MAPK/NF-κB-dependent upregulation of kinin receptors mediates airway hyperreactivity: A new perspective for the treatment

Pharmacological Research

Volumn 71, Issue , 2013, Pages 9-18

  Zhang, Yaping ^a,b   Cardell, Lars Olaf ^b   Edvinsson, Lars ^c   Xu, Cang Bao ^a,c  

^a XI'AN MEDICAL UNIVERSITY   (China)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Airway hyperreactivity; Kinin receptor; MAPK; NF B

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BRADYKININ; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR AGONIST; BRADYKININ B2 RECEPTOR ANTAGONIST; CORTICOSTEROID; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEXAMETHASONE; I KAPPA B KINASE; ICATIBANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INFLIXIMAB; INTERLEUKIN 1BETA; INTERLEUKIN 4; KALLIKREIN; MEN 16132; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEDOCROMIL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; R 954; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ASTHMA; BREATHING DISORDER; BRONCHOSPASM; CYTOKINE PRODUCTION; DRUG MECHANISM; DYSPNEA; ENVIRONMENTAL FACTOR; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; IMMUNOMODULATION; KALLIKREIN KININ SYSTEM; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RESPIRATORY TRACT ALLERGY; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; WHEEZING;

ANIMALS; ASTHMA; HUMANS; INFLAMMATION MEDIATORS; KININS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR TARGETED THERAPY; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, BRADYKININ B1; RECEPTOR, BRADYKININ B2; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84876151202     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.02.004     Document Type: Review

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