IκB kinase β inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma

Clinical and Experimental Allergy

Volumn 41, Issue 1, 2011, Pages 104-115

  Ogawa, H ^a,b   Azuma, M ^a   Muto, S ^c   Nishioka, Y ^a   Honjo, A ^a   Tezuka, T ^a   Uehara, H ^b   Izumi, K ^b   Itai, A ^c   Sone, S ^a  

^a Department of Respiratory Medicine and Rheumatology ^*  (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c Institute of Medicinal Molecular Design Inc   (Japan)

Author keywords

Airway inflammation; Airway remodelling; IKK inhibitor; IMD 0354; NF B; TGF

Indexed keywords

ANTIASTHMATIC AGENT; GAMMA INTERFERON; HOUSE DUST ALLERGEN; I KAPPA B KINASE INHIBITOR; IMD 0354; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 1BETA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AIRWAY REMODELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BODY MASS; CELL HYPERPLASIA; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; EOSINOPHIL; FEMALE; FIBROSIS; GOBLET CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LUNG HOMOGENATE; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; MUSCLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; WESTERN BLOTTING;

AIRWAY REMODELING; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; BENZAMIDES; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; I-KAPPA B KINASE; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE;

EID: 78649986082     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2010.03564.x     Document Type: Article

References (42)

1. Tagaya E, Tamaoki J Mechanisms of airway remodeling in asthma. Allergol Int 2007; 56:331-40.
2. Munakata M Airway remodeling and airway smooth muscle in asthma. Allergol Int 2006; 55:235-43.
3. Sumi Y, Hamid Q Airway remodeling in asthma. Allergol Int 2007; 56:341-8.
4. Henderson WR Jr., Chiang GK, Tien YT, Chi EY Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. Am J Respir Crit Care Med 2006; 173:718-28.
5. Muz MH, Deveci F, Bulut Y, Ilhan N, Yekeler H, Turgut T The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model. Exp Mol Med 2006; 38:109-18.
6. Conron M, Andreakos E, Pantelidis P et al. Nuclear factor-kappaB activation in alveolar macrophages requires IkappaB kinase-beta, but not nuclear factor-kappaB inducing kinase. Am J Respir Crit Care Med 2002; 165:996-1004.
7. Hu Y, Baud V, Delhase M et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999; 284:316-20.
8. Sugita A, Ogawa H, Azuma M et al. Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation. Int Arch Allergy Immunol 2009; 148:186-198.
9. Inayama M, Nishioka Y, Azuma M et al. A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 2006; 173:1016-22.
10. Onai Y, Suzuki J, Kakuta T et al. Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc Res 2004; 63:51-9.
11. Kamon J, Yamauchi T, Muto S et al. A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. Biochem Biophys Res Commun 2004; 323:242-8.
12. Broide DH, Lawrence T, Doherty T et al. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci USA 2005; 102:17723-8.
13. Wakugawa M, Hayashi K, Nakamura K, Tamaki K Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: association between IL-13 and mite-specific IgE levels. J Dermatol Sci 2001; 25:116-26.
14. Nishioka Y, Yano S, Fujiki F et al. Combined therapy of multidrug-resistant human lung cancer with anti-P-glycoprotein antibody and monocyte chemoattractant protein-1 gene transduction: the possibility of immunological overcoming of multidrug resistance. Int J Cancer 1997; 71:170-7.
15. Renard P, Ernest I, Houbion A et al. Development of a sensitive multi-well colorimetric assay for active NFkappaB. Nucleic Acids Res 2001; 29:1-5.
16. Aono Y, Nishioka Y, Inayama M et al. Imatinib as a novel anti-fibrotic agent in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 2005; 171:1279-85.
17. Shirota H, Sano K, Kikuchi T, Tamura G, Shirato K Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator. J Immunol 2000; 164:5575-82.
18. Nagarajan RP, Chen F, Li W et al. Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB. Biochem J 2000; 348 (Part 3):591-6.
19. Tanaka A, Muto S, Jung K, Itai A, Matsuda H Topical application with a new NF-kappaB inhibitor improves atopic dermatitis in NC/NgaTnd mice. J Invest Dermatol 2007; 127:855-63.
20. Birrell MA, Hardaker E, Wong S et al. Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am J Respir Crit Care Med 2005; 172:962-71.
21. Ziegelbauer K, Gantner F, Lukacs NW et al. A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity. Br J Pharmacol 2005; 145:178-92.
22. Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med 1998; 188:1739-50.
23. Bosse Y, Thompson C, Stankova J, Rola-Pleszczynski M Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation. Am J Respir Cell Mol Biol 2006; 34:746-53.
24. Chen G, Khalil N TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases. Respir Res 2006; 7:1-10.
25. Wynn TA Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007; 117:524-9.
26. Minshall EM, Leung DY, Martin RJ et al. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1997; 17:326-33.
27. Vignola AM, Chanez P, Chiappara G et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997; 156:591-9.
28. Lee KY, Ito K, Hayashi R, Jazrawi EP, Barnes PJ, Adcock IM NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol 2006; 176:603-15.
29. Wen FQ, Liu X, Kobayashi T et al. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting SMADS. Am J Respir Cell Mol Biol 2004; 30:816-22.
30. Cho SH, Ryu CH, Oh CK Plasminogen activator inhibitor-1 in the pathogenesis of asthma. Exp Biol Med (Maywood) 2004; 229:138-46.
31. Atkinson JJ, Senior RM Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol 2003; 28:12-24.
32. Lepisto J, Peltonen J, Vaha-Kreula M, Niinikoski J, Laato M Platelet-derived growth factor isoforms PDGF-AA, -AB and -BB exert specific effects on collagen gene expression and mitotic activity of cultured human wound fibroblasts. Biochem Biophys Res Commun 1995; 209:393-9.
33. Carlin SM, Roth M, Black JL Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2003; 284:L1020-L1026.
34. Cho SH, Tam SW, Demissie-Sanders S, Filler SA, Oh CK Production of plasminogen activator inhibitor-1 by human mast cells and its possible role in asthma. J Immunol 2000; 165:3154-61.
35. Mautino G, Henriquet C, Jaffuel D, Bousquet J, Capony F Tissue inhibitor of metalloproteinase-1 levels in bronchoalveolar lavage fluid from asthmatic subjects. Am J Respir Crit Care Med 1999; 160:324-30.
36. Vignola AM, Riccobono L, Mirabella A et al. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 1998; 158:1945-50.
37. Dien J, Amin HM, Chiu N et al. Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer. Am J Pathol 2006; 169:633-42.
38. Desmet C, Gosset P, Pajak B et al. Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma. J Immunol 2004; 173:5766-75.
39. Poynter ME, Cloots R, Van Woerkom T et al. NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness. J Immunol 2004; 173:7003-9.
40. Eickhoff JE, Cotten M NF-kappaB activation can mediate inhibition of human cytomegalovirus replication. J Gen Virol 2005; 86:285-95.
41. Sadikot RT, Zeng H, Joo M et al. Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J Immunol 2006; 176:4923-30.
42. Kweon SM, Wang B, Rixter D et al. Synergistic activation of NF-kappaB by nontypeable H influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK. Biochem Biophys Res Commun 2006; 351:368-75.