Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 11, 2012, Pages 4140-4145

  Du, Juan ^a   Dong, Hao ^a   Zhou, Huan Xiang ^a  

^a Florida State University   (United States)

Author keywords

Antagonist design; ATP binding mode; Channel activation mechanism; Ligand gated ion channels

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYSTEINE; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X4 RECEPTOR;

ARTICLE; BINDING SITE; CHANNEL GATING; CRYSTAL STRUCTURE; DESENSITIZATION; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; VESTIBULE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CYSTEINE; ION CHANNEL GATING; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MOTION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PURINERGIC P2X4; REPRODUCIBILITY OF RESULTS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84863249245     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119546109     Document Type: Article

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