메뉴 건너뛰기




Volumn 27, Issue 2, 2013, Pages 173-206

Biology of Chronic Lymphocytic Leukemia in Different Microenvironments. Clinical and Therapeutic Implications.

Author keywords

B cell receptor signaling; Chronic lymphocytic leukemia; Microenvironment; Targeted therapy

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ATACICEPT; DASATINIB; EVEROLIMUS; FLUDARABINE; FOSTAMATINIB; IBRUTINIB; IDELALISIB; ISOSORBIDE; LENALIDOMIDE; NAVITOCLAX; OBATOCLAX; OBLIMERSEN; PLERIXAFOR; RITUXIMAB; SORAFENIB; THALIDOMIDE;

EID: 84875802229     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2013.01.002     Document Type: Review
Times cited : (90)

References (237)
  • 1
    • 0032941221 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia: a bird of a different feather
    • Caligaris-Cappio F., Hamblin T.J. B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol 1999, 17(1):399-408.
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 399-408
    • Caligaris-Cappio, F.1    Hamblin, T.J.2
  • 2
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial
    • Hallek M., Fischer K., Fingerle-Rowson G., et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010, 376(9747):1164-1174.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 3
    • 0030048565 scopus 로고    scopus 로고
    • Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis P., Jones D., Ganeshaguru K., et al. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br J Haematol 1996, 92(1):97-103.
    • (1996) Br J Haematol , vol.92 , Issue.1 , pp. 97-103
    • Panayiotidis, P.1    Jones, D.2    Ganeshaguru, K.3
  • 4
    • 0033377032 scopus 로고    scopus 로고
    • Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells
    • Lagneaux L., Delforge A., De Bruyn C., et al. Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells. Leuk Lymphoma 1999, 35(5-6):445-453.
    • (1999) Leuk Lymphoma , vol.35 , Issue.5-6 , pp. 445-453
    • Lagneaux, L.1    Delforge, A.2    De Bruyn, C.3
  • 5
    • 0018864596 scopus 로고
    • Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA
    • Andreeff M., Darzynkiewicz Z., Sharpless T.K., et al. Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 1980, 55(2):282-293.
    • (1980) Blood , vol.55 , Issue.2 , pp. 282-293
    • Andreeff, M.1    Darzynkiewicz, Z.2    Sharpless, T.K.3
  • 6
    • 36148992239 scopus 로고    scopus 로고
    • CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
    • Damle R.N., Temburni S., Calissano C., et al. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 2007, 110(9):3352-3359.
    • (2007) Blood , vol.110 , Issue.9 , pp. 3352-3359
    • Damle, R.N.1    Temburni, S.2    Calissano, C.3
  • 7
    • 20044372326 scopus 로고    scopus 로고
    • In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    • Messmer B.T., Messmer D., Allen S.L., et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 2005, 115(3):755-764.
    • (2005) J Clin Invest , vol.115 , Issue.3 , pp. 755-764
    • Messmer, B.T.1    Messmer, D.2    Allen, S.L.3
  • 8
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y., Perez-Galan P., Liu D., et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 2011, 117(2):563-574.
    • (2011) Blood , vol.117 , Issue.2 , pp. 563-574
    • Herishanu, Y.1    Perez-Galan, P.2    Liu, D.3
  • 9
    • 0035353212 scopus 로고    scopus 로고
    • Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
    • Granziero L., Ghia P., Circosta P., et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 2001, 97(9):2777-2783.
    • (2001) Blood , vol.97 , Issue.9 , pp. 2777-2783
    • Granziero, L.1    Ghia, P.2    Circosta, P.3
  • 10
    • 84868013848 scopus 로고    scopus 로고
    • Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia
    • Davids M.S., Deng J., Wiestner A., et al. Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia. Blood 2012, 120(17):3501-3509.
    • (2012) Blood , vol.120 , Issue.17 , pp. 3501-3509
    • Davids, M.S.1    Deng, J.2    Wiestner, A.3
  • 11
    • 46749145421 scopus 로고    scopus 로고
    • CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
    • Patten P.E., Buggins A.G., Richards J., et al. CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment. Blood 2008, 111(10):5173-5181.
    • (2008) Blood , vol.111 , Issue.10 , pp. 5173-5181
    • Patten, P.E.1    Buggins, A.G.2    Richards, J.3
  • 12
    • 0037441762 scopus 로고    scopus 로고
    • The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression
    • Ghia P., Guida G., Stella S., et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 2003, 101(4):1262-1269.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1262-1269
    • Ghia, P.1    Guida, G.2    Stella, S.3
  • 13
    • 1442331700 scopus 로고    scopus 로고
    • CD38 on B-cell chronic lymphocytic leukemia cells has higher expression in lymph nodes than in peripheral blood or bone marrow
    • Jaksic O., Paro M.M., Kardum Skelin I., et al. CD38 on B-cell chronic lymphocytic leukemia cells has higher expression in lymph nodes than in peripheral blood or bone marrow. Blood 2004, 103(5):1968-1969.
    • (2004) Blood , vol.103 , Issue.5 , pp. 1968-1969
    • Jaksic, O.1    Paro, M.M.2    Kardum Skelin, I.3
  • 14
    • 46749101051 scopus 로고    scopus 로고
    • Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: analysis of a series of 432 patients
    • Quijano S., Lopez A., Rasillo A., et al. Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: analysis of a series of 432 patients. Blood 2008, 111(10):5130-5141.
    • (2008) Blood , vol.111 , Issue.10 , pp. 5130-5141
    • Quijano, S.1    Lopez, A.2    Rasillo, A.3
  • 15
    • 33846944718 scopus 로고    scopus 로고
    • Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity
    • Smit L.A., Hallaert D.Y., Spijker R., et al. Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood 2007, 109(4):1660-1668.
    • (2007) Blood , vol.109 , Issue.4 , pp. 1660-1668
    • Smit, L.A.1    Hallaert, D.Y.2    Spijker, R.3
  • 16
    • 80053024575 scopus 로고    scopus 로고
    • Malignant pirates of the immune system
    • Rui L., Schmitz R., Ceribelli M., et al. Malignant pirates of the immune system. Nat Immunol 2011, 12(10):933-940.
    • (2011) Nat Immunol , vol.12 , Issue.10 , pp. 933-940
    • Rui, L.1    Schmitz, R.2    Ceribelli, M.3
  • 17
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • Davis R.E., Ngo V.N., Lenz G., et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010, 463(7277):88-92.
    • (2010) Nature , vol.463 , Issue.7277 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3
  • 18
    • 55949116983 scopus 로고    scopus 로고
    • Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation
    • Ghia P., Chiorazzi N., Stamatopoulos K. Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation. J Intern Med 2008, 264(6):549-562.
    • (2008) J Intern Med , vol.264 , Issue.6 , pp. 549-562
    • Ghia, P.1    Chiorazzi, N.2    Stamatopoulos, K.3
  • 19
    • 80054853285 scopus 로고    scopus 로고
    • B-cell receptor signaling in chronic lymphocytic leukemia
    • Stevenson F.K., Krysov S., Davies A.J., et al. B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2011, 118(16):4313-4320.
    • (2011) Blood , vol.118 , Issue.16 , pp. 4313-4320
    • Stevenson, F.K.1    Krysov, S.2    Davies, A.J.3
  • 20
    • 84870734255 scopus 로고    scopus 로고
    • Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia
    • Wiestner A. Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia. Blood 2012, 120(24):4684-4691.
    • (2012) Blood , vol.120 , Issue.24 , pp. 4684-4691
    • Wiestner, A.1
  • 21
    • 84865176364 scopus 로고    scopus 로고
    • The B-cell receptor signaling pathway as a therapeutic target in CLL
    • Woyach J.A., Johnson A.J., Byrd J.C. The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood 2012, 120(6):1175-1184.
    • (2012) Blood , vol.120 , Issue.6 , pp. 1175-1184
    • Woyach, J.A.1    Johnson, A.J.2    Byrd, J.C.3
  • 22
    • 84868370689 scopus 로고    scopus 로고
    • Targeting the B cell receptor pathway in chronic lymphocytic leukemia
    • Davids M.S., Brown J.R. Targeting the B cell receptor pathway in chronic lymphocytic leukemia. Leuk Lymphoma 2012, 53(12):2362-2370.
    • (2012) Leuk Lymphoma , vol.53 , Issue.12 , pp. 2362-2370
    • Davids, M.S.1    Brown, J.R.2
  • 23
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F., Ghiotto F., Hashimoto S., et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998, 102(8):1515-1525.
    • (1998) J Clin Invest , vol.102 , Issue.8 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3
  • 24
    • 7244232709 scopus 로고    scopus 로고
    • Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia
    • Tobin G., Thunberg U., Karlsson K., et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004, 104(9):2879-2885.
    • (2004) Blood , vol.104 , Issue.9 , pp. 2879-2885
    • Tobin, G.1    Thunberg, U.2    Karlsson, K.3
  • 25
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald A., Alizadeh A.A., Widhopf G., et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001, 194(11):1639-1647.
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3
  • 26
    • 0035803464 scopus 로고    scopus 로고
    • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    • Klein U., Tu Y., Stolovitzky G.A., et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 2001, 194(11):1625-1638.
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1625-1638
    • Klein, U.1    Tu, Y.2    Stolovitzky, G.A.3
  • 27
    • 0036624881 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
    • Damle R.N., Ghiotto F., Valetto A., et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 2002, 99(11):4087-4093.
    • (2002) Blood , vol.99 , Issue.11 , pp. 4087-4093
    • Damle, R.N.1    Ghiotto, F.2    Valetto, A.3
  • 28
    • 34248354409 scopus 로고    scopus 로고
    • Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
    • Mockridge C.I., Potter K.N., Wheatley I., et al. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood 2007, 109(10):4424-4431.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4424-4431
    • Mockridge, C.I.1    Potter, K.N.2    Wheatley, I.3
  • 29
    • 47249152803 scopus 로고    scopus 로고
    • Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
    • Muzio M., Apollonio B., Scielzo C., et al. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood 2008, 112(1):188-195.
    • (2008) Blood , vol.112 , Issue.1 , pp. 188-195
    • Muzio, M.1    Apollonio, B.2    Scielzo, C.3
  • 30
    • 0037306842 scopus 로고    scopus 로고
    • Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
    • Lanham S., Hamblin T., Oscier D., et al. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood 2003, 101(3):1087-1093.
    • (2003) Blood , vol.101 , Issue.3 , pp. 1087-1093
    • Lanham, S.1    Hamblin, T.2    Oscier, D.3
  • 31
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle R.N., Wasil T., Fais F., et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999, 94(6):1840-1847.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 32
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin T.J., Davis Z., Gardiner A., et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999, 94(6):1848-1854.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 33
    • 84861033763 scopus 로고    scopus 로고
    • Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
    • Agathangelidis A., Darzentas N., Hadzidimitriou A., et al. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood 2012, 119(19):4467-4475.
    • (2012) Blood , vol.119 , Issue.19 , pp. 4467-4475
    • Agathangelidis, A.1    Darzentas, N.2    Hadzidimitriou, A.3
  • 34
    • 4344704897 scopus 로고    scopus 로고
    • Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    • Messmer B.T., Albesiano E., Efremov D.G., et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004, 200(4):519-525.
    • (2004) J Exp Med , vol.200 , Issue.4 , pp. 519-525
    • Messmer, B.T.1    Albesiano, E.2    Efremov, D.G.3
  • 35
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
    • Stamatopoulos K., Belessi C., Moreno C., et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007, 109(1):259-270.
    • (2007) Blood , vol.109 , Issue.1 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3
  • 36
    • 55749091407 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
    • Chu C.C., Catera R., Hatzi K., et al. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood 2008, 112(13):5122-5129.
    • (2008) Blood , vol.112 , Issue.13 , pp. 5122-5129
    • Chu, C.C.1    Catera, R.2    Hatzi, K.3
  • 37
    • 78651227932 scopus 로고    scopus 로고
    • Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells
    • Binder M., Lechenne B., Ummanni R., et al. Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells. PLoS One 2010, 5(12):e15992.
    • (2010) PLoS One , vol.5 , Issue.12
    • Binder, M.1    Lechenne, B.2    Ummanni, R.3
  • 38
    • 20444454585 scopus 로고    scopus 로고
    • Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    • Herve M., Xu K., Ng Y.S., et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest 2005, 115(6):1636-1643.
    • (2005) J Clin Invest , vol.115 , Issue.6 , pp. 1636-1643
    • Herve, M.1    Xu, K.2    Ng, Y.S.3
  • 39
    • 43549093570 scopus 로고    scopus 로고
    • A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
    • Lanemo Myhrinder A., Hellqvist E., Sidorova E., et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 2008, 111(7):3838-3848.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3838-3848
    • Lanemo Myhrinder, A.1    Hellqvist, E.2    Sidorova, E.3
  • 40
    • 55749114077 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    • Catera R., Silverman G.J., Hatzi K., et al. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med 2008, 14(11-12):665-674.
    • (2008) Mol Med , vol.14 , Issue.11-12 , pp. 665-674
    • Catera, R.1    Silverman, G.J.2    Hatzi, K.3
  • 41
    • 84873721268 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: a tale of one or two signals?
    • Chiorazzi N., Efremov D.G. Chronic lymphocytic leukemia: a tale of one or two signals?. Cell Res 2012, 10.1038/cr.2012.152.
    • (2012) Cell Res
    • Chiorazzi, N.1    Efremov, D.G.2
  • 42
    • 77952965028 scopus 로고    scopus 로고
    • Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin
    • Chu C.C., Catera R., Zhang L., et al. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood 2010, 115(19):3907-3915.
    • (2010) Blood , vol.115 , Issue.19 , pp. 3907-3915
    • Chu, C.C.1    Catera, R.2    Zhang, L.3
  • 43
    • 23444461024 scopus 로고
    • How B and T cells talk to each other
    • Clark E.A., Ledbetter J.A. How B and T cells talk to each other. Nature 1994, 367(6462):425-428.
    • (1994) Nature , vol.367 , Issue.6462 , pp. 425-428
    • Clark, E.A.1    Ledbetter, J.A.2
  • 44
    • 20144385604 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
    • Contri A., Brunati A.M., Trentin L., et al. Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest 2005, 115(2):369-378.
    • (2005) J Clin Invest , vol.115 , Issue.2 , pp. 369-378
    • Contri, A.1    Brunati, A.M.2    Trentin, L.3
  • 45
    • 38349107623 scopus 로고    scopus 로고
    • The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
    • Longo P.G., Laurenti L., Gobessi S., et al. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 2008, 111(2):846-855.
    • (2008) Blood , vol.111 , Issue.2 , pp. 846-855
    • Longo, P.G.1    Laurenti, L.2    Gobessi, S.3
  • 46
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • Chen L., Widhopf G., Huynh L., et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002, 100(13):4609-4614.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4609-4614
    • Chen, L.1    Widhopf, G.2    Huynh, L.3
  • 47
    • 0025253488 scopus 로고
    • Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C
    • Hivroz C., Geny B., Brouet J.C., et al. Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C. J Immunol 1990, 144(6):2351-2358.
    • (1990) J Immunol , vol.144 , Issue.6 , pp. 2351-2358
    • Hivroz, C.1    Geny, B.2    Brouet, J.C.3
  • 48
    • 20444389401 scopus 로고    scopus 로고
    • Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
    • Petlickovski A., Laurenti L., Li X., et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood 2005, 105(12):4820-4827.
    • (2005) Blood , vol.105 , Issue.12 , pp. 4820-4827
    • Petlickovski, A.1    Laurenti, L.2    Li, X.3
  • 49
    • 77953647130 scopus 로고    scopus 로고
    • Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo
    • Krysov S., Potter K.N., Mockridge C.I., et al. Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo. Blood 2010, 115(21):4198-4205.
    • (2010) Blood , vol.115 , Issue.21 , pp. 4198-4205
    • Krysov, S.1    Potter, K.N.2    Mockridge, C.I.3
  • 50
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Duhren-von Minden M., Ubelhart R., Schneider D., et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012, 489(7415):309-312.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 309-312
    • Duhren-von Minden, M.1    Ubelhart, R.2    Schneider, D.3
  • 51
    • 77954957121 scopus 로고    scopus 로고
    • N-linked glycosylation selectively regulates autonomous precursor BCR function
    • Ubelhart R., Bach M.P., Eschbach C., et al. N-linked glycosylation selectively regulates autonomous precursor BCR function. Nat Immunol 2010, 11(8):759-765.
    • (2010) Nat Immunol , vol.11 , Issue.8 , pp. 759-765
    • Ubelhart, R.1    Bach, M.P.2    Eschbach, C.3
  • 52
    • 0029836635 scopus 로고    scopus 로고
    • CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis
    • Zupo S., Isnardi L., Megna M., et al. CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis. Blood 1996, 88(4):1365-1374.
    • (1996) Blood , vol.88 , Issue.4 , pp. 1365-1374
    • Zupo, S.1    Isnardi, L.2    Megna, M.3
  • 53
    • 10744222814 scopus 로고    scopus 로고
    • ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
    • Wiestner A., Rosenwald A., Barry T.S., et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 2003, 101(12):4944-4951.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4944-4951
    • Wiestner, A.1    Rosenwald, A.2    Barry, T.S.3
  • 54
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M., Bosch F., Villamor N., et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003, 348(18):1764-1775.
    • (2003) N Engl J Med , vol.348 , Issue.18 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 55
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti L.Z., Huynh L., Toy T.L., et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004, 351(9):893-901.
    • (2004) N Engl J Med , vol.351 , Issue.9 , pp. 893-901
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3
  • 56
    • 0347318114 scopus 로고    scopus 로고
    • ZAP-70 expression and prognosis in chronic lymphocytic leukaemia
    • Orchard J.A., Ibbotson R.E., Davis Z., et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 2004, 363(9403):105-111.
    • (2004) Lancet , vol.363 , Issue.9403 , pp. 105-111
    • Orchard, J.A.1    Ibbotson, R.E.2    Davis, Z.3
  • 57
    • 52649143664 scopus 로고    scopus 로고
    • Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia
    • Rassenti L.Z., Jain S., Keating M.J., et al. Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood 2008, 112(5):1923-1930.
    • (2008) Blood , vol.112 , Issue.5 , pp. 1923-1930
    • Rassenti, L.Z.1    Jain, S.2    Keating, M.J.3
  • 58
    • 14944352799 scopus 로고    scopus 로고
    • ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
    • Chen L., Apgar J., Huynh L., et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 2005, 105(5):2036-2041.
    • (2005) Blood , vol.105 , Issue.5 , pp. 2036-2041
    • Chen, L.1    Apgar, J.2    Huynh, L.3
  • 59
    • 41949140313 scopus 로고    scopus 로고
    • ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
    • Chen L., Huynh L., Apgar J., et al. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 2008, 111(5):2685-2692.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2685-2692
    • Chen, L.1    Huynh, L.2    Apgar, J.3
  • 60
    • 33847412872 scopus 로고    scopus 로고
    • ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
    • Gobessi S., Laurenti L., Longo P.G., et al. ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. Blood 2007, 109(5):2032-2039.
    • (2007) Blood , vol.109 , Issue.5 , pp. 2032-2039
    • Gobessi, S.1    Laurenti, L.2    Longo, P.G.3
  • 61
    • 0035892106 scopus 로고    scopus 로고
    • Survival of leukemic B cells promoted by engagement of the antigen receptor
    • Bernal A., Pastore R.D., Asgary Z., et al. Survival of leukemic B cells promoted by engagement of the antigen receptor. Blood 2001, 98(10):3050-3057.
    • (2001) Blood , vol.98 , Issue.10 , pp. 3050-3057
    • Bernal, A.1    Pastore, R.D.2    Asgary, Z.3
  • 62
    • 70349237504 scopus 로고    scopus 로고
    • B cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel Syk inhibitor, R406
    • Quiroga M.P., Balakrishnan K., Kurtova A.V., et al. B cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel Syk inhibitor, R406. Blood 2009, 114(5):1029-1037.
    • (2009) Blood , vol.114 , Issue.5 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3
  • 63
    • 33746924345 scopus 로고    scopus 로고
    • Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression
    • Deglesne P.A., Chevallier N., Letestu R., et al. Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression. Cancer Res 2006, 66(14):7158-7166.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 7158-7166
    • Deglesne, P.A.1    Chevallier, N.2    Letestu, R.3
  • 64
    • 84859398461 scopus 로고    scopus 로고
    • Nurture versus nature: the microenvironment in chronic lymphocytic leukemia
    • Burger J.A. Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2011, 2011:96-103.
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 96-103
    • Burger, J.A.1
  • 65
    • 84863527866 scopus 로고    scopus 로고
    • Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy
    • Dal Bo M., Bomben R., Zucchetto A., et al. Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy. Curr Pharm Des 2012, 18(23):3323-3334.
    • (2012) Curr Pharm Des , vol.18 , Issue.23 , pp. 3323-3334
    • Dal Bo, M.1    Bomben, R.2    Zucchetto, A.3
  • 66
    • 79956275845 scopus 로고    scopus 로고
    • A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
    • Bagnara D., Kaufman M.S., Calissano C., et al. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood 2011, 117(20):5463-5472.
    • (2011) Blood , vol.117 , Issue.20 , pp. 5463-5472
    • Bagnara, D.1    Kaufman, M.S.2    Calissano, C.3
  • 67
    • 79956354397 scopus 로고    scopus 로고
    • Two-faced T cells in CLL
    • Devereux S. Two-faced T cells in CLL. Blood 2011, 117(20):5273-5274.
    • (2011) Blood , vol.117 , Issue.20 , pp. 5273-5274
    • Devereux, S.1
  • 68
    • 0021013632 scopus 로고
    • Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia
    • Pizzolo G., Chilosi M., Ambrosetti A., et al. Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia. Blood 1983, 62(6):1289-1296.
    • (1983) Blood , vol.62 , Issue.6 , pp. 1289-1296
    • Pizzolo, G.1    Chilosi, M.2    Ambrosetti, A.3
  • 69
    • 2942584865 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: revelations from the B-cell receptor
    • Stevenson F.K., Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood 2004, 103(12):4389-4395.
    • (2004) Blood , vol.103 , Issue.12 , pp. 4389-4395
    • Stevenson, F.K.1    Caligaris-Cappio, F.2
  • 70
    • 0036099832 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    • Ghia P., Strola G., Granziero L., et al. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur J Immunol 2002, 32(5):1403-1413.
    • (2002) Eur J Immunol , vol.32 , Issue.5 , pp. 1403-1413
    • Ghia, P.1    Strola, G.2    Granziero, L.3
  • 71
    • 0027092054 scopus 로고
    • Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors
    • Fluckiger A.C., Rossi J.F., Bussel A., et al. Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors. Blood 1992, 80(12):3173-3181.
    • (1992) Blood , vol.80 , Issue.12 , pp. 3173-3181
    • Fluckiger, A.C.1    Rossi, J.F.2    Bussel, A.3
  • 72
    • 4344664011 scopus 로고    scopus 로고
    • A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells
    • Cuni S., Perez-Aciego P., Perez-Chacon G., et al. A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia 2004, 18(8):1391-1400.
    • (2004) Leukemia , vol.18 , Issue.8 , pp. 1391-1400
    • Cuni, S.1    Perez-Aciego, P.2    Perez-Chacon, G.3
  • 73
    • 0034651739 scopus 로고    scopus 로고
    • Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells
    • Furman R.R., Asgary Z., Mascarenhas J.O., et al. Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. J Immunol 2000, 164(4):2200-2206.
    • (2000) J Immunol , vol.164 , Issue.4 , pp. 2200-2206
    • Furman, R.R.1    Asgary, Z.2    Mascarenhas, J.O.3
  • 74
    • 0032147205 scopus 로고    scopus 로고
    • Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells
    • Romano M.F., Lamberti A., Tassone P., et al. Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells. Blood 1998, 92(3):990-995.
    • (1998) Blood , vol.92 , Issue.3 , pp. 990-995
    • Romano, M.F.1    Lamberti, A.2    Tassone, P.3
  • 75
    • 0032851693 scopus 로고    scopus 로고
    • Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia
    • Kitada S., Zapata J.M., Andreeff M., et al. Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia. Br J Haematol 1999, 106(4):995-1004.
    • (1999) Br J Haematol , vol.106 , Issue.4 , pp. 995-1004
    • Kitada, S.1    Zapata, J.M.2    Andreeff, M.3
  • 76
    • 58149378361 scopus 로고    scopus 로고
    • C-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL; implications for therapeutic targeting of chemoresistant niches
    • Hallaert D.Y., Jaspers A., van Noesel C.J., et al. c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL; implications for therapeutic targeting of chemoresistant niches. Blood 2008, 112(13):5141-5149.
    • (2008) Blood , vol.112 , Issue.13 , pp. 5141-5149
    • Hallaert, D.Y.1    Jaspers, A.2    van Noesel, C.J.3
  • 77
    • 0032506524 scopus 로고    scopus 로고
    • Control of apoptosis and mitotic spindle checkpoint by survivin
    • Li F., Ambrosini G., Chu E.Y., et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998, 396(6711):580-584.
    • (1998) Nature , vol.396 , Issue.6711 , pp. 580-584
    • Li, F.1    Ambrosini, G.2    Chu, E.Y.3
  • 78
    • 0026754538 scopus 로고
    • Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression
    • Dancescu M., Rubio-Trujillo M., Biron G., et al. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J Exp Med 1992, 176(5):1319-1326.
    • (1992) J Exp Med , vol.176 , Issue.5 , pp. 1319-1326
    • Dancescu, M.1    Rubio-Trujillo, M.2    Biron, G.3
  • 79
    • 0029939155 scopus 로고    scopus 로고
    • Interleukin-15 promotes the growth of leukemic cells of patients with B-cell chronic lymphoproliferative disorders
    • Trentin L., Cerutti A., Zambello R., et al. Interleukin-15 promotes the growth of leukemic cells of patients with B-cell chronic lymphoproliferative disorders. Blood 1996, 87(8):3327-3335.
    • (1996) Blood , vol.87 , Issue.8 , pp. 3327-3335
    • Trentin, L.1    Cerutti, A.2    Zambello, R.3
  • 80
    • 0025361921 scopus 로고
    • Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease
    • Foa R., Massaia M., Cardona S., et al. Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease. Blood 1990, 76(2):393-400.
    • (1990) Blood , vol.76 , Issue.2 , pp. 393-400
    • Foa, R.1    Massaia, M.2    Cardona, S.3
  • 81
    • 0029937459 scopus 로고    scopus 로고
    • Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia
    • follow 186, color plate VI
    • Reittie J.E., Yong K.L., Panayiotidis P., et al. Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia. Leuk Lymphoma 1996, 22(1-2):83-90. follow 186, color plate VI.
    • (1996) Leuk Lymphoma , vol.22 , Issue.1-2 , pp. 83-90
    • Reittie, J.E.1    Yong, K.L.2    Panayiotidis, P.3
  • 82
    • 0027455756 scopus 로고
    • Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia
    • Buschle M., Campana D., Carding S.R., et al. Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia. J Exp Med 1993, 177(1):213-218.
    • (1993) J Exp Med , vol.177 , Issue.1 , pp. 213-218
    • Buschle, M.1    Campana, D.2    Carding, S.R.3
  • 83
    • 0028174176 scopus 로고
    • Alpha-interferon (alpha-IFN) protects B-chronic lymphocytic leukaemia cells from apoptotic cell death in vitro
    • Panayiotidis P., Ganeshaguru K., Jabbar S.A., et al. Alpha-interferon (alpha-IFN) protects B-chronic lymphocytic leukaemia cells from apoptotic cell death in vitro. Br J Haematol 1994, 86(1):169-173.
    • (1994) Br J Haematol , vol.86 , Issue.1 , pp. 169-173
    • Panayiotidis, P.1    Ganeshaguru, K.2    Jabbar, S.A.3
  • 84
    • 13344282080 scopus 로고    scopus 로고
    • Interleukin-13 inhibits interleukin-2-induced proliferation and protects chronic lymphocytic leukemia B cells from in vitro apoptosis
    • Chaouchi N., Wallon C., Goujard C., et al. Interleukin-13 inhibits interleukin-2-induced proliferation and protects chronic lymphocytic leukemia B cells from in vitro apoptosis. Blood 1996, 87(3):1022-1029.
    • (1996) Blood , vol.87 , Issue.3 , pp. 1022-1029
    • Chaouchi, N.1    Wallon, C.2    Goujard, C.3
  • 85
    • 0028031971 scopus 로고
    • Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells
    • Lotz M., Ranheim E., Kipps T.J. Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J Exp Med 1994, 179(3):999-1004.
    • (1994) J Exp Med , vol.179 , Issue.3 , pp. 999-1004
    • Lotz, M.1    Ranheim, E.2    Kipps, T.J.3
  • 86
    • 0035160749 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome
    • Fayad L., Keating M.J., Reuben J.M., et al. Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome. Blood 2001, 97(1):256-263.
    • (2001) Blood , vol.97 , Issue.1 , pp. 256-263
    • Fayad, L.1    Keating, M.J.2    Reuben, J.M.3
  • 87
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • Ranheim E.A., Kipps T.J. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 1993, 177(4):925-935.
    • (1993) J Exp Med , vol.177 , Issue.4 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 88
    • 24744432528 scopus 로고    scopus 로고
    • Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine
    • Beyer M., Kochanek M., Darabi K., et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005, 106(6):2018-2025.
    • (2005) Blood , vol.106 , Issue.6 , pp. 2018-2025
    • Beyer, M.1    Kochanek, M.2    Darabi, K.3
  • 89
    • 84856555531 scopus 로고    scopus 로고
    • Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia
    • Biancotto A., Dagur P.K., Fuchs J.C., et al. Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia. Mod Pathol 2012, 25(2):246-259.
    • (2012) Mod Pathol , vol.25 , Issue.2 , pp. 246-259
    • Biancotto, A.1    Dagur, P.K.2    Fuchs, J.C.3
  • 90
    • 22144489127 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
    • Gorgun G., Holderried T.A., Zahrieh D., et al. Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest 2005, 115(7):1797-1805.
    • (2005) J Clin Invest , vol.115 , Issue.7 , pp. 1797-1805
    • Gorgun, G.1    Holderried, T.A.2    Zahrieh, D.3
  • 91
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay A.G., Johnson A.J., Lee A.M., et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008, 118(7):2427-2437.
    • (2008) J Clin Invest , vol.118 , Issue.7 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3
  • 92
    • 77951000778 scopus 로고    scopus 로고
    • The 3 Rs in CLL immune dysfunction
    • Ramsay A.G., Gribben J.G. The 3 Rs in CLL immune dysfunction. Blood 2010, 115(13):2563-2564.
    • (2010) Blood , vol.115 , Issue.13 , pp. 2563-2564
    • Ramsay, A.G.1    Gribben, J.G.2
  • 93
    • 0032055818 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells
    • Lagneaux L., Delforge A., Bron D., et al. Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 1998, 91(7):2387-2396.
    • (1998) Blood , vol.91 , Issue.7 , pp. 2387-2396
    • Lagneaux, L.1    Delforge, A.2    Bron, D.3
  • 94
    • 73349126115 scopus 로고    scopus 로고
    • Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
    • Kurtova A.V., Balakrishnan K., Chen R., et al. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 2009, 114(20):4441-4450.
    • (2009) Blood , vol.114 , Issue.20 , pp. 4441-4450
    • Kurtova, A.V.1    Balakrishnan, K.2    Chen, R.3
  • 95
    • 77958178317 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch
    • Ding W., Knox T.R., Tschumper R.C., et al. Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood 2010, 116(16):2984-2993.
    • (2010) Blood , vol.116 , Issue.16 , pp. 2984-2993
    • Ding, W.1    Knox, T.R.2    Tschumper, R.C.3
  • 96
    • 70350459031 scopus 로고    scopus 로고
    • Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression
    • Ding W., Nowakowski G.S., Knox T.R., et al. Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression. Br J Haematol 2009, 147(4):471-483.
    • (2009) Br J Haematol , vol.147 , Issue.4 , pp. 471-483
    • Ding, W.1    Nowakowski, G.S.2    Knox, T.R.3
  • 97
    • 77950352713 scopus 로고    scopus 로고
    • Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression
    • Ghosh A.K., Secreto C.R., Knox T.R., et al. Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression. Blood 2010, 115(9):1755-1764.
    • (2010) Blood , vol.115 , Issue.9 , pp. 1755-1764
    • Ghosh, A.K.1    Secreto, C.R.2    Knox, T.R.3
  • 98
    • 79952320233 scopus 로고    scopus 로고
    • Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2
    • Schulz A., Toedt G., Zenz T., et al. Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2. Haematologica 2011, 96(3):408-416.
    • (2011) Haematologica , vol.96 , Issue.3 , pp. 408-416
    • Schulz, A.1    Toedt, G.2    Zenz, T.3
  • 99
    • 33750301858 scopus 로고    scopus 로고
    • Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma
    • Ruan J., Hyjek E., Kermani P., et al. Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma. Clin Cancer Res 2006, 12(19):5622-5631.
    • (2006) Clin Cancer Res , vol.12 , Issue.19 , pp. 5622-5631
    • Ruan, J.1    Hyjek, E.2    Kermani, P.3
  • 100
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., Gupta P.B., Sgroi D.C., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121(3):335-348.
    • (2005) Cell , vol.121 , Issue.3 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3
  • 101
    • 23944488816 scopus 로고    scopus 로고
    • Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
    • Burger M., Hartmann T., Krome M., et al. Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 2005, 106(5):1824-1830.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1824-1830
    • Burger, M.1    Hartmann, T.2    Krome, M.3
  • 102
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284(5411):143-147.
    • (1999) Science , vol.284 , Issue.5411 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 103
    • 0036489442 scopus 로고    scopus 로고
    • Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine
    • de la Fuente M.T., Casanova B., Moyano J.V., et al. Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine. J Leukoc Biol 2002, 71(3):495-502.
    • (2002) J Leukoc Biol , vol.71 , Issue.3 , pp. 495-502
    • de la Fuente, M.T.1    Casanova, B.2    Moyano, J.V.3
  • 104
    • 76249124026 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain
    • Redondo-Munoz J., Ugarte-Berzal E., Terol M.J., et al. Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain. Cancer Cell 2010, 17(2):160-172.
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 160-172
    • Redondo-Munoz, J.1    Ugarte-Berzal, E.2    Terol, M.J.3
  • 105
    • 33750017080 scopus 로고    scopus 로고
    • MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration
    • Redondo-Munoz J., Escobar-Diaz E., Samaniego R., et al. MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood 2006, 108(9):3143-3151.
    • (2006) Blood , vol.108 , Issue.9 , pp. 3143-3151
    • Redondo-Munoz, J.1    Escobar-Diaz, E.2    Samaniego, R.3
  • 106
    • 11144268038 scopus 로고    scopus 로고
    • Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells
    • Ringshausen I., Dechow T., Schneller F., et al. Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells. Leukemia 2004, 18(12):1964-1970.
    • (2004) Leukemia , vol.18 , Issue.12 , pp. 1964-1970
    • Ringshausen, I.1    Dechow, T.2    Schneller, F.3
  • 107
    • 3242703539 scopus 로고    scopus 로고
    • VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia
    • Lee Y.K., Bone N.D., Strege A.K., et al. VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia. Blood 2004, 104(3):788-794.
    • (2004) Blood , vol.104 , Issue.3 , pp. 788-794
    • Lee, Y.K.1    Bone, N.D.2    Strege, A.K.3
  • 108
    • 17144383220 scopus 로고    scopus 로고
    • VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance
    • Lee Y.K., Shanafelt T.D., Bone N.D., et al. VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance. Leukemia 2005, 19(4):513-523.
    • (2005) Leukemia , vol.19 , Issue.4 , pp. 513-523
    • Lee, Y.K.1    Shanafelt, T.D.2    Bone, N.D.3
  • 109
    • 79960735663 scopus 로고    scopus 로고
    • Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cells
    • Gehrke I., Gandhirajan R.K., Poll-Wolbeck S.J., et al. Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cells. Mol Med 2011, 17(7-8):619-627.
    • (2011) Mol Med , vol.17 , Issue.7-8 , pp. 619-627
    • Gehrke, I.1    Gandhirajan, R.K.2    Poll-Wolbeck, S.J.3
  • 110
    • 77957366071 scopus 로고    scopus 로고
    • Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription
    • Buggins A.G., Pepper C., Patten P.E., et al. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription. Cancer Res 2010, 70(19):7523-7533.
    • (2010) Cancer Res , vol.70 , Issue.19 , pp. 7523-7533
    • Buggins, A.G.1    Pepper, C.2    Patten, P.E.3
  • 111
    • 80052074643 scopus 로고    scopus 로고
    • Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1
    • Herishanu Y., Gibellini F., Njuguna N., et al. Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1. Leuk Lymphoma 2011, 52(9):1758-1769.
    • (2011) Leuk Lymphoma , vol.52 , Issue.9 , pp. 1758-1769
    • Herishanu, Y.1    Gibellini, F.2    Njuguna, N.3
  • 112
    • 11144296197 scopus 로고    scopus 로고
    • How do follicular dendritic cells interact intimately with B cells in the germinal centre?
    • Park C.S., Choi Y.S. How do follicular dendritic cells interact intimately with B cells in the germinal centre?. Immunology 2005, 114(1):2-10.
    • (2005) Immunology , vol.114 , Issue.1 , pp. 2-10
    • Park, C.S.1    Choi, Y.S.2
  • 113
    • 0021051788 scopus 로고
    • Routine immunofluorescent and histochemical analysis of bone marrow involvement of lymphoma/leukaemia: the use of cryostat sections
    • Chilosi M., Pizzolo G., Fiore-Donati L., et al. Routine immunofluorescent and histochemical analysis of bone marrow involvement of lymphoma/leukaemia: the use of cryostat sections. Br J Cancer 1983, 48(6):763-775.
    • (1983) Br J Cancer , vol.48 , Issue.6 , pp. 763-775
    • Chilosi, M.1    Pizzolo, G.2    Fiore-Donati, L.3
  • 114
    • 0023869947 scopus 로고
    • Immunoarchitecture of the " pseudofollicles" of well-differentiated (small) lymphocytic lymphoma: a comparison with true follicles
    • Ratech H., Sheibani K., Nathwani B.N., et al. Immunoarchitecture of the " pseudofollicles" of well-differentiated (small) lymphocytic lymphoma: a comparison with true follicles. Hum Pathol 1988, 19(1):89-94.
    • (1988) Hum Pathol , vol.19 , Issue.1 , pp. 89-94
    • Ratech, H.1    Sheibani, K.2    Nathwani, B.N.3
  • 115
    • 0028335475 scopus 로고
    • Proliferation centres in B-cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study
    • Schmid C., Isaacson P.G. Proliferation centres in B-cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study. Histopathology 1994, 24(5):445-451.
    • (1994) Histopathology , vol.24 , Issue.5 , pp. 445-451
    • Schmid, C.1    Isaacson, P.G.2
  • 116
    • 0021837824 scopus 로고
    • Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia
    • Chilosi M., Pizzolo G., Caligaris-Cappio F., et al. Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia. Cancer 1985, 56(2):328-332.
    • (1985) Cancer , vol.56 , Issue.2 , pp. 328-332
    • Chilosi, M.1    Pizzolo, G.2    Caligaris-Cappio, F.3
  • 117
    • 0036720390 scopus 로고    scopus 로고
    • Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1
    • Pedersen I.M., Kitada S., Leoni L.M., et al. Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood 2002, 100(5):1795-1801.
    • (2002) Blood , vol.100 , Issue.5 , pp. 1795-1801
    • Pedersen, I.M.1    Kitada, S.2    Leoni, L.M.3
  • 118
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger J.A., Tsukada N., Burger M., et al. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood 2000, 96(8):2655-2663.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3
  • 119
    • 0036464610 scopus 로고    scopus 로고
    • Distinctive features of " nurselike" cells that differentiate in the context of chronic lymphocytic leukemia
    • Tsukada N., Burger J.A., Zvaifler N.J., et al. Distinctive features of " nurselike" cells that differentiate in the context of chronic lymphocytic leukemia. Blood 2002, 99(3):1030-1037.
    • (2002) Blood , vol.99 , Issue.3 , pp. 1030-1037
    • Tsukada, N.1    Burger, J.A.2    Zvaifler, N.J.3
  • 120
    • 23044514711 scopus 로고    scopus 로고
    • Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha
    • Nishio M., Endo T., Tsukada N., et al. Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha. Blood 2005, 106(3):1012-1020.
    • (2005) Blood , vol.106 , Issue.3 , pp. 1012-1020
    • Nishio, M.1    Endo, T.2    Tsukada, N.3
  • 121
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann B., Gommerman J.L., Vora K., et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001, 293(5537):2111-2114.
    • (2001) Science , vol.293 , Issue.5537 , pp. 2111-2114
    • Schiemann, B.1    Gommerman, J.L.2    Vora, K.3
  • 122
    • 0035803468 scopus 로고    scopus 로고
    • Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen
    • Schneider P., Takatsuka H., Wilson A., et al. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J Exp Med 2001, 194(11):1691-1697.
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1691-1697
    • Schneider, P.1    Takatsuka, H.2    Wilson, A.3
  • 123
    • 0038692705 scopus 로고    scopus 로고
    • BAFF AND APRIL: a tutorial on B cell survival
    • Mackay F., Schneider P., Rennert P., et al. BAFF AND APRIL: a tutorial on B cell survival. Annu Rev Immunol 2003, 21:231-264.
    • (2003) Annu Rev Immunol , vol.21 , pp. 231-264
    • Mackay, F.1    Schneider, P.2    Rennert, P.3
  • 124
    • 9144220762 scopus 로고    scopus 로고
    • Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway
    • Kern C., Cornuel J.F., Billard C., et al. Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood 2004, 103(2):679-688.
    • (2004) Blood , vol.103 , Issue.2 , pp. 679-688
    • Kern, C.1    Cornuel, J.F.2    Billard, C.3
  • 125
    • 0037108558 scopus 로고    scopus 로고
    • Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival
    • Novak A.J., Bram R.J., Kay N.E., et al. Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood 2002, 100(8):2973-2979.
    • (2002) Blood , vol.100 , Issue.8 , pp. 2973-2979
    • Novak, A.J.1    Bram, R.J.2    Kay, N.E.3
  • 126
    • 78650481186 scopus 로고    scopus 로고
    • B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia
    • Zhang W., Kater A.P., Widhopf G.F., et al. B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2010, 107(44):18956-18960.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.44 , pp. 18956-18960
    • Zhang, W.1    Kater, A.P.2    Widhopf, G.F.3
  • 127
    • 84863393559 scopus 로고    scopus 로고
    • Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells
    • Krysov S., Dias S., Paterson A., et al. Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells. Blood 2012, 119(1):170-179.
    • (2012) Blood , vol.119 , Issue.1 , pp. 170-179
    • Krysov, S.1    Dias, S.2    Paterson, A.3
  • 128
    • 17044406054 scopus 로고    scopus 로고
    • CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival
    • Deaglio S., Vaisitti T., Bergui L., et al. CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival. Blood 2005, 105(8):3042-3050.
    • (2005) Blood , vol.105 , Issue.8 , pp. 3042-3050
    • Deaglio, S.1    Vaisitti, T.2    Bergui, L.3
  • 129
    • 0037369284 scopus 로고    scopus 로고
    • CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes
    • Granziero L., Circosta P., Scielzo C., et al. CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes. Blood 2003, 101(5):1962-1969.
    • (2003) Blood , vol.101 , Issue.5 , pp. 1962-1969
    • Granziero, L.1    Circosta, P.2    Scielzo, C.3
  • 130
    • 0035257205 scopus 로고    scopus 로고
    • Lymphocyte traffic control by chemokines
    • Moser B., Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001, 2(2):123-128.
    • (2001) Nat Immunol , vol.2 , Issue.2 , pp. 123-128
    • Moser, B.1    Loetscher, P.2
  • 131
    • 0033485625 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
    • Burger J.A., Burger M., Kipps T.J. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 1999, 94(11):3658-3667.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3658-3667
    • Burger, J.A.1    Burger, M.2    Kipps, T.J.3
  • 132
    • 0344577963 scopus 로고    scopus 로고
    • Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)
    • Mohle R., Failenschmid C., Bautz F., et al. Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1). Leukemia 1999, 13(12):1954-1959.
    • (1999) Leukemia , vol.13 , Issue.12 , pp. 1954-1959
    • Mohle, R.1    Failenschmid, C.2    Bautz, F.3
  • 133
    • 33646433940 scopus 로고    scopus 로고
    • ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)
    • Richardson S.J., Matthews C., Catherwood M.A., et al. ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood 2006, 107(9):3584-3592.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3584-3592
    • Richardson, S.J.1    Matthews, C.2    Catherwood, M.A.3
  • 134
    • 77952419807 scopus 로고    scopus 로고
    • CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells
    • Vaisitti T., Aydin S., Rossi D., et al. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia 2010, 24(5):958-969.
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 958-969
    • Vaisitti, T.1    Aydin, S.2    Rossi, D.3
  • 135
    • 37049023065 scopus 로고    scopus 로고
    • CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential
    • Deaglio S., Vaisitti T., Aydin S., et al. CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential. Blood 2007, 110(12):4012-4021.
    • (2007) Blood , vol.110 , Issue.12 , pp. 4012-4021
    • Deaglio, S.1    Vaisitti, T.2    Aydin, S.3
  • 136
    • 0032545987 scopus 로고    scopus 로고
    • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
    • Gunn M.D., Ngo V.N., Ansel K.M., et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 1998, 391(6669):799-803.
    • (1998) Nature , vol.391 , Issue.6669 , pp. 799-803
    • Gunn, M.D.1    Ngo, V.N.2    Ansel, K.M.3
  • 137
    • 36148930616 scopus 로고    scopus 로고
    • Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B cell chronic lymphocytic leukemia
    • Burkle A., Niedermeier M., Schmitt-Graff A., et al. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B cell chronic lymphocytic leukemia. Blood 2007, 110(9):3316-3325.
    • (2007) Blood , vol.110 , Issue.9 , pp. 3316-3325
    • Burkle, A.1    Niedermeier, M.2    Schmitt-Graff, A.3
  • 138
    • 35948946952 scopus 로고    scopus 로고
    • Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a
    • Ticchioni M., Essafi M., Jeandel P.Y., et al. Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a. Oncogene 2007, 26(50):7081-7091.
    • (2007) Oncogene , vol.26 , Issue.50 , pp. 7081-7091
    • Ticchioni, M.1    Essafi, M.2    Jeandel, P.Y.3
  • 139
    • 0037034880 scopus 로고    scopus 로고
    • Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
    • Reif K., Ekland E.H., Ohl L., et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 2002, 416(6876):94-99.
    • (2002) Nature , vol.416 , Issue.6876 , pp. 94-99
    • Reif, K.1    Ekland, E.H.2    Ohl, L.3
  • 140
    • 0037089334 scopus 로고    scopus 로고
    • The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes
    • Till K.J., Lin K., Zuzel M., et al. The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. Blood 2002, 99(8):2977-2984.
    • (2002) Blood , vol.99 , Issue.8 , pp. 2977-2984
    • Till, K.J.1    Lin, K.2    Zuzel, M.3
  • 141
    • 33750825517 scopus 로고    scopus 로고
    • CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23+CD5+ B cells
    • Chunsong H., Yuling H., Li W., et al. CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23+CD5+ B cells. J Immunol 2006, 177(10):6713-6722.
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 6713-6722
    • Chunsong, H.1    Yuling, H.2    Li, W.3
  • 142
    • 3442891136 scopus 로고    scopus 로고
    • Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination
    • Lopez-Giral S., Quintana N.E., Cabrerizo M., et al. Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. J Leukoc Biol 2004, 76(2):462-471.
    • (2004) J Leukoc Biol , vol.76 , Issue.2 , pp. 462-471
    • Lopez-Giral, S.1    Quintana, N.E.2    Cabrerizo, M.3
  • 144
    • 64049093376 scopus 로고    scopus 로고
    • High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
    • Burger J.A., Quiroga M.P., Hartmann E., et al. High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. Blood 2009, 113(13):3050-3058.
    • (2009) Blood , vol.113 , Issue.13 , pp. 3050-3058
    • Burger, J.A.1    Quiroga, M.P.2    Hartmann, E.3
  • 145
    • 65949106828 scopus 로고    scopus 로고
    • CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival
    • Zucchetto A., Benedetti D., Tripodo C., et al. CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival. Cancer Res 2009, 69(9):4001-4009.
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 4001-4009
    • Zucchetto, A.1    Benedetti, D.2    Tripodo, C.3
  • 146
    • 79551629508 scopus 로고    scopus 로고
    • CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia
    • Sivina M., Hartmann E., Kipps T.J., et al. CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia. Blood 2011, 117(5):1662-1669.
    • (2011) Blood , vol.117 , Issue.5 , pp. 1662-1669
    • Sivina, M.1    Hartmann, E.2    Kipps, T.J.3
  • 147
    • 60149094697 scopus 로고    scopus 로고
    • Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia
    • Hewamana S., Lin T.T., Rowntree C., et al. Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia. J Clin Oncol 2009, 27(5):763-769.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 763-769
    • Hewamana, S.1    Lin, T.T.2    Rowntree, C.3
  • 148
    • 61849126233 scopus 로고    scopus 로고
    • Fine tuning the immune response with PI3K
    • Fruman D.A., Bismuth G. Fine tuning the immune response with PI3K. Immunol Rev 2009, 228(1):253-272.
    • (2009) Immunol Rev , vol.228 , Issue.1 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 149
    • 77955486127 scopus 로고    scopus 로고
    • Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia
    • 764.e1-4
    • Cuesta-Mateos C., Lopez-Giral S., Alfonso-Perez M., et al. Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia. Exp Hematol 2010, 38(9):756-764. 764.e1-4.
    • (2010) Exp Hematol , vol.38 , Issue.9 , pp. 756-764
    • Cuesta-Mateos, C.1    Lopez-Giral, S.2    Alfonso-Perez, M.3
  • 150
    • 0027239823 scopus 로고
    • Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • Hanada M., Delia D., Aiello A., et al. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 1993, 82(6):1820-1828.
    • (1993) Blood , vol.82 , Issue.6 , pp. 1820-1828
    • Hanada, M.1    Delia, D.2    Aiello, A.3
  • 151
    • 0032079746 scopus 로고    scopus 로고
    • Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses
    • Kitada S., Andersen J., Akar S., et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood 1998, 91(9):3379-3389.
    • (1998) Blood , vol.91 , Issue.9 , pp. 3379-3389
    • Kitada, S.1    Andersen, J.2    Akar, S.3
  • 152
    • 79957514594 scopus 로고    scopus 로고
    • High rate of neoplastic cells with genetic abnormalities in proliferation centers of chronic lymphocytic leukemia
    • Balogh Z., Reiniger L., Rajnai H., et al. High rate of neoplastic cells with genetic abnormalities in proliferation centers of chronic lymphocytic leukemia. Leuk Lymphoma 2011, 52(6):1080-1084.
    • (2011) Leuk Lymphoma , vol.52 , Issue.6 , pp. 1080-1084
    • Balogh, Z.1    Reiniger, L.2    Rajnai, H.3
  • 153
    • 0029038529 scopus 로고
    • Overexpression of cyclin D2 in chronic B-cell malignancies
    • Delmer A., Ajchenbaum-Cymbalista F., Tang R., et al. Overexpression of cyclin D2 in chronic B-cell malignancies. Blood 1995, 85(10):2870-2876.
    • (1995) Blood , vol.85 , Issue.10 , pp. 2870-2876
    • Delmer, A.1    Ajchenbaum-Cymbalista, F.2    Tang, R.3
  • 154
    • 10144241685 scopus 로고    scopus 로고
    • Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes
    • Solvason N., Wu W.W., Kabra N., et al. Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes. J Exp Med 1996, 184(2):407-417.
    • (1996) J Exp Med , vol.184 , Issue.2 , pp. 407-417
    • Solvason, N.1    Wu, W.W.2    Kabra, N.3
  • 155
    • 80054969575 scopus 로고    scopus 로고
    • Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma
    • Igawa T., Sato Y., Takata K., et al. Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma. Cancer Sci 2011, 102(11):2103-2107.
    • (2011) Cancer Sci , vol.102 , Issue.11 , pp. 2103-2107
    • Igawa, T.1    Sato, Y.2    Takata, K.3
  • 156
    • 0037076279 scopus 로고    scopus 로고
    • Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
    • Bichi R., Shinton S.A., Martin E.S., et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A 2002, 99(10):6955-6960.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.10 , pp. 6955-6960
    • Bichi, R.1    Shinton, S.A.2    Martin, E.S.3
  • 157
    • 65549151712 scopus 로고    scopus 로고
    • E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
    • Gorgun G., Ramsay A.G., Holderried T.A., et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci U S A 2009, 106(15):6250-6255.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.15 , pp. 6250-6255
    • Gorgun, G.1    Ramsay, A.G.2    Holderried, T.A.3
  • 158
    • 0026570636 scopus 로고
    • The NZB mouse as a model for chronic lymphocytic leukemia
    • Phillips J.A., Mehta K., Fernandez C., et al. The NZB mouse as a model for chronic lymphocytic leukemia. Cancer Res 1992, 52(2):437-443.
    • (1992) Cancer Res , vol.52 , Issue.2 , pp. 437-443
    • Phillips, J.A.1    Mehta, K.2    Fernandez, C.3
  • 159
    • 34250013672 scopus 로고    scopus 로고
    • Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
    • Raveche E.S., Salerno E., Scaglione B.J., et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 2007, 109(12):5079-5086.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5079-5086
    • Raveche, E.S.1    Salerno, E.2    Scaglione, B.J.3
  • 160
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin G.A., Dumitru C.D., Shimizu M., et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99(24):15524-15529.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.24 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 161
    • 73649116987 scopus 로고    scopus 로고
    • The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
    • Klein U., Lia M., Crespo M., et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010, 17(1):28-40.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 28-40
    • Klein, U.1    Lia, M.2    Crespo, M.3
  • 162
    • 7244229674 scopus 로고    scopus 로고
    • Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus
    • Wen X., Zhang D., Kikuchi Y., et al. Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. Eur J Immunol 2004, 34(10):2740-2749.
    • (2004) Eur J Immunol , vol.34 , Issue.10 , pp. 2740-2749
    • Wen, X.1    Zhang, D.2    Kikuchi, Y.3
  • 163
    • 9344245131 scopus 로고    scopus 로고
    • TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice
    • Zapata J.M., Krajewska M., Morse H.C., et al. TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. Proc Natl Acad Sci U S A 2004, 101(47):16600-16605.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.47 , pp. 16600-16605
    • Zapata, J.M.1    Krajewska, M.2    Morse, H.C.3
  • 164
    • 77949890578 scopus 로고    scopus 로고
    • A novel Rag2-/-gammac-/-xenograft model of human CLL
    • Bertilaccio M.T., Scielzo C., Simonetti G., et al. A novel Rag2-/-gammac-/-xenograft model of human CLL. Blood 2010, 115(8):1605-1609.
    • (2010) Blood , vol.115 , Issue.8 , pp. 1605-1609
    • Bertilaccio, M.T.1    Scielzo, C.2    Simonetti, G.3
  • 165
    • 84875802742 scopus 로고    scopus 로고
    • The NSG - human CLL xenograft model recapitulates the human lymph node microenvironment in regards to B-cell activation and tumor proliferation. ASH Annual Meeting Abstracts
    • [abstract no. 973]
    • Sun X., Herman S.E.M., Hsieh M.M., et al. The NSG - human CLL xenograft model recapitulates the human lymph node microenvironment in regards to B-cell activation and tumor proliferation. ASH Annual Meeting Abstracts. Blood 2011, 118(21). [abstract no. 973].
    • (2011) Blood , vol.118 , Issue.21
    • Sun, X.1    Herman, S.E.M.2    Hsieh, M.M.3
  • 166
    • 34548788589 scopus 로고    scopus 로고
    • A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease
    • Durig J., Ebeling P., Grabellus F., et al. A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease. Cancer Res 2007, 67(18):8653-8661.
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8653-8661
    • Durig, J.1    Ebeling, P.2    Grabellus, F.3
  • 167
    • 84875775573 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor, PCI-32765, inhibits activation and proliferation of human chronic lymphocytic leukemia cells in the NSG xenograph mouse model of the tissue microenvironment. ASH Annual Meeting Abstracts
    • [abstract no. 596]
    • Herman S.E., Sun X., Buggy J.J., et al. The Bruton tyrosine kinase inhibitor, PCI-32765, inhibits activation and proliferation of human chronic lymphocytic leukemia cells in the NSG xenograph mouse model of the tissue microenvironment. ASH Annual Meeting Abstracts. Blood 2011, 118(21). [abstract no. 596].
    • (2011) Blood , vol.118 , Issue.21
    • Herman, S.E.1    Sun, X.2    Buggy, J.J.3
  • 168
    • 79959533404 scopus 로고    scopus 로고
    • Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model
    • Aydin S., Grabellus F., Eisele L., et al. Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model. Eur J Haematol 2011, 87(1):10-19.
    • (2011) Eur J Haematol , vol.87 , Issue.1 , pp. 10-19
    • Aydin, S.1    Grabellus, F.2    Eisele, L.3
  • 169
    • 77957367164 scopus 로고    scopus 로고
    • The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia - CXCR4 antagonists as potential adjuvants for monoclonal antibodies
    • Buchner M., Brantner P., Stickel N., et al. The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia - CXCR4 antagonists as potential adjuvants for monoclonal antibodies. Br J Haematol 2010, 151(2):167-178.
    • (2010) Br J Haematol , vol.151 , Issue.2 , pp. 167-178
    • Buchner, M.1    Brantner, P.2    Stickel, N.3
  • 170
    • 84855463714 scopus 로고    scopus 로고
    • Preliminary results from a phase I dose escalation study to determine the maximum tolerated dose of plerixafor in combination with rituximab in patients with relapsed chronic lymphocytic leukemia. ASH Annual Meeting Abstracts
    • [abstract no. 2450]
    • Andritsos L., Byrd J.C., Jones J.A., et al. Preliminary results from a phase I dose escalation study to determine the maximum tolerated dose of plerixafor in combination with rituximab in patients with relapsed chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. Blood 2010, 116(21). [abstract no. 2450].
    • (2010) Blood , vol.116 , Issue.21
    • Andritsos, L.1    Byrd, J.C.2    Jones, J.A.3
  • 171
    • 84859642220 scopus 로고    scopus 로고
    • Phase 1b trial of atacicept, a recombinant protein binding BLyS and APRIL, in patients with chronic lymphocytic leukemia
    • Kofler D.M., Gawlik B.B., Elter T., et al. Phase 1b trial of atacicept, a recombinant protein binding BLyS and APRIL, in patients with chronic lymphocytic leukemia. Leukemia 2012, 26(4):841-844.
    • (2012) Leukemia , vol.26 , Issue.4 , pp. 841-844
    • Kofler, D.M.1    Gawlik, B.B.2    Elter, T.3
  • 172
    • 84875199467 scopus 로고    scopus 로고
    • The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (PCI-32765) promotes high response rate, durable remissions, and is tolerable in treatment naive (TN) and relapsed or refractory (RR) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) patients including patients with high-risk (HR) disease: new and updated results of 116 patients in a phase Ib/II study. A
    • [abstract no. 189]
    • Byrd J.C., Furman R.R., Coutre S., et al. The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (PCI-32765) promotes high response rate, durable remissions, and is tolerable in treatment naive (TN) and relapsed or refractory (RR) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) patients including patients with high-risk (HR) disease: new and updated results of 116 patients in a phase Ib/II study. ASH Annual Meeting Abstracts. Blood 2012, 120(21). [abstract no. 189].
    • (2012) Blood , vol.120 , Issue.21
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.3
  • 173
    • 80053079880 scopus 로고    scopus 로고
    • Phase I study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia
    • [abstract no. 6631]
    • Coutre S.E., Byrd J.C., Furman R.R., et al. Phase I study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia. J Clin Oncol 2011, 29(Suppl). [abstract no. 6631].
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Coutre, S.E.1    Byrd, J.C.2    Furman, R.R.3
  • 174
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg J.W., Sharman J., Sweetenham J., et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010, 115(13):2578-2585.
    • (2010) Blood , vol.115 , Issue.13 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3
  • 175
    • 84858636448 scopus 로고    scopus 로고
    • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
    • de Rooij M.F., Kuil A., Geest C.R., et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 2012, 119(11):2590-2594.
    • (2012) Blood , vol.119 , Issue.11 , pp. 2590-2594
    • de Rooij, M.F.1    Kuil, A.2    Geest, C.R.3
  • 176
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader S., Chen S.S., Buggy J.J., et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 2012, 119(5):1182-1189.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1182-1189
    • Ponader, S.1    Chen, S.S.2    Buggy, J.J.3
  • 177
    • 34548097263 scopus 로고    scopus 로고
    • The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib
    • Hantschel O., Rix U., Schmidt U., et al. The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A 2007, 104(33):13283-13288.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.33 , pp. 13283-13288
    • Hantschel, O.1    Rix, U.2    Schmidt, U.3
  • 178
    • 55949135223 scopus 로고    scopus 로고
    • Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro
    • Amrein L., Hernandez T.A., Ferrario C., et al. Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro. Br J Haematol 2008, 143(5):698-706.
    • (2008) Br J Haematol , vol.143 , Issue.5 , pp. 698-706
    • Amrein, L.1    Hernandez, T.A.2    Ferrario, C.3
  • 179
    • 51649130092 scopus 로고    scopus 로고
    • The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes
    • Veldurthy A., Patz M., Hagist S., et al. The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood 2008, 112(4):1443-1452.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1443-1452
    • Veldurthy, A.1    Patz, M.2    Hagist, S.3
  • 180
    • 79953072735 scopus 로고    scopus 로고
    • Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals
    • McCaig A.M., Cosimo E., Leach M.T., et al. Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals. Br J Haematol 2011, 153(2):199-211.
    • (2011) Br J Haematol , vol.153 , Issue.2 , pp. 199-211
    • McCaig, A.M.1    Cosimo, E.2    Leach, M.T.3
  • 181
    • 79955513805 scopus 로고    scopus 로고
    • Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia
    • Amrein P.C., Attar E.C., Takvorian T., et al. Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res 2011, 17(9):2977-2986.
    • (2011) Clin Cancer Res , vol.17 , Issue.9 , pp. 2977-2986
    • Amrein, P.C.1    Attar, E.C.2    Takvorian, T.3
  • 182
    • 77952887713 scopus 로고    scopus 로고
    • The SYK tyrosine kinase: a crucial player in diverse biological functions
    • Mocsai A., Ruland J., Tybulewicz V.L. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 2010, 10(6):387-402.
    • (2010) Nat Rev Immunol , vol.10 , Issue.6 , pp. 387-402
    • Mocsai, A.1    Ruland, J.2    Tybulewicz, V.L.3
  • 183
    • 64849113027 scopus 로고    scopus 로고
    • Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
    • Gobessi S., Laurenti L., Longo P.G., et al. Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells. Leukemia 2009, 23(4):686-697.
    • (2009) Leukemia , vol.23 , Issue.4 , pp. 686-697
    • Gobessi, S.1    Laurenti, L.2    Longo, P.G.3
  • 184
    • 84863781222 scopus 로고    scopus 로고
    • Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration
    • Hoellenriegel J., Coffey G.P., Sinha U., et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia 2012, 26(7):1576-1583.
    • (2012) Leukemia , vol.26 , Issue.7 , pp. 1576-1583
    • Hoellenriegel, J.1    Coffey, G.P.2    Sinha, U.3
  • 185
    • 78649759107 scopus 로고    scopus 로고
    • The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling
    • Suljagic M., Longo P.G., Bennardo S., et al. The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood 2010, 116(23):4894-4905.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4894-4905
    • Suljagic, M.1    Longo, P.G.2    Bennardo, S.3
  • 186
    • 84875767229 scopus 로고    scopus 로고
    • Fostamatinib inhibits BCR signaling, and reduces tumor cell activation and proliferation in patients with relapsed refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts
    • [abstract no. 2882]
    • Herman S.E., Barr P.M., McAuley E.M., et al. Fostamatinib inhibits BCR signaling, and reduces tumor cell activation and proliferation in patients with relapsed refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. Blood 2012, 120(21). [abstract no. 2882].
    • (2012) Blood , vol.120 , Issue.21
    • Herman, S.E.1    Barr, P.M.2    McAuley, E.M.3
  • 187
    • 84872011053 scopus 로고    scopus 로고
    • Kinase inhibitors: a new class of antirheumatic drugs
    • Kyttaris V.C. Kinase inhibitors: a new class of antirheumatic drugs. Drug Des Devel Ther 2012, 6:245-250.
    • (2012) Drug Des Devel Ther , vol.6 , pp. 245-250
    • Kyttaris, V.C.1
  • 188
    • 84860433198 scopus 로고    scopus 로고
    • Bruton tyrosine kinase (BTK) and its role in B-cell malignancy
    • Buggy J.J., Elias L. Bruton tyrosine kinase (BTK) and its role in B-cell malignancy. Int Rev Immunol 2012, 31(2):119-132.
    • (2012) Int Rev Immunol , vol.31 , Issue.2 , pp. 119-132
    • Buggy, J.J.1    Elias, L.2
  • 189
    • 0027399081 scopus 로고
    • Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
    • Tsukada S., Saffran D.C., Rawlings D.J., et al. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 1993, 72(2):279-290.
    • (1993) Cell , vol.72 , Issue.2 , pp. 279-290
    • Tsukada, S.1    Saffran, D.C.2    Rawlings, D.J.3
  • 190
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman S.E., Gordon A.L., Hertlein E., et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 2011, 117(23):6287-6296.
    • (2011) Blood , vol.117 , Issue.23 , pp. 6287-6296
    • Herman, S.E.1    Gordon, A.L.2    Hertlein, E.3
  • 191
    • 84871806385 scopus 로고    scopus 로고
    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    • Advani R.H., Buggy J.J., Sharman J.P., et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol 2012, 31(1):88-94.
    • (2012) J Clin Oncol , vol.31 , Issue.1 , pp. 88-94
    • Advani, R.H.1    Buggy, J.J.2    Sharman, J.P.3
  • 192
    • 77957201023 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman S.E., Gordon A.L., Wagner A.J., et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 2010, 116(12):2078-2088.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2078-2088
    • Herman, S.E.1    Gordon, A.L.2    Wagner, A.J.3
  • 193
    • 84859402041 scopus 로고    scopus 로고
    • ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress
    • Chapman C.M., Sun X., Roschewski M., et al. ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res 2012, 18(7):1979-1991.
    • (2012) Clin Cancer Res , vol.18 , Issue.7 , pp. 1979-1991
    • Chapman, C.M.1    Sun, X.2    Roschewski, M.3
  • 194
    • 79955977369 scopus 로고    scopus 로고
    • The role of phosphatidylinositol 3-kinase-delta in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia
    • Herman S.E., Lapalombella R., Gordon A.L., et al. The role of phosphatidylinositol 3-kinase-delta in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia. Blood 2011, 117(16):4323-4327.
    • (2011) Blood , vol.117 , Issue.16 , pp. 4323-4327
    • Herman, S.E.1    Lapalombella, R.2    Gordon, A.L.3
  • 195
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel J., Meadows S.A., Sivina M., et al. The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011, 118(13):3603-3612.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3
  • 196
    • 78751553221 scopus 로고    scopus 로고
    • CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • Lannutti B.J., Meadows S.A., Herman S.E., et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 2011, 117(2):591-594.
    • (2011) Blood , vol.117 , Issue.2 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Herman, S.E.3
  • 197
    • 3042857530 scopus 로고    scopus 로고
    • PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation
    • Plate J.M. PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation. Leuk Lymphoma 2004, 45(8):1519-1529.
    • (2004) Leuk Lymphoma , vol.45 , Issue.8 , pp. 1519-1529
    • Plate, J.M.1
  • 198
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone M.H., Roy N., Stennicke H.R., et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282(5392):1318-1321.
    • (1998) Science , vol.282 , Issue.5392 , pp. 1318-1321
    • Cardone, M.H.1    Roy, N.2    Stennicke, H.R.3
  • 199
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta S.R., Dudek H., Tao X., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91(2):231-241.
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 200
    • 25444524850 scopus 로고    scopus 로고
    • Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
    • Hahn-Windgassen A., Nogueira V., Chen C.C., et al. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 2005, 280(37):32081-32089.
    • (2005) J Biol Chem , vol.280 , Issue.37 , pp. 32081-32089
    • Hahn-Windgassen, A.1    Nogueira, V.2    Chen, C.C.3
  • 201
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A., Bonni A., Zigmond M.J., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96(6):857-868.
    • (1999) Cell , vol.96 , Issue.6 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 202
    • 77954615408 scopus 로고    scopus 로고
    • MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
    • Hirai H., Sootome H., Nakatsuru Y., et al. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 2010, 9(7):1956-1967.
    • (2010) Mol Cancer Ther , vol.9 , Issue.7 , pp. 1956-1967
    • Hirai, H.1    Sootome, H.2    Nakatsuru, Y.3
  • 203
    • 60349088457 scopus 로고    scopus 로고
    • Perifosine: update on a novel Akt inhibitor
    • Gills J.J., Dennis P.A. Perifosine: update on a novel Akt inhibitor. Curr Oncol Rep 2009, 11(2):102-110.
    • (2009) Curr Oncol Rep , vol.11 , Issue.2 , pp. 102-110
    • Gills, J.J.1    Dennis, P.A.2
  • 204
    • 0025734876 scopus 로고
    • Inhibition of T and B lymphocyte proliferation by rapamycin
    • Kay J.E., Kromwel L., Doe S.E., et al. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 1991, 72(4):544-549.
    • (1991) Immunology , vol.72 , Issue.4 , pp. 544-549
    • Kay, J.E.1    Kromwel, L.2    Doe, S.E.3
  • 205
    • 0037207525 scopus 로고    scopus 로고
    • Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
    • Decker T., Hipp S., Ringshausen I., et al. Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood 2003, 101(1):278-285.
    • (2003) Blood , vol.101 , Issue.1 , pp. 278-285
    • Decker, T.1    Hipp, S.2    Ringshausen, I.3
  • 206
    • 59049091983 scopus 로고    scopus 로고
    • A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL
    • Decker T., Sandherr M., Goetze K., et al. A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL. Ann Hematol 2009, 88(3):221-227.
    • (2009) Ann Hematol , vol.88 , Issue.3 , pp. 221-227
    • Decker, T.1    Sandherr, M.2    Goetze, K.3
  • 207
    • 77951450222 scopus 로고    scopus 로고
    • The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation
    • Zent C.S., LaPlant B.R., Johnston P.B., et al. The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation. Cancer 2010, 116(9):2201-2207.
    • (2010) Cancer , vol.116 , Issue.9 , pp. 2201-2207
    • Zent, C.S.1    LaPlant, B.R.2    Johnston, P.B.3
  • 208
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B., Eisen T., Stadler W.M., et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356(2):125-134.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 209
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet J.M., Ricci S., Mazzaferro V., et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359(4):378-390.
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 210
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64(19):7099-7109.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 211
    • 78751684268 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib
    • Messmer D., Fecteau J.F., O'Hayre M., et al. Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood 2011, 117(3):882-889.
    • (2011) Blood , vol.117 , Issue.3 , pp. 882-889
    • Messmer, D.1    Fecteau, J.F.2    O'Hayre, M.3
  • 212
    • 79955809893 scopus 로고    scopus 로고
    • Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1
    • Huber S., Oelsner M., Decker T., et al. Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia 2011, 25(5):838-847.
    • (2011) Leukemia , vol.25 , Issue.5 , pp. 838-847
    • Huber, S.1    Oelsner, M.2    Decker, T.3
  • 213
    • 84857007592 scopus 로고    scopus 로고
    • Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1)
    • Fecteau J.F., Bharati I.S., O'Hayre M., et al. Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1). Mol Med 2012, 18(1):19-28.
    • (2012) Mol Med , vol.18 , Issue.1 , pp. 19-28
    • Fecteau, J.F.1    Bharati, I.S.2    O'Hayre, M.3
  • 214
    • 84862024500 scopus 로고    scopus 로고
    • Sorafenib targets BCR kinases and blocks migratory and microenvironmental survival signals in CLL cells
    • Lopez-Guerra M., Xargay-Torrent S., Perez-Galan P., et al. Sorafenib targets BCR kinases and blocks migratory and microenvironmental survival signals in CLL cells. Leukemia 2012, 26(6):1429-1432.
    • (2012) Leukemia , vol.26 , Issue.6 , pp. 1429-1432
    • Lopez-Guerra, M.1    Xargay-Torrent, S.2    Perez-Galan, P.3
  • 215
    • 0032755034 scopus 로고    scopus 로고
    • Antisense-mediated suppression of Bcl-2 highlights its pivotal role in failed apoptosis in B-cell chronic lymphocytic leukaemia
    • Pepper C., Thomas A., Hoy T., et al. Antisense-mediated suppression of Bcl-2 highlights its pivotal role in failed apoptosis in B-cell chronic lymphocytic leukaemia. Br J Haematol 1999, 107(3):611-615.
    • (1999) Br J Haematol , vol.107 , Issue.3 , pp. 611-615
    • Pepper, C.1    Thomas, A.2    Hoy, T.3
  • 216
    • 32944475363 scopus 로고    scopus 로고
    • Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia
    • O'Brien S.M., Cunningham C.C., Golenkov A.K., et al. Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia. J Clin Oncol 2005, 23(30):7697-7702.
    • (2005) J Clin Oncol , vol.23 , Issue.30 , pp. 7697-7702
    • O'Brien, S.M.1    Cunningham, C.C.2    Golenkov, A.K.3
  • 217
    • 34047217206 scopus 로고    scopus 로고
    • Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
    • O'Brien S., Moore J.O., Boyd T.E., et al. Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 2007, 25(9):1114-1120.
    • (2007) J Clin Oncol , vol.25 , Issue.9 , pp. 1114-1120
    • O'Brien, S.1    Moore, J.O.2    Boyd, T.E.3
  • 218
    • 70449723145 scopus 로고    scopus 로고
    • 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen
    • O'Brien S., Moore J.O., Boyd T.E., et al. 5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen. J Clin Oncol 2009, 27(31):5208-5212.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5208-5212
    • O'Brien, S.1    Moore, J.O.2    Boyd, T.E.3
  • 219
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    • Nguyen M., Marcellus R.C., Roulston A., et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A 2007, 104(49):19512-19517.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.49 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3
  • 220
    • 58849164097 scopus 로고    scopus 로고
    • Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
    • O'Brien S.M., Claxton D.F., Crump M., et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 2009, 113(2):299-305.
    • (2009) Blood , vol.113 , Issue.2 , pp. 299-305
    • O'Brien, S.M.1    Claxton, D.F.2    Crump, M.3
  • 221
    • 66149147044 scopus 로고    scopus 로고
    • Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
    • Vogler M., Butterworth M., Majid A., et al. Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood 2009, 113(18):4403-4413.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4403-4413
    • Vogler, M.1    Butterworth, M.2    Majid, A.3
  • 222
    • 70450265383 scopus 로고    scopus 로고
    • The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia
    • Mason K.D., Khaw S.L., Rayeroux K.C., et al. The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia. Leukemia 2009, 23(11):2034-2041.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2034-2041
    • Mason, K.D.1    Khaw, S.L.2    Rayeroux, K.C.3
  • 223
    • 84863116430 scopus 로고    scopus 로고
    • Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease
    • Roberts A.W., Seymour J.F., Brown J.R., et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol 2012, 30(5):488-496.
    • (2012) J Clin Oncol , vol.30 , Issue.5 , pp. 488-496
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3
  • 224
    • 59449095496 scopus 로고    scopus 로고
    • AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
    • Balakrishnan K., Burger J.A., Wierda W.G., et al. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 2009, 113(1):149-153.
    • (2009) Blood , vol.113 , Issue.1 , pp. 149-153
    • Balakrishnan, K.1    Burger, J.A.2    Wierda, W.G.3
  • 225
    • 37049007709 scopus 로고    scopus 로고
    • AT-101, a small molecule Bcl-2 antagonist, in treatment naïve CLL patients (pts) with high risk features; preliminary results from an ongoing phase I trial. 2006 ASCO Annual Meeting Proceedings Part I
    • James D.F., Castro J.E., Loria O., et al. AT-101, a small molecule Bcl-2 antagonist, in treatment naïve CLL patients (pts) with high risk features; preliminary results from an ongoing phase I trial. 2006 ASCO Annual Meeting Proceedings Part I. J Clin Oncol 2006, 24(18S):6605.
    • (2006) J Clin Oncol , vol.24 , Issue.18 S , pp. 6605
    • James, D.F.1    Castro, J.E.2    Loria, O.3
  • 226
    • 33749252583 scopus 로고    scopus 로고
    • Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
    • Eckelman B.P., Salvesen G.S., Scott F.L. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 2006, 7(10):988-994.
    • (2006) EMBO Rep , vol.7 , Issue.10 , pp. 988-994
    • Eckelman, B.P.1    Salvesen, G.S.2    Scott, F.L.3
  • 227
    • 78650388973 scopus 로고    scopus 로고
    • Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis
    • Frenzel L.P., Patz M., Pallasch C.P., et al. Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis. Br J Haematol 2011, 152(2):191-200.
    • (2011) Br J Haematol , vol.152 , Issue.2 , pp. 191-200
    • Frenzel, L.P.1    Patz, M.2    Pallasch, C.P.3
  • 228
    • 33947243663 scopus 로고    scopus 로고
    • Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study
    • Chanan-Khan A., Miller K.C., Musial L., et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol 2006, 24(34):5343-5349.
    • (2006) J Clin Oncol , vol.24 , Issue.34 , pp. 5343-5349
    • Chanan-Khan, A.1    Miller, K.C.2    Musial, L.3
  • 229
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A., Lee B.N., Schlette E.J., et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008, 111(11):5291-5297.
    • (2008) Blood , vol.111 , Issue.11 , pp. 5291-5297
    • Ferrajoli, A.1    Lee, B.N.2    Schlette, E.J.3
  • 230
    • 80053350801 scopus 로고    scopus 로고
    • Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
    • Badoux X.C., Keating M.J., Wen S., et al. Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia. Blood 2011, 118(13):3489-3498.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3489-3498
    • Badoux, X.C.1    Keating, M.J.2    Wen, S.3
  • 231
    • 45149115902 scopus 로고    scopus 로고
    • Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia
    • Andritsos L.A., Johnson A.J., Lozanski G., et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008, 26(15):2519-2525.
    • (2008) J Clin Oncol , vol.26 , Issue.15 , pp. 2519-2525
    • Andritsos, L.A.1    Johnson, A.J.2    Lozanski, G.3
  • 232
    • 70349150560 scopus 로고    scopus 로고
    • Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia
    • Aue G., Njuguna N., Tian X., et al. Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia. Haematologica 2009, 94(9):1266-1273.
    • (2009) Haematologica , vol.94 , Issue.9 , pp. 1266-1273
    • Aue, G.1    Njuguna, N.2    Tian, X.3
  • 233
    • 79955515528 scopus 로고    scopus 로고
    • Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response
    • Chanan-Khan A., Miller K.C., Lawrence D., et al. Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response. Cancer 2011, 117(10):2127-2135.
    • (2011) Cancer , vol.117 , Issue.10 , pp. 2127-2135
    • Chanan-Khan, A.1    Miller, K.C.2    Lawrence, D.3
  • 234
    • 84865165316 scopus 로고    scopus 로고
    • Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer
    • Ramsay A.G., Clear A.J., Fatah R., et al. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood 2012, 120(7):1412-1421.
    • (2012) Blood , vol.120 , Issue.7 , pp. 1412-1421
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3
  • 235
    • 84870742003 scopus 로고    scopus 로고
    • Correlates of lenalidomide induced immune stimulation and response in CLL: analysis in patients on treatment. Blood (ASH Annual Meeting Abstracts)
    • Aue G., Pittaluga S., Liu D., et al. Correlates of lenalidomide induced immune stimulation and response in CLL: analysis in patients on treatment. Blood (ASH Annual Meeting Abstracts). Blood 2011, 118(21):979.
    • (2011) Blood , vol.118 , Issue.21 , pp. 979
    • Aue, G.1    Pittaluga, S.2    Liu, D.3
  • 236
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
    • Wu L., Adams M., Carter T., et al. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clin Cancer Res 2008, 14(14):4650-4657.
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3
  • 237
    • 84858299100 scopus 로고    scopus 로고
    • Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner
    • Masood A., Chitta K., Paulus A., et al. Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner. Br J Haematol 2011, 10.1111/j.1365-2141.2011.08984.x.
    • (2011) Br J Haematol
    • Masood, A.1    Chitta, K.2    Paulus, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.