl, G. A homoeotic mutation transforming leg to antenna in Drosophila. Nature 292, 635-638 (1981).
-
(1981)
Nature
, vol.292
, pp. 635-638
-
-
Struhl, G.1
-
78
-
-
0028944665
-
Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
-
Halder, G., Callaerts, P. & Gehring, W. J. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267, 1788-1792 (1995).
-
(1995)
Science
, vol.267
, pp. 1788-1792
-
-
Halder, G.1
Callaerts, P.2
Gehring, W.J.3
-
79
-
-
0035344461
-
A weak signal for strong responses: Interferon-α/β revisited
-
Taniguchi, T. & Takaoka, A. A weak signal for strong responses: interferon-α/β revisited. Nature Rev. Mol. Cell Biol. 2, 378-386 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol.
, vol.2
, pp. 378-386
-
-
Taniguchi, T.1
Takaoka, A.2
-
80
-
-
0009952303
-
Robustness of the bistable behavior of a biological signaling feedback loop
-
Bhalla, U. S. & Iyengar, R. Robustness of the bistable behavior of a biological signaling feedback loop. Chaos 11, 221-226 (2001).
-
(2001)
Chaos
, vol.11
, pp. 221-226
-
-
Bhalla, U.S.1
Iyengar, R.2
-
81
-
-
0029661332
-
Complex adaptations and the evolution of evolvability
-
Wagner, G. P. & Altenberg, L. Complex adaptations and the evolution of evolvability. Evolution 50, 967-976 (1996).
-
(1996)
Evolution
, vol.50
, pp. 967-976
-
-
Wagner, G.P.1
Altenberg, L.2
-
82
-
-
0034609791
-
The large-scale organization of metabolic networks
-
Jeong, H., Tombor, B., Albert, R., Oltvai, Z. N. & Barabasi, A. L. The large-scale organization of metabolic networks. Nature 407, 651-654 (2000).
-
(2000)
Nature
, vol.407
, pp. 651-654
-
-
Jeong, H.1
Tombor, B.2
Albert, R.3
Oltvai, Z.N.4
Barabasi, A.L.5
-
83
-
-
0742305866
-
Network biology: Understanding the cell's functional organization
-
Barabasi, A. L. & Oltvai, Z. N. Network biology: understanding the cell's functional organization. Nature Rev. Genet. 5, 101-113 (2004). A good summary of the scale-free network in biology by the originator of the idea.
-
(2004)
Nature Rev. Genet.
, vol.5
, pp. 101-113
-
-
Barabasi, A.L.1
Oltvai, Z.N.2
-
84
-
-
0034721164
-
Error and attack tolerance of complex networks
-
Albert, R., Jeong, H. & Barabasi, A. L. Error and attack tolerance of complex networks. Nature 406, 378-382 (2000).
-
(2000)
Nature
, vol.406
, pp. 378-382
-
-
Albert, R.1
Jeong, H.2
Barabasi, A.L.3
-
85
-
-
0042093610
-
The connectivity structure, giant strong component and centrality of metabolic networks
-
Me, H. W. & Zeng, A. P. The connectivity structure, giant strong component and centrality of metabolic networks. Bioinformatics 19, 1423-1430 (2003).
-
(2003)
Bioinformatics
, vol.19
, pp. 1423-1430
-
-
Me, H.W.1
Zeng, A.P.2
-
86
-
-
0041828241
-
Scaling laws in the functional content of genomes
-
van Nimwegen, E. Scaling laws in the functional content of genomes. Trends Genet. 19, 479-484 (2003).
-
(2003)
Trends Genet.
, vol.19
, pp. 479-484
-
-
Van Nimwegen, E.1
-
87
-
-
27244440541
-
-
(ed. Koonin, E. V.) (Landes Bioscience, in the press)
-
van Nimwegen, E. in Power Laws, Scale-free Networks, and Genome Biology (ed. Koonin, E. V.) (Landes Bioscience, in the press).
-
Power Laws, Scale-Free Networks, and Genome Biology
-
-
Van Nimwegen, E.1
-
88
-
-
0034069495
-
Gene ontology: Tool for the unification of biology
-
The Gene Ontology Consortium
-
Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genet. 25, 25-29 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 25-29
-
-
Ashburner, M.1
-
89
-
-
0034644509
-
Signaling networks: The origins of cellular multitasking
-
Jordan, J. D., Landau, E. M. & Iyengar, R. Signaling networks: the origins of cellular multitasking. Cell 103, 193-200 (2000).
-
(2000)
Cell
, vol.103
, pp. 193-200
-
-
Jordan, J.D.1
Landau, E.M.2
Iyengar, R.3
-
90
-
-
0032499401
-
Modes of interactions between signaling pathways
-
Jordan, J. D. & Iyengar, R. Modes of interactions between signaling pathways. Biochem. Pharmacol. 55, 1347-1352 (1998).
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 1347-1352
-
-
Jordan, J.D.1
Iyengar, R.2
-
91
-
-
0038540318
-
Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
-
Hermans, E. Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors. Pharmacol. Ther. 99, 25-44 (2003).
-
(2003)
Pharmacol. Ther.
, vol.99
, pp. 25-44
-
-
Hermans, E.1
-
93
-
-
0037446894
-
The G protein-coupled receptor repertoires of human and mouse
-
Vassilatis, D. K. et al. The G protein-coupled receptor repertoires of human and mouse. Proc. Natl Acad. Sci. USA 100, 4903-4908 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4903-4908
-
-
Vassilatis, D.K.1
-
94
-
-
1842584883
-
RNA regulation: A new genetics?
-
Mattick, J. S. RNA regulation: a new genetics? Nature Rev. Genet. 5, 316-323 (2004).
-
(2004)
Nature Rev. Genet.
, vol.5
, pp. 316-323
-
-
Mattick, J.S.1
-
95
-
-
0035195942
-
Non-coding RNAs: The architects of eukaryotic complexity
-
Mattick, J. S. Non-coding RNAs: the architects of eukaryotic complexity. EMBO Rep. 2, 986-991 (2001).
-
(2001)
EMBO Rep.
, vol.2
, pp. 986-991
-
-
Mattick, J.S.1
-
96
-
-
0141867857
-
Challenging the dogma: The hidden layer of non-protein-coding RNAs in complex organisms
-
Mattick, J. S. Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms. Bioessays 25, 930-939 (2003).
-
(2003)
Bioessays
, vol.25
, pp. 930-939
-
-
Mattick, J.S.1
-
97
-
-
0037074010
-
Signaling network model of chromatin
-
Schreiber, S. L. & Bernstein, B. E. Signaling network model of chromatin. Cell 111, 771-778 (2002).
-
(2002)
Cell
, vol.111
, pp. 771-778
-
-
Schreiber, S.L.1
Bernstein, B.E.2
-
98
-
-
0035931911
-
Chance and necessity: The evolution of morphological complexity and diversity
-
Carroll, S. B. Chance and necessity: the evolution of morphological complexity and diversity. Nature 409, 1102-1109 (2001).
-
(2001)
Nature
, vol.409
, pp. 1102-1109
-
-
Carroll, S.B.1
-
99
-
-
0000290649
-
Highly optimized tolerance: A mechanism for power laws in designed systems
-
Carlson, J. M. & Doyle, J. Highly optimized tolerance: a mechanism for power laws in designed systems. Phys. Rev. E 60, 1412-1427 (1999).
-
(1999)
Phys. Rev. E
, vol.60
, pp. 1412-1427
-
-
Carlson, J.M.1
Doyle, J.2
-
100
-
-
0037133146
-
Complexity and robustness
-
Carlson, J. M. & Doyle, J. Complexity and robustness. Proc. Natl Acad. Sci. USA 99 (Suppl 1), 2538-2545 (2002). An introductory article on the highly optimized tolerance (HOT) theory.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, Issue.SUPPL. 1
, pp. 2538-2545
-
-
Carlson, J.M.1
Doyle, J.2
-
101
-
-
0038483826
-
Emergence of scaling in random networks
-
Barabasi, A. L. & Albert, R. Emergence of scaling in random networks. Science 286, 509-512 (1999).
-
(1999)
Science
, vol.286
, pp. 509-512
-
-
Barabasi, A.L.1
Albert, R.2
-
102
-
-
15744401041
-
Self-organized criticality
-
Bak, P., Tang, C. & Wiesenfeld, K. Self-organized criticality. Phys. Rev. A 38, 364-374 (1988).
-
(1988)
Phys. Rev. A
, vol.38
, pp. 364-374
-
-
Bak, P.1
Tang, C.2
Wiesenfeld, K.3
-
103
-
-
0036500834
-
Reverse engineering of biological complexity
-
Csete, M. E. & Doyle, J. C. Reverse engineering of biological complexity. Science 295, 1664-1669 (2002). An inspiring piece that discusses the complexity of biological systems from engineering and control-theory perspective.
-
(2002)
Science
, vol.295
, pp. 1664-1669
-
-
Csete, M.E.1
Doyle, J.C.2
-
104
-
-
84976699318
-
The Byzantine generals problem
-
Lamport, L., Shostak, R. & Pease, M. The Byzantine generals problem. ACM Trans. Program. Lang. Sys. 4, 382-401 (1982).
-
(1982)
ACM Trans. Program. Lang. Sys.
, vol.4
, pp. 382-401
-
-
Lamport, L.1
Shostak, R.2
Pease, M.3
-
105
-
-
0347349553
-
Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system
-
Cassel, D. & Pfeuffer, T. Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system. Proc. Natl Acad. Sci. USA 75, 2669-2673 (1978).
-
(1978)
Proc. Natl. Acad. Sci. USA
, vol.75
, pp. 2669-2673
-
-
Cassel, D.1
Pfeuffer, T.2
-
106
-
-
0024550752
-
Guanine nucleotide-binding proteins (G proteins) in activation of adenylyl cyclase: Lessons learned from cholera and 'travelers' diarrhea'
-
Moss, J. & Vaughan, M. Guanine nucleotide-binding proteins (G proteins) in activation of adenylyl cyclase: lessons learned from cholera and 'travelers' diarrhea'. J. Lab. Clin. Med. 113, 258-268 (1989).
-
(1989)
J. Lab. Clin. Med.
, vol.113
, pp. 258-268
-
-
Moss, J.1
Vaughan, M.2
-
107
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris, A. L. Hypoxia - a key regulatory factor in tumour growth. Nature Rev. Cancer 2, 38-47 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
108
-
-
0036187615
-
The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
-
Bingle, L., Brown, N. J. & Lewis, C. E. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196, 254-265 (2002).
-
(2002)
J. Pathol.
, vol.196
, pp. 254-265
-
-
Bingle, L.1
Brown, N.J.2
Lewis, C.E.3
-
109
-
-
0037079012
-
Engineered gene circuits
-
Hasty, J., McMillen, D. & Collins, J. J. Engineered gene circuits. Nature 420, 224-230 (2002).
-
(2002)
Nature
, vol.420
, pp. 224-230
-
-
Hasty, J.1
McMillen, D.2
Collins, J.J.3
-
110
-
-
0035912222
-
Cellular immune responses to HIV
-
McMichael, A. J. & Rowland-Jones, S. L. Cellular immune responses to HIV. Nature 410, 980-987 (2001).
-
(2001)
Nature
, vol.410
, pp. 980-987
-
-
McMichael, A.J.1
Rowland-Jones, S.L.2
-
111
-
-
0035912232
-
+ T-cell depletion in HIV disease
-
+ T-cell depletion in HIV disease. Nature 410, 974-979 (2001).
-
(2001)
Nature
, vol.410
, pp. 974-979
-
-
McCune, J.M.1
-
112
-
-
0035912249
-
HIV chemotherapy
-
Richman, D. D. HIV chemotherapy. Nature 410, 995-1001 (2001).
-
(2001)
Nature
, vol.410
, pp. 995-1001
-
-
Richman, D.D.1
-
113
-
-
0037043694
-
HIV: A tough viral nut to crack
-
Pomerantz, R. J. HIV: a tough viral nut to crack. Nature 418, 594-595 (2002).
-
(2002)
Nature
, vol.418
, pp. 594-595
-
-
Pomerantz, R.J.1
-
114
-
-
0029764099
-
A conditionally replicating HIV-1 vector interferes with wild-type HIV-1 replication and spread
-
Dropulic, B., Hermankova, M. & Pitha, P. M. A conditionally replicating HIV-1 vector interferes with wild-type HIV-1 replication and spread. Proc. Natl Acad. Sci. USA 93, 11103-11108 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 11103-11108
-
-
Dropulic, B.1
Hermankova, M.2
Pitha, P.M.3
-
115
-
-
0141570489
-
Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection
-
Weinberger, L. S., Schaffer, D. V. & Arkin, A. P. Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection. J. Virol. 77, 10028-10036 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 10028-10036
-
-
Weinberger, L.S.1
Schaffer, D.V.2
Arkin, A.P.3
-
116
-
-
0036165770
-
Gene therapy of HIV-1 infection using lentiviral vectors expressing anti-HIV-1 genes
-
Mautino, M. R. & Morgan, R. A. Gene therapy of HIV-1 infection using lentiviral vectors expressing anti-HIV-1 genes. AIDS Patient Care STDS 16, 11-26 (2002).
-
(2002)
AIDS Patient Care STDS
, vol.16
, pp. 11-26
-
-
Mautino, M.R.1
Morgan, R.A.2
-
119
-
-
0024715909
-
State-space solutions to standard H2 and H1 control problems
-
Doyle, J., Glover, K., Khargonekar, P. & Francis, B. State-space solutions to standard H2 and H1 control problems. IEEE Trans. Automat. Control 34, 831-847 (1989).
-
(1989)
IEEE Trans. Automat. Control
, vol.34
, pp. 831-847
-
-
Doyle, J.1
Glover, K.2
Khargonekar, P.3
Francis, B.4
-
120
-
-
0642281331
-
Quantifying robustness of biochemical network models
-
Ma, L. & Iglesias, P. A. Quantifying robustness of biochemical network models. BMC Bioinformatics 3, 38 (2002).
-
(2002)
BMC Bioinformatics
, vol.3
, pp. 38
-
-
Ma, L.1
Iglesias, P.A.2
-
122
-
-
0142215247
-
-
IEEE, Denver, Colorado
-
Prajna, S. & Papachristodoulou, A. in Proceedings of American Control Conference 2779-2784 (IEEE, Denver, Colorado, 2003).
-
(2003)
Proceedings of American Control Conference
, pp. 2779-2784
-
-
Prajna, S.1
Papachristodoulou, A.2
-
123
-
-
0036990890
-
-
IEEE, Las Vegas
-
Prajna, S., Papachristodoulou, A. & Parrilo, P. A. in Proceedings of IEEE Conference on Decision and Control 741-746 (IEEE, Las Vegas, 2002).
-
(2002)
Proceedings of IEEE Conference on Decision and Control
, pp. 741-746
-
-
Prajna, S.1
Papachristodoulou, A.2
Parrilo, P.A.3
-
124
-
-
3343020085
-
Integrative analysis of cell cycle control in budding yeast
-
Chen, K. C. et al. Integrative analysis of cell cycle control in budding yeast. Mol. Biol. Cell 16, 3841-3862 (2004).
-
(2004)
Mol. Biol. Cell
, vol.16
, pp. 3841-3862
-
-
Chen, K.C.1
-
125
-
-
7644231616
-
-
Univ. Illinois, Urbana-Champaign
-
Martins, N. C. & Dahleh, M. A. in Forty-Second Annual Allerton Conference on Communication, Control, and Computing (Univ. Illinois, Urbana-Champaign, 2004).
-
(2004)
Forty-Second Annual Allerton Conference on Communication, Control, and Computing
-
-
Martins, N.C.1
Dahleh, M.A.2
-
126
-
-
7644231615
-
-
IEEE, Nassau, The Bahamas, in the press
-
Martins, N. C., Dahleh, M. A. & Elia, N. in IEEE Conference on Decision and Control (IEEE, Nassau, The Bahamas, in the press).
-
IEEE Conference on Decision and Control
-
-
Martins, N.C.1
Dahleh, M.A.2
Elia, N.3
-
128
-
-
0014695874
-
Symmetry breaking instabilities in biological systems
-
Prigogine, I., Lefever, R., Goldbeter, A. & Herschkowitz-Kaufman, M. Symmetry breaking instabilities in biological systems. Nature 223, 913-916 (1969).
-
(1969)
Nature
, vol.223
, pp. 913-916
-
-
Prigogine, I.1
Lefever, R.2
Goldbeter, A.3
Herschkowitz-Kaufman, M.4
-
129
-
-
0016136849
-
Nonequilibdum problems in biological phenomena
-
Prigogine, I., Nicolis, G. & Babloyantz, A. Nonequilibdum problems in biological phenomena. Ann. NY Acad. Sci. 231, 99-105 (1974).
-
(1974)
Ann. NY Acad. Sci.
, vol.231
, pp. 99-105
-
-
Prigogine, I.1
Nicolis, G.2
Babloyantz, A.3
-
131
-
-
0742288604
-
Potential in stochastic differential equations: Novel construction
-
Ao, P. Potential in stochastic differential equations: novel construction. J. Phys. A 37, L25-L30 (2004).
-
(2004)
J. Phys. A
, vol.37
-
-
Ao, P.1
|