A novel dithiol amide CB3 attenuates allergic airway disease through negative regulation of p38 mitogen-activated protein kinase

American Journal of Respiratory and Critical Care Medicine

Volumn 183, Issue 8, 2011, Pages 1015-1024

  Kim, So Ri ^a   Lee, Kyung Sun ^a   Park, Seoung Ju ^a   Min, Kyung Hoon ^a   Lee, Min Hee ^a   Lee, Kyung Ae ^a   Bartov, Orit ^b   Atlas, Daphne ^b   Lee, Yong Chul ^a  

^a Jeonbuk National University Medical School and Hospital   (South Korea)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Asthma; Glutathione; N acetyl cysteine proline cysteine amide; Nuclear factor b; Oxidative stress; P38 mitogen activated protein kinase

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; ANTIINFLAMMATORY AGENT; BAY 117085; CB 3; GLUTATHIONE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; N ACETYLCYSTEINE PROLINE CYSTEINE AMIDE; OVALBUMIN; PROTEIN SERINE THREONINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; HYDROPHOBICITY; IC 50; INFLAMMATORY CELL; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TH2 CELL; UPREGULATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; FEMALE; GLUTATHIONE; GLUTATHIONE DISULFIDE; IMIDAZOLES; LUNG; MICE; MICE, INBRED C57BL; NITRILES; OLIGOPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIMIDINES; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; SULFONES;

EID: 79954608968     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200906-0902OC     Document Type: Article

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