Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells

Toxicology and Applied Pharmacology

Volumn 259, Issue 2, 2012, Pages 248-256

  Khoi, Pham Ngoc ^a   Park, Jung Sun ^a   Kim, Nam Ho ^a   Jung, Young Do ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Endothelia; Invasiveness; MAPK; Nicotine; ROS; UPAR

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUTRALIZING ANTIBODY; NICOTINE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UROKINASE RECEPTOR;

ARTICLE; BINDING SITE; CELL INVASION; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXPRESSION VECTOR; GENE EXPRESSION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ANTHRACENES; ENDOTHELIAL CELLS; FLAVONOIDS; HUMANS; IMIDAZOLES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NICOTINE; PROTEIN KINASE INHIBITORS; PYRIDINES; REACTIVE OXYGEN SPECIES; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1;

NICOTIANA TABACUM;

EID: 84862798471     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.002     Document Type: Article

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