-
1
-
-
74749084658
-
A new look at the pathogenesis of asthma
-
Holgate ST, Arshad HS, Roberts GC, Howarth PH, Thurner P, Davies DE. A new look at the pathogenesis of asthma. Clin Sci (Lond) 2010; 118(7): 439-50.
-
(2010)
Clin Sci (Lond)
, vol.118
, Issue.7
, pp. 439-450
-
-
Holgate, S.T.1
Arshad, H.S.2
Roberts, G.C.3
Howarth, P.H.4
Thurner, P.5
Davies, D.E.6
-
2
-
-
76149124216
-
Mucus hypersecretion in asthma: Intracellular signalling pathways as targets for pharmacotherapy
-
Lai HY, Rogers DF. Mucus hypersecretion in asthma: intracellular signalling pathways as targets for pharmacotherapy. Curr Opin Allergy Clin Immunol 2010; 10(1): 67-76.
-
(2010)
Curr Opin Allergy Clin Immunol
, vol.10
, Issue.1
, pp. 67-76
-
-
Lai, H.Y.1
Rogers, D.F.2
-
3
-
-
73049112293
-
Identification of asthma phenotypes using cluster analysis in the severe asthma research program
-
Moore WC, Meyers DA, Wenzel SE, et al. Identification of Asthma Phenotypes using Cluster Analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2009.
-
(2009)
Am J Respir Crit Care Med
-
-
Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
-
4
-
-
35649028488
-
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
-
Woodruff PG, Boushey HA, Dolganov GM, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007; 104(40): 15858-63.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.40
, pp. 15858-15863
-
-
Woodruff, P.G.1
Boushey, H.A.2
Dolganov, G.M.3
-
5
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360(10): 973-84.
-
(2009)
N Engl J Med
, vol.360
, Issue.10
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
7
-
-
69249222635
-
Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: Present and future
-
Chung KF, Caramori G, Adcock IM. Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future. Eur J Clin Pharmacol 2009.
-
(2009)
Eur J Clin Pharmacol
-
-
Chung, K.F.1
Caramori, G.2
Adcock, I.M.3
-
8
-
-
52049113214
-
New targets for drug development in asthma
-
Adcock IM, Caramori G, Chung KF. New targets for drug development in asthma. Lancet 2008; 372(9643): 1073-87.
-
(2008)
Lancet
, vol.372
, Issue.9643
, pp. 1073-1087
-
-
Adcock, I.M.1
Caramori, G.2
Chung, K.F.3
-
9
-
-
49449089908
-
Molecular mechanisms of corticosteroid resistance
-
Adcock IM, Barnes PJ. Molecular mechanisms of corticosteroid resistance. Chest 2008; 134(2): 394-401.
-
(2008)
Chest
, vol.134
, Issue.2
, pp. 394-401
-
-
Adcock, I.M.1
Barnes, P.J.2
-
10
-
-
65849427529
-
Glucocorticoid resistance in inflammatory diseases
-
Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet 2009; 373(9678): 1905-17.
-
(2009)
Lancet
, vol.373
, Issue.9678
, pp. 1905-1917
-
-
Barnes, P.J.1
Adcock, I.M.2
-
11
-
-
77954033984
-
New therapies for asthma: Is there any progress?
-
Barnes PJ. New therapies for asthma: is there any progress? Trends Pharmacol Sci 2010; 31(7): 335-43.
-
(2010)
Trends Pharmacol Sci
, vol.31
, Issue.7
, pp. 335-343
-
-
Barnes, P.J.1
-
12
-
-
73249115366
-
Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
-
Beck IM, Vanden BW, Vermeulen L, Yamamoto KR, Haegeman G, De BK. Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev 2009; 30(7): 830-82.
-
(2009)
Endocr Rev
, vol.30
, Issue.7
, pp. 830-882
-
-
Beck, I.M.1
vanden, B.W.2
Vermeulen, L.3
Yamamoto, K.R.4
Haegeman, G.5
De, B.K.6
-
13
-
-
33644776504
-
Update on glucocorticoid action and resistance
-
Ito K, Chung KF, Adcock IM. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 2006; 117(3): 522-43.
-
(2006)
J Allergy Clin Immunol
, vol.117
, Issue.3
, pp. 522-543
-
-
Ito, K.1
Chung, K.F.2
Adcock, I.M.3
-
14
-
-
77952732147
-
Corticosteroid insensitivity in severe asthma: Significance, mechanisms and aetiology
-
Hew M, Chung KF. Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology. Intern Med J 2010; 40(5): 323-34.
-
(2010)
Intern Med J
, vol.40
, Issue.5
, pp. 323-334
-
-
Hew, M.1
Chung, K.F.2
-
15
-
-
33745625334
-
The physiology of human glucocorticoid receptor beta (hGRbeta] and glucocorticoid resistance
-
Lewis-Tuffin LJ, Cidlowski JA. The physiology of human glucocorticoid receptor beta (hGRbeta] and glucocorticoid resistance. Ann N Y Acad Sci 2006; 1069: 1-9.
-
(2006)
Ann N Y Acad Sci
, vol.1069
, pp. 1-9
-
-
Lewis-Tuffin, L.J.1
Cidlowski, J.A.2
-
16
-
-
26844433194
-
Antiinflammatory action of glucocorticoids--new mechanisms for old drugs
-
Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. N Engl J Med 2005; 353(16): 1711-23.
-
(2005)
N Engl J Med
, vol.353
, Issue.16
, pp. 1711-1723
-
-
Rhen, T.1
Cidlowski, J.A.2
-
17
-
-
70349881524
-
Human glucocorticoid receptor isoform beta: Recent understanding of its potential implications in physiology and pathophysiology
-
Kino T, Su YA, Chrousos GP. Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology. Cell Mol Life Sci 2009; 66(21): 3435-48.
-
(2009)
Cell Mol Life Sci
, vol.66
, Issue.21
, pp. 3435-3448
-
-
Kino, T.1
Su, Y.A.2
Chrousos, G.P.3
-
18
-
-
34547684065
-
HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
-
Boyault C, Sadoul K, Pabion M, Khochbin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 2007; 26(37): 5468-76.
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5468-5476
-
-
Boyault, C.1
Sadoul, K.2
Pabion, M.3
Khochbin, S.4
-
19
-
-
0034698087
-
The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor
-
Rajapandi T, Greene LE, Eisenberg E. The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor. J Biol Chem 2000; 275(29): 22597-604.
-
(2000)
J Biol Chem
, vol.275
, Issue.29
, pp. 22597-22604
-
-
Rajapandi, T.1
Greene, L.E.2
Eisenberg, E.3
-
20
-
-
34948900221
-
Steroid receptor phosphorylation: A key modulator of multiple receptor functions
-
Weigel NL, Moore NL. Steroid receptor phosphorylation: a key modulator of multiple receptor functions. Mol Endocrinol 2007; 21(10): 2311-9.
-
(2007)
Mol Endocrinol
, vol.21
, Issue.10
, pp. 2311-2319
-
-
Weigel, N.L.1
Moore, N.L.2
-
21
-
-
78649893594
-
Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
-
Bhavsar P, Khorasani N, Hew M, Johnson M, Chung KF. Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma. Eur Respir J 2009.
-
(2009)
Eur Respir J
-
-
Bhavsar, P.1
Khorasani, N.2
Hew, M.3
Johnson, M.4
Chung, K.F.5
-
22
-
-
77954935957
-
T cells from burninjured mice demonstrate a loss of sensitivity to glucocorticoids
-
D'Elia M, Patenaude J, Dupras C, Bernier J. T cells from burninjured mice demonstrate a loss of sensitivity to glucocorticoids. Am J Physiol Endocrinol Metab 2010; 299(2): E299-307.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
, Issue.2
-
-
D'Elia, M.1
Patenaude, J.2
Dupras, C.3
Bernier, J.4
-
23
-
-
59149087048
-
IFN-gamma reverses IL-2- and IL-4- mediated T-cell steroid resistance
-
Goleva E, Li LB, Leung DY. IFN-gamma reverses IL-2- and IL-4- mediated T-cell steroid resistance. Am J Respir Cell Mol Biol 2009; 40(2): 223-30.
-
(2009)
Am J Respir Cell Mol Biol
, vol.40
, Issue.2
, pp. 223-230
-
-
Goleva, E.1
Li, L.B.2
Leung, D.Y.3
-
24
-
-
59649102494
-
Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2- methylphenyl)-7-oxo-7,8-dihy dropyrido[2,3-d] pyrimidin-2- yl]amino}ethyl)guanidine (SB706504)
-
Kent LM, Smyth LJ, Plumb J, et al. Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2- methylphenyl)-7-oxo-7,8-dihy dropyrido[2,3-d] pyrimidin-2- yl]amino}ethyl)guanidine (SB706504). J Pharmacol Exp Ther 2009; 328(2): 458-68.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, Issue.2
, pp. 458-468
-
-
Kent, L.M.1
Smyth, L.J.2
Plumb, J.3
-
25
-
-
7944220552
-
Superantigeninduced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK] pathway
-
Li LB, Goleva E, Hall CF, Ou LS, Leung DY. Superantigeninduced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK] pathway. J Allergy Clin Immunol 2004; 114(5): 1059-69.
-
(2004)
J Allergy Clin Immunol
, vol.114
, Issue.5
, pp. 1059-1069
-
-
Li, L.B.1
Goleva, E.2
Hall, C.F.3
Ou, L.S.4
Leung, D.Y.5
-
26
-
-
1642326111
-
Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells
-
Tsitoura DC, Rothman PB. Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells. J Clin Invest 2004; 113(4): 619-27.
-
(2004)
J Clin Invest
, vol.113
, Issue.4
, pp. 619-627
-
-
Tsitoura, D.C.1
Rothman, P.B.2
-
27
-
-
69949173906
-
Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation
-
Zhang Y, Leung DY, Nordeen SK, Goleva E. Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation. J Biol Chem 2009; 284(36): 24542-52.
-
(2009)
J Biol Chem
, vol.284
, Issue.36
, pp. 24542-24552
-
-
Zhang, Y.1
Leung, D.Y.2
Nordeen, S.K.3
Goleva, E.4
-
28
-
-
0042834254
-
Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands
-
Paul-Clark MJ, Roviezzo F, Flower RJ, et al. Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol 2003; 171(6): 3245-52.
-
(2003)
J Immunol
, vol.171
, Issue.6
, pp. 3245-3252
-
-
Paul-Clark, M.J.1
Roviezzo, F.2
Flower, R.J.3
-
29
-
-
33750620057
-
Oxidative stress and redox regulation of lung inflammation in COPD
-
Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J 2006; 28(1): 219-42.
-
(2006)
Eur Respir J
, vol.28
, Issue.1
, pp. 219-242
-
-
Rahman, I.1
Adcock, I.M.2
-
30
-
-
2342567291
-
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients
-
Matthews JG, Ito K, Barnes PJ, Adcock IM. Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004; 113(6): 1100-8.
-
(2004)
J Allergy Clin Immunol
, vol.113
, Issue.6
, pp. 1100-1108
-
-
Matthews, J.G.1
Ito, K.2
Barnes, P.J.3
Adcock, I.M.4
-
31
-
-
0033538027
-
Redox-dependent regulation of nuclear import of the glucocorticoid receptor
-
Okamoto K, Tanaka H, Ogawa H, et al. Redox-dependent regulation of nuclear import of the glucocorticoid receptor. J Biol Chem 1999; 274(15): 10363-71.
-
(1999)
J Biol Chem
, vol.274
, Issue.15
, pp. 10363-10371
-
-
Okamoto, K.1
Tanaka, H.2
Ogawa, H.3
-
32
-
-
66349134442
-
Suppression of GATA-3 nuclear import and phosphorylation: A novel mechanism of corticosteroid action in allergic disease
-
Maneechotesuwan K, Yao X, Ito K, et al. Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med 2009; 6(5): e1000076.
-
(2009)
PLoS Med
, vol.6
, Issue.5
-
-
Maneechotesuwan, K.1
Yao, X.2
Ito, K.3
-
33
-
-
24944482440
-
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy
-
Usmani OS, Ito K, Maneechotesuwan K, et al. Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med 2005; 172(6): 704-12.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, Issue.6
, pp. 704-712
-
-
Usmani, O.S.1
Ito, K.2
Maneechotesuwan, K.3
-
34
-
-
0034889129
-
Cross-talk between pro-inflammatory transcription factors and glucocorticoids
-
Adcock IM, Caramori G. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol Cell Biol 2001; 79(4): 376-84.
-
(2001)
Immunol Cell Biol
, vol.79
, Issue.4
, pp. 376-384
-
-
Adcock, I.M.1
Caramori, G.2
-
35
-
-
34347324118
-
Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor
-
So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto KR. Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet 2007; 3(6): e94.
-
(2007)
PLoS Genet
, vol.3
, Issue.6
-
-
So, A.Y.1
Chaivorapol, C.2
Bolton, E.C.3
Li, H.4
Yamamoto, K.R.5
-
36
-
-
4644252538
-
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
-
Leung TH, Hoffmann A, Baltimore D. One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell 2004; 118(4): 453-64.
-
(2004)
Cell
, vol.118
, Issue.4
, pp. 453-464
-
-
Leung, T.H.1
Hoffmann, A.2
Baltimore, D.3
-
37
-
-
65249167505
-
DNA binding site sequence directs glucocorticoid receptor structure and activity
-
Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science 2009; 324(5925): 407-10.
-
(2009)
Science
, vol.324
, Issue.5925
, pp. 407-410
-
-
Meijsing, S.H.1
Pufall, M.A.2
So, A.Y.3
Bates, D.L.4
Chen, L.5
Yamamoto, K.R.6
-
38
-
-
44449126207
-
Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes
-
So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci USA 2008; 105(15): 5745-9.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.15
, pp. 5745-5749
-
-
So, A.Y.1
Cooper, S.B.2
Feldman, B.J.3
Manuchehri, M.4
Yamamoto, K.R.5
-
39
-
-
18244381020
-
The glucocorticoid receptor blocks PTEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression
-
Luecke HF, Yamamoto KR. The glucocorticoid receptor blocks PTEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev 2005; 19(9): 1116-27.
-
(2005)
Genes Dev
, vol.19
, Issue.9
, pp. 1116-1127
-
-
Luecke, H.F.1
Yamamoto, K.R.2
-
40
-
-
51249109929
-
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared to non-severe asthma
-
Bhavsar P, Hew M, Khorasani N, et al. Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared to non-severe asthma. Thorax 2008; 63(9): 784-90.
-
(2008)
Thorax
, vol.63
, Issue.9
, pp. 784-790
-
-
Bhavsar, P.1
Hew, M.2
Khorasani, N.3
-
41
-
-
77449099481
-
Glucocorticoid Regulation of Mouse and Human Dual Specificity Phosphatase 1 (DUSP1] Genes
-
Tchen CR, Martins JRS, Paktiawal N, Perelli R, Saklatvala J, Clark AR. Glucocorticoid Regulation of Mouse and Human Dual Specificity Phosphatase 1 (DUSP1] Genes. J Biol Chem 2010; 285(4): 2642-52.
-
(2010)
J Biol Chem
, vol.285
, Issue.4
, pp. 2642-2652
-
-
Tchen, C.R.1
Martins, J.R.S.2
Paktiawal, N.3
Perelli, R.4
Saklatvala, J.5
Clark, A.R.6
-
42
-
-
31044447205
-
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients
-
Xystrakis E, Kusumakar S, Boswell S, et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 2006; 116(1): 146-55.
-
(2006)
J Clin Invest
, vol.116
, Issue.1
, pp. 146-155
-
-
Xystrakis, E.1
Kusumakar, S.2
Boswell, S.3
-
43
-
-
33845768987
-
Integrating cell-signalling pathways with NF-kappaB and IKK function
-
Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007; 8(1): 49-62.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.1
, pp. 49-62
-
-
Perkins, N.D.1
-
44
-
-
31344446119
-
Histone deacetylase 2- mediated deacetylation of the glucocorticoid receptor enables NFkappaB suppression
-
Ito K, Yamamura S, Essilfie-Quaye S, et al. Histone deacetylase 2- mediated deacetylation of the glucocorticoid receptor enables NFkappaB suppression. J Exp Med 2006; 203(1): 7-13.
-
(2006)
J Exp Med
, vol.203
, Issue.1
, pp. 7-13
-
-
Ito, K.1
Yamamura, S.2
Essilfie-Quaye, S.3
-
45
-
-
42149156064
-
Steroid resistance in asthma: Mechanisms and treatment options
-
Adcock IM, Ford PA, Bhavsar P, Ahmad T, Chung KF. Steroid resistance in asthma: mechanisms and treatment options. Curr Allergy Asthma Rep 2008; 8(2): 171-8.
-
(2008)
Curr Allergy Asthma Rep
, vol.8
, Issue.2
, pp. 171-178
-
-
Adcock, I.M.1
Ford, P.A.2
Bhavsar, P.3
Ahmad, T.4
Chung, K.F.5
-
46
-
-
33646752928
-
Transcription factors in asthma: Are transcription factors a new target for asthma therapy?
-
Roth M, Black JL. Transcription factors in asthma: are transcription factors a new target for asthma therapy? Curr Drug Targets 2006; 7(5): 589-95.
-
(2006)
Curr Drug Targets
, vol.7
, Issue.5
, pp. 589-595
-
-
Roth, M.1
Black, J.L.2
-
47
-
-
33746674992
-
Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoidresistant asthmatic patients
-
Loke TK, Mallett KH, Ratoff J, et al. Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoidresistant asthmatic patients. J Allergy Clin Immunol 2006; 118(2): 368-75.
-
(2006)
J Allergy Clin Immunol
, vol.118
, Issue.2
, pp. 368-375
-
-
Loke, T.K.1
Mallett, K.H.2
Ratoff, J.3
-
48
-
-
38449118061
-
The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells
-
Tudhope SJ, Catley MC, Fenwick PS, et al. The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells. J Immunol 2007; 179(9): 6237-45.
-
(2007)
J Immunol
, vol.179
, Issue.9
, pp. 6237-6245
-
-
Tudhope, S.J.1
Catley, M.C.2
Fenwick, P.S.3
-
49
-
-
41449101856
-
Cytokines induce an early steroid resistance in airway smooth muscle cells: Novel role of interferon regulatory factor-1
-
Tliba O, Damera G, Banerjee A, et al. Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1. Am J Respir Cell Mol Biol 2008; 38(4): 463-72.
-
(2008)
Am J Respir Cell Mol Biol
, vol.38
, Issue.4
, pp. 463-472
-
-
Tliba, O.1
Damera, G.2
Banerjee, A.3
-
50
-
-
73949127444
-
Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
-
Bhandare R, Damera G, Banerjee A, et al. Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells. Am J Respir Cell Mol Biol 2010; 42(1): 9-15.
-
(2010)
Am J Respir Cell Mol Biol
, vol.42
, Issue.1
, pp. 9-15
-
-
Bhandare, R.1
Damera, G.2
Banerjee, A.3
-
51
-
-
58949097528
-
Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction
-
Ronacher K, Hadley K, Avenant C, et al. Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction. Molecular and Cellular Endocrinology 2009; 299(2): 219-31.
-
(2009)
Molecular and Cellular Endocrinology
, vol.299
, Issue.2
, pp. 219-231
-
-
Ronacher, K.1
Hadley, K.2
Avenant, C.3
-
52
-
-
71749089652
-
Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children
-
Su RC, Becker AB, Kozyrskyj AL, Hayglass KT. Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children. J Allergy Clin Immunol 2009; 124(5): 1116-8.
-
(2009)
J Allergy Clin Immunol
, vol.124
, Issue.5
, pp. 1116-1118
-
-
Su, R.C.1
Becker, A.B.2
Kozyrskyj, A.L.3
Hayglass, K.T.4
-
53
-
-
21044458874
-
Decreased histone deacetylase activity in chronic obstructive pulmonary disease
-
Ito K, Ito M, Elliott WM, et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 2005; 352(19): 1967-76.
-
(2005)
N Engl J Med
, vol.352
, Issue.19
, pp. 1967-1976
-
-
Ito, K.1
Ito, M.2
Elliott, W.M.3
-
54
-
-
65649112534
-
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2
-
Osoata GO, Yamamura S, Ito M, et al. Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun 2009; 384(3): 366-71.
-
(2009)
Biochem Biophys Res Commun
, vol.384
, Issue.3
, pp. 366-371
-
-
Osoata, G.O.1
Yamamura, S.2
Ito, M.3
-
55
-
-
52149108919
-
SNitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons
-
Nott A, Watson PM, Robinson JD, Crepaldi L, Riccio A. SNitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature 2008; 455(7211): 411-5.
-
(2008)
Nature
, vol.455
, Issue.7211
, pp. 411-415
-
-
Nott, A.1
Watson, P.M.2
Robinson, J.D.3
Crepaldi, L.4
Riccio, A.5
-
56
-
-
65249151877
-
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice
-
Marwick JA, Caramori G, Stevenson CS, et al. Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med 2009; 179(7): 542-8.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, Issue.7
, pp. 542-548
-
-
Marwick, J.A.1
Caramori, G.2
Stevenson, C.S.3
-
57
-
-
79954462423
-
Targeting Phosphoinositide-3-kinase- {delta} with Theophylline Reverses Corticosteroid Insensitivity COPD
-
To Y, Ito K, Kizawa Y, et al. Targeting Phosphoinositide-3-kinase- {delta} with Theophylline Reverses Corticosteroid Insensitivity COPD. Am J Respir Crit Care Med 2010.
-
(2010)
Am J Respir Crit Care Med
-
-
To, Y.1
Ito, K.2
Kizawa, Y.3
-
58
-
-
33847070442
-
The Role of Chromatin during Transcription
-
Li B, Carey M, Workman JL. The Role of Chromatin during Transcription. Cell 2007; 128(4): 707-19.
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 707-719
-
-
Li, B.1
Carey, M.2
Workman, J.L.3
-
59
-
-
46249112085
-
Combinatorial patterns of histone acetylations and methylations in the human genome
-
Wang Z, Zang C, Rosenfeld JA, et al. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet 2008; 40(7): 897-903.
-
(2008)
Nat Genet
, vol.40
, Issue.7
, pp. 897-903
-
-
Wang, Z.1
Zang, C.2
Rosenfeld, J.A.3
-
60
-
-
69449102464
-
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
-
Wang Z, Zang C, Cui K, et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 2009; 138(5): 1019-31.
-
(2009)
Cell
, vol.138
, Issue.5
, pp. 1019-1031
-
-
Wang, Z.1
Zang, C.2
Cui, K.3
-
61
-
-
33750488431
-
The genomic landscape of histone modifications in human T cells
-
Roh TY, Cuddapah S, Cui K, Zhao K. The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci USA 2006; 103(43): 15782-7.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.43
, pp. 15782-15787
-
-
Roh, T.Y.1
Cuddapah, S.2
Cui, K.3
Zhao, K.4
-
62
-
-
65549104157
-
Histone modifications at human enhancers reflect global cell-type-specific gene expression
-
Heintzman ND, Hon GC, Hawkins RD, et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 2009; 459(7243): 108-12.
-
(2009)
Nature
, vol.459
, Issue.7243
, pp. 108-112
-
-
Heintzman, N.D.1
Hon, G.C.2
Hawkins, R.D.3
-
64
-
-
40049086405
-
The role of histone deacetylases in asthma and allergic diseases
-
Bhavsar P, Ahmad T, Adcock IM. The role of histone deacetylases in asthma and allergic diseases. J Allergy Clin Immunol 2008; 121(3): 580-4.
-
(2008)
J Allergy Clin Immunol
, vol.121
, Issue.3
, pp. 580-584
-
-
Bhavsar, P.1
Ahmad, T.2
Adcock, I.M.3
-
65
-
-
33847258674
-
Discovery and development of SAHA as an anticancer agent
-
Marks PA. Discovery and development of SAHA as an anticancer agent. Oncogene 2007; 26(9): 1351-6.
-
(2007)
Oncogene
, vol.26
, Issue.9
, pp. 1351-1356
-
-
Marks, P.A.1
-
66
-
-
33751104763
-
Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease
-
Bilodeau S, Vallette-Kasic S, Gauthier Y, et al. Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. Genes Dev 2006; 20(20): 2871-86.
-
(2006)
Genes Dev
, vol.20
, Issue.20
, pp. 2871-2886
-
-
Bilodeau, S.1
Vallette-Kasic, S.2
Gauthier, Y.3
-
67
-
-
33745746529
-
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma
-
Hew M, Bhavsar P, Torrego A, et al. Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med 2006; 174(2): 134-41.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, Issue.2
, pp. 134-141
-
-
Hew, M.1
Bhavsar, P.2
Torrego, A.3
-
68
-
-
33644777427
-
Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma
-
Bergeron C, Fukakusa M, Olivenstein R, et al. Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma. J Allergy Clin Immunol 2006; 117(3): 703-5.
-
(2006)
J Allergy Clin Immunol
, vol.117
, Issue.3
, pp. 703-705
-
-
Bergeron, C.1
Fukakusa, M.2
Olivenstein, R.3
-
69
-
-
74849106935
-
Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease
-
Barnes PJ. Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009; 6(8): 693-6.
-
(2009)
Proc Am Thorac Soc
, vol.6
, Issue.8
, pp. 693-696
-
-
Barnes, P.J.1
-
70
-
-
67650073195
-
Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells
-
Bartling TR, Drumm ML. Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009; 297(1): L35-L43.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
, Issue.1
-
-
Bartling, T.R.1
Drumm, M.L.2
-
71
-
-
77958165660
-
Inhibition of Histone Deacetylase 2 Expression by Elevated Glucocorticoid Receptor Beta in Steroid Resistant Asthma
-
Li LB, Leung DY, Martin RJ, Goleva E. Inhibition of Histone Deacetylase 2 Expression by Elevated Glucocorticoid Receptor Beta in Steroid Resistant Asthma. Am J Respir Crit Care Med 2010.
-
(2010)
Am J Respir Crit Care Med
-
-
Li, L.B.1
Leung, D.Y.2
Martin, R.J.3
Goleva, E.4
-
72
-
-
77953310216
-
Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD
-
Ford PA, Durham AL, Russell RE, Gordon F, Adcock IM, Barnes PJ. Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest 2010; 137(6): 1338-44.
-
(2010)
Chest
, vol.137
, Issue.6
, pp. 1338-1344
-
-
Ford, P.A.1
Durham, A.L.2
Russell, R.E.3
Gordon, F.4
Adcock, I.M.5
Barnes, P.J.6
-
73
-
-
20744443470
-
Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment
-
Jee YK, Gilmour J, Kelly A, et al. Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment. J Biol Chem 2005; 280(24): 23243-50.
-
(2005)
J Biol Chem
, vol.280
, Issue.24
, pp. 23243-23250
-
-
Jee, Y.K.1
Gilmour, J.2
Kelly, A.3
-
74
-
-
67849116564
-
Bag-1M inhibits the transactivation of the glucocorticoid receptor via recruitment of corepressors
-
Hong W, Baniahmad A, Li J, Chang C, Gao W, Liu Y. Bag-1M inhibits the transactivation of the glucocorticoid receptor via recruitment of corepressors. FEBS Lett 2009; 583(15): 2451-6.
-
(2009)
FEBS Lett
, vol.583
, Issue.15
, pp. 2451-2456
-
-
Hong, W.1
Baniahmad, A.2
Li, J.3
Chang, C.4
Gao, W.5
Liu, Y.6
-
75
-
-
36348975290
-
SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription
-
Amat R, Solanes G, Giralt M, Villarroya F. SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription. J Biol Chem 2007; 282(47): 34066-76.
-
(2007)
J Biol Chem
, vol.282
, Issue.47
, pp. 34066-34076
-
-
Amat, R.1
Solanes, G.2
Giralt, M.3
Villarroya, F.4
-
76
-
-
40849126933
-
Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A] gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter
-
Islam KN, Mendelson CR. Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A] gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter. Mol Endocrinol 2008; 22(3): 585-96.
-
(2008)
Mol Endocrinol
, vol.22
, Issue.3
, pp. 585-596
-
-
Islam, K.N.1
Mendelson, C.R.2
-
77
-
-
34548838542
-
ATF2 impairs glucocorticoid receptor-mediated transactivation in human CD8+ T cells
-
Li LB, Leung DY, Strand MJ, Goleva E. ATF2 impairs glucocorticoid receptor-mediated transactivation in human CD8+ T cells. Blood 2007; 110(5): 1570-7.
-
(2007)
Blood
, vol.110
, Issue.5
, pp. 1570-1577
-
-
Li, L.B.1
Leung, D.Y.2
Strand, M.J.3
Goleva, E.4
-
78
-
-
33644875471
-
Intracellular glucocorticoid signaling: A formerly simple system turns stochastic
-
Chrousos GP, Kino T. Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci STKE 2005; 2005(304): e48.
-
(2005)
Sci STKE
, vol.2005
, Issue.304
-
-
Chrousos, G.P.1
Kino, T.2
-
79
-
-
27744479712
-
Modulating molecular chaperone Hsp90 functions through reversible acetylation
-
Aoyagi S, Archer TK. Modulating molecular chaperone Hsp90 functions through reversible acetylation. Trends Cell Biol 2005; 15(11): 565-7.
-
(2005)
Trends Cell Biol
, vol.15
, Issue.11
, pp. 565-567
-
-
Aoyagi, S.1
Archer, T.K.2
-
80
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs JJ, Murphy PJ, Gaillard S, et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 2005; 18(5): 601-7.
-
(2005)
Mol Cell
, vol.18
, Issue.5
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
-
81
-
-
16244366803
-
Class II histone deacetylases: From sequence to function, regulation, and clinical implication
-
Yang XJ, Gregoire S. Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol 2005; 25(8): 2873-84.
-
(2005)
Mol Cell Biol
, vol.25
, Issue.8
, pp. 2873-2884
-
-
Yang, X.J.1
Gregoire, S.2
-
82
-
-
33646232018
-
Basiliximab for the treatment of steroid-resistant ulcerative colitis: Further experience in moderate and severe disease
-
Creed TJ, Probert CS, Norman MN, et al. Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease. Aliment Pharmacol Ther 2006; 23(10): 1435-42.
-
(2006)
Aliment Pharmacol Ther
, vol.23
, Issue.10
, pp. 1435-1442
-
-
Creed, T.J.1
Probert, C.S.2
Norman, M.N.3
-
83
-
-
0026026319
-
Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
-
Hurley DM, Accili D, Stratakis CA, et al. Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest 1991; 87(2): 680-6.
-
(1991)
J Clin Invest
, vol.87
, Issue.2
, pp. 680-686
-
-
Hurley, D.M.1
Accili, D.2
Stratakis, C.A.3
-
85
-
-
43249102598
-
Generalized glucocorticoid resistance: Clinical aspects, molecular mechanisms, and implications of a rare genetic disorder
-
Charmandari E, Kino T, Ichijo T, Chrousos GP. Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder. J Clin Endocrinol Metab 2008; 93(5): 1563-72.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, Issue.5
, pp. 1563-1572
-
-
Charmandari, E.1
Kino, T.2
Ichijo, T.3
Chrousos, G.P.4
-
86
-
-
15144360854
-
A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo
-
Huizenga NA, Koper JW, de Lange P, et al. A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 1998; 83(1): 144-51.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, Issue.1
, pp. 144-151
-
-
Huizenga, N.A.1
Koper, J.W.2
de Lange, P.3
-
87
-
-
0035187441
-
Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: Importance of the ligand-binding domain for intracellular GR trafficking
-
Kino T, Stauber RH, Resau JH, Pavlakis GN, Chrousos GP. Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking. J Clin Endocrinol Metab 2001; 86(11): 5600-8.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, Issue.11
, pp. 5600-5608
-
-
Kino, T.1
Stauber, R.H.2
Resau, J.H.3
Pavlakis, G.N.4
Chrousos, G.P.5
-
88
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009; 360(10): 985-93.
-
(2009)
N Engl J Med
, vol.360
, Issue.10
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
-
89
-
-
35348909044
-
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
-
Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007; 370(9596): 1422-31.
-
(2007)
Lancet
, vol.370
, Issue.9596
, pp. 1422-1431
-
-
Wenzel, S.1
Wilbraham, D.2
Fuller, R.3
Getz, E.B.4
Longphre, M.5
-
90
-
-
62549084077
-
A randomized, doubleblind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
-
Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, doubleblind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 2009; 179(7): 549-58.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, Issue.7
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
-
91
-
-
50649101494
-
Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages
-
Goleva E, Hauk PJ, Hall CF, et al. Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages. J Allergy Clin Immunol 2008; 122(3): 550-9.
-
(2008)
J Allergy Clin Immunol
, vol.122
, Issue.3
, pp. 550-559
-
-
Goleva, E.1
Hauk, P.J.2
Hall, C.F.3
-
92
-
-
26144467138
-
Rhinovirus infection reduces glucocorticoid receptor nuclear translocation in airway epithelial cells
-
Bellattato C, Adcock IM, Ito K, et al. Rhinovirus infection reduces glucocorticoid receptor nuclear translocation in airway epithelial cells. Eur Respir J 2003; 22(Suppl): 565S.
-
(2003)
Eur Respir J
, vol.22
, Issue.SUPPL.
-
-
Bellattato, C.1
Adcock, I.M.2
Ito, K.3
-
94
-
-
66649127821
-
Immunologic aspects of chronic obstructive pulmonary disease
-
Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 2009; 360(23): 2445-54.
-
(2009)
N Engl J Med
, vol.360
, Issue.23
, pp. 2445-2454
-
-
Cosio, M.G.1
Saetta, M.2
Agusti, A.3
-
95
-
-
77953723966
-
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
-
Guiducci C, Gong M, Xu Z, et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature 2010; 465(7300): 937-41.
-
(2010)
Nature
, vol.465
, Issue.7300
, pp. 937-941
-
-
Guiducci, C.1
Gong, M.2
Xu, Z.3
|