Recycling side-effects into clinical markers for drug repositioning

Genome Medicine

Volumn 4, Issue 1, 2012, Pages

  Duran Frigola, Miquel ^a   Aloy, Patrick ^a,b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Drug repositioning; Mechanism of action; Polypharmacology; Side effects

Indexed keywords

ADVERSE DRUG REACTION; CLINICAL DECISION MAKING; DRUG EFFECT; DRUG EFFICACY; DRUG INFORMATION; DRUG MARKETING; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG REPOSITIONING; DRUG SAFETY; DRUG TARGETING; GENE EXPRESSION; GENOME ANALYSIS; HUMAN; NONHUMAN; NOTE; PHENOTYPE; POLYPHARMACY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 84856055845     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm302     Document Type: Note

References (10)

1. Giles FJ, O'Dwyer M, Swords R. Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia 2009, 23:1698-1707. 10.1038/leu.2009.111, 19474800.
2. Pujol A, Mosca R, Farres J, Aloy P. Unveiling the role of network and systems biology in drug discovery. Trends Pharmacol Sci 2010, 31:115-123. 10.1016/j.tips.2009.11.006, 20117850.
3. Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008, 4:682-690. 10.1038/nchembio.118, 18936753.
4. Swinney DC, Anthony J. How were new medicines discovered?. Nat Rev Drug Discov 2011, 10:507-519. 10.1038/nrd3480, 21701501.
5. Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006, 313:1929-1935. 10.1126/science.1132939, 17008526.
6. Pammolli F, Magazzini L, Riccaboni M. The productivity crisis in pharmaceutical R&D. Nat Rev Drug Discov 2011, 10:428-438. 10.1038/nrd3405, 21629293.
7. Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. Drug target identification using side-effect similarity. Science 2008, 321:263-266. 10.1126/science.1158140, 18621671.
8. Kuhn M, Campillos M, Letunic I, Jensen LJ, Bork P. A side effect resource to capture phenotypic effects of drugs. Mol Syst Biol 2010, 6:343. 2824526, 20087340.
9. Gottlieb A, Stein GY, Ruppin E, Sharan R. PREDICT: a method for inferring novel drug indications with application to personalized medicine. Mol Syst Biol 2011, 7:496. 3159979, 21654673.
10. Yang L, Agarwal P. Systematic drug repositioning based on clinical side-effects. PLoS ONE 2011, 6:e28025. 10.1371/journal.pone.0028025, 3244383, 22205936.