Airways hyper-responsiveness to bradykinin and methacholine: Effects of inhaled fluticasone

Clinical and Experimental Allergy

Volumn 32, Issue 8, 2002, Pages 1174-1179

  Reynolds, C J ^a   Togias, A ^a   Proud, D ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Asthma; Bradykinin; Corticosteroids; Hyper responsiveness; Methacholine

Indexed keywords

BRADYKININ; FLUTICASONE; METHACHOLINE;

ADULT; AIRWAY; ALLERGIC ASTHMA; ARTICLE; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT FAILURE;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANDROSTADIENES; ASTHMA; BRADYKININ; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; DEPRESSION, CHEMICAL; DOUBLE-BLIND METHOD; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; LUNG; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED; VASODILATOR AGENTS;

EID: 0036037327     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2745.2002.01443.x     Document Type: Article

References (47)

1. Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics: Cellular, mediator, and permeability changes
2. Elevation of tissue kallikrein and kinin in the airways of asthmatic subjects after endobronchial allergen challenge
3. Detection of tissue kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects
4. The effects of bradykinin aerosol in guinea pigs and man
5. Bradykinin-induced bronchoconstriction in humans. Mode of actions
6. Kinin formation: Mechanisms and role in inflammatory disorders
7. Bradykinin and asthma
8. Efficacy and tolerability of icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma
9. In vivo and in vitro effects of bradykinin on bronchial motor tone in normal subjects and patients with airway obstruction
10. Contractile effects of bradykinin on the isolated human small bronchus
11. 2 and thromboxane prostanoid receptors
12. Airway responsiveness to bradykinin is related to eosinophilic inflammation in asthma
13. Sputum eosinophilia is more closely associated with airway responsiveness to bradykinin than methacholine in asthma
14. Allergen-induced hyper-responsiveness to bradykinin is more pronounced than that to methacholine
15. Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by neural reflexes
16. Perennial rhinitis subjects have altered vascular, glandular, and neural responses to bradykinin nasal provocation
17. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma
18. Placebo-controlled immunopathologic study of 4 months of inhaled corticosteroids in asthma
19. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: A placebo-controlled study
20. The effects of regular inhaled formoterol, budesonide and placebo on mucosal inflammation and clinical indices in mild asthma
21. Effect of budesonide on bronchial hyperresponsiveness and pulmonary function in patients with mild to moderate asthma
22. Objective indicators of severity of asthma
23. Aerosol beclomethasone diproprionate spray compared with theophylline as primary treatment for chronic mild-to-moderate asthma
24. Bronchial biopsies in asthma: An ultrastructural, quantitative study and correlation with hyper-reactivity
25. Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry
26. Characteristics of the inflammation in biopsies from large airways of subjects with asthma and subjects with chronic airflow limitation
27. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma
28. Respiratory function tests. Normal values at median altitudes and the prediction of normal results
29. Efficacy of inhaled corticosteroids in asthma
30. Development of fluticasone propionate and comparison with other inhaled corticosteroids
31. Effect of high dose inhaled fluticasone propionate on airway inflammation in asthma
32. Differential inhibitory effect of regular inhaled corticosteroid on airway responsiveness to adenosine 5′ monophosphate, methacholine, and bradykinin in symptomatic children with recurrent wheeze
33. Action of budesonide on asthmatic bronchial hyperresponsiveness. Effects on directly and indirectly acting bronchoconstrictors
34. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: Relationship to bronchial reactivity
35. Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
36. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma: Relationship to symptoms and bronchial responsiveness
37. Bronchial hyperresponsiveness in asthmatic children: Correlation with macrophages and eosinophils in broncolavage fluid
38. Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage: The effects of antiasthmatic treatment with budesonide of terbutaline
39. Allergen-induced increase in non-allergic bronchial reactivity
40. Asthma and increases in nonallergic bronchial responsiveness from seasonal pollen exposure
41. The contribution of histamine to immediate bronchoconstriction provoked by inhaled allergen and adenosine 5′ monophosphate in atopic asthma
42. Induction of histamine release from human skin mast cells by bradykinin analogs
43. Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthma
44. 20 methacholine
45. 20 of methacholine
46. Adenosine provocation: A new test for allergic type airway inflammation