Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cells

Molecular Medicine

Volumn 17, Issue 7-8, 2011, Pages 619-627

  Gehrke, Iris ^a   Gandhirajan, Rajesh Kumar ^a   Poll Wolbeck, Simon Jonas ^a   Hallek, Michael ^a   Kreuzer, Karl Anton ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL INTERFERING RNA; VASCULOTROPIN;

ANTIBODY DETECTION; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STROMA CELL;

ANTIBODIES, MONOCLONAL; APOPTOSIS; BONE MARROW CELLS; BREFELDIN A; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; RNA INTERFERENCE; STROMAL CELLS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 79960735663     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2010.00210     Document Type: Article

References (32)

1. Keating MJ. (1999) Chronic lymphocytic leukemia. Semin. Oncol. 26:107-114.
2. Reed JC. (1998) Molecular biology of chronic lymphocytic leukemia. Semin Oncol. 25:11-8.
3. Meinhardt G, Wendtner CM, Hallek M. (1999) Molecular pathogenesis of chronic lymphocytic leukemia: factors and signalling pathways regulating cell growth and survival. J. Mol. Med. 77:282-293.
4. Ferrara N, Gerber HP, LeCouter J. (2003) The biology of VEGF and its receptors. Nat. Med. 9:669-676.
5. Bairey O, et al. (2004) All three receptors for vascular endothelial growth factor (VEGF) are expressed on B-chronic lymphocytic leukemia (CLL) cells. Leuk. Res. 28:243-248.
6. Molica S, Vitelli G, Levato D, Gandolfo GM, Liso V. (1999) Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia. Br. J. Haematol. 107:605-610.
7. Gora-Tybor J, Blonski JZ, Robak T. (2001) Circulating vascular endothelial growth factor (VEGF) and its soluble receptors in patients with chronic lymphocytic leukemia. Eur. Cytokine Netw. 16:41-46.
8. Ferrajoli A, et al. (2001) High levels of vascular endothelial growth factor receptor-2 correlate with shortened survival in chronic lymphocytic leukemia. Clin. Cancer Res. 7:795-799.
9. Kini AR, Kay NE, Peterson LC. (2000) Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia. Leukemia. 14:1414-1418.
10. Gerber HP, et al. (2002) VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature. 417:954-958.
11. Masood R, et al. (2001) Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood. 98:1904-1913.
12. Lee YK, et al. (2004) VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia. Blood. 104:788-794.
13. Wang L, Coad JE, Fortney JM, Gibson LF. (2005) VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation. Leukemia. 19:1486-1487.
14. Paesler J, et al. (2010) The VEGF receptor tyrosine kinase inhibitors vatalanib and pazopanib potently induce apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo. Clin. Can. Res. 16:3390-3398.
15. Lee YK, et al. (2005) VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance. Leukemia. 19:513-523.
16. Farahani M, et al. (2005) Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells. Leukemia. 19:524-530.
17. Collins RJ, et al. (1989) Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro. Br. J. Haematol. 71:343-350.
18. Burger JA, Kipps TJ. (2002) Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells. Leuk. Lymphoma. 43:461-6.
19. Caligaris-Cappio F. (2003) Role of the microenvironment in chronic lymphocytic leukaemia. Br. J. Haematol. 123:380-388.
20. Rozman C, Montserrat E. (1995) Chronic lymphocytic leukemia. N. Engl. J. Med. 333:1052-7.
21. Pedersen-Munk I, Reed J. (2004) Microenvironmental interactions and survival of CLL B-cells. Leukemia Lymphoma. 45:2365-2372.
22. Chilosi M, et al. (1985) Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia. Cancer. 56:328-332.
23. Jewell AP, Yong KL. (1997) Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukaemia. Acta. Haematol. 97:67-72.
24. Ghia P, Caligaris-Cappio F. (2000) The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms. Adv. Cancer Res. 79:157-173.
25. Cheson BD, et al. (1996) National Cancer Institute- sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 87:4990-4997.
26. Di Fiore PP, De Camilli P. (2001) Endocytosis and signaling. an inseparable partnership. Cell. 13;106(1):1-4.
27. Kay NE, et al. (2006) Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch." Leuk. Res. 31:899-906.
28. Lagneaux L, Delforge A, Bron D, De BC, Stryckmans P. (1998) Chronic lymphocytic leukemic B cells, but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood. 91:2387-2396.
29. Seiffert M, Stilgenbauer S, Dohner H, Lichter P. (2007) Efficient nucleofection of primary human B cells and B-CLL cells induces apoptosis, which depends on the microenvironment and on the structure of transfected nucleic acids. Leukemia. 21:1977-1983.
30. Panayiotidis P, Jones D, Ganeshaguru K, Foroni L, Hoffbrand AV. (1996) Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br. J. Haematol. 92:97-103.
31. Ghosh AK, et al. (2010) Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression. Blood. 115:1755-1764.
32. Ghia P, et al. (2002) Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur. J. Immunol. 32:1403-1413.