Bradykinin B1 receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-β and VEGF in a murine model of asthma

Neuropeptides

Volumn 44, Issue 2, 2010, Pages 107-113

  Vasquez Pinto, Luciana M C ^a   Nantel, François ^b   Sirois, Pierre ^b   Jancar, Sonia ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Asthma; Bradykinin; Eosinophils; TGF ; VEGF

Indexed keywords

BRADYKININ B1 RECEPTOR ANTAGONIST; R 954; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BONE MARROW; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DRUG ACTIVITY; EOSINOPHIL; EOSINOPHIL COUNT; IMMUNOHISTOCHEMISTRY; LIPID ANALYSIS; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; IMMUNOHISTOCHEMISTRY; LUNG; MICE; RECEPTOR, BRADYKININ B1; RECEPTOR, BRADYKININ B2; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MURINAE; MUS;

EID: 77049085922     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2009.11.001     Document Type: Article

References (29)

1. Bartram U., and Speer C.P. The role of transforming growth factor beta in lung development and disease. Chest 125 (2004) 754-765
2. Bertram C.M., Misso N.L., Fogel-Petrovic M., Figueroa C.D., Foster P.S., Thompson P.J., and Bhoola K.D. Expression of Kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. J. Leukoc. Biol. 85 (2009) 544-552
3. Bozza P.T., Melo R.C., and Bandeira-Melo C. Leukocyte lipid bodies regulation and function: contribution to allergy and host defence. Pharmacol. Ther. 113 (2007) 30-49
4. Chavakis E., and Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 887-893
5. Chiappara G., Gagliardo R., Siena A., Bonsignore M.R., Bousquet J., Bonsignore G., and Vignola A.M. Airway remodelling in the pathogenesis of asthma. Curr. Opin. Allergy Clin. Immunol. 1 (2001) 85-93
6. Coker R.K., Laurent G.J., Shahzeidi S., Hernadez-Rodriguez N.A., Pantelidis P., du Bois R.M., Jeffery P.K., and McAnulty R.J. Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lung. Eur. Respir. J. 9 (1996) 2501-2507
7. Farmer S.G., Wilkins D.E., Meeker S.A., Seeds E.A., and Page C.P. Effects of bradykinin receptor antagonists on antigen-induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea-pigs. Br. J. Pharmacol. 107 (1992) 653-659
8. Fattouh R., and Jordana M. TGF-beta, eosinopils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerations. Inflamm. Allergy Drug. Targets 7 (2008) 224-236
9. Ferrara N., Gerber H.P., and Le Couter J. The biology of VEGF and its receptors. Nat. Med. 9 (2003) 669-676
10. 1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy. Biol. Chem. 387 (2006) 127-143
11. Heijink, I.H., Postma, D.S., Noordhoek, J.A., Broekema, M., Kapus, A., 2009. House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. Am. J. Respir. Cell Mol. Biol. (epub ahead of print).
12. Horiuchi T., and Weller P.F. Expression of VEGF by human eosinophils: upregulation by granulocyte/macrophage colony stimulating factor and interleukin-5. Am. J. Respir. Cell Mol. Biol. 17 (1997) 70-77
13. Hoshino M., Takahashi M., and Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J. Allergy Clin. Immunol. 107 (2001) 295-301
14. Kay A.B., Phipps S., and Robinson D.S. A role for eosinophils in airway remodeling in asthma. Trends Immunol. 25 (2004) 477-482
15. Khalil N., Bereznay O., Sporn M., and Greenberg A.H. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 170 (1989) 727-737
16. Kingston P.A., Sinha S., David A., Castro M.G., Lowestein P.R., and Heagerty A.M. Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition. Circulation 104 (2001) 2595-2601
17. Landgraf R.G., Steil A.A., Sirois P., and Jancar S. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Inflamm. Res. 53 (2003) 78-83
18. Landgraf R.G., Sirois P., and Jancar S. Differential modulation of murine lung inflammation by bradykinin B1 and B2 selective receptor antagonists. Eur. J. Pharmacol. 460 (2004) 75-83
19. Lee C.G., Link H., Baluk P., Homer R.J., Chapoval S., Bhandari V., Kang M.J., Cohn L., Kim Y.K., McDonald D.M., and Elias J.A. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat. Med. 10 (2004) 1095-1103
20. Letterio J.J., and Roberts A.B. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 16 (1998) 137-161
21. Marceau F., and Regoli D. Bradykinin receptor ligands: therapeutic perspectives. Nat. Rev. Drug. Discov. 3 (2004) 845-852
22. Mauviel A. Transforming growth factor beta: a key mediator of fibrosis. Meth. Mol. Med. 117 (2005) 69-80
23. Pasquale C.P., Martins M.A., Bozza P.T., Silva P.M., Faria-Neto H.C., Pires A.L., and Cordeiro R.S. Bradykinin induces eosinophil accumulation in the rat pleural cavity. Int. Arch. Allergy Appl. Immunol. 95 (1991) 244-247
24. Perron M.S., Gobeil Jr. F., Pelletier S., Regoli D., and Sirois P. Involvement of bradykinin B1 and B2 receptors in pulmonary leukocyte accumulation induced by Sephadex beads in guinea pigs. Eur. J. Pharmacol. 376 (1999) 83-89
25. Robinson D.S., North J., Zeibecoglou K., Ying S., Meng Q., Rankin S., Hamid Q., Tavernier J., and Kay A.B. Eosinophil development and bone marrow and tissue eosinophils in atopic asthma. Int. Arch. Allergy Immunol. 118 (1999) 89-100
26. Salib, R.J., Howarth, P.H., 2009. Transforming growth factor-beta in allergic inflammatory disease of the upper airways: friend or foe? Clin. Exp. Allergy (epub ahead of print).
27. Smith N., and Broadley K.J. Optimisation of the sensitisation conditions for an ovalbumin challenge model of asthma. Int. Immunopharmacol. 7 (2007) 183-190
28. Thomas, B.J., Lindsay, M., Dagher, H., Freezer, N.J., Ghildyal, R., Bardin, P.G., 2009. Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses. Am. J. Respir. Cell Mol. Biol. (epub ahead of print).
29. Woisin F.E., Matsumoto T., Douglas G.L., Paul W., Walley E.T., and Page C.P. Effect of antagonists for NK2 and B2 receptors on antigen induced airway responses in allergic rabbits. Pulmon. Pharmacol. Ther. 13 (2000) 13-23