Allosteric modulation of Ca 2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals

Journal of Biological Chemistry

Volumn 287, Issue 10, 2012, Pages 7594-7602

  Samways, Damien S K ^a,c   Khakhs, Baljit S ^b   Egan, Terrance M ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CLARKSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC AMINO ACIDS; ALLOSTERIC MODULATION; CATION CHANNELS; CELL SURFACE MEMBRANE; CHANNEL GATING; ION CHANNEL; ION CONDUCTION; IVERMECTIN; MACROCYCLIC LACTONES; MICROGLIA; NEGATIVE CHARGE; NEUROPATHIC PAIN; P2X RECEPTORS; SIGNALING PATHWAYS; TRANS-MEMBRANE PORES;

AMINO ACIDS; CELL MEMBRANES;

CALCIUM;

ADENOSINE TRIPHOSPHATE; CALCIUM ION; GLUTAMIC ACID; IVERMECTIN; LACTONE; PURINERGIC P2X4 RECEPTOR; RECOMBINANT PROTEIN; TRYPTOPHAN; ANTIPARASITIC AGENT; CALCIUM; NERVE PROTEIN;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CONTROLLED STUDY; DOWN REGULATION; EVOKED RESPONSE; INTRACELLULAR SIGNALING; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; SITE DIRECTED MUTAGENESIS; AMINO ACID SUBSTITUTION; CELL LINE; DRUG EFFECT; GENETICS; HUMAN; ION TRANSPORT; METABOLISM; MISSENSE MUTATION; NEURALGIA; PATHOLOGY; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; ANTIPARASITIC AGENTS; CALCIUM; CELL LINE, TRANSFORMED; HUMANS; ION CHANNEL GATING; ION TRANSPORT; IVERMECTIN; MICROGLIA; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; NEURALGIA; RECEPTORS, PURINERGIC P2X4; SIGNAL TRANSDUCTION;

EID: 84857718067     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.322461     Document Type: Article

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