A novel Rag2-/-γc-/--xenograft model of human CLL

Blood

Volumn 115, Issue 8, 2010, Pages 1605-1609

  Bertilaccio, Maria Teresa Sabrina ^a   Scielzo, Cristina ^a,b   Simonetti, Giorgia ^a,c   Ponzoni, Maurilio ^a   Apollonio, Benedetta ^a,d   Fazi, Claudia ^a   Scarfò, Lydia ^a,e   Rocchi, Martina ^a   Muzio, Marta ^a   Caligaris Cappio, Federico ^a,d   Ghia, Paolo ^a,d  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^e Unità Operativa di Medicina Interna Gerontologia e Geriatria   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RAG2 PROTEIN; DNA BINDING PROTEIN; RAG2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; CANCER CELL CULTURE; CELL TRANSPLANTATION; CHRONIC LYMPHATIC LEUKEMIA; CYTOTOXICITY; ENGRAFTMENT; IN VITRO STUDY; INOCULATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; DISEASE MODEL; HUMAN; MOUSE MUTANT; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 77949890578     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-05-223586     Document Type: Article

References (13)

1. Bichi R, Shinton SA, Martin ES, et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A. 2002;99(10):6955-6960. (Pubitemid 34526239)
2. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3(7):730-737. (Pubitemid 27298715)
3. Kondo A, Imada K, Hattori T, et al. A model of in vivo cell proliferation of adult T-cell leukemia. Blood. 1993;82(8):2501-2509.
4. Pearce DJ, Taussig D, Zibara K, et al. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood. 2006; 107(3):1166-1173. (Pubitemid 43156319)
5. Wang JC, Lapidot T, Cashman JD, et al. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood. 1998;91(7):2406-2414. (Pubitemid 28155515)
6. Pilarski LM, Seeberger K, Coupland RW, et al. Leukemic B cells clonally identical to myeloma plasma cells are myelomagenic in NOD/SCID mice. Exp Hematol. 2002;30(3):221-228. (Pubitemid 34203728)
7. Hummel JL, Lichty BD, Reis M, Dube I, Kamel-Reid S. Engraftment of human chronic lymphocytic leukemia cells in SCID mice: in vivo and in vitro studies. Leukemia. 1996;10(8):1370-1376. (Pubitemid 26261438)
8. Shimoni A, Marcus H, Dekel B, et al. Autologous T cells control B-chronic lymphocytic leukemia tumor progression in human3mouse radiation chimera. Cancer Res. 1999;59(23): 5968-5974. (Pubitemid 30004959)
9. Dürig J, Ebeling P, Grabellus F, et al. A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease. Cancer Res. 2007;67(18):8653-8661. (Pubitemid 47437441)
10. Stacchini A, Aragno M, Vallario A, et al. MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation. Leuk Res. 1999;23(2):127-136. (Pubitemid 29067556)
11. Johnson AJ, Lucas DM, Muthusamy N, et al. Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Blood. 2006; 108(4):1334-1338. (Pubitemid 44232033)
12. Loisel S, Ster KL, Quintin-Roue I, et al. Establishment of a novel human B-CLL-like xenograft model in nude mouse. Leuk Res. 2005;29(11): 1347-1352. (Pubitemid 41297648)
13. Caligaris-Cappio F, Ghia P. Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol. 2008;26(27):4497-4503.