메뉴 건너뛰기




Volumn 120, Issue 17, 2012, Pages 3501-3509

Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BH3 PROTEIN; IDELALISIB; IMMUNOGLOBULIN M; STROMAL CELL DERIVED FACTOR 1;

EID: 84868013848     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-02-414060     Document Type: Article
Times cited : (106)

References (28)
  • 2
    • 79952093131 scopus 로고    scopus 로고
    • Update on therapy of chronic lymphocytic leukemia
    • Gribben JG, O'Brien S. Update on therapy of chronic lymphocytic leukemia. J Clin Oncol. 2011; 29(5):544-550.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 544-550
    • Gribben, J.G.1    O'Brien, S.2
  • 4
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y, Perez-Galan P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117(2):563-574.
    • (2011) Blood , vol.117 , Issue.2 , pp. 563-574
    • Herishanu, Y.1    Perez-Galan, P.2    Liu, D.3
  • 5
    • 42549133659 scopus 로고    scopus 로고
    • Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia
    • Chen J, McMillan NA. Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia. Cancer Biol Ther. 2008;7(2): 174-179. (Pubitemid 351590419)
    • (2008) Cancer Biology and Therapy , vol.7 , Issue.2 , pp. 174-179
    • Chen, J.1    McMillan, N.A.J.2
  • 6
    • 33845994359 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
    • DOI 10.1172/JCI28281
    • Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest. 2007;117(1):112-121. (Pubitemid 46048458)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 112-121
    • Moore, V.D.G.1    Brown, J.R.2    Certo, M.3    Love, T.M.4    Novina, C.D.5    Letai, A.6
  • 7
    • 33646354381 scopus 로고    scopus 로고
    • Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    • DOI 10.1016/j.ccr.2006.03.027, PII S1535610806001139
    • Certo M, Del Gaizo Moore V, Nishino M, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006;9(5):351-365. (Pubitemid 43668734)
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 351-365
    • Certo, M.1    Moore, V.D.G.2    Nishino, M.3    Wei, G.4    Korsmeyer, S.5    Armstrong, S.A.6    Letai, A.7
  • 8
    • 77955616572 scopus 로고    scopus 로고
    • Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes
    • Ryan JA, Brunelle JK, Letai A. Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes. Proc Natl Acad Sci U S A. 2010;107(29):12895-12900.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.29 , pp. 12895-12900
    • Ryan, J.A.1    Brunelle, J.K.2    Letai, A.3
  • 9
    • 82255192310 scopus 로고    scopus 로고
    • Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
    • Ni Chonghaile T, Sarosiek KA, Vo TT, et al. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science. 2011;334(6059):1129-1133.
    • (2011) Science , vol.334 , Issue.6059 , pp. 1129-1133
    • Ni Chonghaile, T.1    Sarosiek, K.A.2    Vo, T.T.3
  • 10
    • 73349126115 scopus 로고    scopus 로고
    • Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: Development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
    • Kurtova AV, Balakrishnan K, Chen R, et al. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood. 2009;114(20):4441-4450.
    • (2009) Blood , vol.114 , Issue.20 , pp. 4441-4450
    • Kurtova, A.V.1    Balakrishnan, K.2    Chen, R.3
  • 11
    • 66149147044 scopus 로고    scopus 로고
    • Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
    • Vogler M, Butterworth M, Majid A, et al. Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood. 2009;113(18):4403-4413.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4403-4413
    • Vogler, M.1    Butterworth, M.2    Majid, A.3
  • 12
    • 77957201023 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078-2088.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2078-2088
    • Herman, S.E.1    Gordon, A.L.2    Wagner, A.J.3
  • 13
    • 78751553221 scopus 로고    scopus 로고
    • CAL- 101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • Lannutti BJ, Meadows SA, Herman SE, et al. CAL- 101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2011;117(2):591-594.
    • (2011) Blood , vol.117 , Issue.2 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Herman, S.E.3
  • 14
    • 79953655788 scopus 로고    scopus 로고
    • CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
    • abstract. (ASH Annual Meeting Abstracts)
    • Furman RR, Byrd JC, Brown JR, et al. CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts). 2010;116(21):55.
    • (2010) Blood , vol.116 , Issue.21 , pp. 55
    • Furman, R.R.1    Byrd, J.C.2    Brown, J.R.3
  • 15
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3 -kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel J, Meadows SA, Sivina M, et al. The phosphoinositide 3 -kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood. 2011;118(13):3603- 3612.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3
  • 16
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute- Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute- Working Group 1996 guidelines. Blood. 2008; 111(12):5446-5456.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 18
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger JA, Tsukada N, Burger M, Zvaifler NJ, Dell'Aquila M, Kipps TJ. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood. 2000;96(8):2655-2663.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3    Zvaifler, N.J.4    Dell'Aquila, M.5    Kipps, T.J.6
  • 19
    • 1442282234 scopus 로고    scopus 로고
    • Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
    • Ghobrial IM, Bone ND, Stenson MJ, et al. Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. Mayo Clin Proc. 2004;79(3):318-325. (Pubitemid 38269234)
    • (2004) Mayo Clinic Proceedings , vol.79 , Issue.3 , pp. 318-325
    • Ghobrial, I.M.1    Bone, N.D.2    Stenson, M.J.3    Novak, A.4    Hedin, K.E.5    Kay, N.E.6    Ansell, S.M.7
  • 21
    • 0033485625 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
    • Burger JA, Burger M, Kipps TJ. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood. 1999;94(11):3658-3667.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3658-3667
    • Burger, J.A.1    Burger, M.2    Kipps, T.J.3
  • 22
    • 84863116430 scopus 로고    scopus 로고
    • Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase i study of Navitoclax in patients with relapsed or refractory disease
    • Roberts AW, Seymour JF, Brown JR, et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of Navitoclax in patients with relapsed or refractory disease. J Clin Oncol. 2012;30(5):488-496.
    • (2012) J Clin Oncol , vol.30 , Issue.5 , pp. 488-496
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3
  • 23
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848-1854. (Pubitemid 29430400)
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 24
    • 0037306842 scopus 로고    scopus 로고
    • H gene mutational status and CD38 expression in chronic lymphocytic leukemia
    • DOI 10.1182/blood-2002-06-1822
    • Lanham S, Hamblin T, Oscier D, Ibbotson R, Stevenson F, Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood. 2003;101(3):1087-1093. (Pubitemid 36139383)
    • (2003) Blood , vol.101 , Issue.3 , pp. 1087-1093
    • Lanham, S.1    Hamblin, T.2    Oscier, D.3    Ibbotson, R.4    Stevenson, F.5    Packham, G.6
  • 25
    • 41349120731 scopus 로고    scopus 로고
    • Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia
    • DOI 10.1182/blood-2007-05-092759
    • Roos G, Krober A, Grabowski P, et al. Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood. 2008; 111(4):2246-2252. (Pubitemid 351451432)
    • (2008) Blood , vol.111 , Issue.4 , pp. 2246-2252
    • Roos, G.1    Krober, A.2    Grabowski, P.3    Kienle, D.4    Buhler, A.5    Dohner, H.6    Rosenquist, R.7    Stilgenbauer, S.8
  • 26
    • 79955846227 scopus 로고    scopus 로고
    • IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells
    • Coscia M, Pantaleoni F, Riganti C, et al. IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells. Leukemia. 2011;25(5):828-837.
    • (2011) Leukemia , vol.25 , Issue.5 , pp. 828-837
    • Coscia, M.1    Pantaleoni, F.2    Riganti, C.3
  • 27
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-1174.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 28
    • 84857497433 scopus 로고    scopus 로고
    • Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia
    • Paterson A, Mockridge CI, Adams JE, et al. Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia. Blood. 2012;119(7):1726-1736.
    • (2012) Blood , vol.119 , Issue.7 , pp. 1726-1736
    • Paterson, A.1    Mockridge, C.I.2    Adams, J.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.