메뉴 건너뛰기




Volumn 42, Issue 5, 2012, Pages 638-649

Lung damage and airway remodelling in severe asthma

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY REMODELING; ASTHMA; DISEASE ACTIVITY; DISEASE SEVERITY; GENETIC ASSOCIATION; HUMAN; LUNG INJURY; PATHOGENESIS; PERSONALIZED MEDICINE; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 84859983419     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03917.x     Document Type: Review
Times cited : (92)

References (141)
  • 1
    • 78049457548 scopus 로고    scopus 로고
    • Uniform definition of asthma severity, control, and exacerbation: document presented for the World Health Organisation Consultation on Severe Asthma
    • Bousquet J, Mantzouranis E, Cruz AA et al. Uniform definition of asthma severity, control, and exacerbation: document presented for the World Health Organisation Consultation on Severe Asthma. J Allergy Clin Immunol 2010; 126:926-38.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 926-938
    • Bousquet, J.1    Mantzouranis, E.2    Cruz, A.A.3
  • 2
    • 0034526865 scopus 로고    scopus 로고
    • Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions
    • American Thoracic Society.
    • American Thoracic Society. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000; 162:2341-51.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2341-2351
  • 3
    • 0033025989 scopus 로고    scopus 로고
    • Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society
    • Chung KF, Godard P, Adelroth E et al.Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. Eur Respir J 1999; 13:1198-208.
    • (1999) Eur Respir J , vol.13 , pp. 1198-1208
    • Chung, K.F.1    Godard, P.2    Adelroth, E.3
  • 4
    • 53049084809 scopus 로고    scopus 로고
    • A new perspective on concepts of asthma severity and control
    • Taylor DR, Bateman ED, Boulet LP et al.A new perspective on concepts of asthma severity and control. Eur Respir J 2008; 32:545-54.
    • (2008) Eur Respir J , vol.32 , pp. 545-554
    • Taylor, D.R.1    Bateman, E.D.2    Boulet, L.P.3
  • 5
    • 34249912039 scopus 로고    scopus 로고
    • Severe asthma in adults: what are the important questions?
    • Chanez P, Wenzel SE, Anderson GP et al. Severe asthma in adults: what are the important questions? J Allergy Clin Immunol 2007; 119:1337-48.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1337-1348
    • Chanez, P.1    Wenzel, S.E.2    Anderson, G.P.3
  • 6
    • 46149087663 scopus 로고    scopus 로고
    • Global Initiative for Asthma (GINA)
    • Global strategy for asthma management and prevention, 2008 update), Available at: (accessed 15 October)., 2006
    • Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention, 2006, (2008 update). Available at: (accessed 15 October 2011).
    • (2011)
  • 7
    • 74849096564 scopus 로고    scopus 로고
    • The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis
    • Holgate ST, Roberts G, Arshad HS, Howarth PH, Davies DE. The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proc Am Thorac Soc. 2009; 6:655-9.
    • (2009) Proc Am Thorac Soc. , vol.6 , pp. 655-659
    • Holgate, S.T.1    Roberts, G.2    Arshad, H.S.3    Howarth, P.H.4    Davies, D.E.5
  • 8
    • 0032558685 scopus 로고    scopus 로고
    • A 15-year follow-up study of ventilatory function in adults with asthma
    • Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339:1194-200.
    • (1998) N Engl J Med , vol.339 , pp. 1194-1200
    • Lange, P.1    Parner, J.2    Vestbo, J.3    Schnohr, P.4    Jensen, G.5
  • 9
    • 77950297480 scopus 로고    scopus 로고
    • Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: a 5-year follow-up
    • Contoli M, Baraldo S, Marku B et al. Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: a 5-year follow-up. J Allergy Clin Immunol 2010; 125:830-7.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 830-837
    • Contoli, M.1    Baraldo, S.2    Marku, B.3
  • 11
    • 73149096712 scopus 로고    scopus 로고
    • Qualitative analysis of high-resolution CT scans in severe asthma
    • Gupta S, Siddiqui S, Haldar P et al. Qualitative analysis of high-resolution CT scans in severe asthma. Chest 2009; 136:1521-8.
    • (2009) Chest , vol.136 , pp. 1521-1528
    • Gupta, S.1    Siddiqui, S.2    Haldar, P.3
  • 12
    • 0030042991 scopus 로고    scopus 로고
    • Computed tomography of the lungs in asthma: influence of disease severity and etiology
    • Paganin F, Seneterre E, Chanez P et al. Computed tomography of the lungs in asthma: influence of disease severity and etiology. Am J Respir Crit Care Med 1996; 153:110-4.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 110-114
    • Paganin, F.1    Seneterre, E.2    Chanez, P.3
  • 13
    • 33746242235 scopus 로고    scopus 로고
    • High-resolution computed tomography findings in elderly patients with asthma
    • Yilmaz S, Ekici A, Ekici M et al. High-resolution computed tomography findings in elderly patients with asthma. Eur J Radiol 2006; 59:238-43.
    • (2006) Eur J Radiol , vol.59 , pp. 238-243
    • Yilmaz, S.1    Ekici, A.2    Ekici, M.3
  • 14
    • 0027162170 scopus 로고
    • Uncomplicated asthma in adults: comparison of CT appearance of the lungs in asthmatic and healthy subjects
    • Lynch DA, Newell JD, Tschomper BA et al. Uncomplicated asthma in adults: comparison of CT appearance of the lungs in asthmatic and healthy subjects. Radiology 1993; 188:829-33.
    • (1993) Radiology , vol.188 , pp. 829-833
    • Lynch, D.A.1    Newell, J.D.2    Tschomper, B.A.3
  • 15
    • 3543146737 scopus 로고    scopus 로고
    • Parameters associated with persistent airflow obstruction in chronic severe asthma
    • Bumbacea D, Campbell D, Nguyen L et al. Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J 2004; 24:122-8.
    • (2004) Eur Respir J , vol.24 , pp. 122-128
    • Bumbacea, D.1    Campbell, D.2    Nguyen, L.3
  • 16
    • 4644357433 scopus 로고    scopus 로고
    • Bronchial dilatation in asthma: relation to clinical and sputum indices
    • Takemura M, Niimi A, Minakuchi M et al. Bronchial dilatation in asthma: relation to clinical and sputum indices. Chest 2004; 125:1352-8.
    • (2004) Chest , vol.125 , pp. 1352-1358
    • Takemura, M.1    Niimi, A.2    Minakuchi, M.3
  • 17
    • 77956796272 scopus 로고    scopus 로고
    • Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
    • Gupta S, Siddiqui S, Haldar P et al. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax 2010; 65:775-81.
    • (2010) Thorax , vol.65 , pp. 775-781
    • Gupta, S.1    Siddiqui, S.2    Haldar, P.3
  • 18
    • 57349134464 scopus 로고    scopus 로고
    • Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology
    • Aysola RS, Hoffman EA, Gierada D et al. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest 2008; 134:1183-91.
    • (2008) Chest , vol.134 , pp. 1183-1191
    • Aysola, R.S.1    Hoffman, E.A.2    Gierada, D.3
  • 19
    • 65549162207 scopus 로고    scopus 로고
    • Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis
    • Siddiqui S, Gupta S, Cruse G et al. Airway wall geometry in asthma and nonasthmatic eosinophilic bronchitis. Allergy 2009; 64:951-8.
    • (2009) Allergy , vol.64 , pp. 951-958
    • Siddiqui, S.1    Gupta, S.2    Cruse, G.3
  • 20
    • 34250380373 scopus 로고    scopus 로고
    • Single-scan acquisition of registered hyperpolarized (3)He ventilation and ADC images using a hybrid 2D gradient-echo sequence
    • Wild JM, Woodhouse N, Teh K. Single-scan acquisition of registered hyperpolarized (3)He ventilation and ADC images using a hybrid 2D gradient-echo sequence. Magn Reson Med 2007; 57:1185-9.
    • (2007) Magn Reson Med , vol.57 , pp. 1185-1189
    • Wild, J.M.1    Woodhouse, N.2    Teh, K.3
  • 21
    • 73249132982 scopus 로고    scopus 로고
    • Hyperpolarised 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial
    • van BE, Dahmen AM, Stavngaard T et al. Hyperpolarised 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial. Eur Respir J 2009; 34:1311-21.
    • (2009) Eur Respir J , vol.34 , pp. 1311-1321
    • van, B.E.1    Dahmen, A.M.2    Stavngaard, T.3
  • 22
    • 58249121587 scopus 로고    scopus 로고
    • A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis
    • Busacker A, Newell JD Jr, Keefe T et al. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest 2009; 135:48-56.
    • (2009) Chest , vol.135 , pp. 48-56
    • Busacker, A.1    Newell Jr, J.D.2    Keefe, T.3
  • 23
    • 54049156047 scopus 로고    scopus 로고
    • Respiratory impedance measurements for assessment of lung mechanics: focus on asthma
    • Prad AS, Lutchen KR. Respiratory impedance measurements for assessment of lung mechanics: focus on asthma. Respir Physiol Neurobiol 2008; 163:64-73.
    • (2008) Respir Physiol Neurobiol , vol.163 , pp. 64-73
    • Prad, A.S.1    Lutchen, K.R.2
  • 24
    • 0037975652 scopus 로고    scopus 로고
    • Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout
    • Gustafsson PM, Ljungberg HK, Kjellman B. Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout. Eur Respir J 2003; 21:1033-9.
    • (2003) Eur Respir J , vol.21 , pp. 1033-1039
    • Gustafsson, P.M.1    Ljungberg, H.K.2    Kjellman, B.3
  • 25
    • 66149136533 scopus 로고    scopus 로고
    • Probing airway conditions governing ventilation defects in asthma via hyperpolarised MRI inmage functional modeling
    • Campana L, Kenyon J, Zhalehdoust-Sani S et al. Probing airway conditions governing ventilation defects in asthma via hyperpolarised MRI inmage functional modeling. J Appl Physiol 2009; 106:1293-300.
    • (2009) J Appl Physiol , vol.106 , pp. 1293-1300
    • Campana, L.1    Kenyon, J.2    Zhalehdoust-Sani, S.3
  • 26
    • 84860014727 scopus 로고    scopus 로고
    • Localisation of the site of fixed airflow obstruction in moderate to severe asthma using hyperpolarised helium-3 magnetic resonance imaging
    • (abstract).
    • Gonem S, Ball I, Corkill S et al. Localisation of the site of fixed airflow obstruction in moderate to severe asthma using hyperpolarised helium-3 magnetic resonance imaging. British Thoracic Society Winter Meeting 2011 (abstract).
    • (2011) British Thoracic Society Winter Meeting
    • Gonem, S.1    Ball, I.2    Corkill, S.3
  • 29
    • 58149101483 scopus 로고    scopus 로고
    • Receptor for advanced gylcation end products is subjected to protein ectodomain shedding by metalloproteinases
    • Zhang L, Bukulin M, Kojro E et al. Receptor for advanced gylcation end products is subjected to protein ectodomain shedding by metalloproteinases. J Biol Chem 2008; 283:35507-16.
    • (2008) J Biol Chem , vol.283 , pp. 35507-35516
    • Zhang, L.1    Bukulin, M.2    Kojro, E.3
  • 30
    • 73349143302 scopus 로고    scopus 로고
    • Genome-wide association study identifies five loci associated with lung function
    • Repapi E, Sayers I, Wain LV et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet 2010; 42:36-44.
    • (2010) Nat Genet , vol.42 , pp. 36-44
    • Repapi, E.1    Sayers, I.2    Wain, L.V.3
  • 31
    • 73349111257 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identify multiple loci associated with pulmonary function
    • Hancock DB, Eijgelsheim M, Wilk JB et al. Meta-analysis of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet 2010; 42:45-52.
    • (2010) Nat Genet , vol.42 , pp. 45-52
    • Hancock, D.B.1    Eijgelsheim, M.2    Wilk, J.B.3
  • 32
    • 77952307233 scopus 로고    scopus 로고
    • Expression of high-mobility group box 1 and the receptor for advanced glycation end products in COPD
    • Ferhani N, Letuve S, Kozhich A et al. Expression of high-mobility group box 1 and the receptor for advanced glycation end products in COPD. Am J Respir Crit Care Med 2010; 181:917-27.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 917-927
    • Ferhani, N.1    Letuve, S.2    Kozhich, A.3
  • 33
    • 79151480125 scopus 로고    scopus 로고
    • Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD
    • Wu L, Ma L, Nicholson LFB, Black PN. Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD. Respir Med 2011; 105:329-36.
    • (2011) Respir Med , vol.105 , pp. 329-336
    • Wu, L.1    Ma, L.2    Nicholson, L.F.B.3    Black, P.N.4
  • 34
    • 84860014726 scopus 로고    scopus 로고
    • Soluble RAGE is deficient in neutrophilic asthma and chronic obstructive pulmonary disease
    • in press.
    • Sukkar MB, Wood LG, Tooze M et al. Soluble RAGE is deficient in neutrophilic asthma and chronic obstructive pulmonary disease. Eur Respir J 2011, in press.
    • (2011) Eur Respir J
    • Sukkar, M.B.1    Wood, L.G.2    Tooze, M.3
  • 35
    • 77649119443 scopus 로고    scopus 로고
    • Disordered microbial communities in asthmatic airways
    • Hilty M, Burke C, Pedro H et al. Disordered microbial communities in asthmatic airways. PLoS ONE 2010; 5:e8578.
    • (2010) PLoS ONE , vol.5
    • Hilty, M.1    Burke, C.2    Pedro, H.3
  • 36
    • 79551495183 scopus 로고    scopus 로고
    • National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    • e1-3.
    • Huang YJ, Nelson CE, Brodie EL et al. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol 2011; 127:372-81.e1-3.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 372-381
    • Huang, Y.J.1    Nelson, C.E.2    Brodie, E.L.3
  • 37
    • 78649874113 scopus 로고    scopus 로고
    • IgE sensitization to Aspergillus fumigates is associated with reduced lung function in asthma
    • Fairs A, Agbetile J, Hargadon B et al. IgE sensitization to Aspergillus fumigates is associated with reduced lung function in asthma. Am J Respir Crit Care Med 2010; 182:1362-8.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1362-1368
    • Fairs, A.1    Agbetile, J.2    Hargadon, B.3
  • 38
    • 0035093489 scopus 로고    scopus 로고
    • Persistent airflow limitation in adult onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumonia infection
    • Ten Brinke A, van Dissel JT, Sterk PJ, Zwinderman AH, Rabe KF, Bel EH. Persistent airflow limitation in adult onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumonia infection. J Allergy Clin Immunol 2001; 107:449-54.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 449-454
    • Ten Brinke, A.1    van Dissel, J.T.2    Sterk, P.J.3    Zwinderman, A.H.4    Rabe, K.F.5    Bel, E.H.6
  • 39
    • 77957769295 scopus 로고    scopus 로고
    • Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma
    • Thomas B, Rutman A, Hirst RA et al. Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma. J Allergy Clin Immunol 2010; 126:722-9.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 722-729
    • Thomas, B.1    Rutman, A.2    Hirst, R.A.3
  • 40
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark PA, Johnston SL, Bucchieri F et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201:937-47.
    • (2005) J Exp Med , vol.201 , pp. 937-947
    • Wark, P.A.1    Johnston, S.L.2    Bucchieri, F.3
  • 41
    • 33748446393 scopus 로고    scopus 로고
    • Role of deficient type III interferon-lambda production in asthma exacerbations
    • Contoli M, Message SD, Laza-Stanca V et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 2006; 12:1023-6.
    • (2006) Nat Med , vol.12 , pp. 1023-1026
    • Contoli, M.1    Message, S.D.2    Laza-Stanca, V.3
  • 42
    • 0037090945 scopus 로고    scopus 로고
    • Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma
    • Little SA, MacLeod KJ, Chalmers GW, Love JG, McSharry C, Thomson NC. Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma. Am J Med 2002; 112:446-52.
    • (2002) Am J Med , vol.112 , pp. 446-452
    • Little, S.A.1    MacLeod, K.J.2    Chalmers, G.W.3    Love, J.G.4    McSharry, C.5    Thomson, N.C.6
  • 44
    • 34447297847 scopus 로고    scopus 로고
    • Bronchial inflammtion and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease
    • Slats AM, Janssen K, van Schadewijk A et al. Bronchial inflammtion and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 176:121-8.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 121-128
    • Slats, A.M.1    Janssen, K.2    van Schadewijk, A.3
  • 45
    • 79957512933 scopus 로고    scopus 로고
    • Effect of bronchoconstriction on airway remodelling in asthma
    • Grainge CL, Lau LC, Ward JA et al. Effect of bronchoconstriction on airway remodelling in asthma. N Engl J Med 2011; 364:2006-15.
    • (2011) N Engl J Med , vol.364 , pp. 2006-2015
    • Grainge, C.L.1    Lau, L.C.2    Ward, J.A.3
  • 46
    • 7944237374 scopus 로고    scopus 로고
    • Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis
    • Berry MA, Parker D, Neale N et al. Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2004; 114:1106-9.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 1106-1109
    • Berry, M.A.1    Parker, D.2    Neale, N.3
  • 47
    • 0036882155 scopus 로고    scopus 로고
    • TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis
    • Brightling CE, Symon FA, Birring SS et al. TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2002; 110:899-905.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 899-905
    • Brightling, C.E.1    Symon, F.A.2    Birring, S.S.3
  • 48
    • 40049099397 scopus 로고    scopus 로고
    • Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    • Saha SK, Berry MA, Parker D et al. Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol 2008; 121:685-91.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 685-691
    • Saha, S.K.1    Berry, M.A.2    Parker, D.3
  • 49
    • 77950296865 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway
    • Semlali A, Jacques E, Koussih L et al. Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway. J Allergy Clin Immunol 2010; 125:844-50.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 844-850
    • Semlali, A.1    Jacques, E.2    Koussih, L.3
  • 50
    • 69249148319 scopus 로고    scopus 로고
    • FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells
    • Okayama Y, Okumura S, Sagara H et al. FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells. Eur Respir J 2009; 34:425-35.
    • (2009) Eur Respir J , vol.34 , pp. 425-435
    • Okayama, Y.1    Okumura, S.2    Sagara, H.3
  • 51
    • 34547646319 scopus 로고    scopus 로고
    • Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease
    • Zhang K, Shan L, Rahman MS et al. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2007; 293:L375-82.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Zhang, K.1    Shan, L.2    Rahman, M.S.3
  • 52
    • 80051636834 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin is produced by dendritic cells
    • Epub ahead of print].
    • Kashyap M, Rochman Y, Spolski R et al. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol 2011. [Epub ahead of print].
    • (2011) J Immunol
    • Kashyap, M.1    Rochman, Y.2    Spolski, R.3
  • 53
    • 53149097377 scopus 로고    scopus 로고
    • Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease
    • Ying S, O'Connor B, Ratoff J et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol 2008; 181:2790-8.
    • (2008) J Immunol , vol.181 , pp. 2790-2798
    • Ying, S.1    O'Connor, B.2    Ratoff, J.3
  • 54
    • 84859999133 scopus 로고    scopus 로고
    • Mast cell-airway smooth muscle crosstalk promotes mast cell activation via thymic stromal lymphopoietin
    • in press.
    • Kaur D, Doe C, Woodman L et al. Mast cell-airway smooth muscle crosstalk promotes mast cell activation via thymic stromal lymphopoietin. Chest 2011, in press.
    • (2011) Chest
    • Kaur, D.1    Doe, C.2    Woodman, L.3
  • 56
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57:875-9.
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Woltmann, G.3    Parker, D.4    Wardlaw, A.J.5    Pavord, I.D.6
  • 57
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160:1001-8.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3
  • 58
    • 33646478111 scopus 로고    scopus 로고
    • Clinical applications of induced sputum
    • Brightling CE. Clinical applications of induced sputum. Chest 2006; 129:1344-8.
    • (2006) Chest , vol.129 , pp. 1344-1348
    • Brightling, C.E.1
  • 59
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • Barnes PJ The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008; 118:3546-56.
    • (2008) J Clin Invest , vol.118 , pp. 3546-3556
    • Barnes, P.J.1
  • 60
    • 10744231300 scopus 로고    scopus 로고
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J. 2003; 22:470-7.
    • (2003) Eur Respir J , vol.22 , pp. 470-477
  • 62
    • 78349269946 scopus 로고    scopus 로고
    • Brightling expression of the Th17-associated cytokines interleukin (IL)-17A and F in asthma and chronic obstructive pulmonary disease
    • Doe C, Bafadhel M, Siddiqui S et al. Brightling expression of the Th17-associated cytokines interleukin (IL)-17A and F in asthma and chronic obstructive pulmonary disease. Chest 2010; 138:1140-7.
    • (2010) Chest , vol.138 , pp. 1140-1147
    • Doe, C.1    Bafadhel, M.2    Siddiqui, S.3
  • 63
    • 67349203306 scopus 로고    scopus 로고
    • T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma
    • Al-Ramli W, Préfontaine D, Chouiali F et al. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J Allergy Clin Immunol 2009; 123:1185-7.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1185-1187
    • Al-Ramli, W.1    Préfontaine, D.2    Chouiali, F.3
  • 64
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973-84.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 65
    • 27744437460 scopus 로고    scopus 로고
    • Risk factors of frequent exacerbations in difficult-to-treat asthma
    • Ten Brinke A, Sterk PJ, Masclee AA et al. Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur Respir J 2005; 26:812-8.
    • (2005) Eur Respir J , vol.26 , pp. 812-818
    • Ten Brinke, A.1    Sterk, P.J.2    Masclee, A.A.3
  • 66
    • 0035177659 scopus 로고    scopus 로고
    • Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma
    • Woodruff PG, Khashayar R, Lazarus SC et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 2001; 108:753-8.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 753-758
    • Woodruff, P.G.1    Khashayar, R.2    Lazarus, S.C.3
  • 67
    • 37549004387 scopus 로고    scopus 로고
    • Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    • Shaw DE, Berry MA, Hargadon B et al. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. Chest 2007; 132:1871-5.
    • (2007) Chest , vol.132 , pp. 1871-1875
    • Shaw, D.E.1    Berry, M.A.2    Hargadon, B.3
  • 68
    • 28244479315 scopus 로고    scopus 로고
    • Tumournecrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroiddependent asthma
    • Howarth P, Babu K, Arshad H et al. Tumournecrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroiddependent asthma. Thorax 2005; 60:1012-8.
    • (2005) Thorax , vol.60 , pp. 1012-1018
    • Howarth, P.1    Babu, K.2    Arshad, H.3
  • 69
    • 79551511756 scopus 로고    scopus 로고
    • Mast cell phenotype, location, and activation in severe asthma. Data from the severe asthma research program
    • Balzar S, Fajt ML, Comhair SA et al. Mast cell phenotype, location, and activation in severe asthma. Data from the severe asthma research program. Am J Respir Crit Care Med 2011; 183:299-309.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 299-309
    • Balzar, S.1    Fajt, M.L.2    Comhair, S.A.3
  • 70
    • 15944362722 scopus 로고    scopus 로고
    • Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    • Balzar S, Chu HW, Strand M, Wenzel S Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med 2005; 171:431-9.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 431-439
    • Balzar, S.1    Chu, H.W.2    Strand, M.3    Wenzel, S.4
  • 71
    • 0033923224 scopus 로고    scopus 로고
    • Involvement of the epidermal growth factor receptor in epithelial repair in asthma
    • Puddicombe SM, Polosa R, Richter A et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000; 14:1362-74.
    • (2000) FASEB J , vol.14 , pp. 1362-1374
    • Puddicombe, S.M.1    Polosa, R.2    Richter, A.3
  • 72
    • 0038016770 scopus 로고    scopus 로고
    • Transforming growth factor-beta and its role in asthma
    • Duvernelle C, Freund V, Frossard N. Transforming growth factor-beta and its role in asthma. Pulm Pharmacol Ther 2003; 16:181-96.
    • (2003) Pulm Pharmacol Ther , vol.16 , pp. 181-196
    • Duvernelle, C.1    Freund, V.2    Frossard, N.3
  • 73
    • 33645233889 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma
    • Chetta A, Zanini A, Foresi A et al. Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy 2005; 35:1437-42.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1437-1442
    • Chetta, A.1    Zanini, A.2    Foresi, A.3
  • 74
    • 0032967436 scopus 로고    scopus 로고
    • Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3
    • Eickelberg O, Kohler E, Reichenberger F et al. Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3. Am J Physiol 1999; 276:L814-24.
    • (1999) Am J Physiol , vol.276
    • Eickelberg, O.1    Kohler, E.2    Reichenberger, F.3
  • 75
    • 34447318645 scopus 로고    scopus 로고
    • Epithelial cell proliferation contributes to airway remodeling in severe asthma
    • the NHLBI Severe Asthma Research Program (SARP).
    • Cohen L, Tarsi EX, Ramkumar J et al.; the NHLBI Severe Asthma Research Program (SARP). Epithelial cell proliferation contributes to airway remodeling in severe asthma. Am J Respir Crit Care Med 2007; 176:138-45.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 138-145
    • Cohen, L.1    Tarsi, E.X.2    Ramkumar, J.3
  • 76
    • 39449123817 scopus 로고    scopus 로고
    • Differences in airway cytokine profile in severe asthma compared to moderate asthma
    • Shannon J, Ernst P, Yamauchi Y et al. Differences in airway cytokine profile in severe asthma compared to moderate asthma. Chest 2008; 133:420-6.
    • (2008) Chest , vol.133 , pp. 420-426
    • Shannon, J.1    Ernst, P.2    Yamauchi, Y.3
  • 78
    • 70350312668 scopus 로고    scopus 로고
    • Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma
    • Macedo P, Hew M, Torrego A et al. Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma. Clin Exp Allergy 2009; 39:1668-76.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1668-1676
    • Macedo, P.1    Hew, M.2    Torrego, A.3
  • 79
    • 67649224092 scopus 로고    scopus 로고
    • Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction
    • Kaminska M, Foley S, Maghni K et al. Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J Allergy Clin Immunol 2009; 12:45-51.
    • (2009) J Allergy Clin Immunol , vol.12 , pp. 45-51
    • Kaminska, M.1    Foley, S.2    Maghni, K.3
  • 81
    • 0035423346 scopus 로고    scopus 로고
    • Airway smooth muscle cell proliferation is increased in asthma
    • Johnson PR, Roth M, Tamm M et al. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 2001; 164:474-7.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 474-477
    • Johnson, P.R.1    Roth, M.2    Tamm, M.3
  • 82
    • 33845519705 scopus 로고    scopus 로고
    • Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma
    • Kaur D, Saunders R, Berger P et al. Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med 2006; 174:1179-88.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1179-1188
    • Kaur, D.1    Saunders, R.2    Berger, P.3
  • 85
    • 48349132646 scopus 로고    scopus 로고
    • Airway hyperresponsiveness is dissociated from airway wall structural remodelling
    • Siddiqui S, Mistry V, Doe C et al. Airway hyperresponsiveness is dissociated from airway wall structural remodelling. J Allergy Clin Immunol 2008; 122:335-41.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 335-341
    • Siddiqui, S.1    Mistry, V.2    Doe, C.3
  • 86
    • 59449083238 scopus 로고    scopus 로고
    • Fibrocyte localisation to the airway smooth muscle is a feature of asthma
    • Saunders R, Siddiqui S, Kaur D et al. Fibrocyte localisation to the airway smooth muscle is a feature of asthma. J Allergy Clin Immunol 2009; 123:376-84.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 376-384
    • Saunders, R.1    Siddiqui, S.2    Kaur, D.3
  • 87
    • 51849104192 scopus 로고    scopus 로고
    • Increased circulating fibrocytes in asthma with chronic airflow obstruction
    • Wang CH, Huang CD, Lin HC et al. Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care 2008; 178:583-91.
    • (2008) Am J Respir Crit Care , vol.178 , pp. 583-591
    • Wang, C.H.1    Huang, C.D.2    Lin, H.C.3
  • 88
    • 52749090828 scopus 로고    scopus 로고
    • What can we learn about airway smooth muscle from the company it keeps?
    • Siddiqui S, Hollins F, Brightling CE. What can we learn about airway smooth muscle from the company it keeps? Eur Respir J 2008; 32:9-11.
    • (2008) Eur Respir J , vol.32 , pp. 9-11
    • Siddiqui, S.1    Hollins, F.2    Brightling, C.E.3
  • 89
    • 34948842015 scopus 로고    scopus 로고
    • Vascular remodelling is a feature of asthma and nonasthmatic eosinophilic bronchitis
    • Siddiqui S, Sutcliffe A, Shikotra A et al. Vascular remodelling is a feature of asthma and nonasthmatic eosinophilic bronchitis. J Allergy Clin Immunol 2007;120:813-9.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 813-819
    • Siddiqui, S.1    Sutcliffe, A.2    Shikotra, A.3
  • 91
    • 34547133973 scopus 로고    scopus 로고
    • Chymase-positive mast cells play a role in the vascular component of airway remodelling in asthma
    • Zannini A, Chetta A, Saetta M et al. Chymase-positive mast cells play a role in the vascular component of airway remodelling in asthma. J Allergy Clin Immunol 2007; 120:329-33.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 329-333
    • Zannini, A.1    Chetta, A.2    Saetta, M.3
  • 92
    • 0036341331 scopus 로고    scopus 로고
    • Increased mast cells and neutrophils insubmucosal mucous glands and mucus plugging in patients with asthma
    • Carroll NG, Mutavdzic S, James AL. Increased mast cells and neutrophils insubmucosal mucous glands and mucus plugging in patients with asthma. Thorax 2002; 57:677-82.
    • (2002) Thorax , vol.57 , pp. 677-682
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 93
    • 0029893414 scopus 로고    scopus 로고
    • Airway structure and inflammatory cells in fatal attacks of asthma
    • Carroll N, Carello S, Cooke C, James A. Airway structure and inflammatory cells in fatal attacks of asthma. Eur Respir J 1996; 9:709-15.
    • (1996) Eur Respir J , vol.9 , pp. 709-715
    • Carroll, N.1    Carello, S.2    Cooke, C.3    James, A.4
  • 94
    • 70350308025 scopus 로고    scopus 로고
    • Severe asthma: a consequence of over exuberant repair?
    • Brightling CE, Desai D, Siddiqui S. Severe asthma: a consequence of over exuberant repair? Clin Exp Allergy 2009; 39:1630-2.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1630-1632
    • Brightling, C.E.1    Desai, D.2    Siddiqui, S.3
  • 95
    • 70350312668 scopus 로고    scopus 로고
    • Inflammatory biomarkers in airways of patients with severe asthma compared to non-severe asthma
    • Macedo P, Hew M, Torrego A et al. Inflammatory biomarkers in airways of patients with severe asthma compared to non-severe asthma. Clin Exp Allergy 2009; 39:1668-76.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1668-1676
    • Macedo, P.1    Hew, M.2    Torrego, A.3
  • 96
    • 67649224092 scopus 로고    scopus 로고
    • Airway remodelling in subjects with severe asthma with or without chronic persistent airflow obstruction
    • Kaminski M, Foley S, Maghni K et al. Airway remodelling in subjects with severe asthma with or without chronic persistent airflow obstruction. J Allergy Clin Immunol 2009; 124:45-51.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 45-51
    • Kaminski, M.1    Foley, S.2    Maghni, K.3
  • 98
    • 0037841704 scopus 로고    scopus 로고
    • Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression
    • Chakir J, Shannon J, Molet S et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 2003; 111:1293-8.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1293-1298
    • Chakir, J.1    Shannon, J.2    Molet, S.3
  • 99
    • 33750533197 scopus 로고    scopus 로고
    • Role of small airways in asthma: investigation using high-resolution computed tomography
    • Ueda T, Niimi A, Matsumoto H et al. Role of small airways in asthma: investigation using high-resolution computed tomography. J Allergy Clin Immunol 2006; 118:1019-25.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 1019-1025
    • Ueda, T.1    Niimi, A.2    Matsumoto, H.3
  • 100
    • 38949165471 scopus 로고    scopus 로고
    • Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    • National Heart, Lung, and Blood Institute Severe Asthma Research Program.
    • Sorkness RL, Bleecker ER, Busse WW et al. ; National Heart, Lung, and Blood Institute Severe Asthma Research Program. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 2008;104:394-403.
    • (2008) J Appl Physiol , vol.104 , pp. 394-403
    • Sorkness, R.L.1    Bleecker, E.R.2    Busse, W.W.3
  • 101
    • 67349109921 scopus 로고    scopus 로고
    • The outer wall of small airways is a major site of remodeling in fatal asthma
    • 1097.e1
    • Dolhnikoff M, da Silva LF, de Araujo BB et al. The outer wall of small airways is a major site of remodeling in fatal asthma. J Allergy Clin Immunol 2009;123:1090-71097.e1
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1090-1097
    • Dolhnikoff, M.1    da Silva, L.F.2    de Araujo, B.B.3
  • 102
    • 5144221335 scopus 로고    scopus 로고
    • Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma
    • Mauad T, Silva LF, Santos MA et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am J Respir Crit Care Med 2004; 170:857-62.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 857-862
    • Mauad, T.1    Silva, L.F.2    Santos, M.A.3
  • 104
    • 23944492390 scopus 로고    scopus 로고
    • Airway proteoglycans are differentially altered in fatal asthma
    • Matsushita MM, Silva LFF, Santos MA et al. Airway proteoglycans are differentially altered in fatal asthma. J Pathol 2005; 207:102-10.
    • (2005) J Pathol , vol.207 , pp. 102-110
    • Matsushita, M.M.1    Silva, L.F.F.2    Santos, M.A.3
  • 105
    • 33846262518 scopus 로고    scopus 로고
    • Differences in proteoglycan depostion in the airways of moderate and severe asthmatics
    • Pini L, Hamid Q, Shannon J et al. Differences in proteoglycan depostion in the airways of moderate and severe asthmatics. Eur Respir J 2007; 29:71-7.
    • (2007) Eur Respir J , vol.29 , pp. 71-77
    • Pini, L.1    Hamid, Q.2    Shannon, J.3
  • 106
    • 33644845766 scopus 로고    scopus 로고
    • Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma
    • De Kluijver J, Schrumpf JA, Evertse CE et al. Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma. Clin Exp Allergy 2005; 35:1361-9.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1361-1369
    • De Kluijver, J.1    Schrumpf, J.A.2    Evertse, C.E.3
  • 107
    • 27644560427 scopus 로고    scopus 로고
    • Evidence of remodelling in peripheral airways of patients with mild to moderate asthma: effects of hydrofluoroalkane-flunisolide
    • Bergeron C, Hauber HP, Gotfried M et al. Evidence of remodelling in peripheral airways of patients with mild to moderate asthma: effects of hydrofluoroalkane-flunisolide. J Allergy Clin Immunol 2005; 116:983-9.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 983-989
    • Bergeron, C.1    Hauber, H.P.2    Gotfried, M.3
  • 108
    • 24644511857 scopus 로고    scopus 로고
    • Differences in airway remodeling between subjects with severe and moderate asthma
    • Pepe C, Foley S, Shannon J et al. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol 2005; 116:544-9.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 544-549
    • Pepe, C.1    Foley, S.2    Shannon, J.3
  • 109
    • 25444522192 scopus 로고    scopus 로고
    • Bronchial CD8 cell infiltrate and lung function decline in asthma
    • van Rensen EL, Sont JK, Evertse CE et al. Bronchial CD8 cell infiltrate and lung function decline in asthma. Am J Respir Crit Care Med 2005; 172:837-41.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 837-841
    • van Rensen, E.L.1    Sont, J.K.2    Evertse, C.E.3
  • 110
    • 0024828192 scopus 로고
    • Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity
    • Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB. Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989; 140:1745-53.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 1745-1753
    • Jeffery, P.K.1    Wardlaw, A.J.2    Nelson, F.C.3    Collins, J.V.4    Kay, A.B.5
  • 111
    • 0026876657 scopus 로고
    • Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma
    • Ohashi Y, Motojima S, Fukuda T, Makino S. Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma. Am Rev Respir Dis 1992; 145:1469-76.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1469-1476
    • Ohashi, Y.1    Motojima, S.2    Fukuda, T.3    Makino, S.4
  • 112
    • 0025128562 scopus 로고
    • Morphological integrity of the bronchial epithelium in mild asthma
    • Lozewicz S, Wells C, Gomez E et al. Morphological integrity of the bronchial epithelium in mild asthma. Thorax 1990; 45:12-5.
    • (1990) Thorax , vol.45 , pp. 12-15
    • Lozewicz, S.1    Wells, C.2    Gomez, E.3
  • 113
    • 0034995813 scopus 로고    scopus 로고
    • Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma
    • Hoshino M, Nakamura Y, Hamid QA. Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. J Allergy Clin Immunol 2001; 107:1034-8.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 1034-1038
    • Hoshino, M.1    Nakamura, Y.2    Hamid, Q.A.3
  • 114
    • 11144358047 scopus 로고    scopus 로고
    • Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    • Woodruff PG, Dolganov GM, Ferrando RE et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004; 169:1001-6.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 1001-1006
    • Woodruff, P.G.1    Dolganov, G.M.2    Ferrando, R.E.3
  • 116
    • 11344278774 scopus 로고    scopus 로고
    • Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound
    • Vachier I, Bonnans C, Chavis C et al. Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. J Allergy Clin Immunol 2005; 115:55-60.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 55-60
    • Vachier, I.1    Bonnans, C.2    Chavis, C.3
  • 117
    • 24344506252 scopus 로고    scopus 로고
    • Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirintriggered lipoxins
    • Petasis NA, Akritopoulou-Zanze I, Fokin VV et al. Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirintriggered lipoxins. Prostaglandins Leukot Essent Fatty Acids 2005; 73:301-21.
    • (2005) Prostaglandins Leukot Essent Fatty Acids , vol.73 , pp. 301-321
    • Petasis, N.A.1    Akritopoulou-Zanze, I.2    Fokin, V.V.3
  • 118
    • 40049100646 scopus 로고    scopus 로고
    • Discovering susceptability genes for asthma and allergy
    • Vercelli D. Discovering susceptability genes for asthma and allergy. Nat Rev Immunol 2008; 8:169-82.
    • (2008) Nat Rev Immunol , vol.8 , pp. 169-182
    • Vercelli, D.1
  • 119
    • 73349095372 scopus 로고    scopus 로고
    • Lung function and airway diseases
    • Weiss ST. Lung function and airway diseases. Nat Genet 2010;42:14-6.
    • (2010) Nat Genet , vol.42 , pp. 14-16
    • Weiss, S.T.1
  • 120
    • 0037173639 scopus 로고    scopus 로고
    • Association of the ADAM33 gene with asthma and bronchial hyperresonsiveness
    • Van Eerdewegh P, Little RD, Dupuis J et al. Association of the ADAM33 gene with asthma and bronchial hyperresonsiveness. Nature 2002; 418:426-30.
    • (2002) Nature , vol.418 , pp. 426-430
    • Van Eerdewegh, P.1    Little, R.D.2    Dupuis, J.3
  • 121
    • 45549093604 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide linkage studies of asthma and related traits
    • Denham S, Koppelman GH, Blakey J et al. Meta-analysis of genome-wide linkage studies of asthma and related traits. Respir Res 2008; 9:38.
    • (2008) Respir Res , vol.9 , pp. 38
    • Denham, S.1    Koppelman, G.H.2    Blakey, J.3
  • 122
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt MF, Kabesch M, Liang L et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448:470-3.
    • (2007) Nature , vol.448 , pp. 470-473
    • Moffatt, M.F.1    Kabesch, M.2    Liang, L.3
  • 123
    • 42249103640 scopus 로고    scopus 로고
    • Effect of variation in CH13L1 on serum YKL-40 level, risk of asthma, and lung function
    • Ober C, Tan Z, Sun Y et al. Effect of variation in CH13L1 on serum YKL-40 level, risk of asthma, and lung function. N Eng J of Med 2008; 358:1682-91.
    • (2008) N Eng J of Med , vol.358 , pp. 1682-1691
    • Ober, C.1    Tan, Z.2    Sun, Y.3
  • 124
    • 65549123032 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies PDE4D as an asthma-susceptability gene
    • Himes BE, Hunninghake GM, Baurley JW et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptability gene. Am J Hum Genet 2009; 84:581-93.
    • (2009) Am J Hum Genet , vol.84 , pp. 581-593
    • Himes, B.E.1    Hunninghake, G.M.2    Baurley, J.W.3
  • 125
    • 75849162175 scopus 로고    scopus 로고
    • Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
    • Li X, Howard TD, Zheng S, Meyers DA, Bleecker ER. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol 2010; 125:328-35.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 328-335
    • Li, X.1    Howard, T.D.2    Zheng, S.3    Meyers, D.A.4    Bleecker, E.R.5
  • 128
    • 33845988321 scopus 로고    scopus 로고
    • Il-4Rα Mutations are associated with asthma exacerbations, airway obstruction, tissue mast cells/IgE expression and racial background
    • Wenzel SE, Balzar S, Ampleford EJ et al. Il-4Rα Mutations are associated with asthma exacerbations, airway obstruction, tissue mast cells/IgE expression and racial background. Am J Resp Crit Care Med 2007; 175:570-6.
    • (2007) Am J Resp Crit Care Med , vol.175 , pp. 570-576
    • Wenzel, S.E.1    Balzar, S.2    Ampleford, E.J.3
  • 130
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the Severe Asthma research Program
    • National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    • Moore WC, Meyers DA, Wenzel SE et al. National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma research Program. Am J Respir Crit Care Med 2010; 181:315-23.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3
  • 131
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    • Green RH, Brightling CE, McKenna S et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002; 360:1715-21.
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3
  • 132
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, Ten Brinke A, Khan J et al.Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356:2144-8.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Ten Brinke, A.2    Khan, J.3
  • 133
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MMM, Kjarsgaard M et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009; 360:985.
    • (2009) N Engl J Med , vol.360 , pp. 985
    • Nair, P.1    Pizzichini, M.M.M.2    Kjarsgaard, M.3
  • 135
    • 74449086375 scopus 로고    scopus 로고
    • A biomechanical model of agonist-initiated contraction in the asthmatic airway
    • Brook BS, Peel SE, Hall IP et al. A biomechanical model of agonist-initiated contraction in the asthmatic airway. Respir Physiol Neurobiol 2010; 170:44-58.
    • (2010) Respir Physiol Neurobiol , vol.170 , pp. 44-58
    • Brook, B.S.1    Peel, S.E.2    Hall, I.P.3
  • 136
    • 84860014728 scopus 로고    scopus 로고
    • Available at (accessed 30 November)
    • Available at (accessed 30 November 2011)
    • (2011)
  • 137
    • 77953397764 scopus 로고    scopus 로고
    • Systems medicine: the future of medical genomics and healthcare
    • Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare. Genome Med 2009; 1:2.
    • (2009) Genome Med , vol.1 , pp. 2
    • Auffray, C.1    Chen, Z.2    Hood, L.3
  • 138
    • 37149034914 scopus 로고    scopus 로고
    • Safety and efficacy of bronchial thermoplasty in symptomatic severe asthma
    • RISA Trial Study Group.
    • Pavord ID, Cox G, Thomson NC et al. RISA Trial Study Group. Safety and efficacy of bronchial thermoplasty in symptomatic severe asthma. Am J Respir Crit Care Med 2007; 176:1185-91.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1185-1191
    • Pavord, I.D.1    Cox, G.2    Thomson, N.C.3
  • 139
    • 74949090750 scopus 로고    scopus 로고
    • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomised, double-blind, sham-controlled clinical trial
    • AIR2 Trial Study Group.
    • Castro M, Rubin AS, Laviolette M et al. AIR2 Trial Study Group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomised, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med 2010; 181:116-24.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 116-124
    • Castro, M.1    Rubin, A.S.2    Laviolette, M.3
  • 140
    • 34047099762 scopus 로고    scopus 로고
    • Asthma control during the year after bronchial thermoplasty
    • AIR Trial Study Group.
    • Cox G, Thomson NC, Rubin AS et al. ; AIR Trial Study Group. Asthma control during the year after bronchial thermoplasty. N Engl J Med 2007; 356:1327-37.
    • (2007) N Engl J Med , vol.356 , pp. 1327-1337
    • Cox, G.1    Thomson, N.C.2    Rubin, A.S.3
  • 141
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren J, Lemanske RF, Hanania NA et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365:1088-98.
    • (2011) N Engl J Med , vol.365 , pp. 1088-1098
    • Corren, J.1    Lemanske, R.F.2    Hanania, N.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.