Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia

Leukemia and Lymphoma

Volumn 22, Issue 1-2, 1996, Pages 83-90

  Reittie, Joyce E ^a   Yong, Kwee L ^a   Panayiotidis, Panayiotis ^a   Hoffbrand, A Victor ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Cell proliferation; Cell survival; DNA synthesis; IL 6; TNF

Indexed keywords

CYTOKINE; DNA; INTERLEUKIN 6; MONOCLONAL ANTIBODY; TRITIUM; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CANCER STAGING; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; LEUKEMIA CELL; MALE; PRIORITY JOURNAL; PROTEIN SECRETION;

EID: 0029937459     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609051732     Document Type: Article

References (21)

1. Rieckmann, P., D'alessandro, F., Nordan, R., Fauci, A. S. and Kehrl, J. H., (1991) IL-6 and tumor necrosis factor-α Autocrine and paracrine cytokines involved B cell function. J. Immunol., 146, 3462-3468.
2. Akira, S., Hirano, T., Taga, T. and Kishimoto, J., (1990) Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). Faseb, J., 4, 2860-2867.
3. Elias, J. A. and Lenz, V. (1990) IL-1 and tumour necrosis factor synergistically stimulate fibroblast IL-6 production and stabilise IL-6 messenger RNA. J. Immunol., 145, 161-166.
4. Cordingley, F. T., Hoffbrand, A. V., Heslop, H. E., Turner, M., Bianchi, A., Reittie, J. E., Vyakarnam, a., Meager, A. and Brenner, M. K. (1988) Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies. Lancet, i, 969-971.
5. Schiller, J. H., Bittner, G. and Spriggs, D. R. (1992) Tumour necrosis factor but not other haemopoietic growth factors, prolongs the survival of hairy cell leukaemia cells. Leukaemia Researh. 16, 337-346.
6. Heslop, H. E., Bianchi, A. C. M., Cordingley, F. T., Turner, M., De mel, C. P., Hoffbrand, A. V. and Brenner, M. K. (1990) Effects of interferon-α on autocrine growth factor loops in B lymphoprolifer-ative disorders. J. Exp. Med., 172, 1729-1734.
7. Foa, R., Guarini, A., diCelle, F.,Trentin, L.,Tos, A. G., Bellone, G., Carbone, A., Attisano, C., Massais, M., Raspadari, D., Pizzolo, G., Chisesi, T. and Semenzato, L. F. (1992) Constitutive production of tumour necrosis factor -alpha in hairy cell leukaemia: Possible role in the pathogenesis of the cytopenias and effect of treatment with interferon-alpha. J. Clin. Oncol., 10, 954-959.
8. Kawano, M., Hirano, T., Matsuda, T., Horii, Y., Iwato, J., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., Kuramoto, A. and Kishimoto, T. (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature, 332, 83-85.
9. Klein, B., Zhang, X. g., Jourdan, M. (1989) Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood, 73, 517-522.
10. Biondi, A., Rossi, V., Bassan, R., Barbui, T., Bettoni, S., Sironi, M., Mantovani, A. and Rambaldi, A., (1989) Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukaemia. Blood73, 1279-1284.
11. Digel, W., Stefanic, M., Schoniger, W., Buck, C., Raghavanachar, A., Frickhofen, N., Heimpel, H., Porzsolt, F. (1989) Tumour necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leukaemia. Blood 73, 1242-1246.
12. Ghaderi, A. A., Richardson, P., Cardona, C., Millsum, M. J., Ling, N., Gillis, S., Ledbetter, J. and Gordon, J. (1988) Stimulation of B-chronic lymphocytic leukaemia populations by recombinant interleukin-4 and other defined growth-promoting agents. Leukaemia, 2, 165-170.
13. Adera, D., Maor, Y., Novick, D., Engelmann, H., Kahn, Y., Wallach, D. and Revel, M. (1993) Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukaemia cells that is induced by tumor necrosis factor-α or β. Blood 81, 2076-2084.
14. Sarfati, M., Foumier, S., Christoffersen, M. and Biron, G. (1990) Expression of CD23 antigen and its regulation by IL-4 in chronic lymphocytic leukaemia. Leukaemia Research 14, 47-55.
15. Campana, D. and Janossy, G., (1986) leukaemia diagnosis and testing of complement-fixing antibodies for bone marrow purging in acute lymphoid leukaemia. Blood 68, 1264-1268.
16. Drexler, H. G., Brenner, M. K., Coustan-smith, E., Gignac, S. M. and Hoffbrand, A. V. 1988. Analysis of signal transduction in B chronic lymphocytic leukaemia cells. Blood 71, 1461-1469.
17. Panayiotidis, P., Ganeshaguru, K., Jabbar, S. A. B., and Hoffbrand, A. V. (1993) Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro. British J. Haem., 83, 439-42.
18. Van Kooten, C., Rensink, I., Aarden, L. and van Oers, R. (1993) Effect of II-4 and IL-6 on the proliferation and differentiation of B-chronic lymphocytic leukaemia cells. Leukaemia 7, 618-624.
19. Trentin, L., Zambello, R., Agostini, C., Siviero, F., Adami, F., Marcolongo, R., Raimondi, R., Chisesi, T., Pizzolo, G. and Semenzato, G. (1993) Expression and functional role of tumor necrosis factor receptors on leukaemic cells from patients with type B chronic lymphoproliferative disorders. Blood, 81, 752-158.
20. Gehr, G., Gentz, R., Brockhaus, M., Loetscher, H. and Lesslauer, W. (1992) Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation. J. of Immunology, 149, 911-917.
21. Tartaglia, L. A. and Goeffel, D. V. (1992) Two TNF receptors. Immunology Today, 13, 151-15.