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Volumn 118, Issue 13, 2011, Pages 3489-3498

Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; LENALIDOMIDE;

EID: 80053350801     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-03-339077     Document Type: Article
Times cited : (159)

References (45)
  • 2
    • 70350720141 scopus 로고    scopus 로고
    • First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia
    • Eichhorst BF, Busch R, Stilgenbauer S, et al. First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia. Blood. 2009;114(16):3382-3391.
    • (2009) Blood. , vol.114 , Issue.16 , pp. 3382-3391
    • Eichhorst, B.F.1    Busch, R.2    Stilgenbauer, S.3
  • 3
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25(35):5616-5623.
    • (2007) J Clin Oncol. , vol.25 , Issue.35 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 4
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-1174.
    • (2010) Lancet. , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 5
    • 34249092894 scopus 로고    scopus 로고
    • Treatment of patients with CLL 70 years old and older: A single center experience of 142 patients
    • Ferrajoli A, O'Brien S, Wierda WG, et al. Treatment of patients with CLL 70 years old and older: a single center experience of 142 patients. Leuk Lymphoma. 2005;46:48.
    • (2005) Leuk Lymphoma. , vol.46 , pp. 48
    • Ferrajoli, A.1    O'Brien, S.2    Wierda, W.G.3
  • 6
    • 59149090791 scopus 로고    scopus 로고
    • Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemia
    • Foon KA, Boyiadzis M, Land SR, et al. Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27(4):498-503.
    • (2009) J Clin Oncol. , vol.27 , Issue.4 , pp. 498-503
    • Foon, K.A.1    Boyiadzis, M.2    Land, S.R.3
  • 8
    • 61449135843 scopus 로고    scopus 로고
    • Treatment of elderly patients with chronic lymphocytic leukemia
    • Eichhorst B, Goede V, Hallek M. Treatment of elderly patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2009;50(2):171-178.
    • (2009) Leuk Lymphoma. , vol.50 , Issue.2 , pp. 171-178
    • Eichhorst, B.1    Goede, V.2    Hallek, M.3
  • 9
    • 75649140955 scopus 로고    scopus 로고
    • How I treat CLL up front
    • Gribben JG. How I treat CLL up front. Blood. 2010;115(2):187-197.
    • (2010) Blood , vol.115 , Issue.2 , pp. 187-197
    • Gribben, J.G.1
  • 11
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood. 2008;111(11):5291-5297.
    • (2008) Blood , vol.111 , Issue.11 , pp. 5291-5297
    • Ferrajoli, A.1    Lee, B.N.2    Schlette, E.J.3
  • 13
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood. 2001;98(1):210-216.
    • (2001) Blood , vol.98 , Issue.1 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3
  • 14
    • 69749090447 scopus 로고    scopus 로고
    • Treatment with lenalidomide has a positive immunomodulatory effect in patients with chronic lymphocytic leukemia
    • abstract. (ASH Annual Meeting Abstracts). Abstract 2107
    • Gao H, Ferrajoli A, Cohen EN, et al. Treatment with lenalidomide has a positive immunomodulatory effect in patients with chronic lymphocytic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts). 2008;112(11): Abstract 2107.
    • (2008) Blood , vol.112 , Issue.11
    • Gao, H.1    Ferrajoli, A.2    Cohen, E.N.3
  • 15
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87(12):4990-4997. (Pubitemid 26189840)
    • (1996) Blood , vol.87 , Issue.12 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6    Rai, K.R.7
  • 19
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008; 111(12):5446-5456.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 20
    • 0023092594 scopus 로고
    • A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
    • DOI 10.1016/0021-9681(87)90171-8
    • Charlson ME, Pompei P, Ales K, MacKenzie R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40(5):373-383. (Pubitemid 17055592)
    • (1987) Journal of Chronic Diseases , vol.40 , Issue.5 , pp. 373-383
    • Charlson, M.E.1    Pompei, P.2    Ales, K.A.3    MacKenzie, C.R.4
  • 21
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y, Perez-Galan P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2010;117(2):563-574.
    • (2010) Blood. , vol.117 , Issue.2 , pp. 563-574
    • Herishanu, Y.1    Perez-Galan, P.2    Liu, D.3
  • 22
    • 64049093376 scopus 로고    scopus 로고
    • High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
    • Burger JA, Quiroga MP, Hartmann E, et al. High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. Blood. 2009;113(13):3050- 3058.
    • (2009) Blood. , vol.113 , Issue.13 , pp. 3050-3058
    • Burger, J.A.1    Quiroga, M.P.2    Hartmann, E.3
  • 23
    • 79551629508 scopus 로고    scopus 로고
    • CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia
    • Sivina M, Hartmann E, Kipps TJ, et al. CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia. Blood. 2011;117(5):1662-1669.
    • (2011) Blood. , vol.117 , Issue.5 , pp. 1662-1669
    • Sivina, M.1    Hartmann, E.2    Kipps, T.J.3
  • 25
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000;343(24):1750-1757.
    • (2000) N Engl J Med. , vol.343 , Issue.24 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 26
    • 0345593600 scopus 로고    scopus 로고
    • 2-Chlorodeoxyadenosine (Cladribine) in the treatment of elderly patients with B-cell chronic lymphocytic leukemia
    • Robak T, Blasinska-Morawiec M, Blonski JZ, Dmoszynska A. 2-Chlorodeoxyadenosine (cladribine) in the treatment of elderly patients with B-cell chronic lymphocytic leukemia. Leuk Lymphoma. 1999;34(1):151-157. (Pubitemid 29248670)
    • (1999) Leukemia and Lymphoma , vol.34 , Issue.1-2 , pp. 151-157
    • Robak, T.1    Blasinska-Morawiec, M.2    Blonski, J.Z.3    Dmoszynska, A.4
  • 27
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27(26):4378-4384.
    • (2009) J Clin Oncol. , vol.27 , Issue.26 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 28
    • 38349124445 scopus 로고    scopus 로고
    • Should prophylactic granulocyte-colony stimulating factor be used in multiple myeloma patients developing neutropenia under lenalidomide-based therapy?
    • Mateos M-V, Garcia-Sanz R, Colado E, et al. Should prophylactic granulocyte-colony stimulating factor be used in multiple myeloma patients developing neutropenia under lenalidomide-based therapy? Br J Haematol. 2008;140(3):324-326.
    • (2008) Br J Haematol. , vol.140 , Issue.3 , pp. 324-326
    • Mateos, M.-V.1    Garcia-Sanz, R.2    Colado, E.3
  • 29
    • 79955515528 scopus 로고    scopus 로고
    • Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response
    • Chanan-Khan A, Miller KC, Lawrence D, et al. Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response. Cancer. 2011;117(10):2127-2135.
    • (2011) Cancer. , vol.117 , Issue.10 , pp. 2127-2135
    • Chanan-Khan, A.1    Miller, K.C.2    Lawrence, D.3
  • 30
    • 79952769640 scopus 로고    scopus 로고
    • Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia
    • Chen CI, Bergsagel PL, Paul H, et al. Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia. J Clin Oncol. 2011;29(13):1175-1181.
    • (2011) J Clin Oncol. , vol.29 , Issue.13 , pp. 1175-1181
    • Chen, C.I.1    Bergsagel, P.L.2    Paul, H.3
  • 32
    • 77950966887 scopus 로고    scopus 로고
    • Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinasedependent pathway
    • Lapalombella R, Andritsos L, Liu Q, et al. Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinasedependent pathway. Blood. 2010;115(13):2619-2629.
    • (2010) Blood. , vol.115 , Issue.13 , pp. 2619-2629
    • Lapalombella, R.1    Andritsos, L.2    Liu, Q.3
  • 34
    • 70349150560 scopus 로고    scopus 로고
    • Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia
    • Aue G, Njuguna N, Tian X, et al. Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia. Haematologica. 2009;94(9):1266-1273.
    • (2009) Haematologica. , vol.94 , Issue.9 , pp. 1266-1273
    • Aue, G.1    Njuguna, N.2    Tian, X.3
  • 35
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
    • Wu L, Adams M, Carter T, et al. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clin Cancer Res. 2008;14(14):4650-4657.
    • (2008) Clin Cancer Res. , vol.14 , Issue.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3
  • 36
    • 52549088421 scopus 로고    scopus 로고
    • Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation
    • Zhu D, Corral LG, Fleming YW, Stein B. Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation. Cancer Immunol Immunother. 2008;57(12):1849-1859.
    • (2008) Cancer Immunol Immunother. , vol.57 , Issue.12 , pp. 1849-1859
    • Zhu, D.1    Corral, L.G.2    Fleming, Y.W.3    Stein, B.4
  • 37
    • 19944430437 scopus 로고    scopus 로고
    • Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinical application
    • Hayashi T, Hideshima T, Akiyama M, et al. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application. Br J Haematol. 2005;128(2):192-203.
    • (2005) Br J Haematol. , vol.128 , Issue.2 , pp. 192-203
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 38
    • 80051928145 scopus 로고    scopus 로고
    • Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia
    • Lee B-N, Gao H, Cohen EN, et al. Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia Cancer. 2011;117(17): 3999-4008.
    • (2011) Cancer. , vol.117 , Issue.17 , pp. 3999-4008
    • Lee, B.-N.1    Gao, H.2    Cohen, E.N.3
  • 39
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009;114(16):3367-3375.
    • (2009) Blood. , vol.114 , Issue.16 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 40
    • 84880889762 scopus 로고    scopus 로고
    • Phosphoinositide 3 -kinase (PI3K) delta inhibition with CAL-101 blocks B-cell receptor (BCR) signaling andthe prosurvival actions of nurselike cells (NLC), inchronic lymphocytic leukemia
    • abstract. (ASH Annual Meeting Abstracts)
    • Hoellenriegel J, Meadows SA, Wierda WG, Keating MJ, Lannutti B, Burger JA. Phosphoinositide 3 -kinase (PI3K) delta inhibition with CAL-101 blocks B-cell receptor (BCR) signaling andthe prosurvival actions of nurselike cells (NLC), inchronic lymphocytic leukemia [abstract]. Blood(ASH Annual Meeting Abstracts). 2010;116(21):48.
    • (2010) Blood , vol.116 , Issue.21 , pp. 48
    • Hoellenriegel, J.1    Meadows, S.A.2    Wierda, W.G.3    Keating, M.J.4    Lannutti, B.5    Burger, J.A.6
  • 41
    • 78951478963 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase inhibitor PCI-32765 abrogates BCR- And nurse-like cell-derived activation of CLL cells in vitro and in vivo
    • abstract. (ASH Annual Meeting Abstracts)
    • Ponader S, Buggy J, O'Brien S, Wierda WG, Keating M, Burger JA. Bruton's tyrosine kinase inhibitor PCI-32765 abrogates BCR- and nurse-like cell-derived activation of CLL cells in vitro and in vivo [abstract]. Blood (ASH Annual Meeting Abstracts). 2010;116(21):45.
    • (2010) Blood , vol.116 , Issue.21 , pp. 45
    • Ponader, S.1    Buggy, J.2    O'Brien, S.3    Wierda, W.G.4    Keating, M.5    Burger, J.A.6
  • 42
    • 79955769865 scopus 로고    scopus 로고
    • The combination of lenalidomide and rituximab induces complete and partial responses in patients with relapsed and refractory chronic lymphocytic leukemia
    • abstract. (ASH Annual Meeting Abstracts)
    • Ferrajoli A, Badoux X, O'Brien S, et al. The combination of lenalidomide and rituximab induces complete and partial responses in patients with relapsed and refractory chronic lymphocytic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts). 2010;116(21):1395.
    • (2010) Blood , vol.116 , Issue.21 , pp. 1395
    • Ferrajoli, A.1    Badoux, X.2    O'Brien, S.3
  • 43
    • 67649405806 scopus 로고    scopus 로고
    • The THRIL (thalidomide [Th], rituximab [R], and lenalidomide [L]) regimen for chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma: Daily alternating IMiDs and rituximab maintenance
    • Coleman M, Martin P, Ruan J, et al. The THRIL (thalidomide [Th], rituximab [R], and lenalidomide [L]) regimen for chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma: daily alternating IMiDs and rituximab maintenance. ASCO Meeting Abstracts. 2008; 26(15 suppl):7079.
    • (2008) ASCO Meeting Abstracts , vol.26 , Issue.15 SUPPL. , pp. 7079
    • Coleman, M.1    Martin, P.2    Ruan, J.3
  • 44
    • 77956218553 scopus 로고    scopus 로고
    • The REVLIRIT CLL5 AGMT Study: A phase I/II trial combining fludarabine/rituximab with escalating doses of lenalidomide followed by rituximab/lenalidomide in untreated chronic lymphocytic leukemia (CLL). Results of a Planned Interim Analysis
    • abstract. (ASH Annual Meeting Abstracts)
    • Egle A, Steurer M, Melchardt T, Stoll M, Greil R. The REVLIRIT CLL5 AGMT Study: a phase I/II trial combining fludarabine/rituximab with escalating doses of lenalidomide followed by rituximab/lenalidomide in untreated chronic lymphocytic leukemia (CLL). Results of a Planned Interim Analysis [abstract]. Blood (ASH Annual Meeting Abstracts). 2009;114(22):3453.
    • (2009) Blood , vol.114 , Issue.22 , pp. 3453
    • Egle, A.1    Steurer, M.2    Melchardt, T.3    Stoll, M.4    Greil, R.5
  • 45
    • 80053381873 scopus 로고    scopus 로고
    • Lenalidomide and rituximab for the initial treatment of chronic lymphocytic leukemia: Report of an ongoing study
    • abstract.
    • James DF, Brown JR, Werner L, et al. Lenalidomide and rituximab for the initial treatment of chronic lymphocytic leukemia: report of an ongoing study [abstract]. ASCO Meeting Abstracts. 2010;28(15 suppl):6583.
    • (2010) ASCO Meeting Abstracts , vol.28 , Issue.15 SUPPL. , pp. 6583
    • James, D.F.1    Brown, J.R.2    Werner, L.3


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