Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia

Modern Pathology

Volumn 25, Issue 2, 2012, Pages 246-259

  Biancotto, Angélique ^a   Dagur, Pradeep K ^a   Fuchs, John C ^a   Wiestner, Adrian ^a   Bagwell, C Bruce ^b   McCoy Jr , J Philip ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b Verity Software House Inc   (United States)

Author keywords

chronic lymphocytic leukemia; immunophenotyping; T reg

Indexed keywords

CD39 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR7; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOPHENOTYPING; LYMPHOCYTE FUNCTION; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; CELL SEPARATION; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; PHENOTYPE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84856555531     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.164     Document Type: Article

References (49)

1. Scrivener S, Goddard RV, Kaminski ER, Prentice AG. Abnormal T-cell function in B-cell chronic lymphocytic leukaemia. Leuk Lymphoma 2003;44:383-389. (Pubitemid 36118829)
2. Reyes E, Prieto A, Carrion F, et al. Altered pattern of cytokine production by peripheral blood CD2+ cells from B chronic lymphocytic leukemia patients. Am J Hematol 1998;57:93-100. (Pubitemid 28096529)
3. Dianzani U, Omede P, Marmont F, et al. Expansion of T cells expressing low CD4 or CD8 levels in B-cell chronic lymphocytic leukemia: correlation with disease status and neoplastic phenotype. Blood 1994;83: 2198-2205. (Pubitemid 24112731)
4. Mackus WJ, Frakking FN, Grummels A, et al. Expansion of CMV-specific CD8+CD45RA+CD27T cells in B-cell chronic lymphocytic leukemia. Blood 2003;102: 1057-1063. (Pubitemid 36917804)
5. Beyer M, Kochanek M, Darabi K, et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005; 106:2018-2025. (Pubitemid 41291715)
6. Giannopoulos K, Schmitt M, Wlasiuk P, et al. The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with thalidomide. Leukemia 2008; 22:222-224.
7. Jak M, Mous R, Remmerswaal EB, et al. Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia. Leuk Lymphoma 2009;50:788-801.
8. D'Arena G, Laurenti L, Minervini MM, et al. Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease. Leuk Res 2011;35:363-368.
9. Deutsch V, Perry C, Polliack A. Expansion of regulatory T cells in B chronic lymphocytic leukemia: enhanced 'brakes' on host immunity. Leuk Lymphoma 2009;50: 687-688.
10. Giannopoulos K, Schmitt M, Kowal M, et al. Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia. Oncol Rep 2008;20: 677-682.
11. Banham AH. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. Trends Immunol 2006;27:541-544. (Pubitemid 44780852)
12. Buckner JH, Ziegler SF. Functional analysis of FOXP3. Ann N Y Acad Sci 2008;1143:151-169.
13. Taams LS, Smith J, Rustin MH, et al. Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 2001;31:1122-1131.
14. Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, et al. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 Tcells through the production of IL-10. J Immunol 2001;166:3008-3018. (Pubitemid 33117296)
15. Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000;164:183-190. (Pubitemid 30012989)
16. Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998;188:287-296. (Pubitemid 28357757)
17. Wing K, Larsson P, Sandstrom K, et al. CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses. Immunology 2005;115:516-525. (Pubitemid 41032439)
18. Seddiki N, Santner-Nanan B, Tangye SG, et al. Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 2006;107:2830-2838.
19. Weiss EM, Schmidt A, Vobis D, et al. Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells. J Immunol 2011;187:1684-1691.
20. Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-949. (Pubitemid 39273735)
21. Ding W, Zent CS. Diagnosis and management of autoimmune complications of chronic lymphocytic leukemia/small lymphocytic lymphoma. Clin Adv Hematol Oncol 2007;5:257-261. (Pubitemid 46779469)
22. Bagwell B. Probability State Modeling-a new paradigm for cytometric analysis. In: Litwin Vand Marder P, (eds). Flow Cytometry in Drug Discovery and Development. John Wiley & Sons: Hoboken, 2009, pp 281-302.
23. Bagwell CB. Data analysis through modeling. In: Dean PN (ed). Current Protocol in Cytometry. John Wiley & Sons: Hoboken, 2001; Unit 10.7.1-10.7.20.
24. Bagwell CB. Breaking the dimensionality barrier. Methods Mol Biol 2011;699:31-51.
25. Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999;94:1840-1847. (Pubitemid 29430399)
26. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848-1854. (Pubitemid 29430400)
27. Ahmed R, Bevan MJ, Reiner SL, Fearon DT. The precursors of memory: models and controversies. Nat Rev Immunol 2009;9:662-668.
28. Appay V, van Lier RA, Sallusto F, Roederer M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 2008;73: 975-983.
29. Song K, Rabin RL, Hill BJ, et al. Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans. Proc Natl Acad Sci USA 2005;102:7916-7921. (Pubitemid 40781038)
30. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp 2003;252:67-88.
31. Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol 2002;169:6210-6217. (Pubitemid 36903467)
32. Venken K, Thewissen M, Hellings N, et al. A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses. J Immunol Methods 2007;322:1-11. (Pubitemid 46560587)
33. Hus I, Bojarska-Junak A, Dmoszynska A, et al. ZAP-70 and CD38 expression are independent prognostic factors in patients with B-cell chronic lymphocytic leukaemia and combined analysis improves their predictive value. Folia Histochem Cytobiol 2008;46:147-152.
34. Hus I, Podhorecka M, Bojarska-Junak A, et al. The clinical significance of ZAP-70 and CD38 expression in B-cell chronic lymphocytic leukaemia. Ann Oncol 2006;17:683-690.
35. Schroers R, Griesinger F, Trumper L, et al. Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia. Leukemia 2005;19:750-758. (Pubitemid 40663094)
36. Feuerer M, Hill JA, Mathis D, Benoist C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009;10:689-695.
37. Siegmund K, Ruckert B, Ouaked N, et al. Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells. J Immunol 2009;182:2124-2130.
38. Chaput N, Louafi S, Bardier A, et al. Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue. Gut 2009;58:520-529.
39. Zelenay S, Lopes-Carvalho T, Caramalho I, et al. Foxp3+ CD25-CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA 2005;102:4091-4096. (Pubitemid 40388560)
40. Valmori D, Merlo A, Souleimanian NE, Hesdorffer CS, Ayyoub M. A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest 2005;115: 1953-1962. (Pubitemid 40979735)
41. Tenorio AR, Spritzler J, Martinson J, et al. The effect of aging on T-regulatory cell frequency in HIV infection. Clin Immunol 2009;130:298-303.
42. Hwang KA, Kim HR, Kang I. Aging and human CD4(+) regulatory T cells. Mech Ageing Dev 2009; 130:509-517.
43. Simone R, Zicca A, Saverino D. The frequency of regulatory CD3+CD8+CD28 CD25+ T lymphocytes in human peripheral blood increases with age. J Leukoc Biol 2008;84:1454-1461. (Pubitemid 352774480)
44. Booth NJ, McQuaid AJ, Sobande T, et al. Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J Immunol 2010;184:4317-4326.
45. Mandapathil M, Lang S, Gorelik E, Whiteside TL. Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J Immunol Methods 2009;346:55-63.
46. Appasamy PM. Biological and clinical implications of interleukin-7 and lymphopoiesis. Cytokines Cell Mol Ther 1999;5:25-39. (Pubitemid 29164357)
47. Hofmeister R, Khaled AR, Benbernou N, et al. Interleukin-7: physiological roles and mechanisms of action. Cytokine Growth Factor Rev 1999;10:41-60. (Pubitemid 29230851)
48. Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-1711. (Pubitemid 44036276)
49. Shevach EM. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006;25: 195-201. (Pubitemid 44224153)